Clinical murine fibrosarcoma tumor cells antigen of tumor. Medical search. Frequent questions

This conjugate preferentially targets the tumor microenvironment to increase local delivery of IL-2 and minimize off-target toxicity. (wikipedia.org)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. (bmj.com)
Design Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular carcinoma (HCC) and colorectal cancer (CRC) to analyse the effect of ferroptosis on tumour cells and the immune tumour microenvironment. (bmj.com)
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. (academicinfluence.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

Immunocytokines are delivered systemically but can specifically target the tumor through overexpressed or unique tumor antigens, cryptic extracellular matrix epitopes found only in tumors, or neovasculature markers indicating tumor angiogenesis. (wikipedia.org)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
CTR1 Silencing Inhibits Angiogenesis by Limiting Copper Entry into Endothelial Cells , PLOS ONE 8(9): e71982. (kreftfri.no)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
The distinctive feature of our vaccine is a highly improved and prolonged antigen presentation by dendritic cells, which results in a stronger activation of immune cells. (cytuvax.com)
Method For immunopharmacological screening campaigns, we built an artificial miniature immune system in which dendritic cells (DCs) derived from immature precursors present MHC (major histocompatibility complex) class I-restricted antigen to a T-cell hybridoma that then secretes interleukin-2 (IL-2). (bmj.com)

A375m (ATCC CRL-1619) and B-1 (20) are human being melanoma cell lines, TE671 is definitely a human being rhabdomyosarcoma cell collection (ATCC CRL-8805), Ecv304 is definitely a human being endothelial cell collection (ATCC CRL-1998), HT1080 is definitely a human being fibrosarcoma cell collection (ATCC CCL-121), and HT29 (ATCC HTB-38) and Mawi (2) are both human being colonic adenocarcinoma cell lines. (vaggi.org)

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
The adjuvant is capable of activating both the humoral and cellular arms of the immune system to induce powerful anti-tumor responses. (cytuvax.com)
A knowledge of the kinetics of the generation and T cell-mediated suppression of the concomitant anti-tumor immune response is crucial for the design of successful immunotherapeutic modalities. (grantome.com)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)

Malignant epithelial cancers, the major cause of cancer morbidity and mortality, arise in organs composed of both epithelial and mesenchyme-derived stromal cells, such as fibroblasts, myofibroblasts, endothelial cells, pericytes, smooth muscle, and hematopoietic cells. (aacrjournals.org)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
In previous studies we found that CS/DS-GAGs are expressed on the cell surface of murine and human breast cancer cell lines with high metastatic capacity and that they play a major role in P-selectin binding and P-selectin-mediated adhesion of cancer cells to platelets and endothelial cells [ 24 ]. (biomedcentral.com)
vascular endothelial cells is as a barrier between blood and vascular tissue. (nartsignaling.com)
This led us to speculate that cancer cells affect endothelial cells during metastasis. (nartsignaling.com)

This finding provides a powerful adoptive immunization assay to follow the generation of concomitant antitumor immunity to progressive tumor growth. (grantome.com)
The generation and loss of T cells capable of adoptively immunizing against an established tumor corresponded temporally to the acquisition and loss of concomitant immunity to growth of a tumor cell implant. (grantome.com)
The adoptive immunization assay showed that the T cells that mediate concomitant immunity are Ly1? (grantome.com)
In contrast, the cells which suppress the immunity are Ly1? (grantome.com)

Cergutuzumab amunaleukin (CEA-IL2v) is an antibody-cytokine conjugate that links the cytokine IL-2 with an antibody targeting the carcinoembryonic antigen (CEA). (wikipedia.org)
LMH2 (14), an scFv which recognizes HMWMAA, and MFE23 (6), an scFv which recognizes carcinoembryonic antigen (CEA) (4), were fused to codon 5 of the mature 4070A SU by proline-rich linkers (Fig. (vaggi.org)

