• Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
  • Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
  • Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
  • This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
  • This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
  • Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
  • Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
  • Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
  • Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • Leukocyte adhesion deficiency (LAD) is a group of rare inherited disorders characterized by immune deficiency and peripheral neutrophilia. (nih.gov)
  • RPL-201 is under development for the treatment of leukocyte adhesion deficiency (LAD) type 1. (pharmaceutical-technology.com)
  • Scrupulous follow-up of infections is necessary for patients with leukocyte adhesion deficiency. (medscape.com)
  • Leukocyte adhesion deficiency type I (LAD I) is often associated with life-threatening infections requiring intensive care. (medscape.com)
  • Patients with leukocyte adhesion deficiency I are at risk for fungal infections with Candida species because of their frequent need for broad-spectrum antibiotics. (medscape.com)
  • The subtle signs of infection, the need to offer stem cell transplantation, and the early deaths in patients with leukocyte adhesion deficiency I that is not properly treated suggest that frequent monitoring by a clinical immunologist is essential. (medscape.com)
  • Prenatal diagnosis for leukocyte adhesion deficiency I is possible by chorionic villus sampling or amniocentesis using DNA methodology in families where the exact mutations have been established. (medscape.com)
  • In leukocyte adhesion deficiency II, ultrasonography for growth retardation, skeletal abnormalities, and distinctive facial features can establish the diagnosis prenatally in some families. (medscape.com)
  • Patients with leukocyte adhesion deficiency I are at risk for graft versus host disease post-stem cell reconstitution, although graft versus host disease has been less common than in other transplantation settings. (medscape.com)
  • Patients with leukocyte adhesion deficiency II experience growth failure and mental retardation, although they are less likely to die of infection. (medscape.com)
  • Without hematopoietic stem cell transplantation (HSCT), patients with leukocyte adhesion deficiency I who have an absence of CD18 expression usually die from infection within 2 years of life. (medscape.com)
  • Earlier reviews of leukocyte adhesion deficiency I indicated that unreconstituted patients most often succumbed to bacterial infections. (medscape.com)
  • Patients with leukocyte adhesion deficiency II show severe developmental delay, which has not been significantly prevented even when fucose replacement seemed to decrease infections and improve phagocytic functions. (medscape.com)
  • Although successful complete immune reconstitution from bone marrow transplantation is reported using fully matched related and unrelated donors or haploidentical donors (ie, parents), patients with leukocyte adhesion deficiency I cannot be guaranteed to have benign courses. (medscape.com)
  • Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
  • Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
  • One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
  • but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
  • In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
  • A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
  • Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
  • Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
  • Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
  • ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
  • Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)
  • Further studies are warranted to assess clinical course and whether the associated movement disorder is also caused by hypocretin deficiency or by additional neurochemical abnormalities. (abic2004.org)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
  • The incidence of PIDs varies greatly from about 1:500 births with selective IgA deficiency to only a few known cases for the rarest disorders. (lu.se)
  • In certain metabolic disorders ( ADA and PNP deficiency) enzyme substitution therapy can be applied. (lu.se)
  • The neutrophil-leukocyte index (NLI) is an independent predictor of an unfavorable outcome in stable ischemic heart disease, as well as of mortality in patients with acute coronary syndromes and uncontrolled heart failure. (almclinmed.ru)
  • We found significant difference in the NLI values for each type of cardiac disorders, compared to that in the patients without history of cardiovascular disorders, including for the patients with arterial hypertension (p 0.001, Kruskal-Wallis test), ischemic heart disease (p 0.001, Mann-Whitney U-test), atherosclerotic cardiosclerosis (p = 0.001, Mann-Whitney U-test), and chronic heart failure (p = 0.040, Kruskal-Wallis test). (almclinmed.ru)
  • Diagnosis is based on specific clinical, laboratory, and imaging features. (merckmanuals.com)
  • The adequate vitamin C intake has been associ- diagnosis of asthma was established from a ated with the protective effects of airways documented clinical history of recurrent responsiveness and lung function [ 1,5-7 ]. (who.int)
  • Students will develop investigative and analytical skills and be able to evaluate test results for the diagnosis of haematological and haemostatic disorders. (edu.au)
