Clinical klebsiella infections. Medical search. Frequent questions

In this study, we performed capsular serotyping, determined the presence of mucoid phenotype and aerobactin production, and assessed lethality in a murine model and correlated these in vitro and in vivo results with the clinical manifestation of patients with K. pneumoniae bloodstream infections. (cdc.gov)
Here we describe the microbiological and clinical characteristics of five cases of bloodstream infections (BSI) caused by carbapenem-resistant Klebsiella pneumoniae and Serratia marcescens having both bla KPC-2 and bla NDM-1 . (biomedcentral.com)
According to surveillance data, bacterial pathogens producing KPC alone are the main cause of bloodstream infections (BSI) in intensive care unit patients (21%) in the state of São Paulo [ 18 ]. (biomedcentral.com)
The present study describes the clinical and microbiological features of five, namely K. pneumoniae (n = 4) and S. marcescens (n = 1), co-harboring KPC-2 and NDM-1, collected from bloodstream infections (BSI). (biomedcentral.com)
Bloodstream infections (BSIs) are a significant burden on the global population and represent a key area of focus in the hospital environment. (biomedcentral.com)
Clinical and genomic analysis of virulence-related genes in bloodstream infections caused by Acinetobacter baumannii. (cdc.gov)
Klebsiella pneumoniae bloodstream infections in neonates in a hospital in the Kingdom of Saudi Arabia. (qxmd.com)
To identify risk factors for Klebsiella pneumoniae bloodstream infections (BSI) in neonates in a hospital in the Kingdom of Saudi Arabia (KSA). (qxmd.com)
Clinical and Molecular Characteristics of Klebsiella pneumoniae Isolates Causing Bloodstream Infections in Japan: Occurrence of Hypervirulent Infections in Health Care. (go.jp)
Abstract Background The incidence of bloodstream infections (BSIs) caused by Escherichia coli and Klebsiella pneumoniae is increasing, with substantial associated morbidity, mortality, and antimicrobial resistance. (ox.ac.uk)

Clinical and Molecular Profile of Carbapenem Resistant Klebsiella pneumoniae Infections in a Tertiary Care Hospital -Mangalore. (bvsalud.org)
Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) is the species of CRE most commonly encountered in the United States. (cdc.gov)
Introduction: The objective of this study was to examine the evolution of carbapenem-resistant Klebsiella pneumoniae (CRKp) infections and their impact at a tertiary care hospital in South India. (elsevierpure.com)
2. Clinical and Molecular Characterizations of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infection in a Chinese Hospital. (nih.gov)
3. Recombination Drives Evolution of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 KL47 to KL64 in China. (nih.gov)
4. Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae. (nih.gov)
5. Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China. (nih.gov)
6. Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae. (nih.gov)
10. A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China. (nih.gov)
12. Multicenter Genomic Analysis of Carbapenem-Resistant Klebsiella pneumoniae from Bacteremia in China. (nih.gov)
13. Emergence of IS26-mediated pLVPK-like virulence and NDM-1 conjugative fusion plasmid in hypervirulent carbapenem-resistant Klebsiella pneumoniae. (nih.gov)
15. Within-host resistance evolution of a fatal ST11 hypervirulent carbapenem-resistant Klebsiella pneumoniae. (nih.gov)
Healthcare associated infections due to carbapenem-resistant Klebsiella pneumoniae (CRKP) are a major concern in Portuguese hospitals. (unl.pt)
This retrospective case-control study aims to evaluate the clinical outcomes of patients diagnosed with nosocomial carbapenem-resistant Klebsiella infection (CRK), identify risk factors of this infection, and determine mortality rate. (journalmeddbu.com)

