Clinical progenitor cells or bone marrow. Medical search. Frequent questions

Peripheral blood stem cell mobilization, which is important as a source of hematopoietic stem cells for transplantation, is generally performed using granulocyte colony-stimulating factor (G-CSF), but is ineffective in around 15 to 20% of patients. (wikipedia.org)
Combination of G-CSF with plerixafor increases the percentage of persons that respond to the therapy and produce enough stem cells for transplantation. (wikipedia.org)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation ( 3 , 4 ). (cdc.gov)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
The number of viable CD45+/CD34+ cells will determine the quality of the harvested specimen for transplantation. (bdbiosciences.com)
An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
Amit has taken 5 volunteers who would eventually undergo heart transplantation after a few months and injected adult stem cells into the patients' hearts. (cellmedicine.com)
Removing and studying the hearts that have been injected with adult stem cells a few months prior to transplantation is a possibility. (cellmedicine.com)
In an earlier study he had shown that "Autologous stem cell transplantation led to significant improvement in cardiac function in patients undergoing off-pump coronary artery bypass grafting for ischemic cardiomyopathy. (cellmedicine.com)
Therefore, a central goal in clinical care of SDS patients is to identify incipient leukemic transformation and initiate pre-emptive treatment with allogeneic stem cell transplantation. (nature.com)
Mature, differentiated cells that accompany the hematopoietic stem cells, disappear rapidly after transplantation as they lack the ability to self-renew. (ca.gov)
It is thus essential when designing clinical approaches that use tissues or cells derived from human embryonic stem cells (hESC), to specifically target the production of stem and progenitors that will survive, proliferate and differentiate normally after transplantation. (ca.gov)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
Bone repair of the femoral head necrosis area was analyzed after MSC transplantation. (biomedcentral.com)
Transplantation of iPSC-MSCs could effectively promote bone repair and angiogenesis in the necrosis area of the femoral head. (biomedcentral.com)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
The model was able to recapitulate the fundamental steady-state features of haematopoiesis and simulate the re-establishment of steady-state conditions after haemorrhage and bone marrow transplantation. (lu.se)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
We also demonstrate that C3AR in combination with GPR56 distinguishes the leukemic stem cells (LSCs) in NPM1-mutated AML from the normal hematopoietic stem cells, defining the LSC population, as shown by transplantation into immunodeficient mice. (lu.se)

However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)

Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
Objectives: To evaluate the safety and feasibility of endobronchial administration of bone marrow autologous MSCs (BM-MSC) in patients with mild-to-moderate IPF. (unav.edu)
Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
These correlations were not observed in group B. Conclusion: Injection of MSCs with marrow stimulation treatment was encouraging in patients older than 50 years compared with patients treated with marrow stimulation treatment alone, especially when the lesion size was larger than 109 mm(2) or a subchondral cyst existed. (researchgate.net)
Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
Cellular therapy based on mesenchymal stem cells (MSCs) is a promising novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is gradually becoming popular, particularly for early-stage ONFH. (biomedcentral.com)
Nonetheless, the MSC-based therapy is challenging due to certain limitations, such as limited self-renewal capability of cells, availability of donor MSCs, and the costs involved in donor screening. (biomedcentral.com)
As an alternative approach, MSCs derived from induced pluripotent stem cells (iPSCs), which may lead to further standardized-cell preparations. (biomedcentral.com)
The bone marrow-derived MSCs (BMSCs) were isolated by density gradient centrifugation. (biomedcentral.com)
Eight weeks after the establishment of the ONFH model, rats in BMSC-treated group and iPSC-MSC-treated group were implanted with BMSCs and iPSC-MSCs through intrabone marrow injection. (biomedcentral.com)
Furthermore, comparing the effectiveness of iPSC-MSCs and the normal BMSCs in an ONFH rat model revealed that the iPSC-MSCs was equivalent to normal BMSCs in preventing bone loss and promoting bone repair in the necrosis region of the femoral head. (biomedcentral.com)
Stem cells, specifically mesenchymal stem cells (MSCs,) stem cells found in tissue, have emerged as a major tool for research into the causes of ALS and in the research for new treatments. (cryo-cell.com)
MSCs are found in adipose (fat tissue), peripheral blood, bone marrow, umbilical cord blood, umbilical cord tissue and placental tissue. (cryo-cell.com)
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) are being studied as a potential therapeutic tool to prevent various neurodegenerative diseases including Alzheimer's. (cryo-cell.com)
[iii] MSCs derived from umbilical cord blood and umbilical cord tissue are a safe, easily collected, readily available, and noncontroversial source of stem cells. (cryo-cell.com)

Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. (nih.gov)
Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). (bioskinrevive.com)
Also available are freshly donated peripheral blood mononuclear cells (PBMC) and/or G-CSF mobilized peripheral blood cells (PBC), which are acquired through our healthy adult donor volunteer recruitment program. (fredhutch.org)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)

Phase 2 clinical trials started in 2021 exploring the combination of plerixafor and MGTA-145, a CXCL2 ligand. (wikipedia.org)
Most adverse effects in clinical trials were mild and transient. (wikipedia.org)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
Clinical research involves clinical epidemiology and clinical studies that occurs in clinical laboratory, and clinical trials. (juntendo.ac.jp)
Stem cell-based therapeutics that enter clinical trials within the next five years will likely enter clinical practice in the next 10 years. (pharmexec.com)
Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. (unav.edu)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
All he has to do is succeed in his ongoing clinical trials using cell therapy in congestive heart failure. (cellmedicine.com)
The U.S. Food and Drug Administration (FDA) has made Amit the only individual in the entire nation to gain its endorsement to undertake clinical trials for treating heart patients by directly injecting adult stem cells into the heart. (cellmedicine.com)
TRC-based products have been used in over 225 patients, and are currently in clinical trials for bone regeneration (long bone fractures and spine fusion) and vascular regeneration (critical limb ischemia) applications. (salesandmarketingnetwork.com)
This document contains forward-looking statements, including without limitation, statements concerning planned clinical trials, product development objectives, and potential product applications, which involve certain risks and uncertainties. (salesandmarketingnetwork.com)
In the last few years, her work highlighted the clinical relevance of chronic inflammation and chronic active/smoldering lesions in driving clinical progression in multiple sclerosis and prompted for the planning of novel-designed MRI-based clinical trials aimed at treating such perilesional chronic inflammation. (the-asci.org)
In randomised clinical trials, a subcutaneous dose of 230 µg/m 2 /day (4.0 to 8.4 µg/kg/day) was used. (medicines.org.uk)
Early Clinical Trials et al.23). (lu.se)

Low SDF-1 expression may contribute to the dysfunctional mobilization of bone marrow Lin - /VEGF-R2 + endothelial progenitor cells, which may contribute to microvascular injury in early diabetes. (biomedcentral.com)

Additionally, our research approach proved to be a powerful tool in the identification of novel biomarkers for cardiovascular and metabolic disease (e.g. circulating endothelial cells and progenitor stem cells [EPCs] for better prognosis). (nymc.edu)
It activates endothelial cells and stimulates nitric oxide release. (escardio.org)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
It's important to remember that in addition to getting past the political stigma, developing stem cell-based therapies is really no different than any other biotech endeavor. (pharmexec.com)
Beck predicts that stem cell-based therapies will also come to market in a systematic fashion. (pharmexec.com)
Routine stem cell therapies for certain types of heart disease will become a reality in 3-5 years according to Dr. Amit of the University of Pittsburgh Medical Center. (cellmedicine.com)
Stem cell work is still quite experimental but is very promising as many beneficial therapies are thought to exist with much scientific value being ascribed to cord blood and its cells. (ndtv.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Future directions will include development of specialized regenerative medicine therapies to enhance reparative cell activity and inhibit fibrotic cell function. (rotrf.org)
Genetically engineering red blood cells to turn them into drug-delivery vehicles could open the door to a vast number of new therapies. (technologyreview.com)
And since mature red cells don't carry any genetic material, they would also carry fewer safety risks than other gene and cell therapies. (technologyreview.com)
In addition to the PKU therapy, Rubius has developed over 50 different therapies based on red blood cells, says Avak Kahvejian , the company's CEO and a partner at Flagship. (technologyreview.com)
Before they become fully mature, mammalian red blood cells eject their genetic material, so as a therapy they are easier to control and less risky than other stem cell and gene therapies, which can lead to abnormal cell growth and tumors. (technologyreview.com)
Human red blood cells circulate for as long as four months, meaning they could potentially form the basis of long-term therapies. (technologyreview.com)
The company is remaining tight-lipped about what additional therapies might be in the pipeline, but Kahvejian says the potential for new drugs based on red blood cells is "only limited by your imagination. (technologyreview.com)
[ii] They have also recently emerged as a promising source of stem and progenitor cells for use in other novel cell therapies. (cryo-cell.com)
This funding was made through an additional investment in Cryo-Cell's cell therapy research affiliate, Saneron CCEL Therapeutics, Inc. The hope is that the IND will lead to regenerative therapies using cord blood to treat devastating neurodegenerative diseases such as ALS. (cryo-cell.com)
Advances in the field of translational stem cell therapy will continue to gain momentum and we are poised to maximize the potential of cellular therapies to provide much-needed treatments for neurodegenerative diseases. (cryo-cell.com)
Therefore, we aimed to identify cell surface proteins specifically expressed on NPM1)-mutated AML cells, allowing for potential targeting with antibody-based therapies. (lu.se)

Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
These findings provide compelling justification for the clinical translation of a NELL-1-based therapy for local or systemic bone formation. (nih.gov)
Both human and animal models of diabetes and obesity were utilized to examine the use of stem cell intervention and gene therapy to amplify HO-1 levels. (nymc.edu)
Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. (nih.gov)
stem cell therapy. (nih.gov)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
He is the director of the Center for Cardiac Cell Therapy at the university. (cellmedicine.com)
Even though the potential is great, it will be a while before stem cell therapy can become a part of routine treatment. (ndtv.com)
Demyelinating conditions are difficult to treat and stem cell therapy using bone marrow mesenchymal stem cells (BMSCs) is a promising novel strategy. (biomedcentral.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
Dr. David Hill is the director of the Lawson Health Research Institute , researching the development of insulin-producing beta cells , studying growth factors and development in animal models in the context of possible therapy targets for gestational, Type 1, and Type 2 Diabetes . (bepress.com)
Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
Lodish says animal tests suggest that engineered red blood cells can be a "very potent" therapy for a range of diseases. (technologyreview.com)
Hyperbaric oxygen therapy (HBOT) has been shown to improve wound healing through induction of stem cell recruitment and the potential to inhibit progression of diabetic complications. (scirp.org)
Over the last 10 years, there has been tremendous interest in developing a cell-based therapy to address this problem. (phys.org)
This is a totally new approach and provides a ready-source of tailored cells , which have the potential to be used as a new clinical therapy. (phys.org)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)
By flow cytometry and single cell RNA-sequencing, we further show that normal hematopoietic stem and progenitor cells lack detectable C3AR gene and protein expression, making it particularly suitable as a target for antibody therapy. (lu.se)

Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. (medscape.com)
Interacts with transmembrane domain of human TPO receptor and induces megakaryocyte proliferation and differentiation from bone marrow progenitor cells. (medscape.com)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
Cultured oligodendrocyte progenitor cells (OPCs) were incubated with HD ± BMSC-derived conditional medium (BMSC-CM). OPC differentiation was studied by immunostaining and morphometric analysis. (biomedcentral.com)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)

Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. (nih.gov)
Hearts that were removed 3-6 months after the stem cells were injected showed, "significant angiogenesis," said Dr. Amit. (cellmedicine.com)

2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
However, it has become apparent more recently that the types of blood cells that hESC can produce under current conditions are more limited functionally than those found in bone marrow or cord blood. (ca.gov)

Conversely, rhNELL-1 systemic administration in mice showed a marked anabolic effect accompanied by increased numbers of Sca-1+CD45-CD31- bone marrow MPCs. (nih.gov)
Based on review of current literature, this study examined the expression level of 35 genes that are known to be involved in endothelial progenitor cell migration and function in magnetically sorted Lin - /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early stages of diabetes (18 weeks) using RT-PCR and Western blotting. (biomedcentral.com)
We observed a significant increase in the number of Lin - /VEGF-R2 + endothelial progenitor cells within the bone marrow in diabetic mice compared with non-diabetic mice. (biomedcentral.com)
Progenitor cells derived from bone marrow have been shown to respond following lung injury in both mice and humans. (rotrf.org)
Research published in 2016 has identified a population of progenitor cells within the pancreas of mice and human that can give rise to new insulin-producing cells in vitro. (bepress.com)
As a step towards mobilizing these cells we have examined the ability of grafted bone marrow-derived stem cells to reverse diabetes in mice. (bepress.com)
The participation of autophagy in hemopoietic stem cell regulation in mice Knockouts. (usp.br)
He says not-yet-published work from his lab has shown that cells modified to produce an antibody to a specific bacterial toxin render mice resistant to many times the lethal dose of that toxin. (technologyreview.com)

