AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Hypochlorous AcidChloraminesPeroxidaseHydrogen PeroxideChlorineOxidantsBromatesTaurineOxidation-ReductionNeutrophilsElectrolysisDisinfectantsChlorine CompoundsHalogenationHydroxyl RadicalThiocyanatesSulfhydryl CompoundsSuperoxidesFree Radical ScavengersAmitrolePeroxidasesGlutathioneHydroxidesPancreatic ElastaseChromatography, High Pressure Liquidalpha 1-AntitrypsinChloridesCatalaseAntioxidantsMethionineGlutathione DisulfidePeroxynitrous AcidFree RadicalsMass Spectrometry
HOClHClOMyeloperoxidaseSodiumDisinfectantsAntimicrobial agent2017BacteriaPotentCatalyzes the productionHypochloriteBiofilmChlorineFormulationsAntisepticPathogensSprayHygienePrimarilyOxidationBiopharmaceutical companySolutionWoundsBacterialElectricityDisinfectantAmino acidSuitableDiagnosisTrialsAntioxidativeTyrosineResultsPracticeResearchProductsOphthalmologySolutionsStudiesProductionPharmaceuticalsPotentialWaterMeat
HOCl17
  • We researched the chemistry of Hypochlorous Acid (HOCl) and saw that not only is it very effective but is also a green product that does not harm humans, pets, or the environment. (bomaconvention.org)
  • At the site of inflammation, cellular DNA is damaged by hypochlorous acid (HOCl), a potent oxidant generated by myeloperoxidase. (elsevierpure.com)
  • WOODSTOCK, GA / ACCESSWIRE / August 2, 2022 / Sonoma Pharmaceuticals, Inc. (Nasdaq:SNOA), a global healthcare leader developing and producing patented Microcyn® technology based stabilized hypochlorous acid (HOCl) products for a wide range of applications, including wound, eye, oral and nasal care, and dermatological conditions, today announced that it has launched a MicrocynVS® line of products exclusively for veterinarians. (accesswire.com)
  • Sonoma Pharmaceuticals is a global healthcare leader for developing and producing stabilized hypochlorous acid (HOCl) products for a wide range of applications, including wound care, animal health care, eye care, nasal care, oral care, and dermatological conditions. (accesswire.com)
  • In-vitro and clinical studies of hypochlorous acid (HOCl) show it to have impressive antipruritic, antimicrobial, antiviral and anti-inflammatory properties. (accesswire.com)
  • Clinical Reset is the only pure, prescription-grade, FDA-cleared hypochlorous acid (HOCl) facial mist. (cellerx.com)
  • Hypochlorous acid (HOCl) is a potent antimicrobial agent that has recently gained attention as a potential alternative to conventional antibiotics. (microbiochemjournal.com)
  • Herein, we discuss the mechanisms of HOCl antimicrobial action, its potential clinical applications, and future directions for research. (microbiochemjournal.com)
  • This review aims to provide an overview of the use of hypochlorous acid (HOCl) as an antibiotic agent. (microbiochemjournal.com)
  • This work describes a novel wound dressing in the form of an electrochemical scaffold (e-scaffold) that generates controlled, low concentrations of hypochlorous acid (HOCl) suitable for killing biofilm communities without substantially damaging host tissue. (ewco.com)
  • Hypochlorous acid, abbreviated as HOCl, can in fact be present in the body as a naturally occurring molecule. (platinumdelux.com)
  • This solution of hypochlorous acid (HOCl) acts as a preservative that inhibits microbial contamination within the solution. (steadmed.com)
  • When inhaled, chlorine rapidly hydrolyzes to form hypochlorous acid, (HOCl), hydrochloric acid (HCl), and hypochlorite (-OCl) (White et. (cdc.gov)
  • NeutroPhase, an FDA cleared 510(k) medical device, is the only skin and wound cleanser with a patented and pure form of hypochlorous acid (HOCl) that doesn't contain bleach impurities. (woundcareweekly.com)
  • Pure hypochlorous acid (HOCl) (0.01% w/v) with no sodium hypochlorite impurity in saline pH 4-5, which was recently shown to both eradicate bacteria and neutralize bacterial toxins in vitro, was administered via flow-through instillation to 6 patients with NF 4-6 times daily as needed. (woundcareweekly.com)
  • Results: Oxidation of ZDEC by hypochlorous acid (bleach, HOCl), iodine, or hydrogen peroxide resulted in production of TETD, tetraethylthiocarbamoyl disulfide, and tetraethyldicarbamoyl disulfide (TEDCD). (cdc.gov)
  • The respiratory burst is a major source of superoxide, hydrogen peroxide, the hydroxyl radical, hypochlorous acid (HOCl), and RNOS. (ecoshelta.com)
