Clinical motor neurons. Medical search. Frequent questions

It is characterized by pyramidal cell loss in the frontal and temporal lobes and degeneration of motor neurons in the hypoglossal nucleus and spinal motor neurons. (medscape.com)
Data now suggest that delocalization, accumulation, and ubiquitination of TDP-43 in the cytoplasm of motor neurons are early dysfunctions in the cascade of the events leading to motor neuron degeneration in ALS. (medscape.com)
MND is characterised by the degeneration of primarily motor neurones, leading to muscle weakness. (nih.gov)
Researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. (sciencedaily.com)
Spinal muscular atrophy (SMA) is an autosomal recessive, inherited genetic disease characterized by degeneration of alpha motor neurons in the spinal cord. (dovepress.com)
Transplanted stem cells release neurotrophic factors and develop into accessory cells like astrocytes and microglia, creating a neuroprotective environment that can delay the degeneration of motor neurons. (selfgrowth.com)
Amyotrophic lateral sclerosis (ALS), also known as Charcot's disease and Lou Gehrig's disease, is a disease of unknown cause characterized by slowly progressive degeneration of upper motor neurons (UMNs) and lower motor neurons (LMNs). (medscape.com)
Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)

Motor neuron disease (MND) encompasses a group of rapidly progressive and universally fatal neurodegenerative disorders of the human motor system, first described in the mid-19th century by the French Neurologist Jean Martin Charcot. (acnr.co.uk)
Motor neuron diseases are a group of disorders characterized by progressive damage to your motor neurons - cells in your nervous system that allow you to perform functions such as speech, breathing, and movement. (healthline.com)
Spinal muscular atrophy (SMA) is a group of disorders of the motor neurons (motor cells). (medlineplus.gov)
Motor neuron degenerative diseases (MNDs) are a large family of neurological disorders. (sflorg.com)
Temporomandibular disorders (TMD) are usually diagnosed by means of comprehensive review of patient history and clinical examination and the symptoms are pain/ discomfort in the jaw, mainly in the region of the temporomandibular joints (TMJs) and/or masticatory muscles, limitation of mandibular function and/or TMJ sounds. (bvsalud.org)

This guideline aims to consider the clinical- and cost-effectiveness evidence for the care of people with MND from the time of diagnosis, including communication of the diagnosis. (nih.gov)
OBJECTIVES--To describe the frequency and characteristics of those patients initially registered with the Scottish Motor Neuron Disease Register (SMNDR) but who subsequently had a diagnosis other than MND made (false positives), to analyse the features which led to a revised diagnosis, and to draw conclusions which might improve routine neurological practice. (bmj.com)
Though experts aren't sure of the exact numbers, many people with PMA eventually develop upper motor neuron damage, which more resembles an ALS diagnosis. (healthline.com)
Survival Motor Neuron Gene Copy Number Analysis by Exome Sequencing: Assisting Spinal Muscular Atrophy Diagnosis and Carrier Screening. (harvard.edu)
Emergency physicians should be familiar with amyotrophic lateral sclerosis (ALS) and should consider the diagnosis in patients with motor symptoms and signs of hyperreflexia. (medscape.com)
The diagnosis of ALS is primarily clinical. (medscape.com)
Understanding the molecular basis of these dementias, their diagnosis, clinical implications, and diagnostic issues, currently represents one of the most pressing issues worldwide. (icgeb.org)
Hardiman is a leading authority on the causes, diagnosis, and treatment of amyotrophic lateral sclerosis (ALS) and other forms of motor neuron disease (MND). (rmn.ie)
The diagnosis is essentially clinical after excluding other neurological, orthopedic or rheumatologic problems. (bvsalud.org)
The nature of the condition remains controversial and diagnosis is essentially clinical after excluding other neurological, orthopedic or rheumatologic problems. (bvsalud.org)
Current diagnosis is based on thorough clinical examinations in order to eliminate other possible diagnosis 7 but it is still unclear at this point time if the occurrence of PPS increases with age 1,3-4,6,s . (bvsalud.org)

