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  • symptoms
  • in particular, patients with neurologic signs and symptoms can see worsening of these with chelation, and, in some instances, therapy needs to be reduced or stopped. (medscape.com)
  • Almost all patients have significant hepatic and neuropsychiatric symptoms before reaching the geriatric age group. (medscape.com)
  • It is very important to recognize that some patients may develop worsening neurologic symptoms when therapy is initiated. (medscape.com)
  • In patients on long-term treatment who show signs of progressive neurologic symptoms on chelating agents, medication compliance and dietary compliance require review, along with an assessment of the efficacy of laboratory testing. (medscape.com)
  • disease
  • Subfulminant hepatic failure is reserved for patients with liver disease for up to 26 weeks before the development of hepatic encephalopathy. (medscape.com)
  • Excessive intrauterine copper concentrations may be responsible for the high rate of spontaneous abortions in patients with Wilson disease. (medscape.com)
  • Also critical is to provide the patient with information and to screen siblings of the index case for the possibility of Wilson disease, because the estimated frequency is 1 in 4 in situations in which the siblings have the same parents. (medscape.com)
  • Disease can be reversed in many patients, and thus clinical management focuses upon the identification and treatment of the precipitant while providing multiorgan-supportive care that addresses the complex pattern of physiological disturbance in critically ill patients with liver disease. (readbyqxmd.com)
  • therapy
  • After the initiation of therapy with a chelating agent, the patient needs to be aware of potential adverse effects of the agents with which he or she is being treated. (medscape.com)