Clinical graft vs leukemia effect. Medical search. Frequent questions

It is closely linked with graft-versus-host disease (GvHD), as the underlying principle of alloimmunity is the same. (wikipedia.org)
CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
Whereas graft-versus-host-disease (GvHD) has a negative impact on the host, GvL is beneficial for patients with hematopeietic malignancies. (wikipedia.org)
The interconnection of those two effects can be seen by comparison of leukemia relapse after HSC transplantation with development of GvHD. (wikipedia.org)
Patients who develop chronic or acute GvHD have lower chance of leukemia relapse. (wikipedia.org)
When transplanting T-cell depleted stem cell transplant, GvHD can be partially prevented, but in the same time the GvL effect is also reduced, because T-cells play an important role in both of those effects. (wikipedia.org)
The possibilities of GvL effect in the treatment of hematopoietic malignancies are limited by GvHD. (wikipedia.org)
When transplanting HSC during AML, T-cells are usually selectively depleted to prevent GvHD while NK cells help with the GvL effect which prevent leukemia relapse. (wikipedia.org)
G-CSF can help to enhance GvL effect and suppress GvHD by reducing levels of LPS and TNF-α. (wikipedia.org)
Relapse and graft- versus -host disease (GvHD) are the main impediments to the clinical success of allogeneic hematopoietic cell transplantation (HCT) in curing malignant blood disorders. (haematologica.org)
Alloreactive donor T cells are important mediators of both relapse control by graft- versus -leukemia (GvL) effects, and of GvHD. (haematologica.org)
1 In unrelated donor (UD)-HCT, frequent human leukocyte antigen (HLA)-DPB1 disparity is the target of T-cell alloreactivity, contributing to both leukemia control and GvHD. (haematologica.org)
Pentostatin is one of the agents being examined in a randomised Phase II study of initial therapy for GVHD by the NIH sponsored Clinical Trials Network. (johnshopkins.edu)
Factors associated with improved OS were adolescent and young adult (AYA) patient (P = .035), first or second CR (P = .026), and chronic graft-versus-host disease (GVHD) (P (bvsalud.org)
These T cells are not alloreactive and do not induce GVHD but can exhibit potent anti-leukemia and anti-infectious activities. (bethematchclinical.org)
Although new techniques are being developed to extend CAR T cell therapy to the allogeneic setting, the risk of graft-versus-host disease (GVHD) remains. (bethematchclinical.org)
At the same time, the so-called graft versus host disease (GvHD) often develops when the donor's lymphocytes are transplanted. (uni-mainz.de)
An obstacle to survival is that the beneficial graft-vs.-tumor effect of a transplant can be offset by concurrent GVHD. (fredhutch.org)
However, because donor stem cells are not selected for specificity for leukemia antigens and commonly recognized proteins expressed by many other host tissues, substantial morbidity and mortality from GVHD can occur. (fredhutch.org)
The development of acute graft-versus-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P=.04) and improved disease-free survival (P=.11). (umn.edu)
The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. (atlantis-press.com)
A new Phase 3 clinical trial at Winship is enrolling participants after extremely encouraging results in the study's first two phases indicate the first-in-class high-precision cell therapy retains the benefits of stem cell transplant without such serious complications as graft versus host disease (GvHD) and disease relapse in patients with certain blood cancers. (emory.edu)
Orca-T combines purified cells from a matched donor to replace a patient's diseased blood and immune system with a healthy one while lowering their risk of developing GvHD and other life-threatening transplant-related side effects. (emory.edu)
These cells expand and help prevent both rejection of the graft and GvHD. (emory.edu)
The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
The diagnosis of GvHD relies almost entirely on clinical signs, and can only be confirmed by biopsy of target organs. (cryostem.org)
Neither pre-transplant clinical characteristics nor transplant characteristics are reliably predictive of GvHD outcomes. (cryostem.org)
These outcomes are expected to have a major impact, because the panels of biomarkers are likely to be applied in future GvHD therapeutic trials as surrogate marker for clinical response, and the biomarkers have potential as GvHD-specific therapeutic targets. (cryostem.org)
Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants . (medlineplus.gov)
The major risk with these procedures is the development of GVHD and several precautions have been put in place to avoid this unfavorable clinical event, such as the infusion of CD3 depleted high pure NK cells or the selection of HLA matched donors [ 8 ]. (biomedcentral.com)
Important insights into NK cell function in cancer eradication originated from the knowledge gained from mismatched NK cells in allo-SCT setting, where these innate immune effectors mediate a remarkable graft-versus-leukemia (GvL) effect towards tumor cells of recipient without attacking their normal tissues, thus limiting the onset of GVHD. (biomedcentral.com)
Moreover, it has been demonstrated HLA-mismatched NK cells in haploidentical allo-SCT improve the overall survival of patients affected by acute myeloid leukemia by controlling tumor relapse without causing GVHD. (biomedcentral.com)
Donor immunity emerging post-transplant plays a pivotal role in the protection against pathogens, such as Aspergillus, CMV and EBV, as well as in the development of graft-versus-host disease (GVHD) and graft-versus-leukemia effect. (ulisboa.pt)
We are particularly interested in developing strategies that may be translated into the clinical setting, such as the use of pathogen-specific T cells, donor regulatory T cells for GVHD and disease-specific T cells, with the aim of improving patient survival. (ulisboa.pt)
Chronic GVHD affects one or more organ systems, and it can continue over a long period of time. (imbruvica.com)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous. (bvsalud.org)
GVHD disease is the most common consequence of allogeneic BMT and the skin is the most commonly affected organ [5, 13]. (bvsalud.org)

Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). (wikipedia.org)
Graft-versus-host disease Hematopoietic stem cell transplantation Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R (January 2013). (wikipedia.org)
This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. (sagepub.com)
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. (sagepub.com)
Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
One of our major goals is to optimize stem cell transplantation - both in making the process of donating stem cells faster and more efficient and in finding ways to control the potentially damaging side effects of the transplant," DiPersio said. (wustl.edu)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Hematopoietic stem cell transplantation (HSCT) is an effective therapy for acute leukemia (AL). (bvsalud.org)
Ideally, the donor's lymphocytes, received during the transplantation will destroy any remaining leukemia cells. (uni-mainz.de)
Allogeneic hematopoietic stem cell transplantation is currently the only available treatment that offers patients a realistic chance of recovery from chemotherapy-resistant leukemias. (uni-mainz.de)
When a donor's lymphocytes are transferred during stem cell transplantation, this is often accompanied by a so-called graft versus leukemia (GvL) effect. (uni-mainz.de)
Moreover, according to Urban, the trail-blazing efforts of the Clinical Research Unit 183 are also relevant to other fields of transplantation and tumor immunology. (uni-mainz.de)
This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. (biomedcentral.com)
SEATTLE - Feb. 27, 2013 - In a significant advance for harnessing the immune system to treat leukemias, researchers at Fred Hutchinson Cancer Research Center for the first time have successfully infused large numbers of donor T-cells specific for a key anti-leukemic antigen to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. (fredhutch.org)
Researchers undertook the clinical trial because relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation for patients with high-risk leukemias. (fredhutch.org)
Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response and the development of a graft versus leukemia effect. (emory.edu)
The platform technology used in this study can be applied to include additional populations of cells that may further improve survival and decrease complications for patients with leukemia and MDS undergoing allogeneic stem cell transplantation," he says. (emory.edu)
While the graft-versus-tumor effect provided by the donor graft can be very powerful in controlling the disease, disease relapse is still the primary reason that patients do not do well after an allogeneic transplantation. (stanford.edu)
While allogeneic transplantation can be life saving for patients with hematologic malignancies, or inherited disorders such as several forms of immuno-deficiency, the transplant-related side effects and complications remain the biggest hurdles. (stanford.edu)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
He contributed to the establishment of graft-engineering techniques to introduce new concepts in haploidentical transplantation, and pioneered the T-cell receptor alpha/beta depletion technology in allogeneic transplantation. (globalleukemiaacademy.com)
Among the different approaches of anti-tumor adoptive cell transfer, allogeneic stem cell transplantation (allo-SCT) represents the first and most consolidated form of immunotherapy on the basis of its graft versus tumor (GvT) effect. (biomedcentral.com)
2015/2021 Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes. (ulisboa.pt)
Graft versus host disease is a common complication after receiving a donor stem-cell or bone marrow transplantation. (imbruvica.com)
Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Houston Methodist, and Texas Children s Hospital have found that a single dose of an otherwise harmless drug can safely control the severe and often lethal side effects associated with haploidentical stem cell transplantation. (regenerativemedicine.net)
Due to the immune-compromising nature of haploidentical stem cell transplantation, where the stem cells are only half matched, patients are at an increased risk of viral infection and of a lethal complication called graft versus host disease, when the graft cells, which have immune potential, attack the tissues of the person whose original immune system has been eliminated as part of treatment. (regenerativemedicine.net)
In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain. (lu.se)

