Clinical phase drug therapy combination. Medical search. Frequent questions

The mesylate salt was approved by the U.S. Food and Drug Administration (FDA) on November 15, 2010, with an indication to treat people with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline- and taxane-based chemotherapies. (wikipedia.org)
On January 28, 2016, the U.S. Food and Drug Administration (FDA) approved eribulin for the treatment of inoperable liposarcoma in people who received prior chemotherapy that contained an anthracycline drug. (wikipedia.org)
1] Until recently, treatment paradigms in gynecologic oncology have mainly included a combination of radical surgery, cytotoxic chemotherapy (CT), and radiation therapy. (cancernetwork.com)
Between 40 and 60 percent respond to the drug when combined with other chemotherapy. (mdanderson.org)
Per the terms of the collaboration, Affimed will fund and conduct a Phase 1b clinical trial to evaluate the combination of Merck's anti-PD-1 therapy, KEYTRUDA (pembrolizumab), with Affimed's proprietary drug candidate AFM13 in patients with Hodgkin lymphoma whose disease has relapsed or is refractory to chemotherapy, including treatment with Adcetris (brentuximab vedotin). (drugdiscoverynews.com)
Ongoing clinical trials are investigating bemcentinib in multiple solid and haematological tumours, in combination with current and emerging therapies (including immunotherapies, targeted therapies and chemotherapy), and as a single agent. (prnewswire.co.uk)
Platinum-based combination chemotherapy is recommended first choice for relapsed ovarian cancer. (frontiersin.org)
Immune checkpoint inhibition is a new standard of targeted therapy in the treatment of advanced or metastatic gastric cancer (GC) and is represented in various combinations with and without chemotherapy in every therapy line within clinical trials. (mdpi.com)
In advanced adenocarcinoma of GC, gastroesophageal junction cancer (GEJC) and esophageal cancer (EC), the combination of nivolumab and chemotherapy in first-line therapy improves overall survival (OS) in PD-L1 (programmed cell death protein 1)-positive patients with approval in Europe (PD-L1 CPS (combined positivity score) ≥ 5), USA and Taiwan (CHECKMATE-649) and pembrolizumab plus chemotherapy for GEJC and EC in Europe (CPS ≥ 10) and the USA (KEYNOTE-590). (mdpi.com)
Then we try to infer targeted therapies from this molecular work-up that we are doing for the relapsed situation because we think, or we hope, that this will be better than just giving a standard oral chemotherapy. (ecancer.org)
at the moment it's at the discretion of the clinician, the local clinician, to take them further for an individual therapy and in the future, once this concept is better established and all the infrastructure is working really on a daily basis, then we want to really run a clinical trial where we compare the principle of individualised therapy versus just giving a backbone chemotherapy as we do now. (ecancer.org)
ALTTO was a clinical trial designed to compare treatments for early stage HER2+ breast cancer in women who had also received chemotherapy. (cancer.gov)
It was approved for use in the United States in 1998 and in Europe in 2000 to treat metastatic HER2+ breast cancer in combination with chemotherapy. (cancer.gov)
Lapatinib (Tykerb) was approved in 2007 for use in combination with capecitabine, a chemotherapy drug, for the treatment of advanced or metastatic HER2+ breast cancer in patients who have received prior treatment, including an anthracycline drug, a taxane drug, and trastuzumab. (cancer.gov)
Generally, radiation therapy and chemotherapy do not have a prominent role in the treatment of thyroid cancer. (medscape.com)

HLB, an international biopharmaceutical company, submitted a new drug application (NDA) for its Rivoceranib liver cancer drug to the U.S. Food and Drug Administration (FDA) on Tuesday. (koreatimes.co.kr)
This is the first time a Korean biopharmaceutical company has completed its own clinical trials for a new anticancer drug and proceeded with the NDA process," a company spokesman said. (koreatimes.co.kr)
NEW YORK, April 12, 2022 (GLOBE NEWSWIRE) -- IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulating cancer therapies based on its T-win ® technology platform, announced today that it has dosed the first patient, in metastatic non-small cell lung cancer (NSCLC), in its Phase 2 IOB-022 / KN-D38 trial ( NCT05077709 ). (biospace.com)
IO Biotech is a clinical-stage biopharmaceutical company developing novel, immune-modulating cancer therapies based on its T-win ® technology platform. (biospace.com)
HEIDELBERG, Germany-Clinical-stage biopharmaceutical company Affimed N.V., which focuses on the discovery and development of targeted cancer immunotherapies, has begun a clinical research collaboration with Merck & Co. (known as MSD outside the United States and Canada) in the field of immuno-oncology, specifically for the combination of their respective therapies. (drugdiscoverynews.com)
BerGenBio is a clinical-stage biopharmaceutical company focused on developing transformative drugs targeting AXL as a potential cornerstone of therapy for advanced and aggressive cancers. (prnewswire.co.uk)
Celator Pharmaceuticals, Inc., formerly Celator Technologies, Inc., is a privately held biopharmaceutical company working to develop new and more effective therapies to treat cancer. (salesandmarketingnetwork.com)
JERUSALEM, Feb. 26, 2020 /PRNewswire/ -- KAHR Medical Ltd., a biopharmaceutical company developing a novel drug platform based on bi-functional, immunotherapeutic fusion proteins known as Dual Signaling Proteins ("DSP") today announced that it has raised US$18 million from a global syndicate of leading investors. (pharmiweb.com)

IO Biotech is advancing in clinical studies its lead immuno-oncology candidate, IO102-IO103, targeting IDO and PD-L1, and through clinical and preclinical development its other pipeline candidates. (biospace.com)
Additionally, preclinical studies indicate that a combination with an anti PD-1 therapy could act synergistically and represent an additional future treatment option for patients. (drugdiscoverynews.com)
This new funding round will be used to support our clinical trials as well as advance our active preclinical program. (salesandmarketingnetwork.com)
Now, data from recent case studies , as well as from emerging preclinical and clinical publications, support the possible role of combination therapy with high-dose vitamin D and Omega-3 fatty acids in stopping the progression of type 1 diabetes in new onset patients. (diabetesresearch.org)
The Ivy Center's Phase 0/1 study has shown a promising translation of the preclinical results of SDT in patients with glioblastoma. (azbio.org)
The same biomarkers that were positive in preclinical studies, and contributed to a significant increase in survival in two animal glioma models, are being seen in the clinical trial patient participants," said Stuart Marcus, MD, PhD, Founder, CEO and CMO of SonALAsense. (azbio.org)
Innovative drugs in Preclinical or Discovery Stage. (globaldata.com)
Proceeds will be used for advancing the Company's next generation immuno-oncology drug candidates including the clinical development of the Company's lead product, DSP107, an anti-CD47 therapy for the treatment of solid tumors through a Phase I/II study and the preclinical advancement of additional pipeline projects. (pharmiweb.com)

