Clinical transplantation immunology. Medical search. Frequent questions

We tested this novel hypothesis in over 6,000 HCT from 8/8 HLA-matched UD reported to the European Group for Blood and Marrow Transplantation (EBMT), to demonstrate that HLA-DPB1 non-TPHE mismatches were associated with worse relapse-free survival and overall survival than TPHE mismatches, present in 21.7% of single HLA-DPB1 disparate pairs. (haematologica.org)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)

Ye is a Professor of Autoimmune liver diseases and Translational Hepatology at the Institute of Immunology and Immunotherapy, University of Birmingham and Consultant Hepatologist at the Queen Elizabeth Hospital where he specialises in the management of autoimmune liver diseases, immune mediated liver injury and liver transplantation. (birmingham.ac.uk)
My expertise extends to immunotherapy and transplantation immunology. (fredhutch.org)

Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
Transplantation Laboratory has been organising Principles of organ transplantation course every other year from 2005 onwards for medical students, nurses, and registrars. (helsinki.fi)
Find here the program of the Principles of organ transplantation 2016 course in Finnish. (helsinki.fi)
Renkonen R, Lemström K, Mäkisalo H. Organ and tissue transplantation, In the textbook of Immunology: microbiology, immunology, and infectious diseases (In Finnish: Elin- ja kudossiirrot, Immunologia: mikrobiologia, immunologia ja infektiosairaudet). (helsinki.fi)
1. To provide an overview of and introduction to transplantation sciences in the context of solid organ and cell transplants. (ncl.ac.uk)
Kidney transplantation is the most common type of solid organ transplantation. (msdmanuals.com)
When after an ischemic event reperfusion is induced, which happens for instance during organ transplantation or resuscitation after cardiac arrest, this reperfusion can paradoxically cause additional damage to the affected tissue. (tu-dresden.de)
The consortium brings together six partners with highly complementary expertise in (oxi-)lipidomics, bioinformatics, drug discovery, immunology, organ transplantation, pre-clinical and clinical research in a highly interdisciplinary approach. (tu-dresden.de)
Transplantation is the most effective treatment for end-stage organ failure, but organ survival is limited by immune rejection and the side effects of immunosuppressive regimens. (lu.se)
In the study, part of the NIH-funded Clinical Trials in Organ Transplantation (CTOT), investigators at five clinical sites collected urine samples from 485 kidney transplant recipients from three days to approximately one year after transplantation. (healthnewstrack.com)
Organ and tissue transplantation in the European union : management of difficulties and health risks linked to donors / edited by Yvon Englert. (who.int)
Legislative responses to organ transplantation / edited by World Health Organization. (who.int)
BACKGROUND: Defining the clinical relevance of donor-specific HLA-antibodies detected by single-antigen flow-beads (SAFB) is important because these assays are increasingly used for pretransplant risk assessment and organ allocation. (unibas.ch)

On reflection of the worldwide transplants, Stinson stated Many centers took up clinical transplantation without the laboratory experience or profound support in clinically related areas such as immunosuppression. (wikipedia.org)
In 2006 he obtained Medical Research Council clinical research training fellowship to undertake a PhD in the laboratory of Professor David Adams at the University of Birmingham. (birmingham.ac.uk)
We are pleased to announce that as of November 1, 2021, Dr. Imir Metushi has joined the Division of Laboratory Medicine as an HS Clinical Assistant Professor. (uclahealth.org)
Prior to joining UCLA, Dr. Metushi was the Laboratory Director of Clinical Chemistry at Endocrine Sciences in Calabasas, California. (uclahealth.org)
I went on postdoctoral training in Dr. Timothy Ley's laboratory at Washington University where I developed mouse models to study cancer immunology. (umaryland.edu)
I joined Roswell Park Cancer Institute as an assistant professor in 2008 and since established an independent laboratory that explores T cell biology using tumor and transplantation models. (umaryland.edu)
Clinical immunology and research cover the fragment of diagnostic techniques used for research survey such as novel immunological methods, clinical laboratory immunology, clinical illustration, immunologic evaluation and diagnostic approach. (scitechnol.com)
Journal of Laboratory & Clinical Medicine 68 (3): 484-93. (cdc.gov)