Analysis of 2007 data regarding health-care--associated infections reported to CDC indicated that 8% of all Klebsiella isolates were CRKP, compared with fewer than 1% in 2000 (CDC, unpublished data, 2008). (cdc.gov)
ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
From the 45 non-duplicate isolates of K. pneumoniae recovered from different clinical specimens, a high prevalence of ertapenem-nonsusceptible isolates (44.4%) was reported using the new lower CLSI breakpoints. (who.int)
As the emergence of carbapenem-resistant clinical isolates has become a serious clinical challenge due to the limited treatment options, the presence of multiple carbapenemases from the same strain further aggravates this issue. (biomedcentral.com)
Epidemiological links and antimicrobial resistance of clinical Salmonella enterica ST198 isolates: a nationwide microbial population genomic study in Switzerland. (cdc.gov)
Whole-genome sequencing was performed on K. pneumoniae isolates to gain insight into how the outbreak progressed, in spite of early implementation of infection control procedures. (nih.gov)
Methods We conducted unselected, population-level genomic surveillance of bloodstream E. coli and Klebsiella pneumoniae isolates from 2008 to 2018 in Oxfordshire, United Kingdom. (ox.ac.uk)
We simulated the investigation of a CRKP outbreak based on WGS, with the aim of determining, in the minimum possible time, genetic relatedness between CRKP clinical and environmental isolates. (unl.pt)
Ten CRKP clinical isolates routinely obtained in the hospital laboratory were used. (unl.pt)
Clinical isolates were characterized in 48 hours: eight strains were confirmed as CRKP, of which six were of ST13 and carried bla KPC-3 . (unl.pt)
Using the genomes of 3594 Klebsiella isolates, we predicted the masses of 56 ribosomal subunit proteins and identified species-specific marker masses. (aku.edu)
Health care-associated infections, particularly Klebsiella pneumoniae and Staphylococcus aureus from bloodstream isolates, are being monitored for their AMR profiles and trends. (samj.org.za)
Klebsiella pneumoniae isolates positive for carbapenemases typically exhibit resistance to almost all available antimicrobial agents, and infection with a KPC-positive organism has been associated with high rates of morbidity and mortality, increased length of stay, and high costs. (ahrq.gov)
In addition, traditional infection control strategies that only target monitoring of clinical isolates as a trigger for initiating control interventions have not proved effective for KPC control, and are only addressing the "tip of the iceberg," since there are about 100 colonized patients for every infected patient. (ahrq.gov)
Hypervirulent Klebsiella pneumoniae isolates of capsular serotype K2 (hvKP-K2) that cause community-acquired invasive infections represent several unrelated clones, which all belong to phylogenetic group KpI. (microbiologyresearch.org)
Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. (microbiologyresearch.org)
Development of a rapid identification method for Klebsiella pneumoniae phylogenetic groups and analysis of 420 clinical isolates. (microbiologyresearch.org)
Among total 30 ESBL isolates selected by systematic random sampling, 3 isolates (all three E. coli ) showed presence of TEM and 3 other isolates (two E. coli and one Klebsiella spp. (nepjol.info)

This study was undertaken to evaluate the association, if any between antibiotic use and resistance in a hospital setting, and also detect the predominant mechanism of antibiotic resistance in Escherichia coli and Klebsiella pneumoniae over a period of 10 years. (nih.gov)
Prevalence of Extended Spectrum Beta Lactamase producing Escherichia coli and Klebsiella spp. (nepjol.info)
Escherichia coli and Klebsiella spp. (nepjol.info)

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Lincomycin and other antibacterial drugs, Lincomycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
For six months last year, a deadly outbreak of antibiotic-resistant bacteria kept infection-control specialists at the National Institutes of Health's Clinical Center in a state of high alert. (nih.gov)
A New York City patient carrying a multi-drug resistant strain of Klebsiella pneumoniae, a microbe frequently associated with hospital-borne infections, introduced the dangerous bacteria into the 243-bed research hospital while participating in a clinical study in the summer of 2011. (nih.gov)
Infectious outbreaks happen in every hospital in the world, afflicting millions of patients each year in the United States alone," said NHGRI Director Eric D. Green, M.D., Ph.D. "By marshaling the ability to sequence bacterial genomes in real time to accurately trace the bacteria as it spread among our Clinical Center patients, our researchers successfully elucidated what happened, which in turn has taught us some important lessons. (nih.gov)
Despite these measures, immune-suppressed patients elsewhere in the hospital began to develop K. pneumoniae infections, but the Clinical Center staff could not determine whether the same strain of bacteria carried by the New Yorker caused the new infections. (nih.gov)
When combined with the traditional epidemiology tracking data, the genome sequence results showed that Patient 1 transmitted the bacteria to other patients on two separate occasions from infections on different parts of her body, creating two major clusters of infected patients. (nih.gov)
Secondary infections with other bacteria are common and can cause extensive tissue destruction. (msdmanuals.com)
PHAXIAM is developing a portfolio of phages targeting 3 of the most resistant and dangerous bacteria, which together account for more than two-thirds of resistant hospital-acquired infections: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. (wreg.com)
More than a third of all humans are colonized by rod-shaped bacteria of a species called Klebsiella , which is found primarily on the nasal mucosa and in the gut. (news-medical.net)
Oral and respiratory tract infections caused by bacteria such as Streptococcus pneumoniae and Klebsiella pneumoniae pose a particular threat because of the rise of antibiotic-resistant strains, with vulnerable patient populations at high risk of infection [ 2 , 3 ]. (springer.com)
All cultures from blood an abdomen grew In chapter 1 you learnt in regards to the overall medical, microbial Klebsiella pneumoniae: and financial impact of infections with drug resistant bacteria allergy eats [url=http://dtekerala.gov.in/buy/FML-Forte/]buy fml forte 5 ml[/url]. (ehd.org)
Recent outbreaks of carbapenem-resistant gram-negative bacteria (CRGNB) among hospitalized patients have elicited national attention and underscored the danger of healthcare-associated infections. (ahrq.gov)
As soon as the pandemic started, our scientists realized there would be a benefit to sequencing genomes of all bacteria and fungi causing infection in COVID-19 patients while on ICU," said Professor Jonathan Edgeworth, who led the research team. (the-hospitalist.org)
The main Gram-negative bacteria identified were Klebsiella spp. (the-hospitalist.org)
Infections caused by urease-producing bacteria, mainly Staphylococcus spp, predispose dogs and cats to form struvite uroliths, also known as "infection stone", "urease stone" and "urea stone", which is composed by calcium, magnesium, ammonium and phosphate (Osborne et al . (vin.com)
Other isolated bacteria totalized 12.3% (n = 11) which three of them were mixed infection. (vin.com)
are two important uropathogens showing resistance to beta-lactams by producing extended spectrum beta lactamase (ESBL), leading to difficulty in treating infections with these bacteria. (nepjol.info)

Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. (nih.gov)
Because these strains are susceptible to carbapenems, they are not identified as potential clinical or infection control risks using current susceptibility testing guidelines. (cdc.gov)
9. The Molecular Epidemiology of Prevalent Klebsiella pneumoniae Strains and Humoral Antibody Responses against Carbapenem-Resistant K. pneumoniae Infections among Pediatric Patients in Shanghai. (nih.gov)
18. Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains. (nih.gov)
For decades, we used pulsed-field gel electrophoresis to differentiate bacterial strains," said Tara N. Palmore, M.D., the NIH Clinical Center's deputy hospital epidemiologist who led the outbreak investigation. (nih.gov)
The emergence of strains resistant to carbapenems has left few treatment options, making infection containment critical. (nih.gov)
Cefpodoxime proxetil is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below. (druglib.com)
Acute, uncomplicated ano-rectal infections in women due to Neisseria gonorrhoeae (including penicillinase-producing strains). (druglib.com)
Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including penicillinase-producing strains) or Streptococcus pyogenes . (druglib.com)
these infections are caused by NTHi strains, which colonize the maternal genital tract. (medscape.com)
Summary The ability to form biofilm is seen as an increasingly important colonization strategy among both pathogenic and environmental Klebsiella pneumoniae strains. (academicconcepts.net)
wzi gene sequencing, a rapid method for determination of capsular type for Klebsiella strains. (microbiologyresearch.org)

A secondary goal, centered on increasing treatment options, is to facilitate enrollment in clinical trials for new antibacterial therapeutics against these pathogens. (nih.gov)
Multidrug-resistant organism (MDRO) screening may identify high-risk patients for MDRO infection and curb the spread of these resistant pathogens. (beds.ac.uk)
are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. (aku.edu)
Classic' community-acquired infections such as sexually transmitted infections (STIs), opportunistic HIV/AIDS-related infections (e.g. cryptococcosis), specific enteric infections, and those caused by respiratory and meningeal pathogens (with particular, but not exclusive, focus on pneumococcal disease) have been researched in depth. (samj.org.za)
In addition to those of doctors and nurses, the roles of the infection prevention control practitioner and the clinical pharmacist must be enhanced to assist prevention of transmission of MDR pathogens and to curb inappropriate/incorrect use of antimicrobials. (samj.org.za)
The goal of Dr. Simon's research is the development of vaccines to prevent invasive infections with bacterial pathogens, including Salmonella enterica and Klebsiella pneumoniae . (umaryland.edu)
Comparison of pyogenic liver abscesses caused by Klebsiella pneumoniae and non-K. pneumoniae pathogens. (udea.edu.co)
Up to half of pathogens causing surgical site infections and over a quarter of those causing infections after chemotherapy are already resistant to standard prophylactic antibiotics in the USA. (pmlive.com)

Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species and extra-intestinal pathogenic Escherichia coli . (nih.gov)
1999). Other urease-producing microbes include Proteus spp (which is reported to be the main cause of struvite stones in humans), Pseudomonas spp and Klebsiella spp. (vin.com)
Search string used was "(Colistin OR polymyxin) AND ( Enterobacteriaceae OR Klebsiella OR Acinetobacter OR Escherichia coli OR Pseudomonas ) AND (random OR prospective OR retrospective OR cohort OR observational OR blind). (ijccm.org)

Hypervirulent Klebsiella pneumoniae ( hvKP ) is emerging globally and can cause various, severe infections in healthy individuals. (biomedcentral.com)

