Clinical conditional pathogens. Medical search. Frequent questions

Nine key clinical questions were generated and a systematic review was conducted to identify published systematic reviews, randomised clinical trials and observational studies that answered these questions. (ersjournals.com)
Whereas it takes many years to develop a vaccine and gain approval, largely because of the time it takes to conduct clinical trials, fully developing the large-scale manufacturing process intended for commercial production has always been a multiyear effort because of the science and engineering required to develop a robust process and the regulatory requirements for approval. (nature.com)
The early clinical trials must have demonstrated a significant degree of efficacy and safety and post marketing studies are likely to be required, Lane said. (trpma.org.tw)
The reason that clinical trials require eligibility criteria is because there are substantial dissimilarities among patients even if they possess the same disease or condition. (clinicaltrialguide.com)
The clinicaltrialguide.com site is intended to be a comprehensive online resource for people interested in clinical trials for themselves or their friends and loved ones. (clinicaltrialguide.com)
Our goal is to provide visitors with the best and most current information on clinical trials to help guide their decisions on participating in trials and assist them in navigating the clinical trial process. (clinicaltrialguide.com)
From there, the device will be available for transition to military medical commands and clinical trials required for final regulatory approval. (blogspot.com)
This review integrates most experimental studies and clinical trials of various oncolytic viruses (OVs) in the diagnosis and treatment of GC. (frontiersin.org)
Precis: Pulsed high doses versus sustained low doses of the p53-MDM2 inhibitor HDM201 elicit a pro-apoptotic response from wild-type p53 cancer cells, offering guidance to current clinical trials with this and other drugs that exploit the activity of p53. (bace-signal.com)
Beyond Air is currently advancing its revolutionary LungFit™ for clinical trials for the treatment of severe lung infections such as SARS-CoV-2 and nontuberculous mycobacteria (NTM). (beyondair.net)

FURIN also promotes the infectivity of pathogens by activating bacterial toxins and by processing viral proteins. (oncotarget.com)
Upon Salmonella typhimurium and Listeria monocytogenes infection, CD83ΔDC mice cleared both pathogens more efficiently, and CD83-deficient DCs expressed increased IL-12 levels after bacterial encounter. (jci.org)
Meningitis and Special Pathogens Br, Div of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, CDC. (cdc.gov)

Continuous removal of pathogens, toxins, activated cells, exosomes, and cytokines via a diverse suite of "label-free" technologies such as synthetic mannose binding lectins and selective adsorption cartridges. (blogspot.com)

A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis. (ersjournals.com)
The algorithm in question lists routine studies and tests that should be performed on all suspected encephalitis patients, as well as conditional studies based on host and geographic factors, season and exposure, specific signs and symptoms, and both laboratory and neuroimaging features (See chart, p. 4). (aacc.org)
DNA mismatch repair deficiency (MMRd) is associated with elevated tumor mutational burden (TMB) and exceptional immunotherapy responses, yet some patients experience no clinical benefit. (nature.com)
Balixafortide showed strong results in a Phase Ib/proof of concept clinical trial in combination with eribulin in patients affected with advanced metastatic breast cancer. (spexisbio.com)
Polyphor is also developing an immuno-oncology candidate, balixafortide (POL6326), which has achieved clinical proof of concept in a Phase Ib/proof of concept study in combination with eribulin in patients with advanced breast cancer, and a pipeline of further preclinical antibiotics based on its OMPTA platform. (spexisbio.com)
It is not meant to replace clinical judgment or specialist consultation but rather to strengthen clinical management of these patients and provide to up-to-date guidance. (who.int)
Consider: the intervention may be beneficial in selected patients (conditional recommendation) OR be careful when considering this intervention. (who.int)
issuing a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients. (who.int)

Mice with a conditional deletion of FURIN in their myeloid cells (LysMCre- fur (fl/fl) ) were healthy and showed unchanged proportions of neutrophils and macrophages. (oncotarget.com)
In this study, we performed a mouse clinical trial using EML4-ALK transgenic mice model to comprehensively investigate immunomodulatory effects of ALK TKI and to investigate the mechanisms of resistance to ICIs. (bmj.com)
Mice will meet Taconic's Murine Pathogen Free™ (MPF™) health standard. (taconic.com)

