• We report on the clinical outcomes of a large cohort treated with ketamine as part of clinical practice. (psychiatrist.com)
  • The Comparative Effectiveness Research Translation Network (CERTAIN) is a learning healthcare system in Washington State focused on patient-centered outcomes research (PCOR) and comparative effectiveness research (CER), leveraging existing healthcare data for research and healthcare improvement, incorporating patient and other healthcare stakeholder voices into research, and facilitating dissemination and implementation of research evidence into clinical practice. (wikipedia.org)
  • CERTAIN emerged from experience creating the Surgical Care and Outcomes Assessment Program (SCOAP), a clinician-led, performance benchmarking and quality improvement (QI) registry for surgical and interventional procedures CERTAIN serves as a partner for research and development to SCOAP, utilizing SCOAP's QI registry to answer CER questions and develop quality improvement programs. (wikipedia.org)
  • Standardized care that reduces clinical variation-defined here as the over-, under-, or unnecessary utilization of healthcare services and resources-has been shown to improve quality and outcomes in the ambulatory, acute, and post-acute settings. (hfma.org)
  • Patients and their caregivers rely on the healthcare system to provide the "standard of care" with reliable outcomes at reasonable costs. (hfma.org)
  • Standardized care may not always lead to desired outcomes or completely avoid complications. (hfma.org)
  • However, given the increasingly rapid and analytically complex decision-making needs of both the pharmaceutical industry and the field of health economics and outcomes research (HEOR), the demands of cost-effectiveness analyses may be better met by the programming language R. (springer.com)
  • and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes. (nih.gov)
  • AHRQ invites applications to develop a prospective clinical registry of orthopedic devices, drugs, and procedures through a practice-based research collaborative and clinical and outcomes data resource (P50 grant mechanism). (nih.gov)
  • The data collection efforts funded by this FOA should be ideally designed in a way to take advantage of and advance in scientific, technical, and operational terms existing local clinical and patient outcomes data collection effort and/or registries. (nih.gov)
  • The newly developed registry will also provide the infrastructure to conduct multi-center collaborative clinical studies to address effectiveness and patient outcomes questions as well as emerging public health issues related to orthopedic procedures and devices. (nih.gov)
  • The primary effectiveness outcome is a composite index of unfavourable end-of-treatment outcomes (lost to follow-up, death or treatment failure) or treatment recurrence within 6 months of end-of-treatment. (lu.se)
  • For the cost-effectiveness analysis, end-of-treatment outcomes will be used to estimate disability-adjusted life years (DALYs) averted. (lu.se)
  • We will conduct a societal cost-effectiveness analysis using Bayesian hierarchical models that account for the individual-level correlation between costs and outcomes as well as intra-cluster correlation. (lu.se)
  • Findings are reported for clinical and functional outcomes, and harms. (ahrq.gov)
  • The Patient-Centered Outcomes Research Institute aims to compare the effectiveness of different treatment options to allow physicians to choose the most beneficial and effective care for their patients [4]. (ama-assn.org)
  • Research: Self-management of chronic conditions, health system interventions to improve outcomes for adult patients with chronic conditions, care transitions, medication safety and management. (sc.edu)
  • The authors suggested that a translational research collaboration can be built onto well characterized populations with already available sequence data (in a biobank/research environment), risk factor information, intervention information, and clinical outcomes. (cdc.gov)
  • In addition to observational studies, randomized clinical trials can be designed to assess individual, family, system and population outcomes based on returning versus not returning the results of selected genes/variants for specific clinical scenarios, depending on existing level of evidence. (cdc.gov)
  • COVID-19 vaccination provides protection against serious illness and outcomes associated with COVID-19, including emergency department or urgent care visits, hospitalizations, and death. (cdc.gov)
  • The Pfizer/BioNTech vaccine has shown an efficacy of 95% in preventing COVID-19 in randomized clinical trials ( 5 ). (cdc.gov)
