• In this 12-week placebo-controlled multicentre study, we randomly assigned 35 patients with active ankylosing spondylitis to intravenous infliximab (5 mg/kg) and 35 to placebo at weeks 0, 2, and 6. (nih.gov)
  • Our results show that treatment with infliximab is effective in patients with active ankylosing spondylitis. (nih.gov)
  • To determine the safety and efficacy of etanercept in a multicenter, randomized, placebo-controlled, double-blind trial of adults with moderate to severe active ankylosing spondylitis (AS). (nih.gov)
  • NICE are recommending it as an option to treat adults with active ankylosing spondylitis (AS) who have responded inadequately to conventional therapy. (europeanpharmaceuticalreview.com)
  • This subanalysis of the RHAPSODY study (Review of Safety and Effectiveness with Adalimumab in Patients with Active Ankylosing Spondylitis) was conducted to evaluate the effect of adalimumab on sleep in patients with active AS. (jrheum.org)
  • ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis. (enbrel.com)
  • The group of axial spondyloarthritis comprises ankylosing spondylitis (AS), a rheumatic disease characterized by chronic inflammation of the joints in the spine. (dntb.gov.ua)
  • [2] Radiographic axial spondyloarthritis is also known as ankylosing spondylitis (AS). (physio-pedia.com)
  • Is there a difference between spondyloarthritis and ankylosing spondylitis? (medicalnewstoday.com)
  • Ankylosing spondylitis (AS) is a common type of spondyloarthritis. (medicalnewstoday.com)
  • How good is the agreement between clinical diagnoses and classification criteria fulfilment in axial spondyloarthritis? (gu.se)
  • 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. (nature.com)
  • Non-radiographic axial spondyloarthropathy (nr-axSpA) is a term used to describe patients with predominantly axial features and includes patients with clinical features of AS but with normal plain radiographs of the sacroiliac joints and spine. (medscape.com)
  • BACKGROUND Treatment options for patients with ankylosing spondylitis are few. (nih.gov)
  • The primary outcome measures were the percentages of patients achieving the Assessments in Ankylosing Spondylitis 20% response (ASAS20) at weeks 12 and 24. (nih.gov)
  • This study is aimed at investigating IL-17A, IL-17F, IL-17RA, and IL-17RC polymorphisms as potential biomarkers of disease susceptibility, clinical parameters, and anti-TNF treatment outcome in a cohort of Polish ankylosing spondylitis patients. (dntb.gov.ua)
  • Clinical studies included four comparative pharmacokinetic (PK) studies in 216 healthy volunteers and a confirmatory efficacy and safety similarity study in 531 patients with chronic plaque psoriasis. (europeanpharmaceuticalreview.com)
  • Next, we collected the blood samples and clinical characteristics of 359 patients (197 with AS and 162 without AS). (figshare.com)
  • On the basis of the clinical characteristics and results of the routine blood tests, we selected immune-related cells whose numbers were significantly different in patients with AS and patients without AS. (figshare.com)
  • Genomic DNA obtained from 262 persons (122 patients with ankylosing spondylitis and 140 healthy controls) was used in the study. (molvis.org)
  • Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
  • A retrospective study of consecutive ankylosing spondylitis (AS) patients with spinal pseudarthrosis. (johnshopkins.edu)
  • To review the clinical characteristics and assess the outcomes of surgical treatment of spinal pseudarthrosis in advanced AS patients with sagittal plane deformity. (johnshopkins.edu)
  • Fatigue and sleep problems are significant in patients with ankylosing spondylitis (AS). (jrheum.org)
  • A randomized, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study. (setpublisher.com)
  • Results showed a significantly higher proportion of patients achieved a Hidradenitis Suppurativa Clinical Response (HiSCR) when treated with Cosentyx 300 mg, dosed every two weeks (after standard weekly loading doses), compared with placebo at Week 16 in both the SUNSHINE and SUNRISE trials (45.0% vs 33.7% [P=.0070] and 42.3% vs 31.2% [P=0.0149], respectively) 1 . (novartis.com)
  • The development of the center stemmed from desire to participate in clinical trials in a focused and well-managed setting, offering contracting companies high-quality service while giving our patients access to new therapies. (centerwatch.com)