The David Geffen School of Medicine is pleased to announce that Dr. Gay Crooks has accepted the position of director of the Immunology, Inflammation, Infection and Transplantation (I3T) Research Theme. (uclahealth.org)
The treatment markedly improved clinical and hemodynamic parameters and decreased blood plasma markers of vascular fibrosis, injury and inflammation. (nature.com)

Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Chapters in this book present current challenges in the use of bone allografts in complex orthopedic procedures, in addition to dealing in depth with the use of hepatic and renal allografts in liver and kidney transplantation. (novapublishers.com)
His team will collaborate on articles focused on liver and kidney transplantation on Medscape. (medscape.com)

We have focused on studying T cells in the setting of allogeneic hematopoietic cell transplantation (allo-HCT). (umaryland.edu)
Relapse and graft- versus -host disease (GvHD) are the main impediments to the clinical success of allogeneic hematopoietic cell transplantation (HCT) in curing malignant blood disorders. (haematologica.org)
The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)

Dr. Krensky's research interests are in human cellular and molecular immunology, transplantation immunology, and tumor immunology. (nih.gov)
The scientific interests of my lab have been directed towards understanding the complexities of T cell biology and how T cells contribute to tumor immunity and transplantation immunity. (umaryland.edu)

Genetic modification of hematopoietic stem cells with genes that inhibit replication of human immunodeficiency virus-1 (HIV-1) could lead to development of T lymphocytes and monocytic cells resistant to HIV-1 infection after transplantation. (nih.gov)
However, infection can persist for years, and infected persons can remain at risk for developing clinical TB, especially if the immune system becomes impaired. (cdc.gov)

Following work as a post-doctoral associate at the La Jolla Institute for Allergy and Immunology in San Diego, he completed a post-doctoral fellowship in clinical chemistry at the University of California, San Diego. (uclahealth.org)

[ 3 ] Seemingly impossible without genetic identity, the field of transplantation was left silent for another 20 years. (medscape.com)
Long-term transplant acceptance in the absence of immunosuppressive therapy remains the ultimate goal in the field of transplantation and many studies are exploring potential therapies. (lu.se)

I moved to UMB in October 2017 as an associate professor in Microbiology and Immunology. (umaryland.edu)

At the Stanford University School of Medicine, Dr. Krensky most recently served as professor of pediatrics, Chief of the Division of Immunology and Transplantation Biology, Associate Chair for Research in the Department of Pediatrics, and Associate Dean for Children's Health. (nih.gov)

Pancreas Transplantation Pancreas transplantation is a form of pancreatic beta-cell replacement that can restore normoglycemia in diabetic patients. (msdmanuals.com)
Dr. Kulkarni specializes in liver transplantation, kidney transplantation, pancreas transplantation and laparopscopic living donor nephrectomy. (medscape.com)

Nonetheless, immune tolerance remains the holy grail of transplantation immunology and clinical transplantation. (medscape.com)
1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression. (ncl.ac.uk)
Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD. (cdc.gov)
After transplantation the immune response is activated and the body tries to reject the transplanted tissue. (ki.se)
with careful selection of donors and recipients and with pretransplant treatment (plasma exchange and/or IV immune globulins [IVIG]), outcomes can be comparable to those of ABO-compatible transplantation. (msdmanuals.com)
Journal of Clinical Immunology and Research is a full length quality article describing the state of the art diagnostic and therapeutic care of patients with immune mediated disease and provides insights into high level investigative research on clinical description, pathogenesis, diagnosis approach, genetic and functional mechanisms, immunologic assessment and prognosis and treatment intervention. (scitechnol.com)
Immune therapy act as suppressor so, it is also called as suppressor immunology therapy. (scitechnol.com)
Sen heads the Unit on Clinical and Translational Studies where her research aims to characterize critical inflammatory and metabolic pathways in uveitis and other immune-mediated eye diseases with the goal of identifying candidate biomarkers and novel mechanistic targets for therapeutic intervention. (nih.gov)
I was brought up to be a specialist in a lot of different things, but it was really immunology (the study of how the immune system functions) that grabbed on to my imagination. (fredhutch.org)