  • design of a randomized clinical trial. (cdc.gov)
  • For vaccinated persons with no previous infection, vaccine effectiveness was 81.8% (95% CI 81.0%-82.7%), and 11.6 (95% CI 11.3-11.9) cases were prevented per 10,000 vaccinated/day. (cdc.gov)
  • Our results confirm vaccine effectiveness in this population and suggest indirect protection in nonvaccinated persons. (cdc.gov)
  • Therefore, interest in estimating vaccine effectiveness (VE) in this population after widespread vaccination is great. (cdc.gov)
  • The early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP provided an opportunity to examine vaccine effectiveness in a real-world setting. (cdc.gov)
  • The first U.S. multisite test-negative design vaccine effectiveness study among HCP found a single dose of Pfizer-BioNTech or Moderna COVID-19 vaccines to be 82% effective against symptomatic COVID-19 and 2 doses to be 94% effective. (cdc.gov)
  • A test-negative case-control study is underway to evaluate mRNA COVID-19 vaccine effectiveness (VE) against symptomatic illness among HCP at 33 U.S. sites across 25 U.S. states. (cdc.gov)
  • We included comparisons of treatment effectiveness in subgroups of patients with OME, and whether outcome differences were related to factors affecting health care delivery or the receipt of pneumococcal vaccine inoculation. (ahrq.gov)
  • mRNA COVID-19 vaccine effectiveness (VE) against emergency department or urgent care (ED/UC) encounters was evaluated within the VISION Network during July 4, 2022-June 17, 2023, among children with COVID-19-like illness aged 6 months-5 years. (medscape.com)
  • Effectiveness of ≥1 bivalent dose, comparing children with at least a complete primary series and ≥1 bivalent dose to unvaccinated children, irrespective of vaccine manufacturer, was 80% (95% CI = 42%-96%) among children aged 6 months-5 years a median of 58 days (IQR = 32-83 days) after the dose. (medscape.com)
  • [ 3-5 ] Because efficacy data were limited, postauthorization vaccine effectiveness (VE) data are necessary to understand how well the vaccines work and to help guide development of future vaccine policy for this age group. (medscape.com)
  • During this COCA Call, presenters will discuss updates on bivalent vaccines including the most recent vaccine effectiveness data, the Centers for Disease Control and Prevention's clinical guidance for bivalent vaccines, and strategies for communicating with patients about COVID-19 vaccination. (cdc.gov)
  • The intervention group will receive pessary self-management teaching, a self-management information leaflet, a follow up phone call and access to a local telephone number for clinical support. (stir.ac.uk)
  • Title : Effectiveness of Clinical Decision Support Based Intervention in the Improvement of Care for Adult Sickle Cell Disease Patients in Primary Care Personal Author(s) : Mainous, Arch G.;Carek, Peter J.;Lynch, Kim;Tanner, Rebecca J.;Hulihan, Mary M.;Baskin, Jacquelyn;Coates, Thomas D. (cdc.gov)
  • This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI). (centerwatch.com)
  • We applied cost-effectiveness analysis to identify optimal thresholds of predicted risk to target a low-cost community-based intervention in the USA. (springer.com)
  • The aim of this study was to apply the framework of cost-effectiveness analysis to identify optimal thresholds of predicted risk from noninvasive diabetes risk scores to target a low-cost community-based intervention. (springer.com)
  • We simulated the long-term cost-effectiveness of prevention intervention in high-risk individuals in the context of the US population. (springer.com)
  • This FOA supports pilot effectiveness research to evaluate the feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches and inform the design of definitive effectiveness trials. (nih.gov)
  • METHODS AND DESIGN: A total of 78 health facilities have been randomised (1:1:1) into one of two intervention arms or a standard-of-care arm. (lu.se)
  • The primary hypothesis is that stepped care interventions for older hazardous alcohol users reduce alcohol consumption compared with a minimal intervention at 12 months post randomisation. (biomedcentral.com)
  • Methods A 2-group effectiveness study was completed comparing patients who received the 'Ottawa Model' for Smoking Cessation intervention (n=726) to usual care controls (n=641). (bmj.com)
  • Potential harm caused by physicians' a-priori beliefs in the clinical effectiveness of hydroxychloroquine and its impact on clinical and economic outcome--a simulation approach. (ahrq.gov)
  • The main outcome measures were costs (in Euros), true-positive type 2 diabetic cases, incremental cost-effectiveness ratios (ICERs), third-party payers, and societal perspectives. (diabetesjournals.org)