Other nosocomial infections in which klebsiellae may also be implicated include cholangitis, meningitis, endocarditis, and bacterial endophthalmitis. (medscape.com)
We found that although nosocomial infections with K. pneumoniae occurred worldwide, some manifestations of community-acquired infection (namely, liver abscess and community-acquired pneumonia) were geographically restricted. (cdc.gov)
Klebsiella pneumoniae is a major cause of nosocomial infections, primarily among immunocompromised patients. (nih.gov)
Expanded critical care capacity raised the risk of nosocomial infections, with attendant increased antimicrobial prescriptions and the threat of antimicrobial resistance. (the-hospitalist.org)

Uncomplicated urinary tract infections (cystitis) caused by Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , or Staphylococcus saprophyticus . (druglib.com)

Abstract BACKGROUND: Glycerol dehydrogenase [EC.1.1.1.6] and 1,3-propanediol oxidoreductase [EC.1.1.1.202] were proved to be two of the key enzymes for glycerol conversion to 1,3-propanediol in Klebsiella pneumoniae under anaerobic conditions. (academicconcepts.net)

Carbapenemase producing Klebsiella pneumoniae infection has increased in recent years, leading to limitations in treatment options. (bvsalud.org)
14. Convergence of two serotypes within the epidemic ST11 KPC-producing Klebsiella pneumoniae creates the "Perfect Storm" in a teaching hospital. (nih.gov)

Pyogenic liver abscess and the emergence of Klebsiella as an etiology: a retrospective study. (udea.edu.co)

We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. (cdc.gov)
Klebsiella pneumoniae ( K. pneumoniae ) causes a wide range of infections, including pneumonia, urinary tract infections, bacteremia and liver abscesses, and mainly infects immunocompromised people. (wreg.com)
1 UTI infection exhibits a variety of symptoms including mild burning micturition, bacteremia, sepsis and even death. (ojhas.org)

Potential explanations for these geographic differences in clinical manifestations include host factors such as rates of diabetes mellitus, alcoholism, access to healthcare, and socioeconomic factors. (cdc.gov)
Our aim was to determine whether the different manifestations of infection occurring in different geographic regions could be correlated with differences in organism characteristics. (cdc.gov)
Clinical manifestations of Hib meningitis are indistinguishable from other causes of bacterial meningitis. (medscape.com)
Monitor patients carefully for signs and indicators which may be clinical manifestations of underlying immune-mediated adverse reactions. (ehd.org)
Pyometra is typically a post-oestral syndrome in adult bitches associated with a variety of clinical and pathological manifestations of genital and multisystemic disease 2-5,7,11,20,27 . (scielo.org.za)

Enterobacter aerogenes Hormaeche and Edwards 1960 (Approved Lists 1980) and Klebsiella mobilis Bascomb et al. (wikipedia.org)
Most commonly detected in healthcare associated CPE infections are Klebsiella pneumoniae, Escherichia coli and Enterobacter spp. (biomedcentral.com)

While this information is important to treat critically ill patients with higher antibiotics , strict infection control practices need to be in place to prevent the spread of these infections in the hospital . (bvsalud.org)
Clinicians need to be aware of this infection to use appropriate antibiotics to save the lives of critically ill patients with the infection . (bvsalud.org)
Aminoglycoside antibiotics from clinical viewpoint]. (nih.gov)
infections accordingly become quickly resistant to standard antibiotics during treatment, necessitating a change in antibiotic to avoid worsening of the sepsis. (wikipedia.org)
The production of carbapenemases, such as Klebsiella pneumoniae carbapenemase (KPC) and the New Delhi metallo-β-lactamase (NDM), constitutes one of the most important mechanisms of resistance to β-lactam antibiotics [ 16 ]. (biomedcentral.com)
Conclusions: CRKp continues to pose a significant clinical threat, despite the introduction of new antibiotics. (elsevierpure.com)
In addition, Klebsiella pneumoniae is a frequent cause of hospital-acquired infections and is increasingly resistant to antibiotics. (news-medical.net)
A proportion of the hospital-acquired infections is caused by germs that are resistant to antibiotics, frequently by Klebsiella pneumoniae . (news-medical.net)
The engine uses natural language processing and other methods to parse key data elements needed for infection control alerts: organism, antibiotics tested, minimum inhibitory concentrations, susceptibility interpretation, body source of the culture, and health care facility where drawn. (ahrq.gov)