3. To highlight the research areas in transplantation where applications of immunology, cell biology and novel technologies are impacting on clinical outcome and patient wellbeing. (ncl.ac.uk)
Cellular and molecular research into the interactions of bacteria and human beings occupies the boundaries between bacteriology, cell biology and immunology. (ki.se)

Omicron is therefore much less sensitive to the anti-SARS-CoV-2 antibodies currently used in clinical practice or obtained after two vaccine doses. (pasteur.fr)
The scientists began by testing nine monoclonal antibodies used in clinical practice or currently in preclinical development. (pasteur.fr)
The authors present the therapeutic problems seen in clinical practice and offer possible solutions, based on their extensive experience. (novapublishers.com)

To establish and announce the NIAID Policy for Extension of Investigator-Initiated Clinical Trials (type 4) and simplify the process for submission and review of applications requesting administrative extension of investigator-initiated clinical trial grants and cooperative agreements. (nih.gov)
In 2005, NIAID announced a new policy for investigator-initiated clinical trials that put in place a two-part application and award process (see https://grants.nih.gov/grants/guide/notice-files/NOT-AI-05-021.html ). (nih.gov)
Because the initial peer review addressed all aspects of the trial, the research plan through trial completion, NIAID has established a streamlined, noncompetitive process, the NIAID Policy for Extension of Clinical Trials, to provide funds to complete ongoing trials that meet specific criteria. (nih.gov)
Only awardees of NIAID investigator-initiated clinical trials will be considered for extension awards. (nih.gov)
His team develop and deliver translational GMP Regulatory T clinical trials in autoimmune liver diseases. (birmingham.ac.uk)
For low risk clinical trials, NIAID will utilize the two NIH Clinical Trial FOAs, PA-18-345 and PA-18-344 , that invite applications for NIH Research Project Grant (Parent R01 Clinical Trials Required) and NIH Research Project Grant (Parent R21 Clinical Trial Required) respectively. (nih.gov)
The BNT162b2 vaccine is highly effective at protecting against COVID-19 hospitalization and death, with efficacies of 90-95% reported in phase 3 clinical trials 9 and confirmed in large-scale real-life studies 10 . (nature.com)
I divide my time between caring for patients - about five months out of the year - and conducting clinical trials, up to four or five at a time. (fredhutch.org)
We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. (fredhutch.org)
The NIAID Partnership for Access to Clinical Trials (PACT) is a collaboration in the Washington, D.C., metropolitan area that connects health care providers and their patients with researchers at NIAID who are conducting clinical trials at the NIH Clinical Center in Bethesda, Maryland. (nih.gov)
The primary goal of the collaboration is to increase access to research by people who may be underrepresented in clinical trials. (nih.gov)
Order or download materials available at no cost to patients, family members, and healthcare professionals who want to learn more about infectious diseases and NIAID clinical trials. (nih.gov)
The NIAID PACT team can answer questions and facilitate entry into many clinical trials. (nih.gov)

Simpson E, 2015, Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) 'Quantitative studies on tissue transplantation immunity. (imperial.ac.uk)

Edward B. Stinson (born 1938) is an American retired cardiothoracic surgeon living in Los Altos, United States, who assisted Norman Shumway in America's first adult human-to-human heart transplantation on 6 January 1968 at Stanford University. (wikipedia.org)
For over twenty years, Stinson was the principal investigator for the National Institutes of Health programme project in heart transplantation at Stanford. (wikipedia.org)
As staff associate, he was responsible for both clinical activity in cardiac surgery in the Clinic of Surgery of the National Heart Lung and Blood Institute and for intramural research programs addressing cardiac physiology and heart transplantation. (wikipedia.org)
In late 1980, he was part of the team that first introduced the anti-rejection drug cyclosporine for heart transplantation. (wikipedia.org)
Lemström K, Lommi J. Heart failure - surgical treatment and heart transplantation. (helsinki.fi)
Lemström K. Heart transplantation and mechanical circulatory support and lung and heart-lung transplantation. (helsinki.fi)