  • Diagnosis of MS can be challenging because of variable disease presentation and significant clinical overlap with diseases such as neuromyelitis optica spectrum disorders (NMOSDs) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). (arupconsult.com)
  • Diagnosis of MS relies primarily on clinical evaluation and imaging studies such as magnetic resonance imaging (MRI), particularly in patients who present with typical disease progression. (arupconsult.com)
  • Laboratory evaluation such as cerebrospinal fluid (CSF) studies can support a diagnosis when clinical and imaging analyses are inconclusive. (arupconsult.com)
  • Multiple sclerosis (MS) can be diagnosed based on clinical criteria, and imaging and laboratory findings may support that diagnosis. (arupconsult.com)
  • Blood typing, leukocyte function test, and chromosomal study will confirm diagnosis. (mhmedical.com)
  • We report the prenatal diagnosis of a transient myeloproliferative disorder suggestive of leukaemia in a fetus with hepatosplenomegaly, hydrops and 47,XY,+21 karyotype. (johnshopkins.edu)
  • Ladilen is a gene-modified cell therapy commercialized by Rocket Pharmaceuticals, with a leading Phase II program in Leukocyte Disorders (White Blood Cell Disorders). (pharmaceutical-technology.com)
  • This course presents the disease processes leading to abnormal white and red cell morphology, and white blood cell disorders, including both benign and malignant states. (iowacentral.edu)
  • Totzeck A, Stettner M, Hagenacker T.. Early platelet and leukocyte decline in patients with neuroinflammatory disorders after intravenous immunoglobulins. (legehandboka.no)
  • Children with Down syndrome (DS) are at increased risk of developing distinctive clonal myeloid disorders, including transient abnormal myelopoiesis (TAM) and myeloid leukaemia of DS (ML-DS). (smj.org.sg)
  • DS is also characterised by an increased susceptibility to childhood leukaemia,( 2 - 4 ) including an increased frequency of distinctive clonal myeloid disorders in early childhood. (smj.org.sg)
  • Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. (springer.com)
  • Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. (springer.com)
  • Although recent advances in next-generation sequencing have increased the accuracy of this line of research, there has been greater emphasis placed on epigenetic changes versus DNA sequence changes as the probable cause of discordant psychiatric disorders in MZs. (springer.com)
  • As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions. (springer.com)
  • In recent years, studies on the differences between genomic and epigenomic characteristics of MZs have led to the development of new approaches for elucidating the etiology of psychiatric disorders (Liang et al. (springer.com)
  • However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor ( BDNF ) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. (biomedcentral.com)
  • Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers for understanding the trajectory of early stress-induced susceptibility to adult psychiatric disorders. (biomedcentral.com)
  • The impact of early adversity on the susceptibility to psychiatric disorders in later life is influenced by a number of factors. (biomedcentral.com)
  • paediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsREM? (abic2004.org)
  • Stressor exposure during early life has the potential to increase an individual's susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. (biomedcentral.com)
  • Clinical characteristics included short stature, severe mental retardation, and autistic features. (nih.gov)
  • Une corrélation significative positive a été trouvée entre la vitamine C plasmatique et l'apport alimentaire en vitamine C. Le taux de vitamine C plasmatique et leucocytaire était significativement moins élevé dans le groupe des patients asthmatiques. (who.int)
  • PATIENTS: An independent validation cohort of 526 nondiabetic patients with a clinical indication for coronary angiography. (duke.edu)
  • LIMITATION: Patients with chronic inflammatory disorders, elevated levels of leukocytes or cardiac protein markers, or diabetes were excluded. (duke.edu)
  • In half of the patients there is also an excessive production of leukocytes and blood platelets. (fundacionmapfre.org)
  • Upon entering clinical trials, acalabrutinib showed substantial efficacy in patients with multiple forms of hematologic malignancies, leading to acquisition by Astrazeneca in 2015 for $4B upfront and $3B in milestone payments. (frazierls.com)
  • To evaluate the clinical value of NLI in hospitalized patients with COVID-19 depending on their concomitant cardiac disorders. (almclinmed.ru)
  • Ninety four (41.6%) patients had no previously diagnosed cardiovascular disorders. (almclinmed.ru)
  • Median NLI in the patients with cardiac disorders (irrespective of their nosology) was significantly higher than that in the patients without any history of cardiovascular problems: 3.30 (2.095.42) versus 1.95 (1.423.62) (p 0.001, Mann-Whitney U-test). (almclinmed.ru)
  • Testing for these autoantibodies is recommended in patients who present with acute central nervous system (CNS) demyelination and clinical, imaging, or laboratory features that are atypical for MS. Research to identify MS-specific autoantibodies is ongoing. (arupconsult.com)