Klebsiella aerogenes is a nosocomial, pathogenic bacterium that causes opportunistic infections of most types. (wikipedia.org)
Upon pneumococcal colonization or infection, the respiratory epithelium controls the bacterium through antimicrobial peptides, such as LL-37 and defensins ( Bals and Hiemstra, 2004 ). (frontiersin.org)
However, in studies with the bacterium Klebsiella pneumoniae , researchers led by Wardemann have now been the first to find that the immune system also produces antibodies that recognize and neutralize various microorganisms. (news-medical.net)

PVP-I was tested against Klebsiella pneumoniae and Streptococcus pneumoniae according to bactericidal quantitative suspension test EN13727 and against severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses (SARS-CoV and MERS-CoV), rotavirus strain Wa and influenza virus A subtype H1N1 according to virucidal quantitative suspension test EN14476. (springer.com)
PVP-I gargle/mouthwash diluted 1:30 (equivalent to a concentration of 0.23% PVP-I) showed effective bactericidal activity against Klebsiella pneumoniae and Streptococcus pneumoniae and rapidly inactivated SARS-CoV, MERS-CoV, influenza virus A (H1N1) and rotavirus after 15 s of exposure. (springer.com)
Streptococcus viridans and Klebsiella pneumoniae were the most common organisms (33.9%, 33.9%) identified through pus cultures. (academicconcepts.net)

Such experience has now become extremely important with the rapidly-increasing spread of antibiotic-resistant bacterial infections which are almost impossible to overcome these days. (researchgate.net)

The objective of this review was to compare the effectiveness of Colistin monotherapy and combination therapy for the treatment of multidrug-resistant gram-negative bacterial infections. (ijccm.org)
Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. (ijccm.org)

The present study was undertaken to detect the Carbapenemase-producing genes in K. pneumoniae, the risk factors for acquiring them, and their impact on clinical outcomes. (bvsalud.org)
Infection with carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae is emerging as an important challenge in health-care settings ( 1 ). (cdc.gov)
This report provides updated recommendations from CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC) for the control of CRE or carbapenemase-producing Enterobacteriaceae in acute care (inpatient) facilities. (cdc.gov)
For all acute care facilities, CDC and HICPAC recommend an aggressive infection control strategy, including managing all patients with CRE using contact precautions and implementing Clinical and Laboratory Standards Institute (CLSI) guidelines for detection of carbapenemase production. (cdc.gov)
If the MHT reveals the presence of a carbapenemase, CLSI recommends that a comment be added to the microbiology report to inform clinicians and infection preventionists. (cdc.gov)
Clinical outcome in patients is therefore poor and overall morbidity, length of stay and mortality are increased compared to cases infected with non-carbapenemase-producing Enterobacterales [ 6 , 10 ]. (biomedcentral.com)

We aimed to explore Klebsiella group- and species-specific clinical impact, antimicrobial resistance (AMR) and virulence. (aku.edu)

Patients with these infections have similar presentations to those with infections caused by other organisms. (medscape.com)
Dr. Segre's laboratory also develops genomic tools to track hospital-acquired infections of multi-drug resistant organisms, including the NIH's recent Klebsiella pneumoniae outbreak. (nih.gov)
In developing countries the burden of infectious diseases is greater and exacerbated by limited access to, and availability and affordability of, antimicrobials required to treat infections caused by AMR organisms. (samj.org.za)
Endemic in areas such as the northeastern United States, Israel, Colombia, and Greece, KPC colonization is routinely found in patients in both acute- and long-term-care facilities, but reports of community-onset infections with KPC-producing organisms have been rare. (ahrq.gov)
The spread of KPC-producing organisms in health care settings represents a serious infection control issue. (ahrq.gov)
The team performed a proof-of-concept study of nanopore metagenomics sequencing - a type of DNA sequencing that allows direct rapid unbiased detection of all organisms present in a clinical sample - on 43 surplus respiratory samples from 34 intubated COVID-19 patients with suspected secondary bacterial or fungal pneumonia. (the-hospitalist.org)
are amongst the organisms mostly isolated from pyometra cases, either in pure culture or mixed infections 6,9,10,25 .As pyometra may have fatal complications, clients opting to retain their bitch's reproductive capacity should be warned of potential risks of medical or surgical treatments. (scielo.org.za)