In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)

He is a member of the American Society for Clinical Investigation and the Association of American Physicians and is a co-author of more than 240 research papers. (nih.gov)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
1 Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA. (nih.gov)
The RNCP, along with the Division of Allergy, Immunology, and Transplantation (DAIT) Office of Regulatory Affairs and Clinical Research Operations Program, is tremendously proud to have been a part of the team involved in this regulatory approval. (orau.gov)
Journal of Clinical Immunology and Research , peer reviewed open access journal, dedicated to promote clinical and experimental immunology studies. (scitechnol.com)
Journal Line-up is to impact readers with a broad spectrum of subject matter in clinical immunology, all details of immunology research in Human ill health. (scitechnol.com)
The journal consolidate scientific knowledge to promote and explore various innovative works in clinical immunology and research field for rapid publication of critical research, scientific papers and technical notes in form of Research article, Review articles, Mini reviews, Case reports, Opinion article, Short communications, Letter to the Editor, etc. (scitechnol.com)
His research interests include the role of endothelial cells in graft rejection, complement activation in both kidney and liver transplantation. (medscape.com)
The National Institutes of Health has selected eight scientists as Lasker Clinical Research Scholars, part of a joint initiative with the Albert and Mary Lasker Foundation, to foster the next generation of great clinical scientists. (nih.gov)
This highly competitive program provides talented, early stage researchers the opportunity to carry out independent clinical and translational research for five to seven years at NIH. (nih.gov)
Lasker Scholars have access to the NIH Clinical Center, the largest hospital in the world devoted to clinical research. (nih.gov)
Kanakry's goal is to develop safer and more effective transplantation treatments for patients with malignant and non-malignant hematologic disorders at the institute's Experimental Transplantation and Immunology Branch of the Center for Cancer Research. (nih.gov)
The Lasker Clinical Research Scholars program supports accomplished young investigators who are working to discover new knowledge and improve health," said Lasker Foundation President Claire Pomeroy, M.D. "We celebrate the eight new scientists who join the program this year and look forward to watching them thrive as they benefit from the opportunities available at NIH. (nih.gov)
I went to medical school so I could learn to perform transplants and implement research about how to use immunology to cure cancer. (fredhutch.org)

There is a strong tradition of molecular immunology at Karolinska Institutet. (ki.se)
Dekker aims to understand the molecular mechanisms that underlie drug-resistant phenotypes of bacteria and their evolution, and to apply this knowledge to develop novel clinical diagnostic tools as the head of the institute's Bacterial Pathogenesis and Antimicrobial Resistance Unit. (nih.gov)

5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor organs for transplantation. (ncl.ac.uk)
Dr. Emre and his team have collaborated on topics such as living donor liver transplantation, and pediatric liver transplantation on Medscape, an area of expertise at Yale. (medscape.com)

The notion of allografts is explored in specialty areas ranging from orthopedics and thoracic surgery to kidney and liver transplantation, in an effort to identify certain common themes having to do with the immunological response to the allograft and the various methods to avoid rejection. (novapublishers.com)
Dr. Geibel's team will contribute clinical reference articles and video commentary in the areas of general surgery and gastrointestinal medicine on Medscape. (medscape.com)

Patients in their 70s and sometimes 80s may be candidates for transplants if they are otherwise healthy and functionally independent with good social support, if they have a reasonably long life expectancy, and if transplantation is likely to substantially improve function and quality of life beyond simply freeing them from dialysis. (msdmanuals.com)

Journal of Investigational Allergology and Clinical Immunology is indexed/abstracted in Chemical Abstracts, Current Biology, Current Contents - Clinical Medicine, Database Subidase, Excerpta Medica - Immunology, Serology and Transplantation EMBASE, Index Medicus - Medline/Medlars, IBECS, Pascal INIST and Science Citation Index and its impact factor reaches 7.2 (2022) . (jiaci.org)

