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  • donor
  • HCT is an immunotherapy procedure during which a healthy donor provides hematopoietic cells including stem and progenitor cells to a diseased host. (frontiersin.org)
  • For these types of grafts, extraction of the part of the periosteum and accompanying blood vessels along with donor bone is required. (wikipedia.org)
  • patients
  • A recently-completed internal review of the Crohn's Disease program reinforced Mesoblast's intention to complete the ongoing Phase 3 trial in adult patients with Crohn's Disease refractory to treatment with steroids, classic immunosuppressives and biologic therapy. (cnbc.com)
  • The Company expects to have a readout by the end of the year on whether the primary endpoint of day 28 remission in biologic-refractory patients has been achieved, whether there is evidence of efficacy in high-risk groups such as those with fistulizing disease, and whether repeat dosing can result in longer-term maintenance of effect. (cnbc.com)
  • Patients with moderate to severe Crohn's Disease Activity Index (CDAI) of at least 220, who had previously failed treatment with steroids and other immunosuppressive agents, were given two infusions of Prochymal® seven days apart. (cnbc.com)
  • Patients entering this study had suffered from Crohn's Disease for an average of 14.2 years, and 80% of the patients required prior surgical intervention to treat their Crohn's disease. (cnbc.com)
  • MaaT Pharma has created a new generation of drugs using Fecal Microbiota Transfer (FMT) which rebuilds and restores the entire gut ecosystem of patients with life-threatening diseases. (maatpharma.com)
  • With its breakthrough proprietary platforms (GMP Fecal Microbiome Transfer platform and gΛt Print, its proprietary data science platform), MaaT Pharma is creating FMT-based products and solutions for patients suffering from severe diseases. (maatpharma.com)
  • In this phase I/II two-arm clinical trial, 50 patients with myeloma received autografts after high-dose melphalan followed by infusions of ex-T at day +2 after transplant. (aacrjournals.org)
  • rs9277534 was genotyped in 3,505 patients to define rs9277534-DPB1 haplotypes, and clinical outcomes were assessed in 2,029 recipients of transplants from unrelated donors who had acute leukemia, chronic myeloid leukemia, or the myelodysplastic syndrome between 1988 and 2008. (ashclinicalnews.org)
  • In 2006, Osiris Therapeutics announced positive results from a pilot Phase 1/2 study.using Prochymal® for the treatment of patients with moderate to severe Crohn's disease who had failed to respond to standard treatments such as steroids and infliximab (Remicade(R)). The trial was a prospective, randomized, open label trial, conducted at 4 leading centers in the United States. (orphan-drugs.org)
  • Ukonu AB, Augustine U. The prevalence of hepatitis C Virus (HCV) among lichen planus patients and its clinical pattern at the University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. (springer.com)
  • Guo Mei brings her passion and knowledge for treating blood disease with microtransplantation in 307th Hospital, and with an equally dedicated medical and support team, works hard every day to improve the quality of lives of the patients. (wikipedia.org)
  • The RDCRN Contact Registry aims to provide up-to-date information for patients and assist in connecting patients with advocacy groups, expert doctors, and clinical research opportunities. (wikipedia.org)
  • Thymoma-associated multiorgan autoimmunity (TAMA) is a severe often fatal disease that presents in some patients with thymoma. (wikipedia.org)
  • Patients often have a refractory disease course but some patients may respond to phototherapy. (wikipedia.org)
  • As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell cytology, cell growth in vitro and enzymatic markers. (wikipedia.org)
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector-memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. (wikipedia.org)
  • Kv1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral insulin sensitivity in patients with type-2 diabetes mellitus, and for preventing bone resorption in periodontal disease. (wikipedia.org)
  • treatment
  • We review here the results of these studies and discuss some challenges of this treatment modality in this disease setting. (hindawi.com)
  • Addressing currently unmet clinical needs, MaaT Pharma's revolutionary and rapid approach plays a considerable part in the evolution of treatment therapies. (maatpharma.com)
  • Graft-vs-Host Disease: Immunology, Pathophysiology, and Treatment. (jamanetwork.com)
  • On June 29, 2011, Mesoblast announced that it received clearance from the Food and Drug Administration to begin a Phase 2 trial with its MPC cells for treatment of disc degenerative disease. (wikipedia.org)
  • Many groups are developing Kv1.3 blockers for the treatment of autoimmune diseases. (wikipedia.org)
  • posttransplant
  • Some but not all retrospective studies suggest that more rapid lymphocyte recovery during the early posttransplant period may be associated with better clinical outcomes for myeloma and other hematologic neoplasms ( 9 - 11 ). (aacrjournals.org)
  • patient's
  • Bone grafts may be autologous (bone harvested from the patient's own body, often from the iliac crest), allograft (cadaveric bone usually obtained from a bone bank), or synthetic (often made of hydroxyapatite or other naturally occurring and biocompatible substances) with similar mechanical properties to bone. (wikipedia.org)
  • When a block graft will be performed, autogenous bone is the most preferred because there is less risk of the graft rejection because the graft originated from the patient's own body. (wikipedia.org)
  • monoclonal
  • Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell, with transfer of their coding sequence facilitated by retroviral vectors. (wikipedia.org)
  • Therapy
  • Founded at the end of 2014, MaaT Pharma (Microbiota as a Therapy) is a clinical-stage biotech company revolutionizing and shaping a new approach to therapies in order to treat serious diseases linked to gut microbiota imbalances. (maatpharma.com)
  • cells
  • An immuno-competent graft is administered, with viable and functional immune cells. (wikipedia.org)
  • MHC multimers may also be used to eliminate harmful or unwanted T-cells in vivo, such as those that target self cells and lead to autoimmune disease. (wikipedia.org)
  • The principles involved in successful bone grafts include osteoconduction (guiding the reparative growth of the natural bone), osteoinduction (encouraging undifferentiated cells to become active osteoblasts), and osteogenesis (living bone cells in the graft material contribute to bone remodeling). (wikipedia.org)
  • Phase
  • Lyon-France, March 5th, 2018 - MaaT Pharma, a clinical-stage biopharmaceutical company, received authorization from competent authorities to launch its phase II prospective multicenter clinical trial in France. (maatpharma.com)
  • It is currently undergoing a Phase III clinical trial to determine efficacy and clinical usefulness. (wikipedia.org)
  • Benign
  • Morgan M, Stevens G, Switlyk S. Benign lichenoid keratosis: a clinical and pathologic reappraisal of 1040 cases. (springer.com)
  • occurs
  • Osteoconduction occurs when the bone graft material serves as a scaffold for new bone growth that is perpetuated by the native bone. (wikipedia.org)
  • Osteogenesis occurs when vital osteoblasts originating from the bone graft material contribute to new bone growth along with bone growth generated via the other two mechanisms. (wikipedia.org)
  • Orthopedic
  • Doctors that do bone graft procedures are commonly orthopedic surgeons, otolaryngology head and neck surgeon, neurosurgeons, craniofacial surgeons, oral and maxillofacial surgeons, podiatric surgeons and periodontists, dental surgeons, oral surgeons and implantologists. (wikipedia.org)