Clinical connective tissue. Medical search. Frequent questions

A new study by researchers at Hospital for Special Surgery (HSS) has further clarified the clinical manifestations of undifferentiated connective tissue disease (UCTD). (news-medical.net)
People of all races and ethnic backgrounds may develop undifferentiated connective tissue disease. (nationaljewish.org)
Unclassifiable symptoms, physical examination findings, or serological results suggestive of a CTD frequently lead to diagnoses such as incomplete lupus, latent lupus, overlap syndrome, and undifferentiated connective-tissue disease (UCTD). (medscape.com)
Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? (nih.gov)
We hypothesized that idiopathic NSIP is an autoimmune disease and the lung manifestation of undifferentiated connective tissue disease (UCTD), a recently described, distinct entity. (nih.gov)

UCTD is inherently challenging to define, but it's very important to understand what features differentiate patients with UCTD from those with defined connective tissue diseases (CTD) such as lupus so that we can better manage patients with this condition and ultimately predict who may go on to develop more severe clinical manifestations. (news-medical.net)
Connective-tissue diseases (CTDs) manifest with a wide range of clinical findings and laboratory abnormalities. (medscape.com)
Some connective tissue diseases such as lupus erythematosus are associated with a specific type of hepatitis. (cdc.gov)
In autoimmune diseases the immune system produces antibodies that attack the body's own cells, tissues and organs, resulting in inflammation and damage. (allergy.org.au)
Autoimmune diseases are usually diagnosed using a combination of clinical history, blood tests (autoantibodies, inflammation, organ function) and other investigations such as x-rays. (allergy.org.au)
Whilst localised (organ specific) autoimmune diseases mainly affect a single organ or tissue, the effects frequently extend to other body systems and organs. (allergy.org.au)
Systemic autoimmune diseases can affect many body organs and tissues at the same time. (allergy.org.au)
These diseases are often managed by clinical immunology/allergy specialists and/or rheumatologists. (allergy.org.au)
The main aims of treatments for autoimmune diseases are to relieve symptoms, minimise organ and tissue damage and preserve organ function. (allergy.org.au)
Providing patients compassionate care and comprehensive treatment of diseases affecting the joints and connective tissues. (uab.edu)
Our division provides state-of-the-art diagnosis and treatment of diseases affecting the joints and connective tissue (rheumatic diseases), including more than 100 types of arthritis and many autoimmune diseases, ranging in complexity and severity, and requiring the treatment and expertise of trained and experienced rheumatologists. (uab.edu)
I conduct clinical trials of novel agents in these diseases and strive to offer personalized medical care for all sarcoma patients. (uclahealth.org)
Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)

The Ehlers-Danlos syndromes comprise a clinically and genetically heterogeneous group of heritable connective tissue disorders, which are characterised by joint hypermobility, skin hyperextensibility, and tissue fragility [9] . (rbht.nhs.uk)
Microvascular filtration in subjects with connective tissue disorders. (bmj.com)
Rates of filtration under a standard hydrostatic pressure were measured in 20 normal female subjects and 44 female subjects with connective tissue disorders. (bmj.com)
The following are select resources most commonly requested and available throughout our website and grouped here for your convenience for the topic of Fibromyalgia and other Connective Tissue Disorders. (barralinstitute.com)
This book is based on the most common pelvic disorders encountered in clinical practice and provides practitioners with key treatments to aid with patient care and recovery. (barralinstitute.com)
Clinical manifestations of specific vasculitic disorders are diverse and depend on the size and location of the involved vessels, the extent of the organ involvement, and the degree and pattern of extravascular inflammation. (merckmanuals.com)
Pulmonary renal syndromes, connective tissue disorders and drugs make up the majority of the cases of DAH. (medscape.com)
The following review will discuss the clinical, radiographic and pathologic findings in a variety of disorders that cause DAH. (medscape.com)

We studied 28 consecutive patients with idiopathic interstitial pneumonia (IIP) enrolled in the University of California, San Francisco Interstitial Lung Disease Center who met prespecified criteria for UCTD, as follows: at least one clinical manifestation of connective tissue disease, serologic evidence of systemic inflammation in the absence of clinical infection, and absence of sufficient American College of Rheumatology criteria for another connective tissue disease. (nih.gov)

Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. (bvsalud.org)
The purpose of this randomized clinical trial (RCT) is to compare xenogeneic collagen matrix (XCM) versus connective tissue graft (CTG) to increase buccal soft tissue thickness at implant site. (bvsalud.org)
Background: The aim of the study was to compare the root coverage percentage and other clinical outcomes in Millers Class I and Class II gingival recessions (GR) treated with modified coronally advanced flap (MCAF) combined with connective tissue graft (CTG) using macro and microsurgical approaches. (ac.ir)
16 Without a connective tissue graft, a convex design in this zone can help create the illusion of thicker tissues. (researchgate.net)

Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
The most frequent presentation of mixed connective tissue disease (MCTD) is a child with polyarthritis, general malaise, and Raynaud phenomenon. (medscape.com)
Specific causes of mixed connective tissue disease remain undefined. (medscape.com)
As mentioned in the Introduction, the hallmark of mixed connective tissue disease is the presence of autoantibodies to U1 small nuclear ribonucleoproteins, in particular a 70-kDa U1 protein. (medscape.com)
Specific anti-RNP autoantibodies that preferentially bind to the apoptotic form of the U1 protein have been demonstrated in a group of patients with mixed connective tissue disease (29 of 53 tested). (medscape.com)
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. (healthline.com)
Patients with this rare autoantibody suffered from a homogenous overlap connective tissue disease defined by Raynaud phenomenon (32/32), features of scleroderma (31/32), arthritis (31/32, erosive in 9/32), myositis (28/32), lung restriction (25/32), calcinosis (15/32), and sicca (11/32). (nih.gov)
I do a weekly connective tissue disease clinic in Basildon, in addition to combined rheumatology/ orthopaedics and paediatrics/rheumatology clinics. (spirehealthcare.com)
Associated with connective tissue disease. (cdc.gov)
These exposure levels put workers, particularly sand mover operators and T-belt operators who had the highest levels, at risk of silicosis and the other silica-related conditions of lung cancer, end-stage renal disease, chronic obstructive pulmonary disease, tuberculosis, and connective tissue disease. (cdc.gov)
However, given the long latency, 20 or more years, of most silica-related health conditions and the fact that fracking did not become widely used until the 2000s, it may be years before health care providers see clinical-related disease in their practices. (cdc.gov)
Furthermore, these results show that the clinical entity idiopathic NSIP is different from idiopathic pulmonary fibrosis and appears to be an autoimmune disease. (nih.gov)
Small series suggest mycophenolate mofetil (MMF) is well tolerated and may be an effective therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD). (jrheum.org)
ILD may arise as a result of a specific occupational or environmental exposure or as a manifestation of underlying connective tissue disease (CTD). (jrheum.org)
Sarcoidosis in patients with mixed connective tissue disease: clinical, genetic, serological and histological observations. (cdc.gov)
Association study between immune-related miRNAs and mixed connective tissue disease. (cdc.gov)

The Masson-Goldner staining kit - for the visualization of connective tissue with trichromic staining, is used for human-medical cell diagnosis and serves the purpose of the histological investigation of sample material of human origin. (sigmaaldrich.com)
Diagnosis is clinical. (merckmanuals.com)
The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. (nih.gov)
Skin biopsy: Skin biopsy should be considered to confirm the clinical diagnosis of a cerebriform connective-tissue nevus. (medscape.com)
Sometimes a biopsy of affected tissues may be required for diagnosis. (allergy.org.au)
There are many aspects to consider regarding the etiology and diagnosis of SD, and the literature on osteopathic issues provides details on physiological signs that characterize it, including tissue texture changes. (mdpi.com)
the focus of this article is on anatomic considerations relevant to the clinical diagnosis and care of patients, with particular emphasis on procedural and urgent medicine. (medscape.com)
[ 2 ] Making the diagnosis requires the clinician to understand the basic clinical presentation, laboratory findings and diagnostic criteria. (medscape.com)

MCTD occurs when your immune system attacks the connective tissue that provides the framework for the organs of your body. (healthline.com)
If your doctor recognizes clinical signs of MCTD, such as swelling around the joints, rash, or evidence of cold sensitivity, they may order a blood test to check for certain antibodies associated with MCTD, such as anti-RNP, as well as the presence of inflammatory markers. (healthline.com)