In this review, we overview the major classes of stem and progenitor cells, including pluripotent stem cells, and summarize the state of the art in applying these cell types for treating myocardial infarction and peripheral arterial disease. (nih.gov)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
Although proliferation of one or more hematopoietic cell types dominates the clinical picture in each of these disorders, all three are caused by clonal proliferation of a pluripotent hematopoietic stem cell, causing an increased proliferation of normal RBC, WBC, and platelet progenitors in the bone marrow. (msdmanuals.com)

The BD ® Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/µL) as well as the percentage of the total viable leucocyte count that is CD34+ (%CD34). (bdbiosciences.com)
Aastrom's TRC-based products are a unique cell mixture containing stromal, stem and progenitor cell populations, produced outside the body from a small amount of bone marrow taken from the patient. (salesandmarketingnetwork.com)
Different populations of progenitors have been shown to have conflicting functions. (rotrf.org)
As a lab within the Cooperative Center of Excellence in Hematology (CCEH) at Fred Hutch, Hematopoietic Cell Procurement and Processing is recognized as a leader in the field of acquisition, analysis, and enrichment of normal hematopoietic cells, this facility provides well defined and highly purified populations of cells to support the research of both internal and external investigators. (fredhutch.org)
For years we have successfully defined and purified cell populations to support research. (fredhutch.org)

1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Her broad experience and leadership in the biotechnology and pharmaceutical industries, along with experience in the manufacturing and marketing of new cell-based products, strongly support and complement the Company's progress in moving its tissue regeneration products through the commercialization process. (salesandmarketingnetwork.com)
Ronnda's experience in developing cell-based products, as well as establishing and improving manufacturing processes, are essential to our commitment of moving Aastrom's tissue regeneration cell products through the development stage and into the market place. (salesandmarketingnetwork.com)
Aastrom Biosciences , Inc. (Nasdaq: ASTM ) is developing autologous cell products for the repair or regeneration of multiple human tissues, based on its proprietary Tissue Repair Cell (TRC) technology. (salesandmarketingnetwork.com)
The Company has reported positive interim clinical trial results for TRCs suggesting both the clinical safety and the ability of TRCs to induce tissue regeneration in long bone fractures and jaw bone reconstruction. (salesandmarketingnetwork.com)
Stem cell scientists have capitalised on the electrical properties of a widely used nanomaterial to develop cells which may allow the regeneration of cardiac cells. (phys.org)

EET/HO acts as a molecular "switch" to genetically reprogram adipocyte stem cells and, subsequently, vascular endothelium through activation of a unique signaling cascade that results in the amplification of protective circuits and provides resistance to vascular dysfunction. (nymc.edu)
We believe that the effect of anti-diabetic drugs alone, or in combination with antioxidant genes, have a differential impact on stem cell function and vascular disease. (nymc.edu)
Depending upon the particular genotype and severity of the SCD the prevalence of ONFH ranges from 3 to 50 % among SCD patients [4 5 Osteonecrosis can be viewed as a vascular and bone disease with altered bone remodeling. (bioskinrevive.com)

Cellularity Generally, there's hypercellularity with total or partial replacement of fat spaces by proliferating myeloid cells. (ehd.org)
To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. (nature.com)
One distinctive result of the research group's work is the specially developed tissue microarrays (TMAs) of MDS bone marrow punch biopsies, which contain biopsies from patients with AML (acute myeloid leukemia) and normal controls for direct comparison. (keyence.com)
[ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)

The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)

Hematopoiesis in protein malnutrition: characterization of bone marrow stroma and. (usp.br)
Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs), alone or in combination, in the circulation and sometimes with fibrosis in the bone marrow and extramedullary hematopoiesis (cell production outside the marrow). (msdmanuals.com)
In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)

The problem is that these human embryonic stem cell lines have been grown in such a way that they are contaminated by animal protein and cannot be used for human therapeutic purposes,' Beck explains. (pharmexec.com)
Using established molecular biology techniques, Rubius's scientists can engineer progenitor cells taken from human bone marrow and grow blood cells that produce specific therapeutic proteins on their surface or inside the cell. (technologyreview.com)
The cells can get anywhere in the body through the bloodstream and can protect the therapeutic agent from the immune system, says Kahvejian. (technologyreview.com)
Finally, we show that antibodies directed against C3AR efficiently elicit NK cell-mediated killing of primary AML cells ex vivo, highlighting C3AR as a candidate therapeutic target in NPM1-mutated AML. (lu.se)