Prior therapy should have included an anthracycline and a taxane unless the people were not suitable for these treatments. (wikipedia.org)
NeuroSense Therapeutics, Ltd. is a clinical-stage biotechnology company focused on discovering and developing treatments for patients suffering from debilitating neurodegenerative diseases. (prnewswire.com)
The results of the clinical trial using the combination therapy showed the two treatments succeeded to meet primary endpoints, which means that both the efficacy and versatility have been proven. (koreatimes.co.kr)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
DeSantes, a UW Carbone Cancer Center researcher and Medical Director for the Pediatric Bone Marrow Transplant and Cell Therapy program , said this phase I-II clinical trial uses a variation of an existing immunotherapy drug as part of a combination therapy for neuroblastoma patients who have advanced stage disease and have failed other treatments. (uwhealth.org)
In this clinical trial, dinutuximab beta is being given continuously by infusion over 10 days, reducing the painful side effects enough so that treatments often do not require a hospital stay. (uwhealth.org)
The number of prescription acne treatments as qualified OTC products is also increasing which improves accessibility of acne drugs. (thebusinessresearchcompany.com)
Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. (disabled-world.com)
test experimental treatments, new combinations of drugs, or new approaches to surgery or radiation therapy. (disabled-world.com)
Ivy Brain Tumor Center at the Barrow Neurological Institute in Phoenix, AZ is a non-profit translational research program that employs a bold, early-phase clinical trials strategy to identify new treatments for aggressive brain tumors, including glioblastoma. (azbio.org)
Patients had gone through 1-4 previous treatments before enrolling in the clinical trial between January 2010 and January 2012. (sciencedaily.com)
The drug could be "a pharmacological alternative to traditional surgical treatments or to not treating this genetic disease," or it "could be used to augment the effectiveness of surgical therapies," speculated Ornitz, of the Washington University School of Medicine, St Louis, Missouri. (medscape.com)
Of course, whether or not you participate in a clinical trial, there are good standard treatments and excellent care available for cancer patients. (ucsf.edu)
Test new treatments (a new cancer drug, new approaches to surgery or radiation therapy, new combinations of treatments, or new methods such as gene therapy). (ucsf.edu)
Clinical trials help us find new and better treatments. (ucsf.edu)

Timothy Low, Head of Healthcare Investments, Pavilion Capital, said, "We are delighted to join KAHR Medical's syndicate of investors, and believe the company has a tremendous opportunity to contribute new targeted therapies to the field of immuno-oncology. (pharmiweb.com)