  • The program remains committed to bringing as many Parkinson's disease clinical trials and studies to Overlook Medical Center as possible, understanding the complexity of the condition and the diverse needs of these patients. (atlantichealth.org)
  • The findings indicate that clinical interventions targeting RA patients' illness representations and resilience may assist patients with RA to improve their HRQoL. (springer.com)
  • The recommended dose for long term treatment of rheumatoid arthritis and ankylosing spondylitis in elderly patients is 7.5 mg (half a 15 mg tablet) per day. (medicines.org.uk)
  • Employment, work disability, and work days lost in patients with ankylosing spondylitis: a cross sectional study of Dutch patients. (nature.com)
  • Radiographs are the single most important imaging technique for the detection, diagnosis, and follow-up monitoring of patients with ankylosing spondylitis. (medscape.com)
  • In patients with ankylosing spondylitis (not non-radiographic axial SpA), initial conventional radiography of the lumbar and cervical spine can detect syndesmophytes, which are predictive of development of new syndesmophytes. (medscape.com)
  • It is 10 to 20 times more common among 1st-degree relatives of patients with ankylosing spondylitis than in the general population. (msdmanuals.com)
  • The human leukocyte antigen B27 (HLA-B27) allele is present in 90% of White patients with ankylosing spondylitis, but it is also present in up to 10% of the general population depending on ethnicity. (msdmanuals.com)
  • Most patients have predominantly axial involvement (called axial ankylosing spondylitis). (msdmanuals.com)
  • Systemic manifestations of ankylosing spondylitis occur in one third of patients. (msdmanuals.com)
  • Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis. (cdc.gov)
  • I think that you have to have the balanced view because there was not much radiologic progression at all in these patients, which is what we are seeing in most clinical trials now. (medscape.com)
  • 1987). Long-term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis. (cdc.gov)
  • Clinical Rheumatology. (wikipedia.org)
  • Members of the group are active in the American College of Rheumatology, the American College of Physicians and the Association of Clinical Research Professionals. (centerwatch.com)
  • The Center for Rheumatology and Bone Research has been conducting clinical research for more than 40 years. (centerwatch.com)
  • I am Dr Jonathan Kay, professor of medicine and director of clinical research in the division of rheumatology at University of Massachusetts Medical School and UMass Memorial Medical Center, both in Worcester. (medscape.com)
  • I am reporting here in San Francisco from the 2015 American College of Rheumatology (ACR) Annual Scientific Meeting and am here today with Dr Ronald van Vollenhoven, professor of clinical therapy research and chief of the Clinical Trials Unit in rheumatology at the Karolinska Institutet in Stockholm, Sweden. (medscape.com)
  • This article is to discuss Ankylosing Spondylitis (AS) regarding its medical definition, Aetiology (Causes and incidence), Pathogenesis and clinical picture (symptoms and signs). (med2date.com)
  • Background: The pathogenesis and diagnosis of Ankylosing Spondylitis (AS) has remained uncertain due to several reasons, including the lack of studies on the local and systemic immune response in AS. (figshare.com)
  • Conclusion: An integral role of IL-33 in the pathogenesis of allergic and nonallergic airway inflammatory disease is evident with several emerging clinical trials investigating therapeutic approaches. (cdc.gov)
  • A complex role of anthrax toxin receptor 2 polymorphisms and capillary morphogenesis protein 2 in ankylosing spondylitis pathogenesis. (cdc.gov)
  • Ankylosing spondylitis (AS), a spondyloarthropathy, is a chronic, multisystem inflammatory disorder involving primarily the sacroiliac (SI) joints and the axial skeleton. (medscape.com)
  • Ankylosing spondylitis, the prototypic radiographic axial SpA, is a chronic inflammatory disease of the joints of the axial skeleton, manifested clinically by pain and progressive fusion of the spine. (mhmedical.com)