3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)

In April 2004, 204 members of the House of Representatives, including 36 Republicans, signed a letter urging President Bush to rethink the restrictions on embryonic stem cell research, suggesting that hundreds of thousands of embryos stored in in-vitro fertilization (IVF) clinics could be used to advance embryonic stem cell research. (pharmexec.com)
Stitching is also useful for evaluating in vitro cultures in bone marrow progenitor cells, where for example we study the mitochondria of erythroblasts as the target structure. (keyence.com)
Clinical and radiographic findings were assessed and data were completed by in vitro analysis. (bioskinrevive.com)
The Hematopoetic Cell Procurement and Processing core can perform up to 4-color flow cytometry staining and analyses, as well as in-vitro colony-forming assays on research specimens. (fredhutch.org)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

Not long ago, Cryo-Cell International provided funding to complete an Investigational New Drug Application (IND) for an FDA approved Phase I clinical trial for patients with ALS using umbilical cord blood cells. (cryo-cell.com)
The study will involve the administration of U-CORD-CELL®, Saneron's proprietary mononuclear enriched cell fraction of umbilical cord blood to be processed in Cryo-Cell's GMP laboratory. (cryo-cell.com)

Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. (cdc.gov)
Here, we report transmission of DENV to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
It is well recognized from adult stem cell studies that the growth of transplanted bone marrow is generated from the hematopoietic ("blood-forming") stem and progenitor cells provided by the donor bone marrow. (ca.gov)
The Hematopoietic Cell Procurement and Processing Core can process normal donor, patient and animal specimens for cell enrichment and/or depletion using small-scale Miltenyi AutoMACS or larger-scale CliniMACS magnetic bead technology. (fredhutch.org)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

Not for use to normalize platelet counts, but used when clinical condition increases bleeding risk. (medscape.com)
Accurate white blood cell, red blood cell and platelet counts. (fredhutch.org)

Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

Also in 2001, David Beck, PhD, president of the Camden, New Jersey-based Coriell Institute for Medical Research, which houses the largest repository of cell cultures in the world, made a prescient remark: 'Much of the controversy regarding embryonic stem-cell research will go away, because we're learning so much about stem cell biology. (pharmexec.com)
Educated at the University of Nottingham and at Worcester College, University of Oxford, he has published over 200 scientific papers and maintains an active program in diabetes research and stem cell biology. (bepress.com)

Important elements of the history, such as characteristics of the pain and important associated symptoms, and past history of or risk factors for cardiovascular disease, are used to determine the likelihood that these symptoms represent acute coronary syndrome (ACS) and to predict the likelihood of clinical outcomes. (medscape.com)
Calpin C, Dick P, Poon A, Feldman W. Is bone marrow aspiration needed in acute childhood idiopathic thrombocytopenic purpura to rule out leukemia? (medscape.com)
Acute leukemias Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
Many investigators have suggested that both lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) may be part of one clinical spectrum of a single malignant lymphoproliferative disorder . (medscape.com)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

The antibody stains epithelial cell and T and b lymphocytes. (bdbiosciences.com)
B lymphocytes, named after their site of origin in the bursa of Fabricius in birds or in the bone marrow in humans, form the basis for humoral immunity by their production of immunoglobulins. (medscape.com)
Chromosomal aberrations (hypo- and hyperdiploidy, deletions, breaks, and gaps) in peripheral lymphocytes and bone marrow cells are the predominant effects seen in humans. (cdc.gov)

Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)

Bone marrow is the source of stem cells for the experiment. (cellmedicine.com)
Human cord blood contains a large number of haematopoietic progenitor cells that can be used as a source of stem cells for treatment of blood disorders and cancers. (ndtv.com)