We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). (nih.gov)
A phase Ib/II trial was initiated in patients with untreated advanced BTC. (nih.gov)
In the phase Ib trial, 20 patients received a median of nine cycles (range, 3-19). (nih.gov)
Devimistat in combination with GC is well tolerated and has an acceptable safety profile in patients with untreated advanced BTC. (nih.gov)
We will accelerate our clinical development programs, hoping to offer more treatment options for cancer patients with unmet medical needs. (pharmiweb.com)
APG-115-US-002 is an open-label, multi-center, Phase Ib/II study in U.S. , which was designed to assess safety, toxicity, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of APG-115 in combination with pembrolizumab in patients with advanced solid tumors. (pharmiweb.com)
As of April 1, 2020, in the Phase Ib study, 19 patients were treated with APG-115 in 4 alternate-day (QOD) dose cohorts (50 mg, 100 mg, 150 mg, and 200 mg) in combination with pembrolizumab. (pharmiweb.com)
NeuroSense's Phase IIb PARADIGM trial is currently enrolling patients to assess PrimeC's efficacy, as well as safety and tolerability, in people living with ALS. (prnewswire.com)
The Phase 3 trial for liver cancer treatment, which began in April 2019, was conducted on 543 patients in 13 countries including Korea, the U.S. and China. (koreatimes.co.kr)
The IOB-022 / KN-D38 trial seeks to evaluate IO Biotech's lead candidate, IO102-IO103, in combination with KEYTRUDA ® (pembrolizumab), Merck's anti-PD-1 (programmed death receptor-1) therapy, in previously untreated patients with three different tumor types in the first line setting -NSCLC, squamous cell carcinoma of the head and neck (SCCHN), and urothelial bladder cancer (mUBC). (biospace.com)
IO Biotech has also begun patient recruitment into a Phase 3 combination trial (IOB-013 / KN-D18) of IO102-IO103 and KEYTRUDA ® (pembrolizumab) as first-line treatment in advanced melanoma patients, which is designed to be potentially registrational. (biospace.com)
Will we have to give patients six drugs or 10 drugs to block them all? (mdanderson.org)
In this combination approach, the molecule MIBG linked to iodine-131 is given as a targeted radiation therapy to sensitize neuroblastoma cells to immunotherapy treatment: nivolumab, a checkpoint inhibitor commonly used in adult cancer patients, and dinutuximab beta, which targets an antigen called GD2 that is expressed by neuroblastoma cells. (uwhealth.org)
The compound is designed to treat CD30-positive malignancies, including Hodgkin lymphoma and T cell lymphoma, and it is currently in Phase 2 studies in Hodgkin lymphoma patients. (drugdiscoverynews.com)
In parallel with its phase II clinical trial programme, BerGenBio explores predictive biomarker candidates with the aim to develop a companion diagnostic to identify patients most likely to benefit from bemcentinib treatment. (prnewswire.co.uk)
The BGBIL006 trial is a randomised Phase 1b /2 investigator sponsored clinical study of bemcentinib (BGB324) in combination with either the MAPK inhibitors MEKINIST® (trametinib) plus TAFINLAR® (dabrafenib) or the immune checkpoint inhibitor KEYTRUDA® (pembrolizumab) in patients with advanced melanoma. (prnewswire.co.uk)
For instance, in March 2020, Eli Lilly announced plans to delay the start of new clinical trials and did not recruit patients for 78 studies. (thebusinessresearchcompany.com)
Seattle, WA, 13 February 2017 - Janssen Sciences Ireland UC (Janssen) announced positive results from the full data read out for two Phase III studies evaluating the safety and efficacy of switching virologically suppressed patients from a three- or four-drug antiretroviral regimen to the two-drug regimen of dolutegravir (ViiV Healthcare) and rilpivirine (Janssen). (jnj.com)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)
A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
In patients with relapsed ovarian cancer, treatment becomes increasingly challenging to subsequent therapies because of renal impairment and emerging drug resistance. (frontiersin.org)
For platinum-resistant or platinum-sensitive ovarian cancer patients, non-platinum drugs such as doxorubicin, paclitaxel, gemcitabine, docetaxel and etoposide are recommended ( 5 ). (frontiersin.org)
A study reported acute kidney injury (AKI) in 10880 patients of 163,071 patients on systemic therapy for cancer with an cumulative incidence of 9.3% ( 7 ). (frontiersin.org)
PARPi such as niraparib and olaparib, are approved by FDA as maintenance therapy for patients with PSROC and as posterior line therapy for patients with BRCA mutated recurrent ovarian cancer. (frontiersin.org)
NOVA study is the first study to report effectiveness of niraparib as maintenance therapy in patients with PSROC regardless of BRCA mutation ( 9 ). (frontiersin.org)
Over 70% of cancer patients in the trial showed a clinical benefit following treatment with CPX-1. (salesandmarketingnetwork.com)
Trial Description: This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. (dana-farber.org)
Trial Description: This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. (dana-farber.org)
The theme of the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting is Partnering With Patients: The Cornerstone of Cancer Care and Research . (cancer.net)
Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
Thirty patients were enrolled in the study and received two doses of nivolumab with relatlimab before surgery, followed by up to 10 additional doses of the combination therapy after surgery. (mdanderson.org)
In a nonrandomized, open-label Phase II study, MD Anderson researchers demonstrated that talazoparib, a PARP inhibitor, showed activity in patients with germline BRCA1/2 mutation-positive, early HER2-negative breast cancer. (mdanderson.org)
After a promising treatment is developed and its safety and effectiveness in the pre-clinical setting proven, clinical investigators obtain regulatory approval to conduct diabetes studies, or clinical trials, in patients. (diabetesresearch.org)
Progress in islet transplantation has allowed many patients with type 1 diabetes to live without the need for insulin therapy, but this cell therapy remains an experimental procedure available only through clinical trials. (diabetesresearch.org)
The results were even better when coupled with a second drug that is commonly used in type 2 diabetes patients to enhance natural insulin production. (diabetesresearch.org)
For instance, researchers are currently conducting phase-I clinical trial evaluating the role of Teclistamab in combination with Darzalex Faspro in patients with relapsed or refractory multiple myeloma (RRMM). (researchandmarkets.com)
For instance, Xencor and Janssen Biotech have entered an exclusive collaboration and global license agreement for the development and commercialization of plamotamab and XmAb CD28 bispecific antibody combinations to treat patients with B-cell malignancies. (researchandmarkets.com)
During the clinical trial, the investigators: recruit patients with the predetermined characteristics, administer the treatment(s), and collect data on the patients' health for a defined period. (disabled-world.com)
Sonodynamic therapy has tremendous potential to become a new nonsurgical therapeutic modality to treat brain tumors," said Nader Sanai, MD. "We found that MR-guided focused ultrasound combined with SONALA-001 demonstrated rapid and selective cell death in the patients' tumors, an encouraging discovery of this new noninvasive treatment option. (azbio.org)
Unlike conventional clinical trials focusing on single drugs, its accelerated trials program tests therapeutic combinations matched to individual patients. (azbio.org)
Adding panobinostat to a combination treatment of bortezomib and dexamethasone in heavily pretreated patients boosts progression-free survival, but overall survival data are not yet mature. (pharmacytimes.com)
In a phase III trial published in the journal Lancet Oncology on September 18, 2014, researchers San-Miguel et al investigated the potential of combination therapy with panobinostat, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma. (pharmacytimes.com)
In a press release, lead author of the 215-site clinical trial Jesus San-Miguel, MD, stated, "The PANORAMA-1 study is the first Phase III trial to show the superiority of LBH589 plus bortezomib and dexamethasone over one of the standard two-drug regimens for patients with relapsing and/or refractory multiple myeloma. (pharmacytimes.com)
Further research will determine whether panobinostat affects overall survival and whether the tradeoff of clinical benefits and adverse events justify approval of the treatment for patients with relapsed multiple myeloma. (pharmacytimes.com)
Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. (pharmacytimes.com)
Together, they put half of the patients with relapsed follicular lymphoma into complete remission in a phase II clinical trial. (sciencedaily.com)
Patients had no indicators of autoimmunity, which can be an issue in the class of drugs that blocks immune system checkpoints and activate T cells. (sciencedaily.com)
Celltrion Healthcare is committed to delivering innovative and affordable medications to promote patients' access to advanced therapies. (pipelinereview.com)
There was no difference in the incidence of side effects in patients receiving the drug or placebo in this phase 3 study of the investigational drug from BioMarin Pharmaceuticals. (medscape.com)
The efficacy results were "encouraging" for this "first potential pharmacological therapy to increase growth of achondroplasia patients. (medscape.com)
Over 100 free commonly used clinical formulas and calculator tools to help diagnose, treat, prevent, and determine prognosis of patients at point of care. (guidelinecentral.com)
Identify clinical preventive services that are appropriate for your patients. (guidelinecentral.com)
Treatment with an investigational drug that induces the release of growth hormone significantly improved the symptoms of HIV lipodystrophy, a condition involving redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (harvard.edu)
In this article, we provide updated data on ruxolitinib therapy for patients with myelofibrosis and offer expert opinion on the appropriate use of this agent in the community practice. (cancernetwork.com)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
After the primary therapy that we give to all patients, usually in nationwide or European protocols, we nowadays can cure about 75% of patients but whoever relapses, however, usually has a very poor survival. (ecancer.org)
In September 2019, KAHR Medical announced a clinical collaboration with Roche to evaluate KAHR Medical's lead program, DSP107, a SIRPα-41BBL DSP, in combination with Roche's PD-L1-blocking checkpoint inhibitor atezolizumab (Tecentriq®) in patients with advanced NSCLC who are refractory to existing immune checkpoint inhibitors. (pharmiweb.com)
We are keen to work with the Company as it matures, and we look forward to helping it fulfil its mission of bringing new therapies to cancer patients. (pharmiweb.com)
The safety and preliminary efficacy of both DSP107 monotherapy and combination therapy with atezolizumab will be evaluated in patients with advanced NSCLC who are refractory to PD-1/PD-L1 inhibitors. (pharmiweb.com)
Specifically, ALTTO was designed to determine which treatment was more effective, which was safer for patients, and whether additional benefit could be derived by taking the drugs together, either in tandem or at the same time. (cancer.gov)
The ALTTO clinical trial was unique in that, for all of patients, there was central pathology review of the primary tumor, including re-evaluation of the cancer's estrogen receptor (ER), progesterone receptor (PR), and HER2 status, before patients were randomly assigned to one of the trial's four treatment groups. (cancer.gov)
Trastuzumab (Herceptin), a drug developed in 1990s to target HER2+ breast cancers, is a large monoclonal antibody that, once injected into patients, binds to the portion of the HER2 protein that sits on the outer surface of the cancer cell. (cancer.gov)
Research studies conducted with cancer patients are called clinical trials. (ucsf.edu)
In cancer research, a clinical trial is a scientific study conducted with volunteer cancer patients. (ucsf.edu)
Patients who volunteer to participate in clinical trials often have the first chance to benefit from an effective new therapy. (ucsf.edu)
Clinical trials are available for patients with many types of cancers at different stages. (ucsf.edu)
Clinical trials help us find out if a promising new treatment is safe and effective for patients. (ucsf.edu)
Only patients who volunteer to participate take part in a clinical trial. (ucsf.edu)
These are highly regulated activities that allow researchers to pose questions that result in reliable information about the drug and protect patients. (ucsf.edu)
A phase I trial usually enrolls only a small number of patients, sometimes as few as a dozen. (ucsf.edu)
The overall goal of this study is to develop Gallium Maltolate (GaM), an experimental drug, as a new oral treatment for patients with glioblastoma brain tumors whose tumor has relapsed after initial treatment or has progressed despite initial treatment. (froedtert.com)
For the antifungal isavuconazole, Basilea and its partner Astellas Pharma Inc. are currently preparing the phase 3 data analyses of the SECURE study in aspergillosis and the VITAL study in aspergillosis patients with kidney impairment or with invasive fungal disease caused by emerging and often fatal fungi. (basilea.com)
This study is designed to determine whether 6 months of anti-HIV drugs given along with tuberculosis treatment will delay the onset of AIDS in HIV infected African patients. (drugpatentwatch.com)
The primary objective is to identify a safe, metabolically favorable, dosing regimen for siplizumab in patients with type 1 diabetes that induces changes in T cell phenotypes observed with alefacept therapy in new-onset T1DM. (policylab.us)
We used the clinical characteristics of genetically confirmed patients with HoFH to query the Family Heart Database, a US anonymized payer health database, to estimate the number of patients with similar lipid profiles in a "real-world" setting. (bvsalud.org)
BACKGROUND: We sought to determine whether circulating modifiers of endothelial function are associated with cardiac structure and clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF). (bvsalud.org)
CONCLUSIONS: Proteins related to endothelial function associate with cardiac size, cardiac function and clinical outcomes in patients with HFrEF. (bvsalud.org)
METHODS: A total of 894 patients with heart failure with reduced ejection fraction were enrolled in The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment trial. (bvsalud.org)
In general, the first decision made in the management of patients with myeloma who require systemic therapy is whether stem cell transplantation is part of the strategy. (medscape.com)
Alkylator and nitrosourea therapy is usually deferred or reduced in patients who may require autologous stem cell collection, to avoid injury to the stem cells. (medscape.com)
All transplant-eligible multiple myeloma patients should receive a triplet induction therapy (immunomodulatory agents, proteasome inhibitor and dexamethasone). (medscape.com)
[ 1 ] Although the combination of carfilzomib (second-generation proteasome inhibitor) with lenalidomide and dexamethasone showed higher efficacy in phase II trials, particularly in high-risk patients, interim analysis in an ongoing phase III clinical trial showed that progression-free survival (PFS) was not superior to that with bortezomib/lenalidomide/dexamethasone. (medscape.com)
Patients who present with active (symptomatic) multiple myeloma are treated with induction therapy. (medscape.com)
After effective short-course therapy for active TB, some patients experience another, recurrent TB episode. (cdc.gov)
TB patients are treated in the TB hospital during the intensive phase. (cdc.gov)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
Drug : The purpose of this study was to compare the lipid level improvement effect and the incidence of side effects of high-dose statin and moderate-intensity statin + ezetimibe combination therapy in elderly (over 65 years old) patients diagnosed with acute coronary syndrome and undergoing coronary angioplasty. (who.int)
The purpose of this study was to compare and evaluate the lipid improvement effect (change in TG/HDL/total cholesterol) and the incidence of side effects at 3 months of high-dose statin therapy and moderate-intensity statin + ezetimibe combination therapy in elderly patients with acute coronary syndrome. (who.int)