  • The diagnosis may be reliably made if the typical radiographic features of ankylosing spondylitis are present. (medscape.com)
  • Questions on clinical trials. (bmj.com)
  • Clinical trials are conducted in the Wheaton, Md., location. (centerwatch.com)
  • We have participated in more than two hundred clinical trials. (centerwatch.com)
  • We routinely offer clinical trials in a range of medical conditions, including cancer, heart disease, and complex neurological conditions. (atlantichealth.org)
  • Our cardiology, cardiovascular medicine and cardiac surgery departments participate in dozens of clinical trials each year. (atlantichealth.org)
  • These findings suggest the need for additional clinical evaluations in trials on a larger scale to allow for confirmation of the efficacy and safety of the treatment. (hcplive.com)
  • Fig. 2: ASAS40 responses from clinical trials in AS. (nature.com)
  • Fig. 3: ASAS40 responses from clinical trials in nr-axSpA. (nature.com)
  • The EU Clinical Trials Register currently displays 43691 clinical trials with a EudraCT protocol, of which 7244 are clinical trials conducted with subjects less than 18 years old. (clinicaltrialsregister.eu)
  • This will provide an RSS feed for clinical trials matching your search that have been added or updated in the last 7 days. (clinicaltrialsregister.eu)
  • Efficacy and safety of switching from reference infliximab to CT-P13 compared with maintenance of CT-P13 in ankylosing spondylitis: 102-week data from the PLANETAS extension study. (setpublisher.com)
  • Ankylosing spondylitis is a distinct disease entity characterized by inflammation of multiple articular and para-articular structures, frequently resulting in bony ankylosis. (medscape.com)
  • The first clinical sign of temporomandibular ankylosis is limited jaw movement. (bvsalud.org)
  • The purpose of this paper is to report a rare case of ankylosis of the temporomandibular joint, secondary to ankylosing spondylitits, and to discuss its clinical and therapeutic aspects. (bvsalud.org)
  • Basel, September 10, 2022 - Novartis announced the results from two pivotal, Phase III studies (SUNSHINE and SUNRISE), in which Cosentyx ® (secukinumab) demonstrated rapid and sustained relief from the common clinical signs and symptoms of moderate-to-severe hidradenitis suppurativa (HS) with a favorable safety profile 5,6 . (novartis.com)
  • There have been several reports describing the clinical findings of spinal pseudarthrosis in AS. (johnshopkins.edu)
  • In the correct clinical context, findings on radiographs are considered diagnostic. (medscape.com)
  • Spondylitis refers to inflammation of one or more vertebrae. (medscape.com)
  • Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that characteristically affects the sacroiliac joints and the spine. (molvis.org)
  • The most frequent manifestation of ankylosing spondylitis is inflammatory back pain, but disease can begin in peripheral joints, especially in children and women, and rarely with acute iridocyclitis (iritis, anterior uveitis). (msdmanuals.com)
  • Benign bone lesions may be incidentally detected on radiographs and are increasingly found on computed tomography (CT) or magnetic resonance imaging (MRI) performed for other clinical indications. (medscape.com)
  • Highly likely the diagnosis of youth's ankylosing spondylitis"(Introduction) Many experts affirms that he had Pott's disease, instead. (wikipedia.org)
  • They reported that diagnosis and management of such lesions require knowledge of their epidemiology, clinical presentation, anatomy, and imaging features. (medscape.com)
  • To assess response, we used validated clinical criteria from the ankylosing spondylitis assessment working group, including disease activity (BASDAI), functional indices (BASFI), metrology (BASMI), and quality of life (short form 36). (nih.gov)
  • range, 35-108 months), and clinical assessment using visual analog scale for back pain and the modified SRS outcome instruments satisfaction domain and the review of postoperative complications. (johnshopkins.edu)
  • Correlation coefficients were calculated to determine the relationship between change in sleep domains and other Week 12 clinical and patient-reported outcomes (Bath AS Disease Activity Index, C-reactive protein, nocturnal pain, total back pain, Bath AS Functional Index, patient's global assessment of disease activity, morning stiffness, Short Form-36 Health Survey, and Work Productivity and Activity Impairment questionnaire components). (jrheum.org)