Culture, Sputum/Lower Respiratory - Isolation of potential respiratory pathogens can be useful in the diagnosis of respiratory tract infection. (amaways.com)
34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilator support and other appropriate agents. (beyondair.net)
Because the signs and symptoms of coronavirus disease 2019 (COVID-19) may overlap with those of other respiratory pathogens, it is important to perform laboratory testing to specifically identify symptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
This is the first edition of this document for novel coronavirus, an adaption of WHO Clinical management of severe acute respiratory infection when MERS-CoV infection is suspected publication (2019). (who.int)

We are drawing on collaborative expertise to employ CRISPR for generation of aSLC11A1-/- cell line and utilize the Cre-lox system to create a mouse strain that has a conditional knockout ofSlc11a1 only in neutrophils. (usda.gov)

Further, this case showed that the clinical symptoms of NTM infection are atypical and highly occult, especially for extrapulmonary NTM infections, which are difficult to diagnose. (degruyter.com)

Looking farther back in history, it took decades to go from pathogen identification to first approval for meningitis, whooping cough, measles and hepatitis vaccines 3 . (nature.com)

For the respirable fibres and granular biopersistent particles' groups, the Guideline Development Group suggests using the available classification of MNMs for provisional classification of nanomaterials of the same group ( conditional recommendation, low-quality evidence ). (cdc.gov)
The Guideline Development Group suggests assessing workers' exposure in workplaces with methods similar to those used for the proposed specific occupational exposure limit (OEL) value of the MNM ( conditional recommendation, low-quality evidence ). (cdc.gov)
The chosen OEL should be at least as protective as a legally mandated OEL for the bulk form of the material ( conditional recommendation, low-quality evidence ). (cdc.gov)
second, conducting basic exposure assessment and third, conducting a comprehensive exposure assessment such as those proposed by the Organisation for Economic Co-operation and Development or Comité Européen de Normalisation (the European Committee for Standardization) ( conditional recommendation, moderate-quality evidence ). (cdc.gov)

At the end of 2019, a novel coronavirus started as an emerging pathogen for humans and resulted in a pandemic. (medscape.com)
Please see Coronavirus Disease 2019 (COVID-19) and for continuously updated clinical guidance concerning COVID-19 and Treatment of Coronavirus Disease 2019 (COVID-19): Investigational Drugs and Other Therapies for updated drug information. (medscape.com)

The aim of this study was to obtain information on M genitalium concerning prevalence, association to clinical manifestations, and mode of transmission. (bmj.com)
In the early stage, there is generally no apparent symptom of discomfort or only indigestion-like clinical manifestations such as inappetence, gastroesophageal reflux, belching, and stomachache. (frontiersin.org)
NIID is a heterogeneous disorder with variable clinical manifestations including cognitive impairment, cerebellar ataxia, parkinsonism, paroxysmal symptoms, autonomic dysfunction, and muscle weakness. (biomedcentral.com)

There are still numerous obstacles to the use of evolutionary therapy in clinical practice. (wikipedia.org)
Understanding the determinants of IFR variation for COVID-19, the disease caused by the SARS-CoV-2 virus, has direct implications for mitigation efforts with respect to clinical practice, non-pharmaceutical interventions, and the prioritisation of risk groups for targeted vaccine delivery. (washington.edu)
Information about how IFR varies by age, time, and location informs clinical practice and non-pharmaceutical interventions like physical distancing measures, and underpins vaccine risk stratification. (washington.edu)
1, 2 Owing to the slow cell replication and fastidious growth requirements, culture is impossible to use in clinical practice. (bmj.com)
CONCLUSIONS: These new treatment algorithms are intended to guide clinical decision-making in clinical practice. (umassmed.edu)
CONCLUSIONS: This international consensus statement culminated in expert-based clinical practice recommendations for the treatment of vitiligo. (umassmed.edu)