Recent studies in women have suggested that some ovarian tumors may arise from the distal oviduct. (raf-receptor.com)
Gene expression profiles in very early stage tumors from hens show a high expression of oviduct-related genes, supporting the possibility of oviduct Omipalisib price origin for some ovarian tumors. (raf-receptor.com)

The experimental results indicate that any attempt to treat a tumor by active or passive immunotherapy represents an attempt to superimpose an immune response on an ongoing concomitant immune response that may be undergoing negative regulation. (grantome.com)

Invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. (aacrjournals.org)

Cytokines are polypeptides or glycoproteins that help immune cells communicate to each other to induce proliferation, activation, differentiation, and inflammatory or anti-inflammatory signals in various cell types. (wikipedia.org)
However, the effect of resveratrol on the hypoxia-enhanced proliferation and invasion of osteosarcoma cells remains unclear. (raf-receptor.com)
In this study, we investigated the role of resveratrol on regulating proliferation and invasion of osteosarcoma cells under hypoxic conditions. (raf-receptor.com)
Proliferation of Saos-2 cells was evaluated by the methabenzthiazuron (MTT) assay. (raf-receptor.com)
Our studies indicate that GDF9 is present in the hen oocyte BLZ945 inhibitor and influences granulosa cell proliferation. (raf-receptor.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)

Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)

Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)

GAGs bind to cytokines and regulate cell recruitment, inflammation, and tissue remodeling by delivering cytokines to the extracellular matrix. (wikipedia.org)
Extracellular adenosine triphosphate (ATP) release BIX 01294 clinical trial was measured using the chemiluminescence of luciferin-luciferase and a photon counting imaging system. (nartsignaling.com)

Altered gene expression in these nontransformed stromal cells provides potential targets for therapy. (aacrjournals.org)
Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)

The vaccine has been successfully tested in preclinical studies with murine model tumors (fibro-sarcoma, melanoma, kidney, colon, mammary carcinoma and B-lymphoma). (cytuvax.com)
Blocking ERK activation rescued IFNÎ³-mediated apoptosis in 17 of 23 (~ 74%) cell lines representing BRAF, NRAS, NF1 mutant, and triple wild type subtypes of cutaneous melanoma. (bvsalud.org)
Materials and Methods: C57BL/6J ob/+ mice, given either water or 20% ethanol, were injected intravenously with B16-BL6 melanoma cells to determine pulmonary metastasis. (iiarjournals.org)
Conclusion: In both animal and in cell culture conditions, ethanol inhibited the metastatic ability of B16-BL6 melanoma cells. (iiarjournals.org)

Treatment with mAb FAP5-DM1 induced long-lasting inhibition of tumor growth and complete regressions in xenograft models of lung, pancreas, and head and neck cancers with no signs of intolerability. (aacrjournals.org)
The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), then inducing a state of protective long-term immune memory. (bmj.com)
The clinical efficacy of local ablative treatment for oligometastasis is widely accepted in most cancers. (koreamed.org)
Results Immunohistochemical analysis eldepryl va availability personnel svc of S100A7 locution in verbal leukoplakia lesions and cancers To determine the clinical significance of S100A7 protein in head-and-neck tumorigenesis, its saying was analyzed in clinical specimens from HNSCC, strong leukoplakia lesions with squamous cell hyperplasia or dysplasia, and histologically conventional tissues, using a specific monoclonal antibody alongside immunohistochemistry. (upb.ro)

The role of CS-GAGs in metastasis was tested using the 4T1 murine mammary cell line (10 mice per group). (biomedcentral.com)
Recruitment of CD11b + CD11c + myelomonocytic cells to the metastatic site was also found after whole thorax irradiation at a dose of 15 Gy of mice that significantly enhanced seeding and metastatic growth of intravenously injected cancer cells. (biomedcentral.com)
Blocking PD-1 or HMGB1 unleashes T cell activation and prolongs survival of mice with Gpx4 -deficient liver tumours. (bmj.com)

Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
however, as cancer cells gain the ability to metastasize, E-cadherin expression is significantly reduced, which allows the cancer cells to disseminate to form distant metastases ( 18 ). (iiarjournals.org)
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases. (kreftfri.no)