  • What are the evidence-based guidelines regarding positioning of long term care immobile patients during rest time? (cadth.ca)
  • 2008), "Evidence-based Care for Midwives: 2nd edition: "Clinical Effectiveness Made Easy ", International Journal of Health Care Quality Assurance , Vol. 21 No. 4. (emerald.com)
  • Discussion The results of the trial will provide robust evidence of the effectiveness of pessary self-management compared to clinic based care in terms of improving women's quality of life, and of its cost-effectiveness. (stir.ac.uk)
  • While there is preliminary evidence suggesting chiropractic spinal manipulative therapy is beneficial for patients with BRLP, there is insufficient evidence currently available to assess the effectiveness of this care. (cdc.gov)
  • There is a strong evidence base for the effectiveness of brief psychosocial interventions in reducing alcohol consumption in populations identified opportunistically in primary care settings. (biomedcentral.com)
  • Advice on how to access the best available online sources of research evidence on clinical and cost effectiveness published in three recent issues of Effectiveness Matters is reviewed. (manchester.ac.uk)
  • Glanville, J , Wilson, P & Richardson, R 2003, ' Accessing the online evidence: A guide to key sources of research information on clinical and cost effectiveness ', Quality In Health Care , vol. 12, no. 3, pp. 229-231. (manchester.ac.uk)
  • Objectives We undertook a rapid systematic review with the aim of identifying evidence that could be used to answer the following research questions: (1) What is the clinical effectiveness of tests that detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to inform COVID-19 diagnosis? (bmj.com)
  • We systematically searched for all published evidence on the effectiveness of tests for the presence of SARS-CoV-2 virus, or antibodies to SARS-CoV-2, up to 4 May 2020, and assessed relevant studies for risks of bias using the QUADAS-2 framework. (bmj.com)
  • Conclusions Evidence is rapidly emerging on the effectiveness of tests for COVID-19 diagnosis and management, but important uncertainties about their effectiveness and most appropriate application remain. (bmj.com)
  • More evidence is needed about the effectiveness of testing outside of hospital settings and in mild or asymptomatic cases. (bmj.com)
  • Currently there is limited direct evidence of clinical utility of sequencing to guide clinical care and disease prevention at the population level. (cdc.gov)
  • In addition, direct-to-consumer genetic testing has been on the rise even with no or limited evidence of clinical validity and utility. (cdc.gov)
  • With this background, a group of authors from CDC, NIH institutes, health systems and academia just published in PLOS Medicine, a proposal for an evidence-based road map to accelerate the evaluation of clinical utility of genome sequencing and its appropriate implementation in health systems. (cdc.gov)
  • Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. (medlineplus.gov)
  • Proton pump inhibitors and the kidney: Implications of current evidence for clinical practice and when and how to deprescribe. (msdmanuals.com)
  • Patients' perception of types of errors in palliative care-results from a qualitative interview study. (ahrq.gov)
  • Changes in management-typically different surgical interventions or palliative care guidance-took place in 77 families as result of rWGS-guided diagnoses. (aacc.org)
  • Most patients in palliative care have problems with dry mouth caused by medication or as a direct result of their condition. (uib.no)
  • Clinical Microbiology and Infection, 23 (9). (lse.ac.uk)
  • Sulphonylureas, when added to metformin, were associated with the most favourable cost-effectiveness estimate, with an incremental cost of $12 757 per quality-adjusted life-year gained, relative to continued metformin monotherapy. (cmaj.ca)
  • 8 As part of a larger initiative to determine optimal prescribing of antihyperglycemic agents, we sought to determine the incremental cost-effectiveness of treatment with alternative second-line agents added to metformin in patients with type 2 diabetes no longer adequately controlled by metformin monotherapy. (cmaj.ca)
  • Incremental cost-effectiveness ratios (ICERs) were calculated for increasing risk score thresholds. (springer.com)
  • The applicant is also expected to develop the infrastructure including at least five Clinical Centers (CC) at institutions performing high volume of hip and knee replacements. (nih.gov)
  • Methods/Design: This study is a two-site, prospective, parallel group, observer-blinded randomized clinical trial (RCT). (cdc.gov)