Given the promising evidence of safety and efficacy in the Phase I trial, further evaluation of efficacy in select solid tumors is warranted. (pharmiweb.com)
NeuroSense completed a Phase IIa clinical study which successfully met its safety and efficacy endpoints including reducing functional and respiratory deterioration and statistically significant changes in ALS-related biological markers indicating PrimeC's biological activity. (prnewswire.com)
Primary endpoints of the study include assessment of ALS biomarkers, evaluation of clinical efficacy, improvement in quality of life, as well as safety and tolerability. (prnewswire.com)
Jang Seong-hoon, chief operating officer of Elevar Therapeutics, HLB's U.S. subsidiary, explains the efficacy and safety of the company's Rivoceranib anticancer drug during a symposium hosted by Korea's Ministry of Food and Drug Safety in Washington, D.C., March 21. (koreatimes.co.kr)
IOB-022 / KN-D38 is a non-comparative, open label trial to investigate the safety and efficacy of IO102-IO103 in combination with pembrolizumab in each of the following first-line indications: NSCLC, SCCHN, and mUBC. (biospace.com)
The study, which is expected to begin in the first half of 2016, will seek to establish a dosing regimen for the combination and determine its safety and efficacy. (drugdiscoverynews.com)
To investigate this possibility, we analyzed a subset of archived P. falciparum DNA samples from clinical infections, derived from a set of large, multicenter comparative artemisinin combination therapy efficacy trials conducted in West Africa by the West African Network for Antimalarial Drugs ( 8 ). (cdc.gov)
Clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. (disabled-world.com)
The global Phase III clinical trial proposed in the IND is designed to evaluate the safety and efficacy profile of the inhaled COVID-19 antibody cocktail. (pipelinereview.com)
Caveats include that daily injections might limit patient compliance and drug effectiveness, and it is not known whether efficacy would be sustained over the many years of treatment that would be required or if adverse effects would emerge later on, he noted. (medscape.com)
At that time, data were insufficient to assess the efficacy of ZDV as a prophylactic agent in humans or the toxicity of this drug in persons not infected with HIV. (cdc.gov)

The SWORD Phase III results represent an important step forward in our efforts to deliver a two-drug regimen that may help simplify dosing regimens and reduce pill burden for people living with HIV," says Lawrence M. Blatt, Global R&D Head, Infectious Diseases & Vaccines, Janssen. (jnj.com)
For the first time since the 1960s, new and novel drugs and regimens for all forms of TB are emerging. (nih.gov)
Such regimens are likely to utilize both repurposed drugs and new chemical entities, and several of these regimens are now progressing through clinical trials. (nih.gov)
[ 14 ] Any one of the combination regimens below may be used for induction therapy. (medscape.com)
Shanghai CDC collects and manages patient information, such as social and demographic characteristics, clinical data, TB treatment regimens, and the result of drug susceptibility testing and species identification. (cdc.gov)

Yu said saracatinib has been tested in phase I and phase II clinical trials as a single treatment against late-stage cancers. (mdanderson.org)
SonALAsense is a clinical-stage company developing sonodynamic therapy (SDT) as a first-in-class, noninvasive drug-device combination for the treatment of recurrent glioblastoma multiforme, diffuse intrinsic pontine gliomas, and other deadly cancers. (azbio.org)

The company's proprietary lead candidate, bemcentinib, is a potentially first-in-class selective AXL inhibitor in a broad phase II clinical development programme. (prnewswire.co.uk)
CombiPlex , the company's drug ratio technology platform, represents a revolutionary new approach to the development of combination therapies based on the optimal ratio of drug agents to target cancer cells effectively. (salesandmarketingnetwork.com)
BioMarin has submitted a new drug application for vosoritide to the US Food and Drug Administration (FDA), and the company's marketing authorization application was validated by the European Medicines Agency (EMA). (medscape.com)
In the first six months of 2013, Basilea made substantial progress toward the company's major milestones: the reporting of the isavuconazole phase 3 data and a potential approval of ceftobiprole. (basilea.com)