  • The human leukocyte antigen (HLA) genotype may be important, since it was observed that autoimmune conditions in the APECED cohort showed HLA associations that were similar to those found in non‐APECED patients with respective autoimmune disorders 4 . (ersjournals.com)
  • and 4) an increased frequency of HLA class II antigens DR3 12 and DQ7 11 have been reported among PPH patients, further suggesting that immune deregulation plays a role in the pathogenesis of the disorder. (ersjournals.com)
  • Patients should be monitored closely with periodic clinical and laboratory evaluations. (drugs.com)
  • Hematologic changes in patients with liver disease are generally nonspecific and overlap with many other systemic disorders. (merckvetmanual.com)
  • Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)
  • However, linezolid should be used with special caution in patients with severe renal insufficiency, and only when the anticipated benefit is considered to outweigh the theoretical risk, because the clinical significance of higher exposure (up to 10 fold) to the two primary metabolites of linezolid is unknown. (who.int)
  • Pemphigoid gestationis is a rare autoimmune vesiculobullous skin disease closely related to the pemphigoid group of blistering disorders. (medscape.com)
  • Alpine Immune Sciences is developing next-generation immunotherapies to treat cancer and autoimmune disorders. (frazierls.com)
  • OMIM 240300), is an autosomal recessive disorder caused by mutations causing loss of function of the autoimmune regulator (AIRE) protein 1 . (ersjournals.com)
  • An overview of hemostasis, thrombosis and anticoagulant therapy, including procedures routinely performed in the clinical hematology and hemostasis laboratory. (iowacentral.edu)
  • The course is designed to help students develop the hands-on and critical thinking skills needed to function as an entry-level medical laboratory technician and satisfies curriculum requirements of the National Accrediting Agency for Clinical Laboratory Sciences. (iowacentral.edu)
  • We have confirmed the contribution of cardiovascular disorders to the course of COVID-19 and the clinical value of NLI as a convenient laboratory marker of the severity of infectious disease. (almclinmed.ru)
  • If the clinical presentation is atypical for MS, additional laboratory testing may be helpful to exclude mimics. (arupconsult.com)
  • Although the disorder is not thought to have a genetic background, there are some familial case reports in the literature. (medscape.com)
  • In this complex picture, intrinsic neurodegenerative mechanisms, also including glial activation and CNS barrier integrity, are shaped by genetic mutations and interact with CNS-extrinsic components such as circulating leukocytes, cytokines and growth factors, as well as environmental factors that predispose to CNS pathogenesis. (frontiersin.org)
  • The similarity of the genetic information in MZs provides a useful means for determining the disorder-causing role of environmental factors. (springer.com)
  • Asthma is a chronic relapsing inflammatory study in Tehran with the hypothesis that disorder of the airways and a major health plasma and leukocyte vitamin C level are problem worldwide [ 1 ]. (who.int)
  • Secondary erythrocytosis occurs due to arterial hypoxemia in chronic pulmonary disease, smoking, some neoplasms or hemoglobin disorders. (fundacionmapfre.org)
  • Beyond cell-autonomous neuronal injury and death, light has been shed on multiple inflammatory properties of glia and invading leukocytes in most brain diseases. (frontiersin.org)
  • 3. Pre-clinical studies targeting the immune system mechanisms for emerging approaches to treat neurodegenerative diseases throughout the lifespan. (frontiersin.org)
  • The polycystic kidney diseases are a group of genetically heterogeneous disorders and a leading cause of kidney failure. (basicmedicalkey.com)
  • NLI variability in COVID-19 with comorbid baseline physical diseases and cardiovascular disorders in particular, has not been studied. (almclinmed.ru)
  • Immune System is made up of network of certain well defined blood cells called 'Leukocytes' and 'Lymphocytes' circulating in our circulatory system, tissues and organs to fight back the diseases and auto- immune disorders which might occur in our body. (speakingtree.in)
  • [ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
  • In conclusion, in LAD II, the main clinical countenance shifts from frequent infections due to immunodeficiency in the early years to the metabolic consequences of the defect in fucose metabolism, i.e., retarded growth and mental retardation, in the later years. (nih.gov)
  • Both disorders are characterised by recurring truncating somatic mutations of the GATA1 gene, which are considered key pathogenetic events. (smj.org.sg)
  • Among them, ABO and Rh are of clinical significance. (academicjournals.org)
  • the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. (semcs.net)
  • The clinical significance of these findings is unknown. (drugs.com)
  • exceptions include lab results for Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma glutamyl transferase (GGT) and Alkaline phosphatase (ALP), which would be exclusionary at Screening and Day -1 if greater than 1.5x +/- upper limit of normal (ULN) of reference ranges regardless of clinical significance. (who.int)
  • To what extent is the infiltration of peripheral leukocytes, such as bone marrow-derived monocytes, neutrophils, B and T cells, ameliorative or propagative for CNS disorders? (frontiersin.org)
  • Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. (ucc.ie)