  • Research: Prevention and recognition of child abuse and neglect, with a focus on child caregivers' protectiveness behaviors, pediatric assessment and developmental approach, clinical and didactic nursing education including critical thinking and technology-based methods. (sc.edu)
  • Such methods inform research and programs on the effectiveness of vaccination programs, whole-genome sequencing analysis, and cluster detection of infections and diseases. (cdc.gov)
  • No relevant literature was identified regarding the of resting in a reclined position chair versus laying in bed of long-term care immobile patients during rest time. (cadth.ca)
  • Extended-release opioid agonists and antagonist medications for addiction treatment (MAT) in patients with opioid use disorder: effectiveness and value. (springer.com)
  • Leveraging a natural experiment approach, the investigators will examine rapidly changing telemedicine and in-person models of care during and after the COVID-19 crisis to determine whether certain patients could safely choose to continue telemedicine or telemedicine-supplemented care, rather than return to in-person care. (mountsinai.org)
  • patients that are attributed to primary care clinics across four health systems in the INSIGHT (Mount Sinai Health System and Weill Cornell Medicine), OneFlorida (University of Florida Health), and STAR (University of North Carolina Health) CRNs. (mountsinai.org)
  • This work uses data provided by patients and collected by the NHS as part of their care and support #DataSavesLives. (medrxiv.org)
  • Effectiveness of Integrated Palliative and Oncology Care for Patients With Acute Myeloid Leukemia: A Randomized Clinical Trial. (massgeneral.org)
  • These systems have become increasingly important in the delivery of perioperative care for patients undergoing cardiac, thoracic, and vascular procedures. (nih.gov)
  • During Clinical Education, the student is supervised by College faculty and clinical staff while interacting with patients in the Radiology Department. (ccp.edu)
  • We will deliver the best clinical care to each of our patients in an individualized and personalized manner. (volunteermatch.org)
  • However, not all patients profit and it remains unclear how I-CBT is best embedded in the care of CFS patients. (jmir.org)
  • Exploratory comparisons were made between the stepped care conditions of invested therapist time and proportion of patients who continued with f2f CBT. (jmir.org)
  • These leading physicians offer their perspectives on the comparative effectiveness of different clinical approaches, developing technology, and new recommendations for care of patients. (medscape.com)
  • RIDTs may be used to help with diagnostic and treatment decisions for patients in clinical settings, such as whether to prescribe antiviral medications. (cdc.gov)
  • Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: cohort study. (msdmanuals.com)
  • Discrepancies between clinical diagnoses and autopsy findings in critically ill children: a prospective study. (ahrq.gov)
  • The findings of this explicit comparison are used to produce recommendations for when R might be more suitable than Excel in contemporary cost-effectiveness analyses. (springer.com)
  • This study suggests that changes are needed to enable more consistent translation of research findings into clinical practice. (npcnow.org)
  • The " Real-World Impact of Comparative Effectiveness Research Findings on Clinical Practice ," authored by researchers from Truven Health Analytics, the National Pharmaceutical Council, Harvard Medical School and the University of Michigan, suggests that changes are needed to enable more consistent translation of research findings into clinical practice. (npcnow.org)
  • Study authors evaluated real-world utilization trends before and after the publication of comparative effectiveness research (CER) findings and the release of relevant clinical practice guidelines (CPGs) from four high-profile CER case studies published within the last decade. (npcnow.org)
  • In clinical practice, while the use of MRI did increase prior to and after the result of findings and new guidelines, MRI utilization was far less than the utilization of ultrasound or mammography, which also increased or remained steady. (npcnow.org)
  • 4. Publish findings of clinical trial comparing effectiveness of N95 filtering facepiece respirators and surgical masks against influenza. (cdc.gov)
  • 1% worked in long-term care facilities and urgent care clinics. (cdc.gov)
  • Ms. Hollowell comes to clinic for both scheduled visits and urgent care walk-ins. (ama-assn.org)