We performed a clinical trial to evaluate the safety and feasibility of this procedure, using bone marrow from four HIV-1-infected pediatric subjects (ages 8 to 17 years). (nih.gov)
Bone marrow transplantation for leukaemia in Europe. (thieme-connect.de)
As a board-certified medical oncologist, I specialize in providing bone marrow transplantations to people with blood cancers. (fredhutch.org)
Bone marrow transplantation 2009 Sep 44 (5): 273-8. (cdc.gov)
Bone Marrow Transplantation. (bvsalud.org)

Immunology is concerned with how the body defends itself against infectious agents, for example, bacteria, parasites and viruses. (ki.se)
Analysis of three biomarkers in the urine of kidney transplant recipients can diagnose - and even predict - transplant rejection, according to results from a clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (healthnewstrack.com)

In this study it was investigated whether and to what extent semantic data models and their methods for data modeling are useful for adequate representation and integration of immunological and clinical data. (thieme-connect.de)
19 Pawelec G, Schlag H, Schwuléra U, Lenz E, Schneider E, Schaudt K, Bühring HJ, Ehninger G. Immunological monitoring of cancer patients during a phase I/II clinical trail of natural interleukin 2. (thieme-connect.de)

2. To provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplantation. (ncl.ac.uk)
Furthermore, ferroptosis-specific biomarkers are supposed to be identified that are urgently needed for clinical monitoring of disease progression and can be used as markers to assess therapeutic success. (tu-dresden.de)

NIAID-funded basic and clinical studies helped establish the fundamental knowledge necessary for the private sector to develop protein vaccines. (nih.gov)
The test described in this study may lead to better, more personalized care for kidney transplant recipients by reducing the need for biopsies and enabling physicians to tailor immunosuppressive therapy to individual patients," said NIAID Transplantation Branch Chief Nancy Bridges, M.D., a co-author of the paper. (healthnewstrack.com)
Watch the video " Participating in an NIAID HIV Clinical Trial " at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland. (nih.gov)
Mire el video " Participando en un Estudio Clínico del VIH del NIAID " en el Centro Clínico de los Institutos Nacionales de la Salud (NIH por sus siglas en inglés) en Bethesda, Maryland. (nih.gov)

Dr. Emre is an expert in adult and pediatric liver transplantations. (medscape.com)
Clinical investiga- tors estimate that up to 20% of adult onset asthma is caused by Disclaimer: The views expressed in this paper are those of the authors and do occupational factors and that roughly 90% of these cases not necessarily reflect the views or policies of the institutions represented by the authors. (cdc.gov)

Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)

Even with this immunosuppressive therapy, approximately 10 to 15 percent of kidney recipients experience rejection within one year after transplantation. (healthnewstrack.com)
Potentially, a noninvasive test for rejection would allow physicians to more accurately and routinely monitor kidney transplant recipients," said Daniel Rotrosen, M.D., director of NIAID's Division of Allergy, Immunology and Transplantation. (healthnewstrack.com)

Dr. Metushi will work closely with Dr. Lu Song to support the division of clinical chemistry. (uclahealth.org)

This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)

Joe Rocco, M.D., is an assistant clinical investigator in the Lab of Immunoregulation. (nih.gov)

Anatomy21

Organisms5

Diseases44

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment79

Phenomena and Processes22

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities4

Information Science3

Named Groups3

Health Care21

Geographicals1

Blood and Marrow Transplantation2

Immunotherapy2

Organ13

Laboratory8

Inflammation2

Hematopoietic Stem Cell Trans3

Liver and Kidney Transplantation2

Allogeneic5

Tumor2

Infection2

Allergy and Immunology1

Field of transplantation2

Microbiology and Immunology1

Pediatrics1

Pancreas Transplantation2

Immune9

Cell biology2

Practice3

Trials13

Cellular1

Heart transplantation6

Tissue1

Research14

Molecular2

Donor2

Surgery2

Transplants1

Biology1

Bone5

Infectious2

Immunological2

Therapeutic2

NIAID4

Adult2

Tolerance1

Kidney2

Division1

Hospital1

Investigator1