• In this paper, we review the management of intracranial atherosclerosis, revisit the skepticism on stenting, and state our position on the topic in the form of recommendations. (hkmj.org)
  • Evidence has accumulated that there is increased atherosclerosis/arteriosclerosis of the intracranial arteries in AD and that this may be additive or synergistic with respect to the generation of hypoxia/ischemia and cognitive dysfunction. (dovepress.com)
  • Intracranial atherosclerosis is one of the leading causes of ischemic stroke and occurs more commonly in patients of Asian, African or Hispanic origin than in Caucasians. (j-stroke.org)
  • Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. (j-stroke.org)
  • The purpose of this review is to describe the histological features of intracranial atherosclerosis and to state current evidences regarding the validation of MR vessel wall imaging with histopathology. (j-stroke.org)
  • Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide, accounting for 30-50% and 10% of ischemic cerebrovascular events in Asians and Whites, respectively [ 1 - 4 ]. (j-stroke.org)
  • Nevertheless, the histopathology of ICAS has not been well studied as extracranial atherosclerosis (ECAS), probably due to the infrequency of ICAS in Caucasians and the relative inaccessibility of intracranial arteries. (j-stroke.org)
  • acute coronary syndrome (ACS), Angina pectoris, Atherosclerosis, Coronary heart disease, Myocardial infarction (heart attack) the clinical importance of cardiology is extremely high. (literaturepublishers.org)
  • Intracranial atherosclerosis-related occlusion (ICAS-O) is frequently encountered at the time of endovascular revascularization treatment (ERT), especially in Asian countries. (j-stroke.org)
  • However, these thrombectomy devises are primarily designed for recanalization of the occluded artery by removing an embolus [ 9 - 11 ], and recanalization may not be sufficiently achieved if a significant stenosis, related to intracranial atherosclerosis (ICAS), is present at the occlusion site [ 12 ]. (j-stroke.org)
  • However, some evidence suggests that the amyloid is produced in the smooth muscle cells of the tunica media as a response to damage to the vessel wall (perhaps by arteriosclerosis or hypertension). (medscape.com)
  • Arteriosclerotic fusiform: caused by severe arteriosclerosis and arterial hypertension. (patient.info)
  • Pentobarbital coma for refractory intracranial hypertension after severe traumatic mind damage: mortality predictions and one-yr outcomes in fifty five patients. (ehd.org)
  • Background: Intracranial Atherosclerotic Disease (ICAD) is the most frequent etiology of stroke with high prevalence among Asians. (psu.edu)
  • Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. (j-stroke.org)
  • As a means of preventing secondary ischaemic stroke, angioplasty and stenting are considered potentially beneficial for patients with severe intracranial atherosclerotic stenosis. (hkmj.org)
  • However, the role of stenting has been challenged since the publication of the first randomised controlled trial on Stenting versus Aggressive Medical Management for Preventing Recurrent stroke in Intracranial arterial Stenosis (SAMMPRIS). (hkmj.org)
  • These are based on the prevalence of the disease in Hong Kong, the high risk of recurrent stroke despite medical therapy in the presence of haemodynamic intracranial stenosis without sufficient collaterals, an analysis of the weak points of SAMMPRIS, and results of clinical studies in Hong Kong. (hkmj.org)
  • Amplified Risk of Intracranial Artery Stenosis/Occlusion Associated With RNF213 p.R4810K in Familial Hypercholesterolemia. (cdc.gov)
  • Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study. (harvard.edu)
  • Objective White matter hyperintensity (WMH), defined as abnormal signals on magnetic resonance imaging (MRI), is an important clinical indicator of aging and dementia. (researchgate.net)
  • The recent success of randomized controlled trials (RCTs) of endovascular revascularization treatment (ERT) for acute ischemic stroke has led us to consider ERT as a standard of care in clinical practice [ 1 - 6 ]. (j-stroke.org)
  • The stroke data after vorapaxar are mixed, dominated with heavy excess of intracranial bleeding risks and slightly worsened second stroke rates, but show less primary ischemic strokes. (johnshopkins.edu)