  • Evaluate newly gained knowledge and skills in clinical effectiveness and clinical governance. (emerald.com)
  • An economic evaluation will be carried out alongside the trial to evaluate cost-effectiveness. (stir.ac.uk)
  • We used a validated Markov-based type 2 diabetes simulation model to evaluate the lifetime cost-effectiveness of alternative thresholds of diabetes risk. (springer.com)
  • NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. (nih.gov)
  • Aim: The present study aimed to evaluate the effectiveness of an educational-preventive oral health activity involving preschoolers. (bvsalud.org)
  • Szigety et al, "Clinical Effectiveness of Telemedicine-Based Pediatric Genetics Care. (chop.edu)
  • VE of partial (1-dose) and complete (2-dose) vaccination in this population is comparable to that reported from clinical trials and recent observational studies, supporting the effectiveness of mRNA COVID-19 vaccines against symptomatic disease in adults, with strong 2-dose protection. (cdc.gov)
  • On June 19, 2022, the original monovalent mRNA COVID-19 vaccines were approved as a primary series for children aged 6 months-4 years (Pfizer-BioNTech) and 6 months-5 years (Moderna) based on safety, immunobridging, and limited efficacy data from clinical trials. (medscape.com)
  • [ 1 , 2 ] The original monovalent mRNA vaccines were authorized in June 2022 for children aged 6 months-4 years (Pfizer-BioNTech*) and 6 months-5 years (Moderna † ) based on safety, immunobridging, and limited efficacy data from clinical trials, with recommendations expanded to include bivalent vaccines in December 2022. (medscape.com)
  • It will be important to explore the clinical and health-care trajectories of the ECLIPSE (clinical effectiveness and cost-effectiveness of levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia) trial participants to 10 years, by which time half of the cohort will have reached menopause. (nih.gov)
  • This trial aims to assess if self‐management of a vaginal pessary is associated with better quality of life for women with prolapse when compared to clinic based care. (stir.ac.uk)
  • Baio G. R for trial and model-based cost-effectiveness analysis. (springer.com)
  • The ASCENT-Ethiopia study is a three-arm cluster randomised trial assessing two DATs with differentiated care for supporting tuberculosis treatment adherence in Ethiopia. (lu.se)
  • The paper presents a protocol for the first pragmatic randomised controlled trial evaluating the effectiveness and cost-effectiveness of stepped care interventions for older hazardous alcohol users in primary care. (biomedcentral.com)
  • Kuwaba K, Kusubata M, Taga Y, Igarashi H, Nakazato K, Mizuno K. Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial. (medlineplus.gov)
  • Women who presented in primary care. (nih.gov)
  • Dr. Perry is a primary care physician in a busy urban clinic in East Harlem in New York City. (ama-assn.org)
  • Research: Lung cancer screening in the post-NLST era: Primary care nurse practitioner perceptions and screening practices - USC College of Nursing. (sc.edu)
  • The control group will receive the clinic based pessary care which is standard at their centre. (stir.ac.uk)
  • Clinic based care usually consists of having a pessary fitted in a primary or secondary care setting, and returning approximately every six months for healthcare professional review and pessary change. (stir.ac.uk)
  • In 2010, the Agency for Healthcare Research and Quality (AHRQ) awarded CERTAIN a $10.8 million grant to develop the network infrastructure, and in 2011, the Life Sciences Discovery Fund (LSDF) awarded CERTAIN a $2.5 million grant to broaden the network to include additional clinical disciplines and healthcare stakeholder groups. (wikipedia.org)
  • CERTAIN is a network of diverse healthcare providers and organizations participating in continuous evaluation of healthcare delivery and learning to improve patient care. (wikipedia.org)
  • Exemplifying the importance of reducing variation, the use of protocol-driven care in the ICU has been observed to lead to a significant reduction in healthcare-acquired conditions. (hfma.org)
  • Clinical studies and news reports are touting the potential for rapid whole genome sequencing (rWGS) to deliver quick and early diagnoses to critically ill newborns and to reduce healthcare costs. (aacc.org)
  • Value assessment frameworks: who is valuing the care in healthcare? (bmj.com)
  • Yet, several health systems in the United States and other countries are beginning to integrate sequencing into patient care and disease prevention independent of disease, leading to unclear benefits, harms and healthcare costs. (cdc.gov)