Fellows can choose their own research theses with reference to variety of research topics listed below, and are expected to obtain competence in basic and clinical knowledge in the field of cardiovascular diseases. (juntendo.ac.jp)
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
Despite the ethical, moral, and political dimensions that currently frame discussions about stem cell research, there are scientists, business professionals, and investors who are solely focused on the scientific promise that one day the most recalcitrant diseases will be addressed by replacing diseased cells with stem cells that can be coaxed into reviving health and functionality. (pharmexec.com)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
His research focuses on malignant diseases in bone marrow, primarily preleukemias, also known as myelodysplastic syndromes (MDS). (keyence.com)
Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody production due to either molecular defects intrinsic to B-cells or a failure of interaction between B-cells and T-cells. (medscape.com)
A startup aims to treat hard-to-treat diseases with genetically modified blood cells. (technologyreview.com)
Research shows that professional football players may be at a higher risk of death from diseases that damage the cells in the brain, such as Alzheimer's and ALS compared to the general U.S. population. (cryo-cell.com)
A study of 3,439 players with an average age of 57 from the National Football League with at least five playing seasons from 1959-1988, found that professional football players were three times more likely to die as a result of diseases that damage brain cells compared to the general population. (cryo-cell.com)
[iv] For those former NFL players battling neurodegenerative diseases, for anyone fighting the battle, stem cell research and treatments will continue to advance long after these athletes have hung up their cleats for the last time. (cryo-cell.com)
Stem Cell Technology for Neurodegenerative Diseases. (cryo-cell.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
Studies utilize the tissue culture of animal and human connective tissue cell types, including myoblasts, fibroblasts and chondrocytes, hepatocytes, and isolated pancreatic islets of Langerhans. (bepress.com)

So far all FDA approval has been for using adult stem cells for treating heart patients due to the ethical dilemmas surrounding embryonic stem cell research. (cellmedicine.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
They then used these nanomaterials to create cells with the characteristics of cardiac progenitors, a special type of cell found in the heart, from adult stem cells . (phys.org)
The electrical properties of the nanomaterial triggered a response in the mesenchymal (adult) stem cells, which we sourced from human bone marrow. (phys.org)

In summary our results indicate that infusion of BMMCs enriched with stem/progenitor cells is a safe and effective treatment for the early stages of ONFH in SCD patients. (bioskinrevive.com)

Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)

Saneron's sponsored preclinical studies using U-CORD-CELL® have demonstrated efficacy in various disease models including: ALS, stroke, myocardial infarction, and Alzheimer's disease. (cryo-cell.com)

Since the use of a patient's own heart cells is not a viable clinical option, many researchers are working to try to find an alternative source of cells that could be used for cardiac tissue repair. (phys.org)

LDH, cytogenetics, blast counts in bone marrow) were correlated with GIN. (uni-regensburg.de)
8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Current surveillance strategies for patients with SDS and other leukemia predisposition syndromes rely on monitoring hematologic status by serial peripheral blood counts to identify worsening cytopenias and bone marrow examinations to identify morphologic changes or development of clonal chromosomal abnormalities 11 . (nature.com)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)

Overlap in of clinical and laboratory findings occurs because of a common etiology. (msdmanuals.com)

Limited evidence on clinical outcomes has suggested that there may be benefits from improving left ventricular ejection fraction, reducing recurrent myocardial infarction, decreasing need for further revascularization, and perhaps even decreasing mortality, although a recent, large, individual patient data meta-analysis reported no improvement in these outcomes. (southcarolinablues.com)
No adequately powered trial has reported benefits in clinical outcomes (e.g., mortality, adverse cardiac outcomes, exercise capacity, quality of life). (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
High-quality RCTs, powered to detect differences in clinical outcomes, are needed to answer this question. (southcarolinablues.com)
However, other clinical outcomes were not reported with sufficient methodologic rigor to permit conclusions. (southcarolinablues.com)
The only phase 3 trial identified was terminated early and insufficiently powered to evaluate clinical outcomes. (southcarolinablues.com)
Secondary outcomes (efficacy) will be measured by assessing clinical, analytical, and imaging-test parameters. (unav.edu)
Purpose: To compare the clinical outcomes of MSC injection and arthroscopic marrow stimulation treatment with those of arthroscopic marrow stimulation treatment alone for the treatment of OLTs in older patients. (researchgate.net)
Patients were divided into 2 groups: 35 patients (37 ankles) treated with arthroscopic marrow stimulation treatment alone (group A) and 30 patients (31 ankles) who underwent MSC injection along with arthroscopic marrow stimulation treatment (group B). Clinical outcomes were evaluated according to the visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, and the Roles and Maudsley score. (researchgate.net)
Large lesion size (≥109 mm(2)) and the existence of subchondral cysts were significant predictors of unsatisfactory clinical outcomes in group A (P = .04 and .03, respectively). (researchgate.net)

Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. (wikipedia.org)
Mobilisation of tumor cells has occurred in patients with leukaemia treated with plerixafor. (wikipedia.org)
Altogether 40 events at 8 of 10 tested loci were identified in CD34+ cells of 22 patients (51%), MSI (n = 20), LOH (n = 30). (uni-regensburg.de)
Ninety eligible patients will be randomly assigned at a ratio 1:1:1 to one of the following: control group (n = 30), low-cell dose treatment group (n = 30), and high-cell dose treatment group (n = 30). (unav.edu)
In a first escalating-dose phase, three patients were included sequentially in three dose cohorts (10×106, 50×106 and 100×106 cells). (unav.edu)
Results: 21 bone marrow samples were obtained from 17 patients. (unav.edu)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Our preliminary data show that patients with end-stage bronchiolitis obliterans syndrome (BOS) have a significantly increased ratio of fibrocytes to CCSP + cells in the peripheral circulation. (rotrf.org)
In addition we will examine the effect of immunosuppressive drugs on lung progenitor cell mobilization from the bone marrow using both clinical patient data and animal models of drug delivery, with the aim of determining specific protocols that optimize the patients own regenerative cell capacity and minimize the contribution of fibrotic cells. (rotrf.org)
Patients typically have recurrent infections and presentation and complications can vary depending upon where the defect has occurred in B-cell development or the degree of functional impairment. (medscape.com)
In addition after the BMMC implantation procedure radiographic assessment showed disease stabilization and only 3.7 % of the treated patients did not achieve a satisfactory clinical result. (bioskinrevive.com)
In the present study, the bone marrow samples of patients with ONFH ( n = 16) and patients with the fracture of the femoral neck ( n = 12) were obtained during operation. (biomedcentral.com)
The CCEH Hematopoietic Cell Procurement and Processing Core maintains and gives access to a Repository of Cryopreserved Specimens consisting of large quantities of PBC components obtained from normal donors or patients with a variety of malignancies and limited quantities of normal bone marrow. (fredhutch.org)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
All patients can evolve into trisomy 8+ MDS [12], cells, since acquiring adequate samples diagnosed with MDS have a reduced in which 8+ appears to confer a favour- for flow cytometric analysis renders the life expectancy compared with age- able prognosis [13]. (who.int)
B19 is the primary etiologic agent causing TAC in patients with chronic hemolytic anemias (e.g., sickle cell disease, hemoglobin SC disease, hereditary spherocytosis, alpha-thalassemia, and autoimmune hemolytic anemia) (22,23). (cdc.gov)

Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Once damaged by heart attack, cardiac muscle has very little capacity for self-repair and at present there are no clinical treatments available to repair damaged cardiac muscle tissue. (phys.org)
In effect, they became electrified, which made them morph into more cardiac-like cells", explains Valerie Barron of REMEDI at National University of Ireland Galway. (phys.org)

This abnormal clone does not, however, produce bone marrow fibroblasts, which can proliferate in a polyclonal, reactive, and reversible fashion in response to the abnormal stem cell. (msdmanuals.com)

Cord blood can be used to treat certain types of bone marrow-related cancers. (medlineplus.gov)

New research published in Nature Medicine on January 23 highlights yet another challenge: The cell lines currently approved for study under federal funding contain a non-human molecule, the sialic acid Neu5Gc, which elicits an immune response in humans. (pharmexec.com)
This will give an opportunity to evaluate the mechanism of the cells delivered into the human heart," he noted. (cellmedicine.com)
The company has so far tested the PKU drug in animals and in human blood in the lab, and it aims to begin clinical testing next year. (technologyreview.com)
The new technology draws on recent advances in the ability to genetically modify and grow human red blood cells from stem cells in culture. (technologyreview.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
As human osteosarcoma cells are a source of additional growth they did not affect osteoinduction. (bvsalud.org)
The human bone marrow harbors a CD45− CD11B+ cell progenitor permitting rapid microglia‐like cell derivative approaches. (lu.se)