Finally, we explored the method for "external validity" in a dual approach: First, we tested whether the degree of cortical involvement is mirrored by our tool (which we hypothesized given it exclusively targets supratentorial gray matter regions) by contrasting different motor neuron diseases (MND) against each other (study 3). (uni-regensburg.de)
completing an undergraduate degree in Clinical Genetics at King's College London before working as a researcher in neuromuscular diseases at the John Walton Muscular Dystrophy Research Centre, Newcastle and the Anne Rowling Regenerative Neurology Clinic, Edinburgh. (gla.ac.uk)
Previous studies indicated that it may start at a younger age than other motor neuron diseases. (healthline.com)
SMA is a collection of different motor nerve (or neuron) diseases. (medlineplus.gov)
A new genetic discovery adds weight to a theory that motor neuron degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells. (sflorg.com)
This new gene finding is consistent with our hypothesis that the correct maintenance of specific lipid processing pathways is crucial for the way brain cells function, and that abnormalities in these pathways are a common linking theme in motor neuron degenerative diseases," said study co-author Professor Andrew Crosby from the University of Exeter. (sflorg.com)
Understanding precisely how lipid processing is altered in motor neuron degenerative diseases is essential to be able to develop more effective diagnostic tools and treatments for a large group of diseases that have a huge impact on people's lives," said study co-author Dr Emma Baple from the University of Exeter. (sflorg.com)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
The subjects demonstrated a range of cognitive and motor symptoms that could distinguish them from patients hospitalized for nonneurologic diseases and PD patients. (cdc.gov)
The authors conclude that the health effects of carbon - disulfide exposure may resemble those of major long term latency neurodegenerative diseases such as PD, motor neuron disease, or dementia. (cdc.gov)
We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. (who.int)

Progressive dementia with symptoms of executive dysfunction, personality change, and motor weakness leads to severe morbidity. (medscape.com)
Signs and symptoms reflect frontal and temporal lobe dysfunction with lower motor neuron-type weakness, muscle atrophy, and fasciculations. (medscape.com)
2 Lower motor neuron signs are clinically characterised by fasciculations, muscle wasting and weakness, while UMN signs include slowness of movement, increased tone, hyper-reflexia and extensor plantar responses. (acnr.co.uk)
In the latest research, the team used cutting-edge genetic sequencing techniques to investigate the genome of three families with individuals affected by hereditary spastic paraplegia - a large group of MNDs in which the motor neurons in the upper part of the spinal cord miscommunicate with muscle fibers, leading to symptoms including muscle stiffness, weakness and wasting. (sflorg.com)
Spasticity and weakness (spastic paresis) are the primary motor impairments after stroke and impose significant challenges for treatment and patient care. (frontiersin.org)
It's a progressive degenerative neurologic disease that affects the motor neurons, resulting in progressive muscle weakness throughout the body. (scienceblogs.com)
It is a motor neuron disease whose clinical course is characterized by progressive weakness, muscle atrophy and spasticity, with ultimate progression to respiratory muscles leading to difficulty breathing and speaking (dysarthria) and to the muscles controlling swallowing. (scienceblogs.com)
The PT after extensive measurement that in someways is broader than the neuro clinical found weakness on my right side involving the hip muscles (glutes + hamstrings etc. (alsforums.com)
He did not see any weakness in my ability to control my thighs using a common clinical measurement. (alsforums.com)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by the selective loss of motor neurons, resulting in muscle atrophy, weakness, and progressive paralysis (Sun et al. (lww.com)
Clinical features of PPS include fatigue, joint and muscle pain, new muscular weakness and bulbar symptoms. (bvsalud.org)

UQ Centre for Clinical Research and Queensland Brain Institute's Associate Professor Robert Henderson and QBI's Professor Perry Bartlett , along with UQ School of Biomedical Sciences Associate Professor Trent Woodruff will trial drugs that may protect motor neurons and delay progression of the disease. (edu.au)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