The present study was undertaken to determine the antitumor effects of an antibody-conjugate against fibroblast activation protein-α, a cell surface protease of activated tumor fibroblasts. (aacrjournals.org)
However, this complex strategy is less attractive for clinical software, as human being tumors will not communicate antigen and protease uniformly. (vaggi.org)
A particle according to any one of the preceding claims, wherein the protease cleavage site is accessible to the relevant protease (i.e. that which recognises the cleavage site) before the viral particle becomes bound to an eukaryotic cell. (sumobrain.com)
A particle according to any one of claims 1 to 9, wherein the protease cleavage site becomes accessible to die relevant protease only after the viral particle has become bound to an eukaryotic cell. (sumobrain.com)
A particle acording to claim 11 , wherein the protease cleavage site becomes accessible after the heterologous polypeptide has bound to its cognate receptor on the eukaryotic cell. (sumobrain.com)

These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)

In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
BACKGROUND: Interferon-gamma (IFNÎ³) exerts potent growth inhibitory effects on a wide range of cancer cells through unknown signaling pathways. (bvsalud.org)
In contrast, the same combination does not affect tumour growth of subcutaneously grown CRC organoids, while it decreases their metastatic growth in liver. (bmj.com)
Recent findings in mammals have indicated that the oocyte produces several oocyte-specific factors, including growth differentiation factor 9 (GDF9) and bone morphogenetic factor 15 (BMP15), which influence the surrounding cells and follicular development. (raf-receptor.com)
In cell culture, ethanol inhibited B16-BL6 cell motility, invasion, and anchorage-independent growth. (iiarjournals.org)
Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. (academicinfluence.com)
Transforming growth factor production by chemically transformed cells. (academicinfluence.com)
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
Experiments with the SA1 sarcoma, Meth A fibrosarcoma, P815 mastocytoma, P388 lymphoma, and L5178Y lymphoma revealed that progressive tumor growth evoked the generation of tumor-sensitized T cells that, on passive transfer, could cause the regression of an established tumor in a gamma-irradiated (500 rad) recipient. (grantome.com)
These T cells were first detected on day 6 of tumor growth, reached peak numbers on days 9 to 10, and were then progressively lost as the tumor increased in size. (grantome.com)
These findings are consistent with the hypothesis that there is progressive growth of a concomitant immune response that is actively down-regulated by suppressor T cells before it reaches sufficient magnitude to destroy the tumor. (grantome.com)

Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells, The Journal of Immunology, 2018, 200: 000-000. (kreftfri.no)

The evidence base and existing literature suggest that upregulation of CX3CR1, migration of immune cells, together with cytomegalovirus (CMV) seropositivity is associated with worse outcomes in patients with dilated cardiomyopathy. (bvsalud.org)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
Instead, GPx4-associated ferroptotic hepatocyte death causes a tumour suppressive immune response characterised by a CXCL10-dependent infiltration of cytotoxic CD8 + T cells that is counterbalanced by PD-L1 upregulation on tumour cells as well as by a marked HMGB1-mediated myeloid derived suppressor cell (MDSC) infiltration. (bmj.com)

Cytokines hinder tumor cell development mostly through antiproliferative or proapoptotic pathways but can also interrupt development indirectly by eliciting immune cells to have cytotoxic effects against tumor cells. (wikipedia.org)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

Both ikarugamycin and astemizole improved the anticancer activity of the immunogenic chemotherapeutic agent oxaliplatin in a T cell-dependent fashion. (bmj.com)

Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. (koreamed.org)

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
hsv specific antibody production was detected in culture supernatants of pbmc from hsv seropositive healthy individuals by stimulating with optimal concentrations of hsv antigen without mitogens. (liverpool.ac.uk)

Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
Additional experiments have revealed that suppressor T cells function in the adoptive immunization assay by inhibiting the ability of passively transferred helper or memory T cells to give rise to an adoptive cytolytic T-cell response in the tumor-bearing recipient. (grantome.com)