The stem cells are then extracted from the blood and transplanted back to the patient. (wikipedia.org)
Plerixafor has been found to be a strong inducer of mobilization of hematopoietic stem cells from the bone marrow to the bloodstream as peripheral blood stem cells. (wikipedia.org)
We and others have shown that blood cells can be generated from hESC. (ca.gov)
First, we have identified some of the key genetic differences in the way blood is formed from hESC that may be particularly important in the formation of the lymphoid cells of the immune system. (ca.gov)
Third, we have developed a way to express genes in hESC and hEMP to try and improve how these cells produce blood. (ca.gov)
During the next year of funding, we will continue to study the hEMP and other blood progenitors with the ultimate goal of learning how to improve production of the lymphoid immune system from hESC. (ca.gov)
Since a certain form of MDS in bone marrow is characterized by pronounced iron overload in the mitochondria of erythroblasts (maturing progenitor cells of red blood cells), he is also interested in specific issues relating to iron metabolism. (keyence.com)
A large number of bone marrow and blood samples have been collected and stored in the MDS registry's biomaterial database by Norbert Gattermann and his colleagues over many years, and they can now be used for molecular biological analysis. (keyence.com)
Introduction Sickle cell disease (SCD) is the most common inherited blood disease with a worldwide distribution. (bioskinrevive.com)
The image shows genetically engineered red blood cells grown in culture using Rubius's proprietary technology. (technologyreview.com)
Lodish, a scientific cofounder and member of Rubius's board of directors, says engineering red blood cells to produce the desired enzyme "answers both problems. (technologyreview.com)
Blood glucose, pancreatic β-cell damage, diabetic nephropathy and wound healing progression were assessed. (scirp.org)
Type 1 diabetes mellitus is characterized by the autoimmune destruction of the insulin-expressing pancreatic β-cells resulting in dependency on exogenous insulin to control blood glucose levels. (scirp.org)
We provide mobilized or non-mobilized peripheral blood cells (PBC) and bone marrow (BM) products. (fredhutch.org)
Comprehensive assessment of red blood cell, white blood cell and platelet indices. (fredhutch.org)
The most characteristic systemic effect resulting from intermediate and chronic benzene exposure is arrested development of blood cells. (cdc.gov)
Early biomarkers of exposure to relatively low levels of benzene include depressed numbers of one or more of the circulating blood cell types. (cdc.gov)
A common clinical finding in benzene hematotoxicity is cytopenia, which is a decrease in various cellular elements of the circulating blood manifested as anemia, leukopenia, or thrombocytopenia in humans and in animals. (cdc.gov)
This disorder is characterized by reduction of all cellular elements in the peripheral blood and in bone marrow, leading to fibrosis, an irreversible replacement of bone marrow. (cdc.gov)
A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. (lu.se)
All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. (lu.se)
It can also cause TAC in other conditions in which increased red cell production is necessary to maintain stable red cell indices, as may occur in anemia due to blood loss. (cdc.gov)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
Single-platform flow cytometric absolute cell counting protocols have been shown to provide increased robustness of CD34 enumeration by limiting potential sources of imprecision. (bdbiosciences.com)
We maintain an inventory of millions of enriched CD34 positive cells available for projects. (fredhutch.org)
We supply purified CD34 positive cells from healthy donors. (fredhutch.org)
We maintain an inventory of more than 400 vials of enriched 5-10 million CD34 positive cells collected from approximately 3-4 healthy donors each month. (fredhutch.org)

Two genes, SDF-1 and SELE, were significantly differentially expressed in diabetic Lin - /VEGF-R2 + endothelial progenitor cells and six other genes, CAV1, eNOS, CLDN5, NANOG, OCLN and BDNF, showed very low levels of expression in diabetic Lin - /VEGF-R2 + progenitor cells. (biomedcentral.com)
Marrow-derived cells migrated to the diabetic pancreas and specifically activated progenitor beta cell proliferation. (bepress.com)
Pancreatic β-cell damage was negligible in rats treated with HBOT for 5 days and longer while diabetic nephropathy was diminished in animals treated for 10 days. (scirp.org)

Platelets originate from megakaryocytes, which are the largest progenitor cells of the bone marrow. (teachmephysiology.com)

Anatomy62

Organisms14

Diseases29

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care1

Transplantation40

Stromal cells5

MSCs27

Mononuclear cells4

Trials17

Mobilization of bone marrow1

Endothelial cells3

Therapies17

Therapy28

Differentiation7

Angiogenesis2

Found in bone marrow2

Mice8

Pluripotent4

Populations5

Regeneration8

Vascular3

Myeloid4

Multipotent1

Hematopoiesis3

Therapeutic4

Chemotherapy2

Vitro5

Umbilical cord2

Donor6

Platelet counts2

Adipose1

Stem Cell Biology2

Acute5

EPCs1

Lymphocytes3

Morphology1

Source of stem cells2

Diseases11

Myoblasts3

Adult stem4

Infusion1

PBPCs1

Preclinical1

Tissue repair1

Counts3

Subtypes3

Etiology1

Outcomes10

Patients16

Cardiac4

Fibroblasts1

Cord blood1

Human8

Blood23

CD347

Diabetic3

Megakaryocytes1