One of the most striking aspects of ALS is that some motor neurons -- specifically, those that control eye movement and eliminative and sexual functions -- remain relatively unimpaired in the disease," said study leader Christopher E. Henderson, PhD, the Gurewitsch and Vidda Foundation Professor of Rehabilitation and Regenerative Medicine, professor of pathology & cell biology and neuroscience (in neurology), and co-director of Columbia's Motor Neuron Center. (sciencedaily.com)
Dr Noad is co-lead of NeuroCoRe (Neuro Cognitive Research), which is a research group based within the Clinical Neurology Research group at Plymouth University Peninsula Schools of Medicine and Dentistry. (plymouthhospitals.nhs.uk)
Professor Hardiman is also the Health Service Executive (HSE) National Clinical Lead for Neurology. (rmn.ie)

Recognizing subtle upper motor neuron arm paresis is fundamental to the neurologic examination. (neurology.org)
1 Amyotrophic lateral sclerosis (ALS) is the commonest MND phenotype, clinically characterised by progressive neurological deterioration and co-existence of upper and lower motor neuron signs. (acnr.co.uk)
2 In addition, the varied clinical presentations of MND also include (i) progressive muscle atrophy (PMA, ~ 10% of MND cases), a clinically pure lower motor neuron (LMN) phenotype, (ii) primary lateral sclerosis (PLS, 1-3% of MND cases), a clinically pure upper motor neuron (UMN) phenotype and (iii) progressive bulbar palsy (PBP, 1-2% of MND cases), an isolated bulbar phenotype with relative preservation of spinal motor neurons. (acnr.co.uk)
Clinically, ALS is characterised by co-existence of upper and lower motor neuron signs encompassing multiple body regions, with evidence of progressive deterioration. (acnr.co.uk)
Still, many people with PMA later develop damage to upper motor neurons, which originate in the brain. (healthline.com)
Now, the team has identified a further new gene - named TMEM63C - which causes a degenerative disease that affects the upper motor neuron cells in the nervous system. (sflorg.com)
The condition is caused by the loss of both upper and lower motor neurons, which results in the deterioration of motor pathways and the disease's paralysing effects. (selfgrowth.com)
He performed a limited clinical exam that did not include reflexes, although I reported and we discussed new intense muscle tension primarily in my upper left arm. (alsforums.com)
Upper MNDs (eg, primary lateral sclerosis) affect neurons of the motor cortex, which extend to the brain stem (corticobulbar tracts) or spinal cord (corticospinal tracts). (msdmanuals.com)
ALS is a rare, progressive, fatal neurological disease affecting both the upper and lower motor neurons. (cdc.gov)

Progeny from this cross with no MMP-9 exhibited an 80-day delay in loss of fast-fatigable motor neuron function and a 25 percent longer lifespan, compared with littermates with two copies of the MMP-9 gene. (sciencedaily.com)
The same effect on motor neuron function was seen when MMP-9 was inactivated in SOD1 mutant mice using chemical injections or virally mediated gene therapy. (sciencedaily.com)
From a mitochondrial cell biologist point of view, identification of TMEM63C as a new motor neuron degenerative disease gene and its importance to different organelle functions reinforce the idea that the capacity of different cellular compartments to communicate together, by exchanging lipids for example, is critical to ensure cellular homeostasis required to prevent disease," said Prudent. (sflorg.com)
Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. (broadinstitute.org)
Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD. (harvard.edu)
We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
Different gene expression profiles in iPSC-derived motor neurons from ALS8 patients with variable clinical courses suggest mitigating pathways for neurodegeneration. (cdc.gov)

There are many different forms of MNDs that have different clinical features and severity. (sflorg.com)
Lower MNDs affect the anterior horn cells or cranial nerve motor nuclei or their efferent axons to the skeletal muscles. (msdmanuals.com)