Patient-reported outcomes and aesthetic evaluation of root coverage procedures: a 12-month follow-up of a randomized controlled clinical trial. (nature.com)
Clinical significance Proper emergence profile design supports esthetic outcomes and provides favorable biological response to implant‐supported restorations. (researchgate.net)
A recent systematic review and meta-analysis in the Journal of Periodontology conducted by Bassir et al found early placement of dental implants (complete soft tissue coverage) had similar postsurgical clinical outcomes when compared to immediate placement after extraction and delayed placement of dental implants. (dentalcare.com)

Peri-implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. (bvsalud.org)
32 Furthermore, the emergence profile of implant restoration could also have an effect on the facial gingival tissue thickness. (researchgate.net)
33 Over-contouring facial gingival profile of implant restoration had been shown to cause horizontal and vertical gingival tissue loss. (researchgate.net)
33 On the other hand, horizontal and vertical facial gingival tissues are generally well preserved in implant restoration with under-contoured emergence profile. (researchgate.net)

We have been interested in studying UCTD because it's commonly encountered in clinical practice but not well characterized. (news-medical.net)
The researchers compared sociodemographic, clinical, serologic, and treatment variables between 59 patients with UCTD and 30 patients who fulfilled criteria for CTD. (news-medical.net)
Our main findings were that patients who met a strict definition of UCTD versus those who met classification criteria for other CTDs were less likely to have clinical and laboratory features such as arthritis and hematologic abnormalities, as well as certain autoantibodies that are commonly seen in lupus,' said Dr. Siegel. (news-medical.net)
[ 13 ] Since that time, innumerable case reports, case series, and clinical studies have used variable criteria to define UCTD. (medscape.com)

While implant positioning and adequate amounts of soft and hard tissues are essential for achieving an esthetic outcome, the emergence profile of an abutment/restoration also plays an important role in the definitive appearance of implant prostheses. (researchgate.net)
31 Many of the current self-care treatments for periodontal maintenance of natural teeth also can be used with dental implants, but a better understanding of these self-care practices by the patient is crucial for the health of the soft and hard tissues and the longevity of their dental implants. (dentalcare.com)

With knowledge of the structures and function of the muscles, joints, and connective tissue and the dynamic pathology that intrudes and impedes normal function, nurses can readily provide quality and often life-saving actions. (netce.com)
A number of adjunctive diagnostic aids can assist in the clinical assessment of oral mucosal pathology. (medscape.com)

Fibroblastic Connective Tissue Nevus: A Rare Cutaneous Lesio. (lww.com)
Fibroblastic connective tissue nevus (FCTN) represents a rare and distinct benign cutaneous mesenchymal lesion of fibroblastic/myofibroblastic lineage, which broadens the spectrum of lesions presently recognized as connective tissue nevus. (lww.com)

The clinical syndrome is characterized by hemoptysis, falling hematocrit, hypoxemic respiratory failure and diffuse pulmonary infiltrates. (medscape.com)

In 1980, LeRoy et al proposed the concept of undifferentiated connective-tissue syndromes (UCTS) to characterize mixed or overlapping syndromes. (medscape.com)

CTG was more effective than XCM to increase buccal peri-implant soft tissue thickness. (bvsalud.org)
14 who focus on the importance of shaping two different areas of the EP to achieve the desired outcome in the peri-implant tissues. (researchgate.net)
Objective Emergence profile design is important for stable peri‐implant tissues and esthetically pleasing results with dental implant restorations, influenced by factors, such as, implant position and surrounding soft tissues. (researchgate.net)
The advantage of this mode of treatment is to reduce the clinical time, in addition to preservation of the shape from the surrounding soft tissue around the implant preserving the peri-implant architecture, optimizing the aesthetics. (bvsalud.org)

Connective tissue proper consists of loose connective tissue (including reticular connective tissue and adipose tissue) and dense connective tissue (subdivided into dense regular and dense irregular connective tissues. (wikipedia.org)
Examples of non-fibrous connective tissue include adipose tissue (fat) and blood. (wikipedia.org)
Adipose tissue gives "mechanical cushioning" to the body, among other functions. (wikipedia.org)
Although there is no dense collagen network in adipose tissue, groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression in place (for example, the sole of the foot). (wikipedia.org)
consequently, analyzing biopsied adipose tissue has been used to measure long-term exposure. (cdc.gov)
This decrease is evidenced by lower PCB levels reported in human adipose tissue, blood serum, and breast milk [Anderson et al. (cdc.gov)