Early T-cell expansion post T-replete mismatched cord transplant with granulocytes is associated with induction of remission and sustenance in relapsed-refractory high risk acute myeloid leukemia. (ebmt.org)
T-replete mismatched cord blood transplant (TRCB) offers an augmented graft versus leukemia (GVL) effect mediated by alloreactive donor T cells and thereby presents a potential for long term remission and cure in high risk and relapsed refractory AML in children. (ebmt.org)
Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
Along with chemotherapy, the standard of care for leukemia is a stem cell transplant, commonly referred to as a bone marrow transplant. (wustl.edu)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
In the last decade, multiple novel cellular therapies have been developed to enhance graft-versus-leukemia (GVL) effects, and these advances have the potential to change the standard of care in preventing or treating post-transplant relapse. (bethematchclinical.org)
Currently, there is little information about the effects of MRD on transplant outcomes in haplo-SCT settings. (biomedcentral.com)
There may be differences in the anti-leukemia effects of haplo-SCT vs. MSDT [ 21 ], so this study investigated both the asso ciation of MRD status with outcomes in haplo-SCT and MDST settings and also possible differences in the transplant outcomes of patients with positive pre-MRD (as determined by MFC) who underwent haplo-SCT versus MDST. (biomedcentral.com)
Principal investigator Edmund K. Waller, MD, PhD, FACP, says the net result of giving the patient a precise number of donor T cells with specific functions "leads to better elimination of cancer with less graft versus host disease and less toxicity from the transplant. (emory.edu)
To create the precision-engineered donor graft, Waller explains that different cellular subsets in the graft are selectively purified and then infused into the transplant recipient in a timed fashion. (emory.edu)
We are a nationally recognized center of excellence, fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a proud member of the Blood and Marrow Transplant Clinical Trials Network of the National Cancer Institute. (stanford.edu)
While the role for the individual cell population of the donor graft is not fully understood after allogeneic transplant, recent works in the field have yielded some interesting observations which may lead to advances in clinical care. (stanford.edu)
A woman with human immunodeficiency virus (HIV) who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months, despite cessation of antiretroviral therapy, according to research presented at the Conference on Retroviruses and. (ascopost.com)

He was one of the first to introduce immunotherapy with bispecific antibodies in children with relapsed/refractory acute lymphoblastic leukemia (R/R ALL), and is also involved in clinical trials using anti-CD19 and anti-CD19/22 chimeric antigen receptors in pediatric R/R ALL. (globalleukemiaacademy.com)

