• Pre-clinical models show interactions between the dopamine and glutamate systems which could contribute to the actions of antipsychotics [ 12 ]. (nature.com)
  • Microdialysis experiments show dopamine antagonists cause an acute increase in extracellular dopamine, which reverts to baseline levels upon chronic treatment [ 13 ]. (nature.com)
  • 6. The dopamine uptake inhibitor GBR 12909 (10 mg kg(-1)) did not alter the hyperthermic response and microdialysis demonstrated that it did not inhibit MDMA-induced striatal dopamine release. (erowid.org)
  • 3) Can microdialysis be used to distinguish dopamine release upon an animal's receiving a reward from dopamine release upon the animal's receiving a cue associated with the reward? (grantome.com)
  • The direction of the analyte flow is determined by the respective concentration gradient and allows the usage of microdialysis probes as sampling as well as delivery tools. (wikipedia.org)
  • The molecular weight cutoff of commercially available microdialysis probes covers a wide range of approximately 6-100kD, but also 1MD is available. (wikipedia.org)
  • Microdialysis probes can consequently be calibrated by either measuring the loss of analyte using drug-containing perfusate or the gain of analyte using drug-containing sample solutions. (wikipedia.org)
  • Before making microsurgical lesions, specific concentric-type microdialysis probes were implanted over a 60-minute period in the DREZ and directed to the DH apex (10 implantations). (thejns.org)
  • Brain metabolites are sampled using FDA-approved microdialysis probes and coupled to a high-temporal resolution 3D printed microfluidic chip housing glucose and lactate biosensors. (rsc.org)
  • Critically, current and precedent microdialysis and microperfusion probes lack the ability to collect neurochemical data that is spatially and temporally coincident with EEG data derived from depth electrodes. (elsevierpure.com)
  • Liu, D & Mcadoo, DJ 1993, ' An Experimental Model Combining Microdialysis with Electrophysiology, Histology, and Neurochemistry for Exploring Mechanisms of Secondary Damage in Spinal Cord Injury: Effects of Potassium ', Journal of neurotrauma , vol. 10, no. 3, pp. 349-362. (utmb.edu)
  • Mcadoo, David J. / An Experimental Model Combining Microdialysis with Electrophysiology, Histology, and Neurochemistry for Exploring Mechanisms of Secondary Damage in Spinal Cord Injury : Effects of Potassium . (utmb.edu)
  • Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review. (cam.ac.uk)
  • A technique using parallel administering and collecting microdialysis fibers was developed to estimate the in vivo concentration of K + outside the administering fiber. (utmb.edu)
  • Acute clozapine challenge (5-40 mg/kg i.p) produced dose-dependent increased extracellular levels of DA and its metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the medial prefrontal cortex of awake, free-moving rats as measured by in vivo brain microdialysis. (elsevierpure.com)
  • We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU · m −2 · min −1 ) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. (diabetesjournals.org)
  • This study involves an ex-vivo microdialysis procedure post-surgery. (ab-direct.eu)
  • Microdialysis results showed that patients with upper gastrointestinal tract lesions had significantly higher levels of postoperative intraperitoneal glucose and glycerol concentrations, as well as lower lactate/pyruvate ratios and lactate/glucose ratios. (biomedcentral.com)
  • Due to the constant perfusion of the microdialysis probe with fresh perfusate, a total equilibrium cannot be established. (wikipedia.org)
  • Two adjacent microdialysis catheters that were identical in membrane length, perfusion fluid, and flow rate showed equivalent results. (thejns.org)
  • Assessment of these metabolites along with other parameters, such as intracranial pressure, brain tissue oxygenation, and cerebral perfusion pressure, may help inform clinical decision making, guide medical treatments, and aid in the prognostication of patient outcomes. (cam.ac.uk)
  • As limited data are available regarding piperacillin CNS exposure in patients without or with low-grade inflammation, a clinical study was conducted (1) to quantify CNS exposure of piperacillin by cerebral microdialysis and (2) to evaluate different dosing regimens in order to improve probability of target attainment (PTA) in brain. (uni-regensburg.de)
  • Cerebral microdialysis was performed as part of the clinical neuromonitoring routine, and brain interstitial fluid samples were retrospectively analyzed for piperacillin concentrations after the first and after multiple doses for at least 5 days and quantified by high-performance liquid chromatography. (uni-regensburg.de)