First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

Successful, non-invasive delivery of biodegradable and non-toxic combination therapies that can target existing cancerous cells and prevent the development of new tumors all in one dose is ideal for clinical treatment. (ntno.org)

The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. (raf-receptor.com)

Background Most immunotherapies approved for clinical use rely on the use of recombinant proteins and cell-based approaches, rendering their manufacturing expensive and logistics onerous. (bmj.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)

Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
Astemizole induced the production of IL-2 and interferon-γ (IFN-γ) by CD4 + and CD8 + T cells both in vitro and in vivo. (bmj.com)
been shown to have antineoplastic effects MLN2238 clinical trial in vivo and in vitro. (raf-receptor.com)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)
trifluorothymidine (tft) is known to be concentrated in herpes simplex virus (hsv) infected cells in vitro in the form of phosphorylated derivatives. (liverpool.ac.uk)
we studied a murine hepatitis model of hsv infection to determine whether this in vitro observation would also be demonstrable in vivo. (liverpool.ac.uk)
We have previously shown that fish primary preadipocytes differentiate into mature adipocytes in vitro and that these cells represent a very helpful model system to study adipose tissue development in fish [ 5 , 6 ]. (biomedcentral.com)

Of note, astemizole enhanced the CD8 + /Foxp3 + ratio in the tumor immune infiltrate as well as IFN-γ production by local CD8 + T lymphocytes. (bmj.com)

These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

Enzymatic removal of tumor-cell surface CS-GAGs significantly inhibited lung colonization of the 4T1 murine mammary cell line ( P = 0.0002). (biomedcentral.com)
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (academicinfluence.com)

Examination of myocardial biopsy tissue often reveals an inflammatory cell infiltrate, T lymphocyte (T cell) infiltration, or other activated immune cells. (bvsalud.org)

This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
CSPG4 serves as a P-selectin ligand through its CS chain and participates in P-selectin binding to the highly metastatic breast cancer cells. (biomedcentral.com)
Removal of CS-GAGs greatly reduces metastatic lung colonization by 4T1 cells. (biomedcentral.com)
Nonetheless, pre-clinical evidence indicates that radiation can entail pro-metastatic effects via multiple pathways. (biomedcentral.com)
In this review we discuss the pre-clinical and clinical data on the local and systemic effect of irradiation on the metastatic process with an emphasis on the molecular pathways involved. (biomedcentral.com)
These cells form ecosystems at the primary and at the metastatic site, mutually communicating with one another and with stem cell-generating organs such as the bone marrow. (biomedcentral.com)
2001 ). Molecular communication between ecosystems is also witnessed by the vasculogenic and pro-metastatic tumor bed effect as discussed by Kuonen et al. (biomedcentral.com)
Specifically, cancer cells that transition from an epithelial to a mesenchymal phenotype have a higher metastatic ability than those with an epithelial phenotype ( 15 ). (iiarjournals.org)
Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer. (kreftfri.no)

It can be applied with a wide range of cytokines aggregates as adjuvant and against a wide range of tumors. (cytuvax.com)

Under nontumor conditions, these cells provide the first line of protection against pathogens. (hindawi.com)
Their advantage lies in the ability to perceive tumors with a low mutation load, thus establishing the first line of defense against pathogens. (explorationpub.com)

Saos-2 cells were cultured under controlled hypoxic conditions (3% O-2) or normoxic conditions. (raf-receptor.com)

In addition, CSPG4 and CHST11 were over-expressed in tumor-containing clinical tissue specimens compared with normal tissues. (biomedcentral.com)

the system is designed to identify and type hsv from direct lesion smears (ds) and from cell culture smears (cs) infected with a swab from the patient's lesion by means of an indirect fluorescence assay (ifa) using hsv type-common and hsv-2 type-specific monoclonal antibodies. (liverpool.ac.uk)

Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)

His work covers various topics, including B cell responses to viral infection and vaccination, human primary immunodeficiency, and biology of lymphocyte development and function and to elucidate etiology of immunological disorders. (stanford.edu)
However, reproducibility in the synthesis procedures of such "smart" platforms that lend themselves to easy scale-up in their manufacturing, as well as the development of new and improved models of cancer that are more predictive of human responses, need to happen soon for this field to make a rapid clinical impact. (ntno.org)