The clinical use of this agent in prevention and treatment of graft-versus-host disease will be examined. (johnshopkins.edu)
High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
Its axatilimab, is a monoclonal antibody that blocks the colony stimulating factor 1 (CSF-1) receptor in chronic graft-versus-host disease (cGVHD), as well as idiopathic pulmonary fibrosis (IPF). (tdameritrade.com)
All four survived after T-cell therapy without relapse for more than 30 months without suffering graft-vs.-host-disease and required no additional anti-leukemic treatment, according to the study. (fredhutch.org)
This talk will survey the use of mass cytometry for systems level characterization of cells in healthy human tissues, including blood, bone marrow, and tonsillar tissue, as well as diseases including melanoma, glioblastoma, lymphoma, leukemia, bone marrow failure and myelodysplastic syndromes, and graft vs. host disease. (uib.no)
Graft versus host disease can cause severe damage to the skin, liver, intestines and lungs," Waller says. (emory.edu)
Graft-versus-host disease and graft-versus-leukemia responses. (medlineplus.gov)
When you have been diagnosed with chronic graft versus host disease (cGVHD), it's normal to feel overwhelmed emotionally and physically. (imbruvica.com)
National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report. (imbruvica.com)
Pathogenesis and management of graft versus host disease. (imbruvica.com)
This is an important advance for patients who develop a life threatening complication called graft versus host disease, said Dr. Xiaoou Zhou. (regenerativemedicine.net)
Investigators have now shown how a molecular switch (inducible caspase 9 or iC9) that is activated by a single dose of a bio-inert chemical is able to clear all symptoms of graft versus host disease without jeopardizing the ability of the infused graft to fight infection. (regenerativemedicine.net)
We have also shown that the switch can turn off the T-cells that reproduce out of control, attacking the patient as graft versus host disease. (regenerativemedicine.net)
This switch allows us to eliminate the donor cells that cause graft versus host disease but leave behind the component that fights viral infection, said Dr. Malcolm Brenner, professor in the Center and a corresponding author on the report. (regenerativemedicine.net)
Four patients who received the T-cell therapy developed graft versus host disease, and treatment with the chemical resolved symptoms within 6 to 48 hours. (regenerativemedicine.net)
Even after the problematic T cells were killed, the remaining T cells were able do their job without causing further graft versus host disease. (regenerativemedicine.net)
In the current study, one patient also developed a potentially life-threatening graft versus host disease-associated cytokine release syndrome, which was rapidly resolved with the administration of one dose of the chemical drug. (regenerativemedicine.net)
Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
Chronic graft-vs-host disease (cGVHD) is the most common complication following allogeneic BMT [10]. (bvsalud.org)
Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)

Apparently, their efficacy in clinical trials has been insufficient for further development ( 4 ). (aacrjournals.org)
This is the first time patients have received an infusion of WT1 specific T-cells, and thus also the first demonstration that such cells can provide a therapeutic anti-leukemic effect, as has been suggested from earlier vaccine trials that induce less potent responses," said Philip Greenberg, M.D. , corresponding author and head of the Immunology Program at Fred Hutch. (fredhutch.org)
More effective preparative chemoradiotherapy and exploitation of the apparent graft-v-leukemia effect may be useful in future trials. (umn.edu)
Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
Prof Locatelli is also involved in the development and validation of gene therapy approaches in patients with thalassemia and sickle cell disease and he has extensive experience in running phase I/II clinical trials. (globalleukemiaacademy.com)
Second, we will determine the threshold of the different biomarkers that will provide the best sensitivity for future use in clinical trials. (cryostem.org)
This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel drugs into the pipeline of clinical trials that target pathogenetic mechanisms of the disease. (ashpublications.org)
Joshua Brody, MD, Director of the CLL/Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai, New York, who was not involved in these trials, commented: "CLL is an extremely prevalent disease affecting nearly 200,000 patients in the United States. (ascopost.com)

All developed clinical cGVHD, with median interval from allo-SCT to LTx of 8.2 (0.7-16) years. (nih.gov)
But in cGVHD, the donor cells (graft) see your body as the threat, so they begin to attack and they recruit your immune system to help in the fight. (imbruvica.com)

This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer. (wikipedia.org)
Chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes (see the image below). (medscape.com)
WT1 is expressed 10 to 1,000 times higher in leukemic cells compared to normal CD34 blood stem cells, and the magnitude of expression correlates with the aggressiveness of acute myeloid leukemia, acute lymphoid leukemia and myelodysplastic syndromes. (fredhutch.org)
The 2016 World Health Organization (WHO) classification of lymphoid neoplasms incorporates genetic data, clinical features, cell morphology, and immunophenotype, all of which have important implications for disease prognosis and management. (msdmanuals.com)