HClO3
  • citation needed] Addition of chlorine to water gives both hydrochloric acid (HCl) and hypochlorous acid (HClO): Cl2 + H2O ⇌ HClO + HCl Cl2 + 4 OH− ⇌ 2 ClO− + 2 H2O + 2 e− Cl2 + 2 e− ⇌ 2 Cl− When acids are added to aqueous salts of hypochlorous acid (such as sodium hypochlorite in commercial bleach solution), the resultant reaction is driven to the left, and chlorine gas is formed. (wikipedia.org)
  • Weakly acidic hypochlorous acid (HClO 200 ppm, pH 6.5) is effective against a broad range of microorganisms. (ewco.com)
  • Sodium hypochlorite (NaClO, SHC)/hypochlorous acid (HClO, HCA) wound irrigation solutions have experienced a renaissance in the prevention and treatment of low-level wound infections. (ewco.com)
Myeloperoxidase5
  • In biology, hypochlorous acid is generated in activated neutrophils by myeloperoxidase-mediated peroxidation of chloride ions, and contributes to the destruction of bacteria. (wikipedia.org)
  • Saline shifts myeloperoxidase activity in epithelial or phagocytic cells to produce hypochlorous acid. (springer.com)
  • Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. (otago.ac.nz)
  • As to myeloperoxidase, oxidants derived from the activity of this enzyme such as hypochlorous acid may critically interfere with several cell functions thereby engendering tissue and organ damage. (hindawi.com)
  • However, until now, there is no randomized clinical trial that tested the effect of VDR activation on AGE and RAGE and on myeloperoxidase in CKD population. (hindawi.com)
Sodium2
  • 27 Although the above solutions received the highest level of consensus, other instillation solutions have been used by the expert panel, notably 0.25% and 1% diluted acetic acid, diluted iodine, and 0.125% sodium hypochlorite (Dakin's solution). (researchgate.net)
  • There are also newer cleansing agents that are super-oxidised hypochlorous acid and sodium hypochlorite. (microdacyn.com.au)
Disinfectants3
Antimicrobial agent2
  • In a 2008 document "Guidance for Industry: Guide to Minimize Microbial Food Safety Hazards of Fresh-cut Fruits and Vegetables" , the FDA acknowledged hypochlorous acid as an antimicrobial agent for processing water used to sanitize fruits and vegetables. (wode.com.sg)
  • In 2017, the FDA officially authorized hypochlorous acid for food contact , allowing it to be used as an antimicrobial agent for preparing produce and meat. (wode.com.sg)
20172
  • In a 2017 study, researchers observed the bacterial reduction on periocular skin twenty minutes after saline-based hypochlorous application¹. (biomiq.health)
  • 21 September 2017 - Realm Therapeutics plc (AIM: RLM), a clinical stage biopharmaceutical company focused on leveraging its proprietary immunomodulatory technology, is pleased to announce today that it has successfully secured funding commitments to raise gross proceeds of approximately £19.3 million ($26 million) through a proposed placing (the "Placing") with new and existing investors, including several healthcare specialist funds based in the US and UK. (mtspartners.com)
Bacteria2
  • Considering conditions such as dry eye and blepharitis can be caused or exacerbated by excessive bacteria around the eyelid, BIHOCL O.D optimizes the bactericidal power of hypochlorous to eliminate harmful bacterial burden. (biomiq.health)
  • Clinical Reset keeps your skin bacteria-free which is the number one thing you can do to help manage perioral dermatitis. (cellerx.com)
Potent1
Catalyzes the production1
  • In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. (lu.se)
Hypochlorite2
  • In water treatment, hypochlorous acid is the active sanitizer in hypochlorite-based products (e.g. used in swimming pools). (wikipedia.org)
  • In the 1940s, London hospitals used acidified hypochlorite solutions in aerosol form (which contain a considerable amount of free hypochlorous acid molecules) to combat airborne pathogens in the air and prevent infections. (wode.com.sg)
Biofilm1
Chlorine1
  • Hypochlorous acid was discovered in 1834 by the French chemist Antoine Jérôme Balard (1802-1876) by adding, to a flask of chlorine gas, a dilute suspension of mercury(II) oxide in water. (wikipedia.org)
Formulations2
Antiseptic3