HLB completed the global Phase 3 clinical trial of the anticancer treatment in May 2022. (koreatimes.co.kr)
The global HIV drugs market Size was valued at $32.8 billion in 2022, and is projected to reach $51.1 billion by 2032, growing at a CAGR of 4.5% from 2023 to 2032. (alliedmarketresearch.com)
The multi-class combination drugs segment held the largest share in the HIV drugs market in 2022. (alliedmarketresearch.com)
It is expected that the drug will be available in the market by end of 2022 and will be sold under the brand name Tecvalyi. (researchandmarkets.com)

The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting , highlight new advances in drug therapy research to improve patient outcomes. (mdanderson.org)
First evidence of anti-tumor activity from phase 1 study data was presented in June at the Annual Meeting of the American Society of Clinical Oncology (ASCO) for Basilea's novel microtubule-destabilizing and vascular disrupting anti-cancer drug, BAL101553. (basilea.com)

adults with unresectable liposarcoma who have received prior anthracycline containing therapy (unless unsuitable) for advanced or metastatic disease. (wikipedia.org)
Metastatic breast cancer impacts about 150,000 people in the U.S. and due to the small patient population, Eisai was able to file a New Drug Application (NDA) under the orphan and rare disease designation. (wikipedia.org)
IO102-IO103, in combination with pembrolizumab, was granted Breakthrough Therapy Designation by the U.S. Food and Drug Administration for treatment of unresectable/metastatic melanoma, based on the results of a Phase 1/2 clinical trial (MM1636). (biospace.com)
Trial Description: This trial is testing whether molecularly targeted oral medications called talazoparib and tazemetostat can be safely combined for the treatment of prostate cancer , and whether the combination is effective in shrinking or preventing the growth of metastatic prostate cancer . (dana-farber.org)

If successful, it would become the first Korean biotechnology company to win a new drug approval in the U.S., the company said Thursday. (koreatimes.co.kr)
PRINCETON, N.J., Aug. 2 (HSMN NewsFeed) -- Celator Pharmaceuticals, a privately-held biotechnology company working to develop combination chemotherapies to treat different types of cancer, today announced that it has closed a $10 million private equity financing round. (salesandmarketingnetwork.com)

current studies are limited to early-phase clinical trials. (cancernetwork.com)

Due to the complexity of neurodegenerative diseases and based on strong scientific research on a large panel of related biomarkers, NeuroSense's strategy is to develop combined therapies targeting multiple pathways associated with these diseases. (prnewswire.com)
This article covers current concepts and recent advances in TB drug discovery and development, including an update of ongoing TB treatment trials, newer clinical trial designs, TB biomarkers and adjunct host-directed therapies. (nih.gov)
Diagnostics, Imaging Agents, Biomarkers, stents and other drug delivery devices (covered in GlobalData's Medical Intelligence Center). (globaldata.com)

Furthermore, we observed some encouraging signs of clinical activity, which warrants further evaluation in specific patient populations, including microsatellite-stable colorectal cancer [CRC] and non-small-cell lung cancer [NSCLC]. (pharmiweb.com)
Particularly, the clinical trial showed a reduction of between 40 percent and 50 percent in the risk of patient death. (koreatimes.co.kr)
This is a very high-risk patient population - usually they've failed a number of different therapies before they would come to participate in this study," DeSantes said. (uwhealth.org)
We give the first cycle (of this trial) in the hospital, and then if the patient tolerates it well, the rest of the therapy is given in the outpatient setting," he said. (uwhealth.org)
She predicts that revenue won't come in until 2024, and when it does, it will be directed back into research, patient access programs, further drug development, and new studies on different indications, as well as non-profit initiatives at MAPS focused on education, harm reduction, and policy reform. (forbes.com)
With guidelines recommending combined LAMA and LABA therapy for a number of COPD patient groups, we believe Duaklir® will make an important contribution to the treatment of this debilitating disease," said Michael Asmus, Circassia's Vice President, US Medical Affairs, Circassia. (pharmacytimes.com)
This drug has the ability to block all estrogen in a patient, including premenopausal women, without the need for additional medications. (wrbl.com)
Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
Islet transplantation studies at the DRI continue to focus on improving the safety, long-term function, and success of islet replacement therapies and each one moves the needle of knowledge and patient application forward. (diabetesresearch.org)
The Ivy Brain Tumor Center dosed its first patient in March 2021 and is currently evaluating SDT using Insightec's magnetic resonance-guided focused ultrasound (MRgFUS) technology in combination with SonALAsense's proprietary intravenous formulation of 5-aminolevulinic acid (SONALA-001) to investigate the feasibility, safety, and biological effects of the treatment. (azbio.org)
We look forward to sharing additional updates on the progress of patient enrolment and global clinical trials in the coming months. (pipelinereview.com)
But this study shows clearly that the novel strategy of inducing the release of endogenous growth hormone can improve symptoms of lipodystrophy, relieving patient distress - which may improve their compliance with therapy - and reducing several cardiovascular risk factors. (harvard.edu)
Despite advances in the treatment of cancer, there is still a clear need for additional therapies to broaden the patient population that will respond to cancer immunotherapies. (pharmiweb.com)
As a cancer patient, you may take part in a clinical trial. (ucsf.edu)
A listing of clinical trials in Missouri actively recruiting patient volunteers. (policylab.us)
On the basis of the sputum smear and culture examination 1 or 2 months after TB therapy is initiated, the patient is discharged from the hospital and finishes treatment as an outpatient. (cdc.gov)
Is the patient being adequately monitored for toxicity and clinical response? (cdc.gov)
At the conclusion of this session the participant will be able to outline key talking points to communicate to a patient who has been prescribed opioid therapy, provide practical strategies to help motivate a patient's commitment to opioid therapy adjustment and apply a patient centered six-step process to minimize conflict when communicating opioid dosing recommendations. (cdc.gov)

Because of the notorious capacities of Plasmodium falciparum to develop drug resistance, many antimalarial programs have recently included dihydroartemisinin/piperaquine (DHA/PPQ) as a second-line antimalarial drug. (cdc.gov)
As I said, the genomes are simpler so it will be much easier to interpret the results of giving a targeted drug, even a monotherapy, and probably the mechanisms of resistance because it's just less noisy and less, what we call, passenger mutations. (ecancer.org)
Basilea's continued commitment to address the medical challenges of resistance is demonstrated by the progress made on Basilea's two phase 1 compounds from its research. (basilea.com)
Ronald Scott, Basilea's CEO stated: 'Basilea is committed to fight the growing global threat of resistance against established therapies. (basilea.com)
We remain open to explore innovative collaboration and transaction structures and we were very pleased to announce a significant agreement with BARDA allowing for non-dilutive funding of up to USD 89 million for our drug candidate BAL30072, which addresses Gram-negative bacterial resistance. (basilea.com)
Recommendations for PEP have been modified to include a basic 4-week regimen of two drugs (zidovudine and lamivudine) for most HIV exposures and an expanded regimen that includes the addition of a protease inhibitor (indinavir or nelfinavir) for HIV exposures that pose an increased risk for transmission or where resistance to one or more of the antiretroviral agents recommended for PEP is known or suspected. (cdc.gov)
The TB hospital sends all mycobacteria-positive cultures to the TB reference laboratory at the Shanghai Municipal Centers for Disease Control and Prevention (Shanghai CDC), which participated in the World Health Organization/International Union against Tuberculosis and Lung Disease global drug resistance surveillance project, for species identification and drug susceptibility testing. (cdc.gov)
Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)