Here we describe the clinical characteristics and outcomes of AL relapse after HSCT in our study population and analyze the impacts of different types of relapse on survival outcomes. (bvsalud.org)
The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
15 ] reported that peri-SCT MRD dynamics, as determined by MFC, are associated with a high risk of leukemia relapse and poor outcomes. (biomedcentral.com)
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
However, disease recurrence remains a major clinical challenge and identification of high-risk patients prior to HSCT is crucial to improve outcomes. (oncotarget.com)
With a proven track record of success, we transform the world's growing scientific and clinical knowledge into better patient outcomes. (globalleukemiaacademy.com)
In the phase II SWOG 1318 trial reported in the Journal of Clinical Oncology, Advani et al found that blinatumomab induction and consolidation followed by maintenance with POMP (prednisone, vincristine, mercaptopurine, and methotrexate) produced good outcomes in patients aged ≥ 65 years with newly. (ascopost.com)
In a study reported in the Journal of Clinical Oncology, Elsayed et al developed a risk score based on single nucleotide polymorphisms (SNPs) associated with cytarabine pharmacodynamics or clinical outcomes that identified pediatric patients with acute myeloid leukemia (AML) who could benefit from. (ascopost.com)
In prior monkeypox outbreaks in Nigeria, co-infection with HIV was associated with worse clinical outcomes, including severe manifestations of monkeypox, hospitalization, and death.2 Providers should also consider othe r immunocompromising conditions * and medications that may increase risk of severe manifestation of monkeypox. (cdc.gov)
In prior monkeypox outbreaks in Nigeria, co-infection with HIV was associated with worse clinical outcomes, including severe manifestations of monkeypox, hospitalization, and death. (cdc.gov)
Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)

Some MDS patients have a deletion in the long arm of chromosome 5, which is associated with acute myeloid leukemia (AML). (healthline.com)

In the allogeneic stem cell technique, what happens is that the leukemia patient's own hematopoietic cells are first destroyed by chemotherapy and radiation therapy. (uni-mainz.de)
This suggests that lymphocytes present in engrafted donor stem cells can cause a concurrent therapeutic graft-vs.-tumor effect. (fredhutch.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)

Stanford Medicine's Lori Muffly, MD and Matthew Frank, MD, PhD from Stanford Medicine in Stanford, CA, were recently featured on The Bloodline with LLS, the podcast by The Leukemia & Lymphoma Society (LLS) for patients and caregivers. (stanford.edu)
Leukemia & Lymphoma Society. (imbruvica.com)

V. Cellular and molecular assessment of TMLI effect on bone marrow environment and TMLI effect on the engraftment and disease relapse. (survivornet.com)

John F. DiPersio, MD, PhD , of Washington University School of Medicine in St. Louis , has received a $6 million outstanding investigator award from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to support research aimed at improving therapies for leukemia. (wustl.edu)
The latest research in cellular therapies, antibody-based treatments, and tyrosine kinase inhibitor (TKI)-based approaches to enhance GVL effects are outlined in articles published in a special edition of Blood . (bethematchclinical.org)
Syndax Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company that is focused on developing a pipeline of cancer therapies. (tdameritrade.com)
The Precision-T study is funded by Orca Bio, a clinical-stage biotechnology company developing purified, high-precision cell therapies for the treatment of cancer, autoimmune diseases and genetic blood disorders. (emory.edu)
His research focuses on developing molecularly targeted therapies for high-risk childhood leukemias. (globalleukemiaacademy.com)

Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. (umn.edu)

Drs. Rupert Handgretinger and Karin Schilbach review the clinical strategies to exploit the full function of these lymphocytes, such as the ex vivo expansion and manipulation of either patient-derived or donor-derived gamma delta T cells and their subsets. (bethematchclinical.org)

This review will cover the basic pharmacology and immunological effects of pentostatin. (johnshopkins.edu)
providing evidence for an immunological graft-versus-leukemia effect (GvL). (frontiersin.org)

Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
After earning his medical degree from the Medical University of South Carolina in Charleston, Dr Brown was an intern and resident in pediatrics at Johns Hopkins, and subsequently completed a joint clinical fellowship with Johns Hopkins and the National Cancer Institute in pediatric hematology/oncology. (globalleukemiaacademy.com)
A 27-year-old female was admitted, in a Hematology Center, in 1997, with previous diagnosis of chronic myeloid leukemia since 1994. (bvsalud.org)