Connective tissue can be broadly classified into connective tissue proper, and special connective tissue. (wikipedia.org)

Dense regular connective tissue, which forms organized structures, is a major functional component of tendons, ligaments and aponeuroses, and is also found in highly specialized organs such as the cornea. (wikipedia.org)
Cutaneous Vasculitis Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (merckmanuals.com)

Loose and dense irregular connective tissue, formed mainly by fibroblasts and collagen fibers, have an important role in providing a medium for oxygen and nutrients to diffuse from capillaries to cells, and carbon dioxide and waste substances to diffuse from cells back into circulation. (wikipedia.org)
The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)

However, long-term stability of hard tissues surrounding the dental implant were greater with early placement than immediate placement of dental implants. (dentalcare.com)
Although the junctional epithelium attachment for dental implants is similar to natural dentition, the connective tissue interface with the dental implant has poor mechanical resistance. (dentalcare.com)

Steroid medications, such as prednisone , can treat inflammation and help stop your immune system from attacking healthy tissues. (healthline.com)
Recent knowledge suggests that how tissue and, in particular, connective tissue, responds to osteopathic treatment may depend on the modulation of the inflammation degree. (mdpi.com)

ASCIA is the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand. (allergy.org.au)

Both the ground substance and proteins (fibers) create the matrix for connective tissue. (wikipedia.org)
Evaluating the Efficacy of Platelet-Rich Fibrin Matrix versus Subepithelial Connective Tissue Grafts in Den. (medscimonit.com)

The histology of cerebriform connective-tissue nevi and epidermal nevi are discussed in Physical Examination , along with a description of their clinical manifestations. (medscape.com)

Outcome measures included buccal soft tissue thickness (GT), apico-coronal keratinized tissue (KT), chair time and post-operative discomfort. (bvsalud.org)

173 In hematopoietic and lymphatic tissues, reticular fibers made by reticular cells provide the stroma-or structural support-for the parenchyma (that is, the bulk of functional substance) of the organ. (wikipedia.org)
For a better understanding of the clinical significance of the inguinal canal and the adjacent femoral sheath, this region may be conceptually broken down into osseous, myotendinous, neurovascular, lymphatic, and genitourinary/spermatic cord components. (medscape.com)

Dense irregular connective tissue provides strength in multiple directions by its dense bundles of fibers arranged in all directions. (wikipedia.org)
Proteus syndrome (PS) is a sporadically occurring hamartomatous disorder associated with irregular asymmetric overgrowth of multiple body tissues and cell lineages. (medscape.com)

Clinical criteria (at least 3) are edema of the hands, Raynaud phenomenon (ie, 2 or 3 color changes), acrosclerosis, synovitis, and myositis (laboratory or biopsy evidence). (medscape.com)
Serum PCB analysis is less invasive than tissue biopsy, and it can be performed by most commercial reference laboratories. (cdc.gov)

Fibromuscular tissue is made up of fibrous tissue and muscular tissue. (wikipedia.org)

citation needed] Special connective tissue consists of cartilage, bone, blood and lymph. (wikipedia.org)
Bone and cartilage can be further classified as supportive connective tissue. (wikipedia.org)
Characteristic plurifocal overgrowths (partial or regional gigantism) can involve any structure of the body but most commonly involve the bone, connective tissue, and fat. (medscape.com)
I specialize in taking care of patients with bone and soft tissue sarcomas. (uclahealth.org)
The lack of the connective tissue barrier around dental implants allows pathogenic bacteria access to destroy bone. (dentalcare.com)

A randomized, controlled clinical trial. (bvsalud.org)

Will Clinical Trials Transform Treatment Options For Sarcoma Patients? (forbes.com)

Spinal Tumors Spinal tumors may develop within the spinal cord parenchyma, directly destroying tissue, or outside the cord parenchyma, often compressing the cord or nerve roots. (msdmanuals.com)
However, treatment advances for solid tumors, namely tumors arising in the liver, connective tissues and brain, remain few in number. (forbes.com)