The standard approach to treat solid tumor cancer that has metastasized to the brain is with whole brain radiation therapy. (froedtert.com)
PRDR) whole brain radiation therapy in combination with the drug Memantine to reduce the neurocognitive effects of treating brain metastases. (froedtert.com)
Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. (dana-farber.org)

Access to thousands of clinical practice guidelines for medical professionals. (guidelinecentral.com)
In an accompanying segment, we discussed modern multimodal analgesia and how incorporating it into clinical practice can enhance pain control and improve outcomes. (medscape.com)
He has nearly 30 years of clinical practice experience in primary care internal medicine. (cdc.gov)

The Phase Ib dose-escalation study has been completed, and the Phase II is ongoing. (pharmiweb.com)
AFM13, a first-in-class NK-cell engager, has shown an acceptable safety profile and preliminary antitumor activity in the first-in-human Phase 1 study. (drugdiscoverynews.com)
As would be expected when switching from a stable regimen to a new regimen (in most cases containing two new drugs), more adverse events were reported and led to withdrawal from the study in the DTG+RPV arm (DTG+RPV: 21, CAR: 3). (jnj.com)
The drug's label also includes clinical data from the phase IV ASCENT study, which shows aclidinium therapy is effective at reducing COPD exacerbations. (pharmacytimes.com)
QUADRA study reported clinical benefit of niraparib in fourth or later line therapy among women with heavily pretreated ovarian cancer, especially in HRD-positive platinum-sensitive ovarian cancer ( 10 ). (frontiersin.org)
The company has obtained Health Canada's approval to commence the EVANGELINE study, a phase 2 clinical trial that focuses on a promising new treatment for pre-menopausal women with breast cancer. (wrbl.com)
What makes this study different is its investigation of the combination therapy involving (Z)-endoxifen versus the conventional regimen of exemestane and goserelin as neoadjuvant treatment. (wrbl.com)
These findings, together with other study results using different drug combinations, have led DRI researchers to believe that a cocktail of multiple agents may be successful as a multi-path approach to address several challenges: halting the immune system attack, preserving the remaining islet function, and possibly, giving the body a chance to recover and regenerate its own islets. (diabetesresearch.org)
These data include measurements like vital signs, amount of study drug in the blood, and whether the patient's health gets better or not. (disabled-world.com)
The study showed CT-P63 to be safe and well tolerated, with no significant drug-related adverse events (AEs). (pipelinereview.com)
The current study followed up an earlier Phase II study of tesamorelin, a growth-hormone-releasing factor that can be dosed only once a day instead of twice. (harvard.edu)
We even have more limitations to get access to drugs, of course, because usually you have to have completed an adult phase I study before you can start a paediatric phase I and usually there is not a lot of interest with the pharma companies to do that at all because this will never be a big market. (ecancer.org)
The planned Phase I/II study will evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of DSP107 in advanced solid tumors. (pharmiweb.com)
The program is anticipated to transition into phase 2a of clinical development this year following establishment of the maximum tolerated dose in the ongoing phase 1 study. (basilea.com)
Study hypothesis: The combination of CsA and LPV/r given to acutely infected individuals will result in lower levels of proviral DNA and latent infectious virus at 48 weeks compared to acute infected individuals treated with LPV/r alone. (drugpatentwatch.com)
The purpose of this study is to compare the effects of anti-HIV drug courses of different lengths in infants who became HIV infected at birth. (drugpatentwatch.com)
This is a multicenter, Phase Ib, open-label, siplizumab dose-finding study in individuals aged 8-45 years with a Type 1 diabetes mellitus (T1DM) diagnosis. (policylab.us)

If approved, this treatment could be the first two-drug regimen for HIV and could offer those living with HIV who are virally suppressed the option to switch to a regimen which does not include a nucleotide reverse transcriptase inhibitor (NRTI). (jnj.com)
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide. (nih.gov)

CombiPlex makes it possible to identify and deliver the precise ratio of drugs that will optimize antitumor activity in combination therapy to treat different types of cancer. (salesandmarketingnetwork.com)

Researchers at Atossa Therapeutics are working diligently to harness the drug's full potential across all three phases of the paradigm. (wrbl.com)
DRI researchers will test this hypothesis in a new clinical trial for children and adults with type 1 diabetes. (diabetesresearch.org)

Pharmacologic studies in rats have revealed that viramidine targets the liver more effectively than ribavirin, as adenosine deaminase conversion of viramidine to ribavirin occurs in the liver, trapping the drug within that organ. (news-medical.net)
This includes exploring new drug targets, conducting clinical trials, and investigating combination therapies. (alliedmarketresearch.com)
Amongst these thirty cases we have identified or been able to identify drug targets in more than half of the cases which we think is quite good. (ecancer.org)
Lapatinib is a second generation drug that is designed to strike multiple targets. (cancer.gov)
We hypothesized that these factors may influence the achievement of NT-proBNP targets and clinical outcomes. (bvsalud.org)

However, their clinical application has been limited because of their systemic toxicities and poor pharmaceutical properties. (genengnews.com)
This indicates increased risk of AKI with systemic therapy for ovarian cancer which cannot be ignored. (frontiersin.org)

a liposomal formulation and antibody drug combination therapy, both are for the treatment of solid tumors. (wikipedia.org)

For instance, in February 2023, Merck & Co., Inc., known as MSD, outside of the U.S. and Canada, announced that the company has opened enrollment in its new Phase 3 clinical program with investigational once-daily islatravir 0.25 mg in combination with doravirine 100 mg (DOR/ISL) for the treatment of HIV-1 infection. (alliedmarketresearch.com)
KAHR Medical expects to begin a Phase I/II trial in H2 2020 at leading sites in the US to evaluate DSP107 as a monotherapy and in combination with atezolizumab, following the filing of an Investigational New Drug (IND) application with the U.S. Food Drug Administration (FDA). (pharmiweb.com)
A Cytomegalovirus (CMV) Investigational Vaccine Clinical Trial for Healthy Women Age 16 to 17 years old. (policylab.us)