The presence of invasive devices in hospitalized patients greatly increases the likelihood of infection. (medscape.com)
This is typically a community-acquired infection that occurs in patients with diabetes mellitus. (cdc.gov)
Clinical outcomes revealed that patients in the CRKP group had higher risk of mortality and were discharged against medical advice, and they also had higher rate of septic shock . (bvsalud.org)
It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections. (nih.gov)
The urinary tract is the most common site of nosocomial infection, accounting for more than 40% of the total number reported by acute-care hospitals and affecting an estimated 600,000 patients per year (1). (cdc.gov)
Reported infection rates vary widely, ranging from 1%-5%, after a single brief catheterization (3) to virtually 100% for patients with indwelling urethral catheters draining into an open system for longer than 4 days (4). (cdc.gov)
In these studies, errors in maintaining sterile closed drainage were common and predisposed patients to infection. (cdc.gov)
Such infection in otherwise healthy patients is often asymptomatic and is likely to resolve spontaneously with the removal of the catheter. (cdc.gov)
Amikacin, a new semisynthetic aminoglycoside antibiotic, was administered parenterally to 20 patients suffering from severe Gram-negative bacterial infections. (nih.gov)
Amikacin therapy of infections in neutropenic patients. (nih.gov)
Gram negative bone and joint infection: sixty patients treated with amikacin. (nih.gov)
RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
Despite enhanced infection-control practices, including patient isolation, the K. pneumoniae began to spread to other Clinical Center patients at the alarming rate of one a week, ultimately colonizing 17 patients, of whom 11 died - six from infection and five from their underlying disease while infected. (nih.gov)
In 2011 the National Institutes of Health Clinical Center experienced an outbreak of carbapenem-resistant K. pneumoniae that affected 18 patients, 10 of who died. (nih.gov)
In high-risk patients (alcoholics and septicemics), the mortality rate associated with this kind of infection is between 50 and 100% 1 . (wreg.com)
The incidence of K. pneumoniae resistances is evaluated between 90-100,000 patients in the US and EU5 2 , mainly in Urinary Tract infections and Respiratory Tract infections. (wreg.com)
KPC infections des patients. (who.int)
The efficacy of cefpodoxime in treating male patients with rectal infections caused by N. gonorrhoeae has not been established. (druglib.com)
Analyses of clinical and microbiological endpoints from a subset of 957 patients with infections from Klebsiella species were performed using generalized linear mixed-effects models. (aku.edu)
Therapeutic antibodies produced in the lab might help patients combat the infection. (news-medical.net)
The control group was randomly selected among patients matched for gender who were hospitalized within the same period (±15 days) and had nosocomial infection but without CRK growth in cultures. (journalmeddbu.com)
This course is designed for physicians, physician assistants, nurses, pharmacists, and allied health professionals involved in the care of patients at risk for or with bacterial sexually transmitted infections. (netce.com)
While active-surveillance-driven initiation of isolation precautions for MDRO control is a controversial topic in infection control circles, the literature suggests that active screening programs can effectively control MDRO prevalence when they rapidly identify colonized patients and place them into contact isolation precautions, such that a high percentage of total MDRO patient colonization days are spent as contact isolation days (see Burton, et al, below). (ahrq.gov)
A retrospective review was conducted of patients who were diagnosed as having deep neck infections in the Department of Otolaryngology at National Taiwan University Hospital from 1997 to 2002. (academicconcepts.net)
The attributing factors to deep neck infections, such as the age and systemic diseases of patients, were also analyzed. (academicconcepts.net)
When dealing with deep neck infections in a high-risk group (older patients with DM or other underlying systemic diseases) in the clinic, more attention should be paid to the prevention of complications and even the possibility of death. (academicconcepts.net)
Recent outbreaks and deaths caused by multidrug-resistant gram-negative "superbugs" among hospitalized patients in the United States have elicited national attention and have underscored the danger posed by these infections. (ahrq.gov)
A study led by researchers from Guy's and St. Thomas' NHS Foundation Trust has shown the potential for clinical metagenomics to become a same-day test for identifying secondary infection in ventilated ICU patients. (the-hospitalist.org)
In addition, treatment of COVID-19 patients with steroid therapy potentially exacerbates bacterial or fungal infections. (the-hospitalist.org)
Additionally, we undertook a major review of all the evidence around the use of CRP testing in patients presenting with RTIs in primary care, incorporating thousands of patients and dozens of clinical trials. (pmlive.com)
The aim of this study was to assess the demographic and bacterial profile of patients presenting with symptoms of urinary tract infections. (ojhas.org)
Patients were selected based on clinical history, clinical signs, laboratory data (urinalysis and urine culture) and imaging exams (ultrasonography and/or radiography). (vin.com)

This undermines the effectiveness of the available treatment options and thus contributes to the persistence of microbial infections. (who.int)
Dr. Segre's laboratory utilizes high-throughput sequencing and develops algorithms to study the microbial diversity of human skin in both health and disease states, with a focus on eczema and other microbial-associated infections. (nih.gov)
Together with the NIH epidemiologist, Tara Palmore, M.D., Segre received the 2013 Service to America Medal, considered among the most prestigious for a federal employee, for their work to establish the clinical utility of microbial genomics. (nih.gov)
Urinary tract infections (UTIs) represent widespread human microbial disorders involving any part of the urinary tract. (ojhas.org)

CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization and those who are critically ill and exposed to invasive devices (e.g., ventilators or central venous catheters). (cdc.gov)
In addition to localized infections such as pneumonia and otitis media, pneumococcus may cause invasive diseases, including meningitis and septicemia. (frontiersin.org)
can be distinguished using a ribosomal marker-based approach for MALDI-TOF MS. Klebsiella groups and species differed in AMR profiles, and in their association with invasive infection, highlighting the importance for species identification to enable effective treatment options. (aku.edu)
In order to prevent spread of nosocomial CRK infections, which has gradually narrowing treatment options, there is a need for further prospective multicenter studies on reducing invasive procedures and inappropriate antibiotic use, identifying correctible risk factors, and taking necessary corrective measures. (journalmeddbu.com)
Simon R and Levine MM. Glycoconjugate vaccine strategies for protection against invasive Salmonella infections . (umaryland.edu)
Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM. Salmonella enterica core O polysaccharide (COPS) conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. Enteritidis . (umaryland.edu)
Pulmonary disease, HIV infection (and other immunodeficiency states), alcoholism, pregnancy, and malignancy may predominate in adults with invasive Hib disease. (medscape.com)
Klebsiella pneumoniae liver abscess: a new invasive syndrome. (udea.edu.co)
Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. (udea.edu.co)

This study was conducted in Clinical Microbiology Department of Nepal Medical College Teaching Hospital from November 2021 to mid-January 2022 to determine prevalence of ESBL and antimicrobial susceptibility pattern among two common uropathogens. (nepjol.info)

A total of 402 E. coli and Klebsiella spp. (nepjol.info)
Prevalence of ESBL among E. coli and Klebsiella spp. (nepjol.info)
Among the E. coli , 16.1% (58/360) and only 4.8% (2/42) of Klebsiella spp. (nepjol.info)

2.) Kashani AH, Eliott D. The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. (udea.edu.co)

The effective therapeutic dose for skin infections was higher than those used in other recommended indications. (druglib.com)
Early diagnosis and therapeutic choice of Klebsiella pneumoniae liver abscess. (udea.edu.co)

The risk of acquiring a urinary tract infection depends on the method and duration of catheterization, the quality of catheter care, and host susceptibility. (cdc.gov)
3 Amongst the various types of urinary tract infection, cystitis (lower urinary tract infection) and pyelonephritis (upper urinary tract infection) constitute the majority of problems. (ojhas.org)
The most common symptoms of lower urinary tract infection include inflammation and irritation in the lining of urethra and bladder, burning sensation or pain while urinating. (ojhas.org)
Urinary tract infection (UTI) occurs when an infectious agent is capable of adhere, multiply and to persist in the urinary tract (Bartges 2005). (vin.com)
The prevalence of bacterial infections associated with urolithiasis has been studied and reported, and urolithiasis may cause or be a consequence of urinary tract infection. (vin.com)

Because lincomycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate, as described in the INDICATIONS AND USAGE section. (nih.gov)
Severe surgical site infections (SSI) that occur after device implantation substantially impact patient morbidity and. (beds.ac.uk)
Themanagement of severe neurologic infections due to multidrug-resistant (MDR) Klebsiella pneumoniae infection remains a challenge. (figshare.com)
Limited antibiotic treatment regimens make treatment of severe MDR K. pneumoniae infection more difficult. (figshare.com)

The burden of healthcare associated infections (HCAIs) in low- and middle-income countries (LMICs) remains underestimated due to diagnostic complexity and lack of quality surveillance systems. (beds.ac.uk)
WGS can be used as a high-resolution effective tool to investigate healthcare associated infections and track routes of dissemination in real-time. (unl.pt)

Dr. Segre had been working with the Clinical Center's Clinical Microbiology Department to study the evolution of bacterial antibiotic resistance when she heard about the outbreak. (nih.gov)
Multiple new Klebsiella species have recently been described, yet their clinical impact and antibiotic resistance profiles are largely unknown. (aku.edu)

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. (qxmd.com)

Both are rare in the United States and are associated with upper respiratory infection. (medscape.com)
The World Health Organization (WHO) placed lower respiratory infections as the fourth most common cause of death in 2016. (frontiersin.org)
Despite the fact that most respiratory tract infections (RTIs) are viral, they account for the majority of general practitioners' antibiotic prescribing in all health economies. (pmlive.com)
Many Northern European countries that use CRP tests as standard in primary care have markedly lower levels of resistant respiratory tract infections. (pmlive.com)
Moreover, these infections contribute to significant burden of morbidity and mortality and are placed second only to respiratory tract infections. (ojhas.org)