Will Near Term Clinical Trial Results Transform Treatment Options For Sarcoma Patients? (forbes.com)
This is particularly true for sarcoma, a cancer of the connective tissues that accounts for approximately 15,000 new cancer cases in the United States annually. (forbes.com)

Abnormal type IV collagen in glomeruli can prevent the kidneys from adequately filtering the blood and allows blood and protein to pass into the urine, resulting in progressive scarring of kidney tissue [2] . (rbht.nhs.uk)
Most types of connective tissue consists of three main components: elastic and collagen fibers, ground substance, and cells. (wikipedia.org)
Dense regular connective tissue, found in structures such as tendons and ligaments, is characterized by collagen fibers arranged in an orderly parallel fashion, giving it tensile strength in one direction. (wikipedia.org)
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the mammalian body. (wikipedia.org)

Cutis laxa (CL) is a connective tissue disorder characterised by excessive loose, wrinkled and inelastic skin due to structural defects in the elastic fibres or abnormal maturation and secretion of proteins involved [4] . (rbht.nhs.uk)
It's an autoimmune disorder , meaning it involves your immune system mistakenly attacking healthy tissue. (healthline.com)

This study was designed to improve our understanding of the role of miR-18a and its target (connective tissue growth factor (CTGF), which are mediators in HBX-induced hepatocellular carcinoma (HCC). (medscimonit.com)

This study aims to learn more about the impact of changes in connective tissue genes on an individual's overall health. (nih.gov)

Classification criteria other than autoantibody status rely on clinical examination and diagnostic tests. (medscape.com)

Clinical follow-up was obtained for 14 patients (median duration, 4 y). (lww.com)
Soft tissue augmentation with XCM (test) or CTG (control) was performed at 60 implants in 60 patients at the time of implant uncovering. (bvsalud.org)
The clinical and laboratory features of 32 patients with anti-PM-Scl were studied. (nih.gov)
Aims: To evaluate the feasibility and accuracy of using comorbidity data extracted from medical records, and estimate the prevalence of comorbidities in patients registered in the Clinical Breast Cancer Registry of Iran (CBCR-IR). (who.int)

However, recent research points towards a strong involvement of the connective tissue. (mdpi.com)
Testing human tissue for PCB content, however, remains principally a research tool. (cdc.gov)
This research considered the remodelling aspects of these conditions using both in vitro and pre-clinical models. (surrey.ac.uk)

Preoperative factors include poor quality or quantity of soft and soft tissues, inadequate preliminary procedures, occlusal relationships, and treatment planning. (dentalcare.com)

But before we perform this type of procedure we must assess the real indication of the placement of concomitant implant tooth extraction, through clinical and radiographic examinations cause a factor of great importance for the success of this technique is that the installed implant achieve a good stability primary at installation time. (bvsalud.org)

Immediate implants can be incorporated as a technique to be used in several clinical cases and should always be subject to the limitations of the cases to be achieved excellent results. (bvsalud.org)
Even when the vessel is camouflaged by tissue in an obese patient or when there is no palpable femoral pulse in an underresuscitated trauma patient, the femoral vein may be successfully located in 90% of cases with this technique. (medscape.com)

It is important for your skin, bones, and connective tissue. (medlineplus.gov)

Anatomy56

Organisms13

Diseases51

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes24

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Information Science3

Undifferentiated connective tissue5

Diseases13

Disorders8

Manifestation of connective tissue1

Graft4

Disease16

Diagnosis8

MCTD2

Outcomes3

Gingival4

UCTD4

Soft and hard tis2

Pathology2

Nevus2

Pulmonary1

Syndromes1

Peri-implant4

Adipose tissue6

Broadly classified1

Organs2

Fibroblasts2

Dental implant2

Inflammation2

Immunology1

Matrix2

Histology1

Discomfort1

Lymphatic2

Irregular2

Biopsy2

Fibromuscular1

Bone5

Controlled clinical trial1

Trials1

Tumors2

Sarcoma2

Collagen4

Disorder2

Growth Factor1

Genes1

Criteria1

Patients4

Research3

Treatment1

Radiographic1

Technique2

Skin1