  • Project: The use of transcranial magnetic stimulation and clinical assessment tools in persons with multiple sclerosis. (mun.ca)
  • Ankylosing spondylitis is considered to be a chronic condition from the group of systemic inflammatory diseases of rheumatic pattern. (bvsalud.org)
  • Any systemic disease that adversely affects ocular health e.g., diabetes, Graves' disease, and auto immune diseases such as ankylosing spondylitis, multiple sclerosis, Sjogrens syndrome, and systemic lupus erythematosus. (who.int)
  • Enthesitis-related Arthritis (ERA) is a specific category of juvenile idiopathic arthritis (JIA) characterized by axial and/or peripheral arthritis, and enthesitis, although other different extra-articular manifestations may encompass its clinical spectrum. (frontiersin.org)
  • Moreover, some relationships between IL-17F rs763780 and IL-17RA rs4819554 polymorphisms with clinical parameters related to the disease activity and anti-TNF treatment outcome were observed. (dntb.gov.ua)
  • Ankylosing spondylitis has a predilection for the axial skeleton, affecting particularly the sacroiliac and spinal facet joints and the paravertebral soft tissues. (medscape.com)
  • Results: In total, 72 publications with relevance to IL-33 immunobiology and/ or clinical lung disease were identified (allergic airway inflammation/allergic asthma n = 26, non-allergic airway inflammation n = 9, COPD n = 8, lung fibrosis n = 10). (cdc.gov)
  • [8] Syndesmophytes are one of the main features of spinal structural damage in ankylosing spondylitis. (physio-pedia.com)
  • Ankylosing spondylitis (AS) is a chronic autoimmune disease that primarily affects the spinal joints, but large joints, such as the hips and shoulders, can also be involved. (healthline.com)
  • This is a list of notable people, living or dead, accompanied by verifiable source citations associating them with ankylosing spondylitis, either based on their own public statements, or (in the case of dead people only) reported contemporary or posthumous diagnoses. (wikipedia.org)
  • Change in the MOS-SS Sleep Problem Index II was moderately correlated with change in most clinical and patient-reported outcomes. (jrheum.org)
  • But baricitinib did win out on the clinical efficacy outcomes-ACR20, ACR50, ACR70, etc. (medscape.com)
  • Across the board, the clinical outcomes were statistically significantly better for baricitinib. (medscape.com)
  • Chief among a flurry of clinical advances in retina disease this year were the FDA approvals of complement inhibitors for GA and a higher-dose aflibercept for diabetic retinopathy. (hcplive.com)
  • Overview of Seronegative Spondyloarthropathies Seronegative spondyloarthropathies (seronegative spondyloarthritides) share certain clinical characteristics (eg, inflammatory back pain, uveitis, gastrointestinal symptoms, rashes). (msdmanuals.com)
  • Single nucleotide polymorphism in IL-33 or ST2 were described in 9 studies (asthma n = 5, inflammatory bowel disease n = 1, mycosis fungoides n = 1, ankylosing spondylitis n = 1, coronary artery disease n = 1). (cdc.gov)
  • When we examine ACE genotype frequencies according to the clinical characteristics there was a statistically significant association between DD genotype and ocular involvement (p=0.04) also sacroiliac joint involvement (p=0.03). (molvis.org)
  • Clinical characteristics including trauma and inflammatory reaction were variable. (johnshopkins.edu)
  • 22 Remicade ® switched) in clinical remission. (setpublisher.com)
  • Twenty-five children achieved clinical remission on medication. (frontiersin.org)
  • χ 2 = 5.50, p = 0.03) the clinical remission on medication. (frontiersin.org)
  • Ankylosing spondylitis (AS) is a chronic, progressive disease , often with multiple complications , with periods of exacerbation and remission. (bvsalud.org)
  • Hence, there are both clinical and economic incentives for the identification of factors associated with treatment persistence. (lu.se)
  • Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene (ANTXR2). (cdc.gov)
  • Protective effect of anthrax toxin receptor 2 polymorphism rs4333130 against the risk of ankylosing spondylitis. (cdc.gov)