  • Dr. Kathuria's areas of interest include the globalization of physician training, clinical research and healthcare. (medscape.com)
  • Factors that influence and elevate costs include the use of unnecessary preoperative testing, physician preference decisions that increase implant costs or extend operating-room time, and a lack of standardized postoperative care that leads to prolonged lengths of stay and inappropriate use of post-acute resources. (hfma.org)
  • Support for fully-powered, definitive effectiveness studies focused on post-acute phase interventions is provided via the R01 in PAR-18-430 . (nih.gov)
  • Our vision is to be the premier provider of post-acute care by perfecting our care competencies. (volunteermatch.org)
  • Conclusions from the CER and clinical practice study suggest areas where continued effort is needed to effectively translate and disseminate CER results to improve the application of CER in clinical practice. (npcnow.org)
  • The Advisory Committee on Immunization Practices recommended prioritization of HCP for COVID-19 vaccination to maintain provision of critical services and reduce spread of infection in health care settings ( 2 ). (cdc.gov)
  • We performed a stochastic cost-effectiveness analysis comparing two treatment strategies -- linezolid versus trimethoprim-sulfamethoxazole plus rifampicin -- for the treatment of MRSA infection. (lse.ac.uk)
  • RIDTs can be useful to identify influenza virus infection as a cause of respiratory outbreaks in any setting, but especially in institutions (i.e., nursing homes, chronic care facilities, and hospitals), cruise ships, summer camps, schools, etc. (cdc.gov)
  • Clinical signs and symptoms consistent with influenza o Having clinical signs and symptoms consistent with influenza increases the pre-test probability of influenza virus infection, which increases the reliability of a positive RIDT result. (cdc.gov)
  • Although risk scores to predict type 2 diabetes exist, cost-effectiveness of risk thresholds to target prevention interventions are unknown. (springer.com)
  • Stepped care interventions involve the delivery of more intensive interventions only to those in the population who fail to respond to less intensive interventions and provide a potentially resource efficient means of meeting the needs of this population. (biomedcentral.com)
  • The study incorporates a comprehensive economic analysis to assess the relative cost-effectiveness of the interventions. (biomedcentral.com)
  • As public health specialists, we analyze microscopic images, as well as gigantic amounts of clinical, public health, and geospatial data to develop interventions that enhance individual and population health. (cdc.gov)
  • Recent clinical practice guidelines, including those produced by the Canadian Diabetes Association 1 and by the American Diabetes Association and the European Association for the Study of Diabetes, 2 have suggested selecting from among several agents on the basis of their respective advantages and disadvantages. (cmaj.ca)
  • Increased use of newer, more costly agents, along with the rising incidence of type 2 diabetes, carries significant budgetary implications for health care systems. (cmaj.ca)
  • We conducted this analysis to determine the relative costs, benefits and cost-effectiveness of options for second-line treatment of type 2 diabetes. (cmaj.ca)
  • We sought to examine the effectiveness of influenza vaccination against admission to hospital for acute cardiovascular and respiratory conditions and all-cause death in people with type 2 diabetes. (cmaj.ca)
  • A common vision for genomic medicine is that genome sequencing will be routinely used in health systems to provide health care and preventive services tailored to each individual. (cdc.gov)
  • Even when research was included in revised or updated CPGs, researchers were not able to consistently find changes in utilization or clinical practice. (npcnow.org)
  • While the research results and CPGs that followed would have suggested an increase in the use of surgery, in clinical practice surgical rates over time remained steady. (npcnow.org)
  • The research would have suggested either steady or decreased use of PCI, yet in clinical practice usage oscillated in the two years following research publication and updated CPGs. (npcnow.org)
  • We conducted a retrospective cohort study using primary and secondary care data from the Clinical Practice Research Datalink in England, over a 7-year period between 2003/04 and 2009/10. (cmaj.ca)
  • The goal of this registry initiative is to support the development of a sustainable data infrastructure and to conduct rigorous clinical and scientific research including comparative effectiveness and safety research. (nih.gov)