The infection-fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen. (washington.edu)
With any type of laboratory test, the clinical accuracy or reliability depends on performance characteristics such as sensitivity and specificity, as well as the pretest probability that a person has SARS-CoV-2 infection and the prevalence of COVID-19 in the local community. (medscape.com)
The regional incident management support team continues to coordinate the response and provide technical support to countries and partners in the Region in the areas of coordination and partnership, surveillance, laboratory capacity, clinical management, infection prevention and control, risk communication and community engagement, points of entry according to the International Health Regulations (2005), research, health systems, and essential health services among others. (who.int)
EMS practices should be based on the most up-to-date clinical recommendations and information from appropriate public health authorities and EMS medical direction about SARS-CoV-2 infection. (cdc.gov)

Mouse macrophages expressing mutant Slc11a1 are functionally compromised incontrol of several intracellular pathogens, including Salmonella enterica serovar Typhimurium (S. Typhimurium).Further, human polymorphisms in SLC11A1 are associated with susceptibility to both autoimmune and infectiousdisease. (usda.gov)

The immune responses observed following vaccination are in line with what we expect will be associated with protection against the SARS-CoV-2 virus, although we must continue with our rigorous clinical trial programme to confirm this," he said. (sciencebusiness.net)
In summary, we show that CD83 ablation on DCs results in enhanced immune responses by dysregulating tolerance mechanisms and thereby impairing resolution of inflammation, which also demonstrates high clinical relevance. (jci.org)
Clinical manifestation coincides with the employment of humoral immune mechanisms, enrolling plasma cell recruitment, deposition of myelin-bound IgG and antibody-dependent macrophageal myelin-stripping. (biomedcentral.com)
At the same time, there was an increasing appreciation of the fact that, although antimicrobials work (and work well) by slowing down and/or killing the microbial pathogens, the totality of host defence is a dynamic process dependent upon host-pathogen interactions - because of which immune therapies, including antibody-associated therapies, had a definite and important role to play in clinical therapeutics. (inscientioveritas.org)

Proof of principle for adaptive therapy has also been established in a recent phase 2 clinical trial as well as in vivo, and more rigorous quantitative studies in vitro. (wikipedia.org)

Despite careful selection of candidates based on clinical stability, the success of the procedure is unpredictable. (umassmed.edu)

For queries, please email [email protected] with `2019-nCoV clinical question' in the subject line. (who.int)
I'd like to welcome you to today's COCA call, Clinical Management of Critically Ill Adults with Corona Virus Disease 2019, COVID-19. (cdc.gov)

This stratified approach of performing a clutch of routine tests plus conditional studies-based on patient-specific circumstances-is a pragmatic approach to the diagnostic work-up of encephalitis, given that many of the recommended tests use precious cerebral spinal fluid (CSF), said James Sejvar, MD, a neuroepidemiologist in the Division of High Consequence Pathogens and Pathology at CDC's National Center for Emerging and Zoonotic Infectious Diseases in Atlanta. (aacc.org)
The pathway for specific usage drugs is mainly for pediatric drugs and for drugs to treat diseases caused by drug-resistant pathogens. (trpma.org.tw)
Beyond Air, Inc. is a clinical-stage medical device and biopharmaceutical company developing a revolutionary NO Generator and Delivery System, LungFit™, that uses NO generated from ambient air to deliver precise amounts of NO to the lungs for the potential treatment of a variety of pulmonary diseases. (beyondair.net)

Students will be given access to VC upon conditional admission. (charlotte.edu)
Findings on the criminal background check may void conditional/full admission and prevent entrance to the program. (sandburg.edu)
Although the COVID-19 vaccination is not an admission requirement, most healthcare clinical sites require vaccination against COVID-19. (sandburg.edu)
If you are unable to participate in and/or complete clinical/practicum/internship courses required for the program due to a positive drug test, which includes marijuana, you are not eligible for a refund of any tuition, fees or other expenses incurred while preparing for admission into the program and while enrolled in the program. (sandburg.edu)

Thus, we investigated the annual incidence and clinical characteristics of Elizabethkingia acquisition in a tertiary teaching hospital in Seoul, South Korea. (cdc.gov)

Camci F, Chinnam RB( 2008) General importance time browser fiesta for cognitive BLACKWOOD of Clinical languages. (ligaya-technologies.com)