Despite clinical and methodological limitations, including small sample sizes of reference groups and varying acquisition parameters, which we are currently improving, we have high hopes that this tool can help clinical practice and can ultimately also be used as a novel endpoint for clinical trials. (uni-regensburg.de)
Three University of Queensland researchers have each received $1 million from the FightMND foundation for clinical trials to help fast-track potential treatments for motor neurone disease. (edu.au)
The drug, which blocks a protein called EphA4, will soon enter clinical trials in MND patients. (edu.au)
Assuming the drug is shown to be safe in pre-clinical testing, human trials could potentially start as early as 2018. (edu.au)
Numerous investigational therapies, many of which are currently in clinical trials like stem cell transplant for ALS , have been developed in response to recent advancements in our knowledge of the disease pathogenesis processes that underlie ALS. (selfgrowth.com)
In clinical trials, stem cells are being utilised to treat ALS effectively. (selfgrowth.com)
Through our clinical trials program, we aim to develop and validate a variety of analytical tools. (kcl.ac.uk)
Generating a hypothesis: Clinical trials exist in order to test a hypothesis. (kcl.ac.uk)
He also conducts clinical trials as part of DeNDRoN and is currently the lead for ENROLL-HD, a cohort study of individuals with Huntington's disease. (plymouthhospitals.nhs.uk)
The EU Clinical Trials Register currently displays 43693 clinical trials with a EudraCT protocol, of which 7245 are clinical trials conducted with subjects less than 18 years old. (clinicaltrialsregister.eu)
NIH-funded preclinical study suggests drug may be ready for early stage clinical trials. (nih.gov)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
3]. As a result of the collective success of stud- moving towards clinical trials. (lu.se)

The predominant reasons which lead to a diagnostic revision were: failure of symptom progression, development of atypical clinical features for MND, and investigation results. (bmj.com)

Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. (medscape.com)
Dr Noad has a clinical interest in early onset dementia and research interests in the field of cognitive assessment and early detection of dementia. (plymouthhospitals.nhs.uk)

Given the reference groups were age- and gender matched, we investigated in a second study whether variance associated with these demographic variables was successfully eliminated, while maintaining information on clinical disability, studying a longitudinal data set of amyotrophic lateral sclerosis (ALS) patients (study 2). (uni-regensburg.de)

A deeper understanding of the mechanisms underlying DAergic neuron susceptibility is needed to generate disease-modifying therapies for PD. (nature.com)
The launch of precision ALS programme is an important step forward in research to find effective therapies for motor neurone disease. (rmn.ie)

MND, as the name suggests, is a pure motor disorder without any significant evidence of sensory symptoms, extraocular movement disturbances, bladder and bowel dysfunction, or cognitive impairment. (medscape.com)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc) and the development of alpha-synuclein-containing aggregates called Lewy-bodies and Lewy-neurites 1 . (nature.com)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)

Motor neurone disease (MND) is a neurodegenerative condition that affects the brain and spinal cord. (nih.gov)
The researchers are still investigating how MMP-9 affects motor neuron function. (sciencedaily.com)
PMA most commonly affects males and involves lower motor neuron damage. (healthline.com)

The patient's symptoms vary, depending on which set of motor neurons is involved. (medscape.com)
without questionnaire included) referring to all the clinical symptoms and rare remedies. (abchomeopathy.com)
Often, these atypical dementias are associated with neurological symptoms and with motor neuron disease. (icgeb.org)
Nomenclature and symptoms vary according to the part of the motor system most affected. (msdmanuals.com)

Administration of these compounds to Δ7 mice, a model of severe SMA, led to an increase in SMN protein levels, improvement of motor function, and protection of the neuromuscular circuit. (broadinstitute.org)

[ 7 ] This condition is clinically classified as taking either a pure (uncomplicated) form or a complicated form, depending on whether the paraparesis exists in isolation or in conjunction with other major clinical features. (medscape.com)

PBP is a progressive degenerative disorder of the motor nuclei in the medulla (specifically involving the glossopharyngeal, vagus, and hypoglossal nerves) that produces atrophy and fasciculations of the lingual muscles, dysarthria, and dysphagia. (medscape.com)