  • The Medicare Prescription Drug, Improvement, and Modernization Act (MMA) Section 1013 (42 USC 299b-7)(see http://effectivehealthcare.ahrq.gov/ ) authorized AHRQ to develop a program of comparative effectiveness research, thus, establishing the Effective Health Care (EHC) Program. (nih.gov)
  • The initial focus of the registry effort will be to develop the necessary infrastructure for data collection and comparative effectiveness research activities with concentration on hip and knee replacements. (nih.gov)
  • Research: Clinical research with neonates and their families to reduce morbidity, mortality and health disparities. (sc.edu)
  • A major challenge in implementing this research collaboration is to have clear lines of demarcation will have to be drawn between the "research" and the "clinical practice" arms. (cdc.gov)
  • These four components are prerequisites to successful implementation of changes in clinical processes and provider behavior. (hfma.org)
  • The adoption of perioperative information management systems (PIMS) has allowed these technologies to enter the operating room and support the clinical work flow of anesthesiologists and operational processes. (nih.gov)
  • Expertise: Mobile applications, critical care, geriatric disease processes and management, nursing and health informatics. (sc.edu)
  • The same is true in health care, whether the issue is an episode of care around a surgical procedure or long-term management of chronic disease. (hfma.org)
  • Unnecessary clinical variation leads to increased costs, as seen in many surgical procedures and the encompassing episodes of care. (hfma.org)
  • What is the clinical effectiveness of residents resting in a reclined positioning chair versus laying in a bed? (cadth.ca)
  • Comparative effectiveness of the sodium-glucose cotransporter 2 inhibitor empagliflozin versus other antihyperglycemics on risk of major adverse kidney events. (msdmanuals.com)
  • From the beginning of the coronavirus disease (COVID-19) pandemic through March 7, 2021, a total of 18,927 residents in long-term care facilities (LTCF) in Spain died from confirmed COVID-19, resulting in a cumulative mortality rate of 67/1,000 residents. (cdc.gov)
  • We obtained clinical data from a systematic review and mixed treatment comparison meta-analysis, and we obtained information on costs and utilities from published sources. (cmaj.ca)
  • Although these and other areas are amenable to CDS systems, the challenges of latency and data reliability represent fundamental limitations on the potential application of these tools to specific types of clinical issues. (nih.gov)
  • The following is the most current program effectiveness data. (ccp.edu)
  • This study aimed to compare the efficacy of stepped care, using therapist-assisted I-CBT, followed by face-to-face (f2f) cognitive behavioral therapy (CBT) when needed, with f2f CBT (treatment as usual [TAU]) on fatigue severity. (jmir.org)
  • Using the EQ-5D, at 2 years, the relative cost-effectiveness of the LNG-IUS compared with usual medical treatment was £1600 per QALY, which by 5 years was reduced to £114 per QALY. (nih.gov)
  • The LNG-IUS is cost-effective in both the short and medium term, using the method generally recommended by the National Institute for Health and Care Excellence. (nih.gov)
  • National Institute for Health and Care Excellence (NICE). (springer.com)
  • Few studies have been published to date exploring the effectiveness of ketamine for treatment-resistant depression (TRD) in large clinical samples. (psychiatrist.com)
  • One of the studies, led by Shareef A. Nahas, PhD, FACMG, CGMB senior director for Rady Children's Institute for Genomic Medicine in San Diego, demonstrated rWGS' ability to improve care, prevent disability, and reduce acute care costs. (aacc.org)
  • To date, our studies have shown a considerable clinical and economic benefit of sequencing children who were identified by clinicians as being suspected of having a genetic disorder. (aacc.org)
  • He has worked with Nahas and other researchers on clinical studies that demonstrate the benefits of rWGS, including one study of 65 infants randomized to receive either standard genetic tests or rWGS plus the standard tests. (aacc.org)
  • We are not aware of studies applying cost-effectiveness analysis to the application of diabetes risk scores alone or to a two-step screening procedure as described above. (springer.com)
  • Fund studies to confirm or shape clinical opinion or current practices. (npcnow.org)
  • Fostering a learning health system can streamline efforts to identify where multiple confirmatory studies should result in changes to clinical practice. (npcnow.org)