  • She recovered fully within 2 weeks after onset of hepatitis and neurologic disorders. (cdc.gov)
  • Živković S.. Intravenous immunoglobulin in the treatment of neurologic disorders. (legehandboka.no)
  • Major histocompatibility complex class III associations have also been observed, as has a high frequency of anti-human leukocyte antigen antibodies. (medscape.com)
  • Detailed immunologic studies including those for p-tolyl isocyanate IgE antibodies and the presence of a leukocyte inhibition factor for isocyanate antigen were negative. (cdc.gov)
  • Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
  • Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (semcs.net)
  • Furthermore, this case indicates that transient abnormal myelopoesis may result in a fulminant clinical picture much like true leukaemia. (johnshopkins.edu)
  • This video presents following topics about Atherosclerosis: Definition Epidemiology Risk factors Clinical aspects. (drbeen.com)
  • Abstract: The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. (cam.ac.uk)
  • There were three groups with major depressive disorder (MDD): treatment-resistant (n = 94), treatment-responsive (n = 47) and untreated (n = 46). (cam.ac.uk)
  • Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder. (cdc.gov)
  • Fundamental to both disorders is the gene-dosage imbalance of the human chromosome 21. (smj.org.sg)
  • In psychiatry, there is a much higher concordance rate for schizophrenia (SCZ) and autism spectrum disorder (ASD) in MZs versus DZs (Hilker et al. (springer.com)
  • In 1899, Emil Kraepelin classified psychosis into 'dementia praecox' [Schizophrenia in DSM-5 (American Psychiatric Association 2013 )] and 'manisch-depressiven Irreseins' (Bipolar Disorder in DSM-5). (springer.com)
  • The pathogenesis behind narcolepsy is found to be due to degeneration of hypocretin/orexin secreting neurones in the central nervous system due to disorder of human leukocyte antigen DQB1*0602.Narcolepsy is a deblitating disorder which causes intense functional impairment and hampers quality of life. (aku.edu)
  • The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research. (semcs.net)
  • We describe a patient with characteristic clinical and histopathologic features of this dermatosis. (medscape.com)
  • The use of leukocyte ultrastructure combined with an awareness of the characteristic clinical picture should lead to the increased recognition of this disorder in American children. (inra.fr)
  • Alpha-9 Theranostics is a clinical-stage company developing a portfolio of radiolabeled imaging and therapeutic molecules for solid and hematologic malignancies. (frazierls.com)
  • Which disorder results in decreased erythrocytes and platelets with changes in leukocytes and has clinical manifestations of pallor, fatigue, petechiae, purpura, bleeding, and fever? (nursingexpertshelp.com)
  • RÉSUMÉ Nous avons passé en revue les manifestations dermatologiques liées à l'infection chronique par le virus de l'hépatite C (VHC) et leur rapport avec l'état hépatique. (who.int)
  • Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury. (medlineplus.gov)
  • Exploration of RNA-seq signatures in other leukocyte populations and single cell RNA sequencing may help uncover more subtle differences. (cam.ac.uk)
  • A role for the involvement of major histocompatibility complex class II antigens seems likely because of the association with human leukocyte antigens DR3 and DR4. (medscape.com)
  • The duration of tuberculosis treatment depends on the regimen chosen, the patient's clinical and radiographical responses, smear and culture results, and susceptibility of Mycobacterium tuberculosis isolates from the patient or the suspected source case. (who.int)
  • Narcolepsy is a sleep disorder known and studied about from time to time is a sleep disorder characterized by a combination of myriad of symptoms including excessive day time sleepiness with recurrent irresistible sleep attacks , hypnogogic hallucinations ,hypnopompic hallucinations ,sleep paralysis and cataplexy (sudden and bilateral loss of muscle tone.1 Narcolepsy may present it self long with cataplexy or without cataplexy. (aku.edu)
  • Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies. (ucc.ie)
  • human leucocyte antigenPANDAS? (abic2004.org)
  • It is not clear which factors are responsible for variation in clinical picture of APECED, but human leukocyte antigen (HLA) genotype may be important. (ersjournals.com)
  • 1 Using human cells in culture, Interferon alfa-2a, recombinant has been shown to have antiproliferative and immunomodulatory activities that are very similar to those of the mixture of interferon alfa subtypes produced by human leukocytes. (drugs.com)
  • It also has a clinical-stage in vivo adeno-associated virus ("AAV") program for Danon disease, a multi-organ lysosomal-associated disorder leading to early death due to heart failure. (pharmaceutical-technology.com)
  • Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors. (ucc.ie)
  • In pre-clinical model ZK 219477 has demonstrated anti-tumorigenic activity for gliomas tumours both in vitro and in vivo. (knowcancer.com)
  • This binding leads to linkage (adhesion) of the leukocyte to the blood vessel wall. (medlineplus.gov)
  • Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. (medlineplus.gov)
  • The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. (semcs.net)
  • Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit. (semcs.net)
  • Leukocytes are produced in stem cells in bone marrow. (lu.se)