Our work provides a synthesis of previous algorithms, mechanistically based on HLA-DPB1 immunopeptidome divergence 5 and expression by residual leukemia cells, 6 , 7 respectively, into a new and integrative model for intelligent mismatching in UD-HCT, to improve survival for future patients. (haematologica.org)
When used at high doses in doseranging studies in patients with acute leukemia , FLUDARA (fludarabine) FOR INJECTION was associated with severe neurologic effects, including blindness, coma, and death. (rxlist.com)
Similar severe central nervous system toxicity, including coma, seizures, agitation and confusion, has been reported in patients treated at doses in the range of the dose recommended for chronic lymphocytic leukemia. (rxlist.com)
If we can control and prevent these side effects, it could have a significant impact on patients. (wustl.edu)
Patients with mpox benefit from supportive care and pain control that is implemented early in the illness ( Clinical Considerations for Pain Management of Mpox ). (cdc.gov)
The results indicated that, for pre-MRD-positive AML patients, haplo-SCT was associated with lower incidence of relapse and better survival, suggesting a stronger anti-leukemia effect. (biomedcentral.com)
Our earlier work indicated that patients with refractory/relapsed leukemia who received haplo-SCT experienced a significantly lower cumulative incidence of relapse compared to those who underwent MSDT (26% vs. 49%, P = 0.008) [ 21 ]. (biomedcentral.com)
Reporting results of a pilot clinical trial in the Feb. 27 issue of the journal Science Translational Medicine , researchers describe the use of T-cells that were taken from a donor, programmed in the lab to recognize the Wilm's Tumor Antigen 1 (WT1) and kill leukemia cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. (fredhutch.org)
Winship is one of several clinical trial sites for the Precision-T study evaluating the safety and efficacy of Orca-T, a cell therapy that combines purified cells from a matched donor, in patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and high-risk myelodysplastic sydromes (MDS). (emory.edu)
Two patients died, one due to septicemia, the other of relapsing leukemia, after 2 and 14 months, respectively. (nih.gov)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
In the early 80s' donor lymphocyte infusions (DLI) with allo-activated haplo-identical cells from family members were infused in patients affected by hematological diseases or solid tumors. (biomedcentral.com)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
In patients with newly diagnosed acute myeloid leukemia (AML) with an IDH1 mutation who were ineligible for intensive chemotherapy, the addition of the IDH1 inhibitor ivosidenib to azacitidine significantly improved survival vs azacitidine alone, according to data presented at the 2021 American. (ascopost.com)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)

Removing all T-cells increases the risk of graft rejection, relapse, and viral infection. (regenerativemedicine.net)

Individuals affected with acquired aplastic anemia are also at risk that it will evolve into another similar disorder known as myelodysplasia. (rarediseases.org)
Clinical and laboratory observations suggest that acquired aplastic anemia is an autoimmune disease. (medscape.com)

Cell separation technologies play a vital role in the graft engineering of hematopoietic cellular fractions, particularly with the rapid expansion of the field of cellular therapeutics. (atlantis-press.com)

Dr Patrick Brown is associate professor of oncology and pediatrics and director of the Pediatric Leukemia Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine in Baltimore, MD. (globalleukemiaacademy.com)
Dr Brown is the vice chair for relapse and an executive steering committee member of the ALL Committee in the Children's Oncology Group, and chairs the National Comprehensive Cancer Network's Clinical Guidelines Panels for adult and pediatric ALL. (globalleukemiaacademy.com)

Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease. (aacrjournals.org)
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)

9] However, oral lesions identified following the diagnosis and control of Crohn disease may not always reflect recurring intestinal disease, but rather treatment adverse effects. (medscape.com)
INTRODUCTION: The diagnosis of vitiligo is mainly based on clinical findings. (bvsalud.org)
The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)
Symptoms and signs of acute lymphoblastic leukemia may be present for only days to weeks before diagnosis. (msdmanuals.com)

ALL accounts for about 20% of adult acute leukemias. (msdmanuals.com)

The state of the art in single cell tumor immunology will be discussed, including tissue collection, technical and biological quality controls, analysis of cell signaling (phospho-flow), computational analysis, and integration of different experimental and clinical data types 3 . (uib.no)

The lymphocytes produced by the donor's immune system then recognize and destroy the leukemia cells still present in the patient's body. (uni-mainz.de)
This approach holds great promise for dissecting cellular microenvironments, monitoring how treatments affect tissues, revealing cellular biomarkers and effector mechanisms, and creating new treatments that productively engage the immune system to fight cancer and other diseases. (uib.no)
The clinical study is the center s most recent quest to pioneer the safety and efficacy of T cell therapy, which harnesses the immune system and specially modified T cells to attack and destroy cancers of the immune system such as leukemia and lymphoma, as well as restore immunity in serious immunodeficiency disorders. (regenerativemedicine.net)