  • III Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees. (cdc.gov)
  • The registry shall serve to enable the conduct of studies focusing on comparative effectiveness and safety of various orthopedic procedures and devices and could also ideally serve as a resource for quality improvement initiatives. (nih.gov)
  • Comparative and cost effectiveness studies (e.g. (varian.com)
  • We found no studies examining the influence of any health care factors on treatment effectiveness. (ahrq.gov)
  • More large clinical studies are needed to prove its effectiveness. (healthline.com)
  • This case study provides an explicit comparison between Excel and R for contemporary cost-effectiveness analysis. (springer.com)
  • Cost-effectiveness analysis in R using a multi-state modeling survival analysis framework: a tutorial. (springer.com)
  • Cost-effectiveness analysis provides a framework for identifying the economically optimal threshold from the perspective of efficiently using health care resources. (springer.com)
  • Informed decisions regarding optimal prescribing and reimbursement of second-line agents by public and private health care payers requires information about clinical benefits, costs and cost-effectiveness. (cmaj.ca)
  • We constructed duplicate cost-effectiveness models using Excel and R (with a user interface built using the Shiny package) to address a hypothetical case study typical of contemporary health technology assessment. (springer.com)
  • In clinical practice, use of intensive therapy remained flat in the three years after study publication, prior to a decline in the use of standard therapy. (npcnow.org)
  • The MRI -study compared the effectiveness of mammography, ultrasound, magnetic resonance imaging (MRI) and clinical breast exam in detecting tumors among carriers of BRCA1 or BRCA2 mutations. (npcnow.org)
  • The registry will be a model and basis for other national device and procedure registries and will actively disseminate study results into clinical practice. (nih.gov)
  • The aim of this study is to determine the costs, cost-effectiveness and equity impact of implementing DATs in Ethiopia. (lu.se)
  • ABSTRACT This study explored the perceived value, role and reported use of clinical guidelines by clinicians in urban paediatric and maternity hospital settings, and the effect of current implementation strategies on clinician attitudes, knowledge and behaviour. (who.int)
  • The wasteful and imprudent use of diagnostic and therapeutic resources is also monitored in the ambulatory setting, and at least one vendor is offering insurers comparisons of providers using a value-of-care index. (hfma.org)
  • But the communication and reinforcement of the appropriateness of therapeutic choices will support confidence in the care team and reduce the chance of frivolous litigation. (hfma.org)
  • For example, there has to be agreement on what genes/variants to return to participants and their providers and medical records, in the course of routine clinical practice. (cdc.gov)
  • A reduction in mortality due to neonatal causes is attributed to the improved status of maternal/safe motherhood programmes and services, supported by much improved paediatric care and the current focus on the integrated management of childhood illness (IMCI) approach. (who.int)
  • Stephen Kingsmore, MB, ChB, DSc, FRCPath, president and CEO of Rady Children's Institute for Genomic Medicine, believes that WGS should become a standard part of care in neonatal intensive care units in the United States. (aacc.org)
  • Clinical decision support (CDS) systems are being used to optimize the increasingly complex care that our health care system delivers. (nih.gov)
  • To assess the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system (LNG-IUS) (Mirena®, Bayer) compared with usual medical treatment, with exploration of women's perspectives on treatment. (nih.gov)
  • Treatment with other agents, including thiazolidinediones and dipeptidyl peptidase-4 inhibitors, had unfavourable cost-effectiveness estimates compared with sulphonylureas. (cmaj.ca)
  • Although poor performance in this area partially can be attributed to issues with clinical documentation, wide variation in care exists across the continuum-especially for certain serious conditions such as the recognition and aggressive treatment of sepsis. (hfma.org)
  • Digital adherence technologies (DATs) may facilitate treatment monitoring and differentiated care. (lu.se)
  • Multiple "tests" can be used to direct health care related activities (e.g., diagnosis, risk assessment, treatment, prevention), for multiple diseases (e.g. heart disease, cancer) and deployed throughout life. (cdc.gov)