  • Unlike other antiseptic solutions, hypochlorous acid is non-cytotoxic, and well-tolerated with prolonged use on ocular tissues, meaning your patients can reach for this product every day without worries about eyelid irritation or skin reactivity. (biomiq.health)
  • By the early 20th century, medical professionals had recognized the antiseptic functions of hypochlorous acid, leading to its use in disinfecting soldiers' wounds during World War One. (wode.com.sg)
  • Although hypochlorous acid is safe and works fantastically as an antiseptic and a disinfectant, its limited shelf life (48-72 hours) has hindered the wide adoption and commercialization of hypochlorous acid. (wode.com.sg)
Pathogens2
  • Decades later, research discovered that hypochlorous acid is naturally produced by the human body and used by the body to fight against pathogens. (wode.com.sg)
  • Avenova contains a solution of pure hypochlorous acid, a substance used by the body as a natural defense against pathogens, but is completely harmless to skin. (lintastungkal.com)
Spray2
Hygiene3
  • Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. (biomiq.health)
  • This means that hypochlorous acid can be used for human hygiene (products that come into contact with the skin), animal hygiene, surface disinfection, and treating drinking water. (wode.com.sg)
  • Keep updated on the latest eyelid-eyelash hygiene clinical safety reports. (lintastungkal.com)
Primarily1
Oxidation1
  • Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. (otago.ac.nz)
Biopharmaceutical company2
  • RLFTF , RLFTY ) ("Relief"), and NRx Pharmaceuticals, Inc. (Nasdaq: NRXP) ("NRx Pharmaceuticals"), a clinical-stage central nervous system biopharmaceutical company, today announced the close of the definitive settlement agreements to resolve the pending litigation between Relief and NRx Pharmaceuticals' wholly owned subsidiary, NeuroRx, Inc (NeuroRx). (relieftherapeutics.com)
  • NRx Pharmaceuticals is a clinical-stage biopharmaceutical company developing therapeutics for the treatment of central nervous system disorders, specifically suicidal depression, and post-traumatic stress disorder (PTSD). (relieftherapeutics.com)
Solution6
  • Despite being relatively easy to make, it is difficult to maintain a stable hypochlorous acid solution. (wikipedia.org)
  • While existing products address bacterial reduction or symptom relief, hypochlorous acid presents an alternative eye care solution that optimally targets a number of eye care needs. (biomiq.health)
  • Existing scholarly research suggests that hypochlorous acid is an effective solution in the treatment of dry eye disease¹⁻³. (biomiq.health)
  • While hypochlorous was effective at reducing harmful bacterias, the solution was shown to uphold the integral bacterial diversity on the eyelid tissue¹. (biomiq.health)
  • Hypochlorous Solution Electrically Produced From Hypertonic Saline as a Disinfectant for Septic Wounds: and for the Throat in Diphtheria, Scarlet Fever, Etc. British Medical Journal , 1 (2930), 256. (wode.com.sg)
  • Expert Recommendations for the Use of Hypochlorous Solution: Science and Clinical Application. (pilonidalsinus-zentrum.de)
Wounds2
  • In wound care, and as of early 2016 the U.S. Food and Drug Administration has approved products whose main active ingredient is hypochlorous acid for use in treating wounds and various infections in humans and pets. (wikipedia.org)
  • Wounds : a compendium of clinical research and practice , 32 (4), 107-114. (pilonidalsinus-zentrum.de)
Bacterial1
  • BIHOCL O.D is formulated specifically for clinical use on the ocular tissues and effectively targets a number of eye care needs, including symptom relief, bacterial load reduction, and preventative care. (biomiq.health)
Electricity1
  • Similarly, in ships and yachts, marine sanitation devices use electricity to convert seawater into hypochlorous acid to disinfect macerated faecal waste before discharge into the sea. (wikipedia.org)
Disinfectant2
Amino acid2
  • Relief's diversified pipeline consists of assets that have the potential to effectively address significant unmet medical needs, including PKU GOLIKE ® , engineered with the proprietary Physiomimic™ technology, which is the first prolonged-release amino acid product commercialized for the dietary management of phenylketonuria (PKU). (relieftherapeutics.com)
  • Stepping into the world of taurine, a powerhouse amino acid, we uncover its vital role in our well-being. (innerfuel.net)