ALS, also known as Lou Gehrig disease, is the most common neurodegenerative disease of adult onset involving the motor neuron system. (medscape.com)
Progressive muscular atrophy (PMA) is a rare adult-onset motor neuron disease. (healthline.com)

On the other hand, animal studies have strongly supported the possible role of RS pathways in motor recovery ( 20 - 36 ), while recent studies with stroke survivors have demonstrated that RS pathways may not always be beneficial ( 37 , 38 ). (frontiersin.org)

Cognitive impairment in amyotrophic lateral sclerosis (ALS) is correlated with pathologic and radiographic changes in the cerebral cortex beyond the motor regions. (medscape.com)
Researchers at the Francis Crick Institute and UCL have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS). (news-medical.net)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. (news-medical.net)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. (biorxiv.org)
The purpose of the Foundation is to support research in Motor Neurone Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS) undertaken by Trinity's MND research group. (rmn.ie)
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND). (msdmanuals.com)

The basis of latest treatments for Motor Neuron Disorder is enhancing the pathological microenvironment. (selfgrowth.com)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)

Local neurons within the spinal cord guide activity of specific motor neurons and muscles for execution of different movements. (biorxiv.org)
Lower motor neurons transmit signals between your spinal cord and muscles. (healthline.com)
MOTOR NCS STUDY (that focused on peroneal nerves + tibial): "remarkable for mildly reduced compound muscle action potential amplitude on the right when compared to the left yet unremarkable and symmetrical when measured from the proximal TA muscles. (alsforums.com)
ALS destroys motor neurons responsible for activating muscles, causing patients to rapidly lose muscle strength and their ability to speak, swallow, move, and breathe. (nih.gov)

The Society changed its name to the Motor Neurone Disease Association of New Zealand (Incorporated) in 1992. (wikipedia.org)
Ten years on : a brief history of the Motor Neurone Disease Association of New Zealand. (wikipedia.org)
National Library of New Zealand: Motor Neurone Disease Association of New Zealand. (wikipedia.org)
Newsletter of the Motor Neurone Disease Association of New Zealand (1/2005): 1. (wikipedia.org)
There's not much recent research on life expectancy for people with PMA, but according to the United Kingdom-based Motor Neurone Disease Association , many people live at least 5 years from the onset of the condition. (healthline.com)

Because of this, stem cell transplants are currently employed to preserve a patient's healthy neurons while also offering the possibility of producing new cells to replace the deceased ones. (selfgrowth.com)

We found a number of candidate 'susceptibility' genes -- genes that were expressed only in vulnerable motor neurons. (sciencedaily.com)

Research at The University of Queensland could eventually help develop viable treatments - and ultimately a cure - for motor neuron disease (MND). (news-medical.net)
Such clinical variation and a limited understanding of the disease basis presents a major challenge to the development and trialling of urgently needed targeted treatments. (gla.ac.uk)
Nevertheless, there is a large heterogeneity in terms of clinical response to currently available treatments, ranging from absence of response to impressive improvement. (dovepress.com)

3,4 Despite the clinical heterogeneity, median survival of MND remains three years, although the atypical phenotypes exhibit a longer survival. (acnr.co.uk)
Rather than a rapidly lethal disease, SMA type 1, the most severe form with the earliest onset of SMA, has become a disease in which long-term event-free survival with the acquisition of important motor milestones is likely. (dovepress.com)
Survival of Motor Neuron 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Survival of Motor Neuron 1 Protein" by people in Harvard Catalyst Profiles by year, and whether "Survival of Motor Neuron 1 Protein" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Survival of Motor Neuron 1 Protein" by people in Profiles. (harvard.edu)
Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy. (harvard.edu)

other lower motor neuron disease (four). (portlandpress.com)
Electrodiagnostic testing contributes to the diagnostic accuracy by objectively looking for lower motor neuron (LMN) involvement. (medscape.com)