The expression of CSPG4 and CHST11 in 15 primary invasive breast cancer clinical specimens was assessed by qRT-PCR. (biomedcentral.com)

Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)

The effects of ethanol on cell phenotypes and markers of the epithelial-to-mesenchymal transition were determined in cell culture. (iiarjournals.org)

CyTuVax is currently testing its vaccine technology in a clinical Phase 2 study of a vaccine for hepatitis B non-responders, persons that do not respond to standard hepatitis B vaccines. (cytuvax.com)
clinical study to investigate the immunogenicity and safety of its Hepatitis B HBAI20 vaccine for Non-responders. (cytuvax.com)
trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19f nuclear magnetic resonance in a murine hepatitis model. (liverpool.ac.uk)

Tumor-stroma interactions. (academicinfluence.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)
1. Nikitovic D, Tsatsakis AM, Karamanos NK, Tzanakakis G. The effects of genistein on the synthesis and distribution of glycosaminoglycans/ proteoglycans by two osteosarcoma cell lines depends on tyrosine kinase and the estrogen receptor density. (aristsatsakis.com)

Then, he moved to Stanford University for a postdoctoral fellowship on the role of transcription factor Pbx1, a leukemia proto-oncogene, on B cell development. (stanford.edu)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)

However, resveratrol selleck chemical or HIF-1 alpha silencing reverted all the above effects of hypoxia in Saos-2 cells. (raf-receptor.com)

We show that mAb FAP5-DM1 combines excellent efficacy and tolerability and provides a first assessment of the mode of action of a novel drug candidate for tumor stroma targeting, thus encouraging further development toward clinical testing of this treatment paradigm. (aacrjournals.org)

It was next shown, with the Meth A fibrosarcoma and P815 mastocytoma, that the progressive loss after day 9 of T cells capable of adoptively immunizing against an established tumor was associated with the progressive acquisition of splenic suppressor T cells capable of inhibiting the capacity of tumor-sensitized T cells from preimmunized donors to cause the regression of an established tumor in T cell-deficient (TXB) recipients. (grantome.com)

Schiavi, J. et al.Expert Consideration on Regulatory Aspects for Perinatal Derivatives in Clinical Settings. (irb.hr)

Analysis of chemically distinct conjugates, resistance models, and biomarkers implicates a unique mode of action, with mitotic arrest and apoptosis of malignant epithelial cells coupled to disruption of fibroblastic and vascular structures. (aacrjournals.org)
in turn, the malignant epithelial cells can undergo reversible epithelial-mesenchymal transitions ( 1 - 5 ). (aacrjournals.org)

Anatomy5

Organisms4

Diseases9

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes5

Information Science1

Microenvironment10

Angiogenesis11

Dendritic Cells3

Human being fibros1

Anti-tumor3

Malignant tumors3

Endothelial cells6

Immunity4

Carcinoembryonic antigen2

Ovarian tumors2

Immunotherapy1

Metastasis of malignant1

Proliferation6

Progression1

Promote tumor1

Extracellular2

Stromal3

Melanoma4

Cancers4

Mice3

Metastases3

Protease5

Inhibition1

Growth12

Immunology1

Upregulation3

Cytotoxic2

Immunogenic1

Immune response1

Antibody3

Adoptive2

Mechanisms1

Therapies1

Sarcoma1

Immunotherapies2

Vitro7

Lymphocytes1

Bone marrow derived2

Mammary2

Infiltrate1

Metastatic9

Cytokines1

Pathogens2

Hypoxic1

Tissues1

Monoclonal1

Presentation1

Responses2

Specimens1

Myeloid-derived suppressor1

Markers1

Hepatitis3

Interactions2

Glycosaminoglycans2

Factor1

Hematopoietic stem1

Hypoxia1

Efficacy1

Suppressor1

Derivatives1

Epithelial cells2