  • Microdialysis provides a window on the brain. (grantome.com)
  • In a traumatically injured brain, the cerebral microdialysis technique allows continuous sampling of fluid from the brain's extracellular space. (cam.ac.uk)
  • Brain tissue PO2, microdialysis, and intracranial pressure were continuously monitored. (ihmera.com)
  • Hence, the objective is to investigate the clinical outcomes and discuss the thermodynamics aspect of direct brain cooling on severely injured brain patients. (surgicalneurologyint.com)
  • Direct brain cooling is feasible, safe, and affects the clinical outcomes of the severely traumatized brain, and physics of thermodynamics may play a role in its pathophysiology. (surgicalneurologyint.com)
  • A specially designed bolt was used to conduct two adjacent microdialysis catheters into the frontal cortex of patients with head injury or poor-grade subarachnoid hemorrhage who were receiving ventilation. (thejns.org)
  • traditional placement of tunneled hemodialysis catheters: clinical outcomes and cost analysis. (web.app)
  • Microdialysis is a minimally-invasive sampling technique that is used for continuous measurement of free, unbound analyte concentrations in the extracellular fluid of virtually any tissue. (wikipedia.org)
  • Hepatic magnetic resonance spectroscopy (MRS) and two-step hyperinsulinemic euglycemic clamps incorporating stable isotopes with concomitant adipose tissue microdialysis were used to evaluate carbohydrate and lipid flux. (whiterose.ac.uk)
  • Although many antimicrobial agents display good in vitro activity against the pathogens frequently implicated in diabetic foot infections, effective treatment can be complicated by reduced tissue penetration in this population secondary to peripheral arterial disease and emerging antimicrobial resistance, which can result in clinical failure. (japmaonline.org)
  • Microdialysis offers advantages over the skin blister and tissue homogenate studies historically used to define antibiotic penetration in skin and soft-tissue infections by defining antibiotic penetration into the interstitial fluid over the entire concentration versus time profile. (japmaonline.org)
  • Microdialysis - Monitoring Tissue Chemistry in Intensive Care Medicine. (lu.se)
  • Experimental Results and Clinical Application of Biochemical Tissue Monitoring in Critical Illness. (lu.se)
  • The AB-Direct Phase 1 study, to investigate tissue distribution of novel antibiotic gepotidacin, has been launched at the beginning of February 2021 at the Department of Clinical Pharmacology, Medical University of Vienna, with INSERM as study Sponsor. (ab-direct.eu)
  • Neither intra- nor postoperative microdialysis-related complications were observed (with a follow up of 18 months). (thejns.org)
  • To our knowledge no previous published study has evaluated IPM as a clinical tool for postoperative monitoring of patients treated for secondary or tertiary peritonitis. (biomedcentral.com)
  • While water-soluble compounds generally diffuse freely across the microdialysis membrane, the situation is not as clear for highly lipophilic analytes, where both successful (e.g. corticosteroids) and unsuccessful microdialysis experiments (e.g. estradiol, fusidic acid) have been reported. (wikipedia.org)
  • In recent years, because of advancements in technology and proliferation of PET scanners, PET is being increasingly used in clinical neurology to improve our understanding of disease pathogenesis, to aid with diagnosis, and to monitor disease progression and response to treatment. (bmj.com)
  • This article aims to provide an overview of the principles of PET and its applications to clinical neurology. (bmj.com)
  • Clinical microdialysis enables monitoring of the cerebral extracellular chemistry of neurosurgical patients. (thejns.org)
  • A microdialysis technique was used to sample AAs in the extracellular fluid of the DH apex in eight patients in whom surgery in the dorsal root entry zone (DREZ) was performed. (thejns.org)
  • Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. (biomedcentral.com)
  • Here, we sampled extracellular microRNAs locally in situ using microdialysis. (nih.gov)
  • The Journal of Clinical Endocrinology & Metabolism, 101 (1). (whiterose.ac.uk)
  • Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance. (avivahealth.com)
  • In theory, the extraction efficiency of a microdialysis probe can be determined by: 1) changing the drug concentrations while keeping the flow rate constant or 2) changing the flow rate while keeping the respective drug concentrations constant. (wikipedia.org)
  • The microdialysis probe is designed to mimic a blood capillary and consists of a shaft with a semipermeable hollow fiber membrane at its tip, which is connected to inlet and outlet tubing. (wikipedia.org)