Spasticity and motor recovery are both related to neural plasticity after stroke. (frontiersin.org)
The relation between spasticity and motor recovery and the role of plastic changes after stroke in this relation, particularly RS hyperexcitability, remain poorly understood among clinicians and researchers. (frontiersin.org)

The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. (sciencedaily.com)
CONCLUSIONS: Our findings demonstrate system usability, including a systematic way to identify caregiver needs and share with the care team in a way that is acceptable to patients and caregivers and perceived by clinicians to benefit clinical care. (bvsalud.org)

This guideline covers assessing and managing motor neurone disease (MND). (bvsalud.org)

Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)

In bulbar palsies, only the cranial nerve motor nuclei in the brain stem (bulbar nuclei) are affected. (msdmanuals.com)

As the condition progresses, the motor neuron cells become damaged and may eventually die. (sflorg.com)

Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

Clinical phenotypes are grouped into five forms depending on the severity of the disease and the age of onset. (dovepress.com)

Avoiding false positive diagnoses of motor neuron disease: lessons from the Scottish Motor Neuron Disease Register. (bmj.com)

In addition to her clinical practice, Dr. Moutvic is an accomplished leader, actively participating in the PM&R Residency and Fellowship training program. (mayoclinic.org)

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. (broadinstitute.org)

To understand why only some motor neurons are vulnerable to ALS, the researchers used DNA microarray profiling to compare the activity of tens of thousands of genes in neurons that resist ALS (oculomotor neurons/eye movement and Onuf's nuclei/continence) with neurons affected by ALS (lumbar 5 spinal neurons/leg movement). (sciencedaily.com)
Further, the researchers found that MMP-9 can be detected not just in lumbar 5 neurons, but also in other types of motor neurons affected by ALS. (sciencedaily.com)

In addition to motor neurons, V2bs inhibit other prominent interneuron classes including V2a, V1 and other V2b neurons, but neither of two categories of dorsal horn sensory neurons. (biorxiv.org)

Dr Elliott is studying her PhD in Motor Neurone Disease (MND) at the University of Edinburgh. (gla.ac.uk)

The neurons were taken from normal mice. (sciencedaily.com)
In other words, having MMP-9 is an absolute predictor that a motor neuron will die if the disease strikes, at least in mice. (sciencedaily.com)
Altogether, these experiments suggest that ERRγ-deficient mice could provide a model for understanding the regulation of transcription in DAergic neurons and that amplifying ERRγ - mediated transcriptional programs should be considered as a strategy to promote DAergic maintenance in PD. (nature.com)
Using rats and mice genetically modified to carry normal or disease-mutant versions of human SOD1, a team of researchers led by Timothy M. Miller, M.D., Ph.D., Washington University, St. Louis, MO, discovered that newer versions of the drug may be more effective at treating ALS than the earlier one that had been tested in a phase 1 clinical trial. (nih.gov)

CLINICAL EXAM: Mild curling of right toes. (alsforums.com)
His clinical exam found mild right foot drop. (alsforums.com)

Anatomy92

Organisms22

Diseases15

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology10

Phenomena and Processes41

Disciplines and Occupations2

Information Science2

Health Care1

Degeneration8

Disorders5

Diagnosis11

Diseases11

Weakness11

Centre2

Neurology3

Upper10

Gene7

MNDs2

Trials13

Progression1

Dementia3

Longitudinal data1

Therapies2

Dysfunction1

Dopaminergic4

Affects3

Symptoms4

Neuromuscular1

Clinically1

Degenerative1

Adult onset2

Pathways1

Amyotrophic6

Disorder2

Muscles4

Disease Association5

Patient's1

Susceptibility1

Treatments3

Survival6

Lower2

Stroke2

Findings2

Guideline1

Pathology1

Cranial nerve1

Progresses1

Parkinson's3

Severity1

Diagnoses1

Practice1

Spinal muscula1

Lumbar2

Sensory1

University of Edinbu1

Mice4

Mild2