Suitable1
  • Recent studies have shown hypochlorous acid water to be suitable for fog and aerosolised application for disinfection chambers and suitable for disinfecting indoor settings such as offices, hospitals and healthcare clinics. (wikipedia.org)
Diagnosis2
  • We included a brief description of the epidemiology, clinical presentation, diagnosis, prevention of exposure, prevention of disease by chemoprophylaxis, treatment of disease, monitoring of adverse effects during treatment, management of treatment failure and relapse cases. (scielo.br)
  • The Small-molecule fluorescent Probes, one of the Chemical fluorescent probes, have been used in environmental monitoring, food detection, clinical disease diagnosis, and become the research hotspot because of the small size and convenient synthesis. (alfa-chemistry.com)
Trials2
  • The published clinical trials support the purported advantages of cold-pressed black cumin seed oil use, which include anti-aging, anti-inflammatory, and antimicrobial benefits. (cosmeticsdesign.com)
  • The antiviral agent cidofovir, a nucleoside analogue that inhibits adenovirus DNA polymerase, 2 was successfully tested through phase II clinical trials for this indication. (arvojournals.org)
Antioxidative2
  • This article reviews the presently available experimental and clinical data on the antioxidative effects of N ‐acetylcysteine in chronic obstructive pulmonary disease. (ersjournals.com)
  • The present article reviews the available experimental and clinical data on the antioxidative effects of NAC in relation to COPD. (ersjournals.com)
Tyrosine1
  • Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. (otago.ac.nz)
Results5
  • The liberation of phosphate from ATP is a source of cellular energy that results in ADP (Adenosine DiPhosphate) and hydrogen ion (acid). (benbest.com)
  • The net breakdown of ATP from glycolysis results in ADP, AMP (Adenosine MonoPhosphate), phosphate, lactate and acid accumulation (acidosis). (benbest.com)
  • Accumulation of carbon dioxide results in carbonic acid (H 2 CO 3 ), which further increases acidity. (benbest.com)
  • Depolarization of presynaptic membranes results in release of the neurotransmitter glutamate (glutamic acid) . (benbest.com)
  • Established an antibiotic stewardship Urgent Care Industry Action Plan and convened a volunteer committee composed of industry clinical leadership to shepherd its implementation and monitor results. (cdc.gov)
Practice1
  • They are attributed with lower cytotoxicity and have therefore gained increasing attention in daily clinical practice. (ewco.com)
Research3
  • Let's take a deeper look at the research about hypochlorous acid for management and treatment of dry eye disease. (biomiq.health)
  • Randomized controlled clinical trial research of this relatively simple and inexpensive instillation protocol is suggested for identified cases of NF. (woundcareweekly.com)
  • We also searched UK Clinical Research Network Portfolio for current projects in the UK and the ClinicalTrials register for on-going or recently completed studies. (who.int)
Products1
Ophthalmology1
  • Christine Sindt, OD, Clinical Associate Professor of Ophthalmology at the University of Iowa, recommends wiping the eyes daily with a new antibacterial eyelid cleanser, such as Avenova from NovaBay Pharmaceuticals . (lintastungkal.com)
Solutions1
  • Tehclo™ is the globally patented nanotechnology platform applied to the production of unique hypochlorous acid solutions that ensures the most consistent quality for best-in-class clinical outcomes. (apr.ch)
Studies1
  • The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. (microbiochemjournal.com)
Production1
  • In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)
Pharmaceuticals1
  • NRx Pharmaceuticals has also initiated a Phase 2b clinical trial in patients with Sub-Acute Suicidality, potentially a substantially broader indication. (relieftherapeutics.com)
Potential1
  • Wang L, et al: Hypochlorous acid as a potential would care agent: Part I, Stabilized hypochlorous acid: A component of the inorganic armamentarium of innate immunity. (steadmed.com)
Water2
Meat1
  • In deodorization, hypochlorous acid has been tested to remove up to 99% of foul odours including garbage, rotten meat, toilet, stool, and urine odours. (wikipedia.org)