  • The recovery can be determined at steady-state using the constant rate of analyte exchange across the microdialysis membrane. (wikipedia.org)
  • Despite technical and analytical limitations related to the intraoperative conditions, this technique offers new possibilities for clinical research on neurotransmitters involved in some relevant pathological states, especially in chronic pain and spasticity. (thejns.org)
  • Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials. (biomedcentral.com)
  • As a result, this population has been traditionally excluded from observational studies and clinical trials of status epilepticus, and the management of these patients varies widely. (biomedcentral.com)
  • Nonetheless, a significant majority of PD patients develop motor fluctuations over their disease course, with a significant impact on quality-of-life, meaning control of such complications translates into a fundamental clinical need. (dovepress.com)
  • The microdialysis principle was first employed in the early 1960s, when push-pull canulas and dialysis sacs were implanted into animal tissues, especially into rodent brains, to directly study the tissues' biochemistry. (wikipedia.org)
  • Describes the nature of a clinical study. (mayo.edu)
  • The present study demonstrates that microdialysis can be performed safely in the human DH during DREZ lesioning. (thejns.org)
  • Setting: The study was performed in the Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, United Kingdom. (whiterose.ac.uk)
  • The present study aimed to assess microdialysis in this setting. (biomedcentral.com)
  • This entails extensive clinical and research practice within vascular surgery, surgery, intensive care and trauma. (oru.se)
  • He is leading various project on tools for bleeding management and resuscitation, as well as heading up research and clinical practice on aortic balloon occlusion (REBOA). (oru.se)
  • Here we aim to overview OPC's lifecycle, since its conception to commercialization, the evidence about its efficacy, tolerability and safety profile, and to discuss its role in the management of motor fluctuations in PD in current clinical practice. (dovepress.com)
  • To address this, recent advances have focussed on developing biosensing techniques for integration with microdialysis to achieve continuous online monitoring. (cam.ac.uk)
  • Intraperitoneal microdialysis (IPM) makes it is possible to obtain continuous monitoring of the intraabdominal condition by measuring several parameters as markers for inflammation or ischaemia. (biomedcentral.com)
  • The proper selection of an appropriate calibration method is critically important for the success of a microdialysis experiment. (wikipedia.org)
  • Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. (benthamscience.com)
  • The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists. (benthamscience.com)
  • The categorical-mechanistic extension strives to address this issue, but requires systematic clinical investigation of more precise relationships between psychotropic profiles and discrete mechanisms of action to assess its merits. (sagepub.com)
  • Two high-quality positive efficacy studies (double-blind Phase III clinical trials) established OPC efficacy with significant reduction in OFF time (average 60 minutes vs placebo), without concomitant increase of distressing dyskinesias during ON time. (dovepress.com)
  • Fifty-eight patients with indication for mucogingival surgery took part in this randomized parallel double-blind clinical trial. (bvsalud.org)
  • This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. (benthamscience.com)
  • Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. (benthamscience.com)
  • This has implications for the clinical treatment of MDMA- induced hyperthermia. (erowid.org)
  • Additional data on the clinical aspects of Ibogaine in the treatment of chemical dependence were reported by Kaplan (1993), Sisko (1993), Sanchez-Ramos & Mash (1994), and Sheppard (1994). (mindvox.com)
  • Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. (elsevierpure.com)
  • A careful history and clinical examination of the jaw and neck muscles will facilitate a tentative diagnosis that may be followed by the need for additional examinations and investigations. (springer.com)
  • Cerebral microdialysis was performed to obtain semi real time measurements of cerebral metabolic status. (lu.se)
  • All clinical observations conducted after 1963 have been made on patients treated outside of the United States. (mindvox.com)
  • Clinical and diagnostic implications of glycated albumin in diabetes mellitus. (benthamscience.com)