  • Fortunately, these conflicting data do not belong purely to vorapaxar per se but rather, reflect unreasonably aggressive strategies, including predominantly triple antiplatelet therapy, utilized in both Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients with Arteriosclerosis (TRA2P) and especially in Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes (TRACER). (johnshopkins.edu)
  • Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating subset of stroke, occurring in relatively young people (mean age around 50 years) of whom around a third die within the initial weeks after the bleed. (biomedcentral.com)
  • Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating subset of stroke. (biomedcentral.com)
  • The most commonly used clinical systems divide ischemic stroke into three major stroke subtypes: large artery or atherosclerotic infarctions, cardioembolic infarctions and small vessel or lacunar infarctions. (vin.com)
  • The Boston Cerebral Amyloid Angiopathy Group has elaborated guidelines for the diagnosis of cerebral amyloid angiopathy (CAA) associated with intracranial hemorrhage (ICH). (medscape.com)
  • Most cases of CAA-related intracranial hemorrhage (ICH) are spontaneous. (medscape.com)
  • However, the pathological validation of HRMRI signal characteristics remains a key step to depict the plaque components and vulnerability in intracranial atherosclerotic lesions. (j-stroke.org)
  • Compared to the late onset of intracranial atherosclerotic lesions in Caucasians, various degrees of ICAS were detected in patients with younger age in Asians [ 12 - 15 ]. (j-stroke.org)
  • Unfortunately, the early macroscopic examination only described the prevalence and severity of ICAS by characterizing the surface involvement of fatty streak, plaque, ulcerated lesion, and calcification changes, failing to provide the detailed features of individual intracranial atherosclerotic lesions. (j-stroke.org)
  • Many of these patients harbor intracranial mass lesions. (medscape.com)
  • However, these five intracranial aneurysm risk loci identified so far explain only up to 5% of the familial risk of intracranial aneurysms, which makes genetic risk prediction tests currently unfeasible for intracranial aneurysms. (biomedcentral.com)
  • Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease. (ucsf.edu)
  • Pediatric patients cleared levofloxacin faster than adult patients resulting in lower plasma exposures than adults for given mg/kg dose [see CLINICAL PHARMACOLOGY (12.3) and CLINICAL STUDIES (14.9)].Inhalational Anthrax (Post-Exposure) Levofloxacin is indicated in pediatric patients months of age and older, for inhalational anthrax (post-exposure). (drugcentral.org)
  • Magnetic Resonance Images (MRI) were centrally reviewed to detect ICAD using the criterion used in the Warfarin-Aspirin Symptomatic Intracranial Disease study. (psu.edu)
  • The main areas of research are to elucidate the earliest signs of brain diseases, before clinical symptoms are present, and to understand how these lead to clinical manifestation of disease. (harvard.edu)
  • Not only am I interested in how these pre-clinical markers lead to clinical disease, I also want to disentangle the intricate relationships between these markers. (harvard.edu)
  • Genetic Testing Enables the Diagnosis of Familial Hypercholesterolemia Underdiagnosed by Clinical Criteria: Analysis of Japanese Early-Onset Coronary Artery Disease Patients. (cdc.gov)
  • Dr. Abramowtiz's clinical interests include central venous occlusive disease, aortic aneurysmal disease, vascular access for hemodialysis, peripheral vascular disease, and limb salvage. (medstarhealth.org)
  • We previously reported that pathologic measures of arteriosclerosis (AS), cerebral infarction, and Alzheimer's disease (AD) are independently correlated with cortical gray matter (CGM) atrophy measured by in vivo magnetic resonance imaging (MRI). (escholarship.org)
  • IgG glycan profiles may be developed as clinical useful biomarkers for chronic disease in the future. (biomedcentral.com)
  • a Korean study reported that around 15% of ICAS-related occlusions (ICAS-O) are found in patients with intracranial artery occlusion in anterior circulation [ 14 ]. (j-stroke.org)
  • Most patients with extracranial metastases experience recurrence of the primary intracranial tumor. (bvsalud.org)