For some forms of hematopoietic malignancies, for example acute myeloid leukemia (AML), the essential cells during HSCT are, beside the donor's T cells, the NK cells, which interact with KIR receptors. (wikipedia.org)

Journal of Clinical Oncology , 5 (9), 1348-1355. (umn.edu)

See Chronic Leukemias: 4 Cancers to Differentiate, a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

GvL requires genetic disparity because the effect is dependent on the alloimmunity principle. (wikipedia.org)
The prognostic impact was also observed independently of other known clinical, genetic, and molecular prognosticators. (oncotarget.com)
The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
Scientists at St. Jude Children's Research Hospital are studying the impact of genetic ancestry on childhood acute lymphoblastic leukemia (ALL). (ascopost.com)
acute lymphoblastic leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)

These clinical cell biology insights have paralleled advances in single cell technology and sparked intense study of the cellular mechanisms driving therapy response and resistance 1 . (uib.no)

A March 3, 2023, MMWR provides updated clinical treatment considerations about using therapeutics to treat severe mpox cases, including ocular infections, neurologic complications, myopericarditis, complications associated with mucosal lesions, and complications from uncontrolled viral spread. (cdc.gov)
Cancer Care provides free, professional support services for people affected by myeloproliferative neoplasms, as well as treatment information and financial help with cancer-related costs and treatment co-pays. (cancercare.org)
It is focused on developing revumenib, a potent, selective, small molecule inhibitor of the menin-MLL binding interaction for the treatment of KMT2A rearranged, also known as mixed lineage leukemia rearranged (MLLr), acute leukemias including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), and nucleophosmin 1 (NPM1) mutant AML. (tdameritrade.com)
The Chief Scientific Director of the Mainz University Medical Center, Professor Reinhard Urban, is convinced that the team led by Professor Wolfgang Herr will be able to achieve significant progress in the field of leukemia treatment: 'I share the view of the German Research Foundation that it will be readily possible to apply the highly relevant research results to clinical practice. (uni-mainz.de)
Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
Basal-like triple-negative breast cancer (TNBC) makes up 12-20% among other histological types, displaying a number of clinicopathological and molecular features that affect treatment strategy. (cttjournal.com)
Indeed, adoptive cell transfer of allogeneic NK cells have been used for the treatment of leukemia, colorectal cancer, hepatocellular cancer, lymphoma and melanoma. (biomedcentral.com)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Brain Tumor Imaging and Treatment Effects. (lu.se)
1981. In vivo metabolism and excretion of propoxur and malathion in the rat: Effect of lead treatment. (cdc.gov)

CDC published "Interim Clinical Considerations for Severe Manifestations of Mpox" in MMWR to provide guidance for these cases. (cdc.gov)
4) There are diagnostic and clinical management strategies that may help address severe manifestations of monkeypox. (cdc.gov)
During the current outbreak, CDC has received reports of people with monkeypox who have severe manifestations of disease, including but not limited to · Atypical or persistent rash with coalescing or necrotic lesions, or both, some which have required extensive surgical debridement or amputation of an affected extremity. (cdc.gov)

When Robin was first diagnosed with acute myeloid leukemia in December 2011, she knew that it would be a long journey for her fight against this cancer. (stanford.edu)

Currently, he coordinates the national protocols for children with newly diagnosed acute myeloid leukemia and relapsed acute lymphoblastic leukemia. (globalleukemiaacademy.com)

Organisms2

Diseases11

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes4

Information Science1

GvHD39

Transplantation47

Transplant14

Relapsed-refractory1

Host disease20

Trials8

CGVHD2

Lymphoid4

Outcomes11

Associated with acute1

Stem3

Lymphoma Society2

Disease relapse1

Therapies5

Relapse-free survival1

Rupert Handgretinger1

Immunological2

Hematology3

Patients18

Rejection1

Aplastic anemia2

Hematopoietic cellular1

Pediatric2

Therapeutic2

Diagnosis4

Adult1

Immunology1

Immune system3

Malignancies1

Journal of Clini1

Cancers1

Genetic5

Cellular1

Treatment10

Severe3

Diagnosed with acute myeloid1

Newly diagnosed acute myeloid1