8.) Lok KH, Li KF, Li KK, Szeto ML. Pyogenic liver abscess: clinical profile, microbiological characteristics, and management in a Hong Kong hospital. (udea.edu.co)
Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics. (udea.edu.co)
Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea. (microbiologyresearch.org)

Common klebsiellae infections in humans include (1) community-acquired pneumonia, (2) UTI, (3) nosocomial infection, (4) rhinoscleroma and ozena, (5) chronic genital ulcerative disease, and (6) colonization. (medscape.com)
In a next step, we will have to do further tests with the antibodies to show their clinical value in humans. (news-medical.net)

Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258. (microbiologyresearch.org)

12.) Pastagia M, Arumugam V. Klebsiella pneumoniae liver abscesses in a public hospital in Queens, New York. (udea.edu.co)

Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. (cdc.gov)
Community acquired Klebsiella pneumoniae, K1 serotype. (udea.edu.co)

Infections in a Tertiary Care Hospital -Mangalore. (bvsalud.org)

These infections are usually hospital-acquired and have a more subtle presentation. (medscape.com)
2 Department of Clinical Laboratory, Union Hospital of Huazhong University of Science and Technology, Wuhan, China. (nih.gov)
3 Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, China. (nih.gov)
4 Department of Clinical Laboratory, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, China. (nih.gov)
5 Department of Clinical Laboratory, General Hospital of Tianjin Medical University, Tianjin, China. (nih.gov)
6 Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing, China. (nih.gov)
Genomics and microbiology experts collaborate in hospital infection control. (nih.gov)
To get the outbreak under control, Clinical Center staff collaborated with investigators at the National Human Genome Research Institute (NHGRI), also part of NIH, to use genome sequencing in the middle of this active hospital epidemic to learn how the microbe spread. (nih.gov)
Whole genome sequencing (WGS) can improve infection control, but this practice is not routinely used by hospital clinical laboratories in Portugal. (unl.pt)
Se presentan los casos de tres pacientes con endoftalmitis endógena asociada a absceso hepático por Klebsiella pneumoniae , atendidos en el Hospital Universitario San Vicente Fundación, de Medellín. (udea.edu.co)

Journal of Clinical Microbiology. (wikipedia.org)

Clinical Microbiology and Infection. (wikipedia.org)

The problem of susceptibility to and spread of infections caused by multidrug-resistant (MDR) infectious agents is fuelled by factors such as limited access to clean water and sanitation to ensure personal hygiene, malnutrition, and the HIV/TB epidemic. (samj.org.za)

Bacterial sexually transmitted infections (BSTIs) are becoming increasingly significant with the approach of a post-antibiotic era. (researchgate.net)
Bacteriophage therapy has been utilized in Poland, Russia and Georgia in the treatment of bacterial illnesses, but not in the treatment of bacterial sexually transmitted infections. (researchgate.net)

The patient 's clinical and demographic details, co morbidity , and mortality were collected. (bvsalud.org)

K granulomatis infection can result in granuloma inguinale or donovanosis, although these are uncommon in developed temperate countries. (medscape.com)
Granuloma inguinale is a progressive infection of genital and perineal skin caused by Klebsiella (formerly Calymmatobacterium ) granulomatis. (msdmanuals.com)
Infections with Klebsiella granulomatis are extremely rare in high-resource countries but have been reported in areas such as Papua New Guinea, Australia, southern Africa, the Caribbean, and parts of Brazil and India. (msdmanuals.com)

Organisms3

Diseases1

Bloodstream Infections10

Carbapenem-Resistant Klebsiella14

Isolates18

Escherichia coli and Klebsiella3

Bacteria17

Strains12

Pathogens8

Pseudomonas3

Hypervirulent Klebsiella pneumoniae1

Nosocomial infections4

Staphylococcus1

Abstract1

Producing Klebsiella pneumoniae2

Retrospective study1

Bacteremia3

Manifestations5

Enterobacter2

Antibiotics9

Bacterium3

Streptococcus3

Spread of antibiotic-resistant1

Multidrug-Resistant Gram-Negative B2

Carbapenemase6

Antimicrobial resistance1

Organisms7

Patients32

Microbial4

Invasive9

20221

Coli3

Emergence1

Therapeutic2

Urinary tract inf5

Severe4

Healthcare-associated2

Antibiotic resistance2

20231

Respiratory5

Characteristics3

Humans2

Third-generation cephalosporins1

Liver abscesses1

Serotype2

Tertiary care1

Hospital10

Journal of Clinical1

Microbiology and Infection1

Caused by multidrug-resistant1

Bacterial sexually transmitte2

Morbidity1

Granulomatis3