As a globally focused biotech company, Ascentage Pharma showcased the research advances of its drug candidates at ASCO for the third consecutive year and attracted global attention. (pharmiweb.com)
This represents an important milestone in the continued development of APG-1387," said Drew W. Rasco, MD, Associate Director of Clinical Research at the START Center for Cancer Care in San Antonio. (pharmiweb.com)
In addition to his interest in clinical, research and lecturing activities, his immense passion for medical writing and scientific communication goes back to his student days. (news-medical.net)
The foundational research that led to this clinical trial was conducted at UW, with Drs. Paul Sondel and Zachary Morris , of the Department of Human Oncology, among the key collaborators. (uwhealth.org)
Evaluating the potential for innovative combination therapies through strategic collaborations in difficult-to-treat tumor types continues to be an important part of our clinical development program for KEYTRUDA," Dr. Eric Rubin, vice president and therapeutic area head, oncology early-stage development at Merck Research Laboratories, said in a press release. (drugdiscoverynews.com)
The outbreak is disrupting clinical research across the globe and has affected the management of ongoing trails and planning of future trials. (thebusinessresearchcompany.com)
Overall, this review highlights the possibilities of synergistic therapy by building on existing research. (nature.com)
The pharmaceutical industry continues to invest in research and development efforts to better understand the underlying mechanisms of HIV and develop innovative therapies. (alliedmarketresearch.com)
Therefore, the rise in research and development in drug discovery drives the growth of HIV drugs market size during the forecast period. (alliedmarketresearch.com)
Our health network operates eastern Wisconsin's only academic medical center and adult Level I Trauma Center at Froedtert Hospital, Milwaukee, an internationally recognized training and research center engaged in thousands of clinical trials and studies. (froedtert.com)
DRI clinical trials offer participants the opportunity to play an active role in the diabetes research process and to access potential new therapies before they are widely available. (diabetesresearch.org)
Clinical trials are defined as research studies that test how well new medical approaches work in people. (disabled-world.com)
Most clinical research that involves testing a potential new treatment progresses in an orderly sequence of steps, called phases. (ucsf.edu)

Kucers' The Use of Antibiotics Sixth Edition: A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs. (news-medical.net)
We continue to focus on achieving our key milestones for this year including a potential approval of our antibiotic ceftobiprole in Europe, reporting phase 3 results for our antifungal isavuconazole and continued improvement of our financial performance. (basilea.com)
drugs which inhibit growth of fungi are called antifungal drugs . (wikipedia.org)

Another SRC inhibitor, dasatinib, has been approved by the U.S. Food and Drug Administration as an anti-cancer drug, but it has harsher side effects, said Siyuan Zhang, Ph.D., a postdoctoral fellow in Yu's lab and the paper's first author. (mdanderson.org)
Bergen, NORWAY , Oct. 9, 2018 /PRNewswire/ -- BerGenBio ASA (OSE:BGBIO) announces that the company and its collaborators will present interim clinical and biomarker data from its Phase II clinical programme with bemcentinib (BGB324), a first-in-class highly selective oral AXL inhibitor at the ESMO 2018 Congress in Munich (19 - 23 October 2018). (prnewswire.co.uk)

Can you tell us about INFORM (INdividualised Therapy FOr Relapsed Malignancies in Childhood and Adolescence)? (ecancer.org)

PrimeC's upgraded formulation, which is a unique extended-release tablet, designed to maximize the synergism between the compounds, is now being evaluated in a Phase IIb clinical trial, PARADIGM, for the treatment of ALS. (prnewswire.com)
What also makes (Z)-endoxifen unique is its ability to potentially work in all three areas of the Breast Cancer Paradigm: the prevention window, neoadjuvant phase and adjuvant phase. (wrbl.com)
Testicular cancer: the perfect paradigm for marker combinations. (cancercentrum.se)

Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)

Through the showcase at ASCO, Ascentage Pharma is demonstrating its capabilities of global clinical development in apoptosis. (pharmiweb.com)
In August 2013, the organizations signed a deal under which LLS committed to co-fund up to $4.4 million over two years for the Phase 2a development of AFM13. (drugdiscoverynews.com)
Companies in the acne drugs market are focusing on the development of narrow-spectrum antibiotics for treating acne. (thebusinessresearchcompany.com)
Clinical trials used in drug development are sometimes described by phase. (disabled-world.com)
The drug-development process will normally proceed through all four phases over many years. (disabled-world.com)
The Ivy Center's Phase 0 clinical trials program is the largest of its kind in the world and enables personalized care in a fraction of the time and cost associated with traditional drug development. (azbio.org)
Gene therapy is under development for the treatment of acute leukaemia such as relapsed and refractory acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplantation. (globaldata.com)
The Likelihood of Approval data is updated regularly based on events that take place which impact the clinical development process and regulatory considerations. (globaldata.com)
Only drugs in development by companies are included in the model. (globaldata.com)
We have accelerated development of our inhaled COVID-19 antibody cocktail therapy, leveraging our antibody platform to address the ongoing challenges of the pandemic" said Dr. HoUng Kim, Ph.D., Head of Medical and Marketing Division at Celltrion Healthcare. (pipelinereview.com)
Both drug candidates are unique and highly differentiated from current therapies or drugs in development. (basilea.com)
The phase 1 development of BAL30072, which will include combination studies with antibiotics from the carbapenem class is ongoing. (basilea.com)

HLB said Dr. Ahmed Omar Kaseb, a professor at the Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine at the University of Texas, commented on the NDA application for Ricoveranib, stating that "the combination therapy shows clear promise as a potential treatment for hepatocellular carcinoma. (koreatimes.co.kr)
The agreement is between Affimed and Merck, through a subsidiary, and includes a provision for a potential expansion of the deal to include a Phase 3 clinical trial. (drugdiscoverynews.com)
A new drug, (Z)-endoxifen, has shown promising potential in the treatment of ER+ breast cancer. (wrbl.com)
In combination with atezolizumab, DSP107 has the potential to enhance anti-tumor immune response. (pharmiweb.com)

If residual disease is found, adjuvant therapy with radioactive iodine (RAI) may be considered. (medscape.com)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)

Treatment is with surgery for early disease and targeted therapy, an experimental protocol, or palliative therapy for advanced disease. (msdmanuals.com)

These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)

Viramidine is available for oral administration and is currently in phase III clinical trials for the treatment of hepatitis C virus infection in combination with pegylated interferon. (news-medical.net)
1 Center for Clinical Microbiology, Division of Infection and Immunity, University College London Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. (nih.gov)
The World Health Organization guidelines on the use of antiretroviral drugs (ARVs) for HIV infection were first published in 2002 and subsequently revised in 2003, 2006 and 2010. (who.int)
3 WHO, Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. (who.int)
Prevention of HIV-1 infection with early antiretroviral therapy. (who.int)

Breast cancer tumors take numerous paths to resist the targeted drug Herceptin, but a single roadblock at a crucial crossroads may restore a tumor's vulnerability to treatment, scientists at The University of Texas MD Anderson Cancer Center report on line at Nature Medicine. (mdanderson.org)
Adding the drug saracatinib to Herceptin treatment shrinks previously resistant tumors by cutting off at least five different molecular pathways, each of which can resist, said senior author Dihua Yu, M.D., Ph.D., professor in MD Anderson's Department of Molecular and Cellular Oncology. (mdanderson.org)

Information and availability of federally and privately supported clinical trials conducted in the United States and around the world. (disabled-world.com)

[5] drugs which inhibit growth of viruses are termed antiviral drugs or antivirals rather than antibiotics. (wikipedia.org)

Celltrion enrolled 24 healthy volunteers in a global Phase I clinical trial to evaluate the safety, tolerability and pharmacokinetics of CT-P63. (pipelinereview.com)

We are proud to continue to support the company together with other existing and new global investors and look forward with anticipation to the beginning of clinical trials. (pharmiweb.com)