  • 75% luminal narrowing) is much higher in the intracranial vessels than extracranial vessels [ 20 ]. (j-stroke.org)
  • In the clinical glioma samples, ACTA2 expression was remarkably increased in recurrent samples compared to the primary samples from the same patients, and the higher the change in ACTCA2 expression from the start to relapse, the shorter the progression-free survival. (bvsalud.org)
  • In this review, we describe the clinical and imaging factors that may possibly differentiate ICAS-O from EMB-O. We will also discuss some current hurdles for treating ICAS-O in the hyperacute period and suggest the optimal ERT strategy for ICAS-O patients. (j-stroke.org)
  • In a large series of patients who developed intracranial hematomas requiring emergent decompression, more than half had lucid intervals and were able to make conversation between the time of their injury and subsequent deterioration. (medscape.com)
  • Acute subdural hematoma is the most common type of traumatic intracranial hematoma, occurring in 24% of patients who present comatose. (medscape.com)
  • Carotid intima-media thickness progression as surrogate marker for cardiovascular risk: meta-analysis of 119 clinical trials involving 100 667 patients. (als-journal.com)
  • Convulsions, increased intracranial pressure (including pseudotumor cerebri), and toxic psychosis have been reported in patients receiving quinolones, including ofloxacin. (recallguide.org)
  • Of these, 38 patients (4.4%) had major bleeds that required hospitalization: gastrointestinal bleeding from any source with or without a transfusion, and retroperitoneal or intracranial bleeding warranting discontinuation of warfarin treatment. (medscape.com)
  • Currently, the conventional lumenography-based neuroimaging modalities, such as magnetic resonance angiography (MRA), computed tomography angiography (CTA), and digital subtraction angiography (DSA), are commonly used in the routine clinical practice to detect ICAS. (j-stroke.org)
  • In this review, we describe the characteristics of ICAS-O, as well as the clinical and imaging findings that may help us to predict ICAS-O. We will also suggest an appropriate ERT strategy for ICAS-O based on literature review and our experiences. (j-stroke.org)
  • Subdural hematoma is the most common type of traumatic intracranial mass lesion. (medscape.com)
  • Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence. (lookformedical.com)
  • It is noteworthy that the newer thrombectomy devices, such as a stent retriever or direct aspiration system, have enabled us to achieve an improved reperfusion rate, which is strongly associated with better clinical outcomes [ 8 ]. (j-stroke.org)
  • A recent genome-wide association study of intracranial aneurysms in Finnish, Dutch and Japanese cohorts totaling 5,891 cases and 14,181 controls identified three new loci strongly associated with intracranial aneurysms on chromosomes 18q11.2 and 10q24.32, and replicated two previously found loci on chromosomes 8q11.23-q12.1 and 9p21.3. (biomedcentral.com)
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (clinicaltrials.gov)
  • When making a decision to put a patient on anticoagulation, we need to employ clinical decision-making tools to [weigh the risks and benefits and to] inform the patient that 'these are the risks, and the fact that you're obese might put you at a higher risk of bleeding,' " Ogunsua said. (medscape.com)
  • Presentation varies widely in acute subdural hematoma (see Clinical). (medscape.com)
  • Unspecified diagnosis codes like I70.9 are acceptable when clinical information is unknown or not available about a particular condition. (icdlist.com)
  • Diagnosis of lymph node metastasis that was delayed because the patient had a fever of unknown origin, no signs of infection, and the primary intracranial tumor did not recur. (bvsalud.org)
  • All in all, our knowledge of risk factors for both the development and rupture of intracranial aneurysms remains rather meager, and hopes are high that genetic research will further increase our understanding of such risk factors. (biomedcentral.com)
  • Clinical and psychometric testing was performed on all individuals, as well as obtaining their magnetic resonance imaging-based hippocampal volumes. (dovepress.com)
  • Journal of Clinical Pharmacy and Therapeutics. (tmu.edu.tw)
  • Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. (tmu.edu.tw)