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  • cytokine
  • On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential. (springer.com)
  • clonal
  • Core Binding Factor (CBF) Acute Myeloid Leukemia (AML) is cytogenetically characterized by either the t(8;21) or the inv(16)/t(16;16) chromosomal abnormalities, which, although being pathognomonic, are not sufficient per se to induce overt leukemia but rather determine a preclinical phase of disease when preleukemic subclones compete until the acquisition of clonal dominance by one of them. (hindawi.com)
  • we will analyze the studies investigating the leukemogenetic role of t(8;21) and inv(16)/t(16;16), the proposed theories of its clonal evolution, and the role played by the hematopoietic niches in preserving the disease. (hindawi.com)
  • Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by clonal hematopoiesis leading to bone marrow dysplasia and cytopenias. (medworm.com)
  • therapy
  • With the ongoing clinical translation of CpG- STAT3 siRNA conjugates to therapy of hematologic malignancies, our results underscore the potential of utilizing these oligonucleotide reagents to immunotherapy of advanced prostate cancers. (aacrjournals.org)
  • Finally, we will discuss the clinical implications of stem cell modeling of CBF AML for the therapy of the disease. (hindawi.com)
  • The induced pluripotent stem cell (iPSC) technology allows generation of patient-specific pluripotent stem cells, thereby providing a novel cell-therapy platform for severe degenerative diseases. (biomedcentral.com)
  • relapse
  • Data for two clinical outcomes-disease remission or relapse-are considered, and we investigate these using Bayesian inference techniques throughout. (pnas.org)
  • mutations
  • Beside standard chemoimmunotherapy, higher risk subgroups -namely those harboring TP53 mutations or deletions of the short arm of chromosome 17 (del17p)- may benefit from newer targeted drugs which act downstream of the B cell receptor. (medworm.com)
  • While SF3B1 mutations have been associated with adverse clinical outcome in CLL, mechanistic understanding of its role in the oncogenic phenotype is lacking. (medworm.com)
  • murine
  • Competitive repopulation of lethally irradiated murine hosts with EAR-2-transduced BM cells resulted in increased engraftment and increased colony formation in serial replating experiments. (springer.com)
  • transcriptional
  • To generate great numbers of very different cells-ranging from erythrocytes to highly specialized lymphocytes-a delicate balance of activity of transcriptional programs and hematopoietic growth factors is required ( 1 ). (pnas.org)
  • Neuroblastoma
  • In this study, we investigated whether Polyphenon E, a clinical grade mixture of green tea catechins under evaluation in multiple clinical cancer trials run by the National Cancer Institute (Bethesda, MD), has anticancer activity in mouse models of neuroblastoma. (aacrjournals.org)
  • granulocyte-colony
  • We found that the level of cyclin-dependent kinase 1 (Cdk1) protein was significantly decreased in controls but unchanged in TLS-ERG-expressing cells after granulocyte colony-stimulating factor treatment or interleukin-3 withdrawal. (aacrjournals.org)
  • genes
  • Furthermore, gene expression profiling of hematopoietic cells demonstrated that PBX3/MEIS1 overexpression, but not HOXA9/MEIS1 , HOXA9/PBX3 , or HOXA9 overexpression, recapitulated the MLL -fusion-mediated core transcriptome, particularly upregulation of the endogenous Hoxa genes. (aacrjournals.org)
  • We previously generated an original strategy to silence genes specifically in Toll-like Receptor-9 (TLR9) positive myeloid cells using CpG-siRNA conjugates. (aacrjournals.org)
  • siRNA
  • Targeting MDSCs using CpG- STAT3 siRNA strategy alleviated their immunosuppressive functions, restoring T-cell activity. (aacrjournals.org)
  • remission
  • Our findings show that, despite CMV infection reshaping the TRG repertoire, TRG composition is not associated with aGvHD development, and several public sequences are associated with clinical remission. (jimmunol.org)
  • progression
  • This is a particularly helpful perspective if interactions between healthy and diseased cell types can affect the disease progression, as is now widely believed. (pnas.org)
  • receptor
  • T Cell Receptor mimic (TCRm) antibodies to low-density peptide epitopes from undruggable intracellular proteins presented in the context of major histocompatibility (MHC) molecules are therapeutically effective in mouse models of human cancers. (medworm.com)
  • Pharmacology
  • Dr. Baker's cancer-relevant research interests broadly cover translational and clinical pharmacology of anti-cancer agents. (osu.edu)
  • Therefore
  • MEIS1 and PBX3 are not individually able to transform cells and were therefore hypothesized to function as cofactors of HOXA9. (aacrjournals.org)
  • Therefore, targeting myeloid cell production in the spleen could ameliorate increased atherosclerotic plaque inflammation after MI. (ahajournals.org)