Different therapies aimed at blocking the inflammatory immune cells that cause the ongoing destruction of the insulin-producing cells have been tested in various intervention studies. (diabetesresearch.org)
All reviews included key questions (KQs) or subquestions on how benefits and harms varied according to demographic (age, sex, race), clinical (severity and duration of pain, medical and psychiatric comorbidities, concomitant medications), and intervention (dose, duration, intensity) characteristics. (cdc.gov)

The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)

The effectiveness and comparative effectiveness (benefits [KQ 1] and harms [KQ 2]) of long-term opioid therapy versus placebo, no opioid therapy, or nonopioid therapy. (cdc.gov)

Since 2010 there has been increasing scientific evidence of the benefits to individuals and populations of early antiretroviral therapy (ART). (who.int)
1 WHO, Scaling up antiretroviral therapy in resource-limited settings: guidelines for a public health approach. (who.int)
Reduction in early mortality on antiretroviral therapy for adults in rural South Africa since change in CD4+ cell count eligibility criteria. (who.int)

The poster only reports the Phase Ib results. (pharmiweb.com)
Based on these results, the FDA indicated that it has "no concerns" with the submission of an NDA for a Rivoceranib-included combination after a pre-NDA meeting. (koreatimes.co.kr)
Forward-looking statements, including regarding future clinical trials, are based on IO Biotech's current assumptions and expectations of future events and trends, which affect or may affect its business, strategy, operations or financial performance, and actual results and other events may differ materially from those expressed or implied in such statements due to numerous risks and uncertainties. (biospace.com)
This industry includes establishments that produce drugs used in treating acne which is a common skin condition that results from the plugging of hair follicles with skin dead cells and sebum. (thebusinessresearchcompany.com)
Celator recently announced positive results from a phase 1 clinical trial of its CPX-1 combination therapy to treat colorectal cancer. (salesandmarketingnetwork.com)
Results from the global, phase 3 COMMANDS clinical trial found that people with lower-risk MDS who received luspatercept (Reblozyl) to treat anemia instead of the current standard of care of weekly erythropoiesis-stimulating agents (ESAs) needed fewer transfusions of red blood cells and clinic visits. (cancer.net)
The approval is based on the positive results of late stage clinical trial which has suggested enhancing its survival rates. (researchandmarkets.com)
Longer-term studies are necessary to confirm our results, and another confirmatory Phase III trial needs to be completed to comply with FDA requirements," says Grinspoon. (harvard.edu)
What have been the results from the pilot phase? (ecancer.org)
Targeted therapies for treating breast cancer have helped to reduce the death rate from the disease, according to results from clinical trials. (cancer.gov)
Completion of anti-TB therapy is based on the examination of sputum smear, culture, and chest radiographic results. (cdc.gov)

The use of antibodies as therapeutic drugs has significantly shifted the landscape of treatment in many areas of medicine including oncology, viral infections and auto-immune diseases. (researchandmarkets.com)

We also look forward to more clinical studies and molecular biological evidence of APG-115. (pharmiweb.com)
Its approval is based on a broad clinical database, including data from 3 phase III studies, ACLIFORM, AUGMENT and AMPLIFY. (pharmacytimes.com)
Phase IV are 'post-approval' studies. (disabled-world.com)
In vitro and in vivo pre- clinical studies showed that CT-P59 strongly binds to SARS-CoV-2 RBD and significantly neutralises the wild type and mutant variants of concern. (pipelinereview.com)
We hope this guide will help you understand how clinical studies are designed and carried out. (ucsf.edu)
These are the first studies done with people to evaluate how a new drug should be given (by mouth, injected into a vein, or injected into the muscle), how often, and what dose is safe. (ucsf.edu)
These studies test a new drug, a new combination of drugs, or a new surgical procedure compared to the current standard treatment. (ucsf.edu)

HLB, which holds global patent rights for Rivoceranib, has been developing a combination therapy of Rivoceranib and Camrelizumab, an anticancer drug of China's Jiangsu Hengrui Medicine, as a first-line treatment for liver cancer through its U.S. subsidiary Elevar Therapeutics. (koreatimes.co.kr)
The combination was already approved in China in February as a first-line treatment for liver cancer. (koreatimes.co.kr)
In August 2014, the US Food and Drug Administration (FDA) approved bevacizumab for the treatment of advanced cervical cancer, the first gynecologic cancer for which an anti-angiogenic agent has demonstrated an advantage in overall survival (OS). (cancernetwork.com)
The use of anti-angiogenesis in uterine cancer is currently still undergoing more basic investigation, with clinical trials in earlier stages. (cancernetwork.com)
This combination is a promising therapy for those with Herceptin-resistant breast cancer. (mdanderson.org)
Only about 26 percent of women with HER2-positive breast cancer respond to Herceptin as single therapy. (mdanderson.org)
It belongs to a class of targeted therapies called selective estrogen receptor modulators (SERMs) which help block estrogen and stop the cancer from spreading. (wrbl.com)
The drug can reduce the density of breast tissue to mitigate the risk of developing breast cancer. (wrbl.com)
However, long-term drug therapy is also being researched to reduce the risk of new or recurrent cancer. (wrbl.com)
Pidilizumab blocks PD-1, and like other drugs that impair immune checkpoints, should unleash T cells to attack cancer cells. (sciencedaily.com)
How do the HER2-positive cancer drugs lapatinib and trastuzumab work? (cancer.gov)
How is lapatinib different from other drugs used to treat breast cancer? (cancer.gov)
A phase II trial continues to test the safety of the drug, and begins to evaluate how well the new drug works against a particular kind of cancer. (ucsf.edu)
Phase III trials often enroll large numbers of people and may be conducted at many doctors' offices, clinics, and cancer centers nationwide. (ucsf.edu)

The DRI has received approval from the Food and Drug Administration to conduct several diabetes clinical trials. (diabetesresearch.org)
The companies received approval from the Therapeutic Goods Administration (TGA) of Australia to conduct a Phase I trial in 24 healthy volunteers. (pipelinereview.com)

However, the overall demand for therapeutic drugs, including HIV drugs, remains relatively stable during economic downturns due to their essential role in treating health conditions. (alliedmarketresearch.com)

Diseases21

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology3

Phenomena and Processes5

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups1

Health Care33

Geographicals1

Chemotherapy15

Biopharmaceutical company8

Preclinical8

Treatments15

Field of immuno-oncology1

Patients92

Efficacy11

Regimens5

Cancers2

Company's4

20224

American Society2

Metastatic4

Biotechnology company2

Early-phase clinical trials1

Biomarkers3

Patient18

Resistance8

Radiation3

Practice3

Study17

Regimen2

Antitumor activity1

Researchers2

Targets5

Systemic2

Solid tumors1

Investigational3

Research13

Antifungal3

Inhibitor2

Malignancies1

PARADIGM3

Ovarian1

Development12

Potential4

Adjuvant2

Experimental1

MAPK1

Infection5

Tumors2

Trials conducted1

Antiviral Drugs1

Trial to evaluate1

Beginning of clinical trials1

Intervention2

Milestones1

Opioid therapy1

Antiretroviral therapy3

Results11

Oncology1

Studies7

Cancer14

Conduct2

Therapeutic drugs1