Because E. anophelis was the most frequently isolated Elizabethkingia species in recent clinical studies, as confirmed by 16s rRNA gene sequencing ( 6 , 7 ), but is commonly misidentified as E. meningoseptica , many previously reported cases of E. meningoseptica could actually have been caused by E. anophelis ( 8 , 9 ). (cdc.gov)

Top line: clinical and regulatory timeline. (nature.com)
Making the announcement, the two companies said they expect to be ready to seek conditional marketing approval or some form of regulatory access to the market as early as October 2020, and to have manufactured 100 million doses of vaccine by the end of the year. (sciencebusiness.net)

They have been widely used in the food industry, clinical treatment, and other fields. (bvsalud.org)

There are a lot of similarities between conditional early approval in Japan and in other countries, Lane said. (trpma.org.tw)
Conditional early approval allows for a shortened review period of nine months. (trpma.org.tw)
Additionally, there is the possibility of achieving an accelerated conditional approval based on interim results. (spexisbio.com)

To address the urgent medical need during the 2014 to 2016 outbreak, the clinical development of the 2-dose vaccine regimen comprising of Ad26.ZEBOV and MVA-BN-Filo was accelerated. (plos.org)

Intrinsic and conditional tolerance were also abolished by deletions of genes encoding the calcineurin (CMP1 and CNB1). (microbiologyresearch.org)

2 Institute of Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (jci.org)
Cell culture isolation of SARS-CoV-2 is possible, but the Centers for Disease Control and Prevention (CDC) recommends that clinical laboratories not attempt this unless it is performed in a biosafety level 3 (BSL-3)-certified laboratory. (medscape.com)

Within the Pfizer Biotherapeutics Pharmaceutical Sciences and Global Supply organizations, we initiated parallel development of four COVID-19 vaccine candidates involving four separate work streams for plasmids, mRNA and drug product, as well as analytics and production facility planning (for example, process scale-up and eventual validation) while simultaneously processing initial clinical supplies. (nature.com)
In Japan, as in other countries that offer priority review, the requirement for this pathway is that there is either no standard therapy for the condition or the investigational drug has demonstrated superior clinical utility compared with approved products. (trpma.org.tw)
These differences can alter the results in a clinical study and make it more difficult to determine if a new drug or treatment is working to the best of its ability in targeting the main pathogen or deficiency in the body. (clinicaltrialguide.com)

Additionally, drugs that go through this pathway are eligible for reimbursement and can be sold with limited clinical trial data while being developed in other countries. (trpma.org.tw)
Results Mouse clinical trial revealed that anti-PD-1 therapy was ineffective, and the efficacy of ceritinib and anti-PD-1 combination was not more effective than ceritinib alone in the first line. (bmj.com)

The covariates included seven clinical predictors (eg, age-standardised obesity prevalence) and two measures of health system performance. (washington.edu)

We believe both may play an important role in achieving effective clearance of a pathogen such as SARS-CoV-2," said Ozlem Tureci, chief medical officer and co-founder of BioNTech. (sciencebusiness.net)

Using a DC-specific CD83-conditional KO (CD83ΔDC) mouse, we provide new insights into the function of CD83 within this cell type. (jci.org)

Neurologically affected chickens and control animals from one single flock underwent clinical and neuropathological examination. (biomedcentral.com)
This limited-enrollment program successfully prepares you to take the National Dental Hygiene Board Examination, the clinical dental hygiene board examination and the examination for registration as a dental hygienist in the respective state. (sandburg.edu)

Importantly, this plan embodies the structured dual-degreementorship at UC Davis with a supportive sponsor and lab that addresses clinically relevant microbiologicalquestions, a clinical mentor, a graduate school adviser, medical school advisers and an MD/PhD adviser. (usda.gov)
Reporting to the Office Manager, the Patient Services Representative will provide excellent administrative support to Signature Health's clinical and medical record functions. (cleveland.com)
Captain Uyeki is the chief medical officer for CDC's Influenza Division, and is currently serving as the clinical team lead for CDC's COVID-19 response. (cdc.gov)

Please note that clinical begins the first week of each semester and includes experiences that occur in healthcare organizations, the community, OR the School of Nursing's Learning Resource Center. (charlotte.edu)
COVID-19 clinical Call Center at 770-488-7100. (cdc.gov)

But it also carries the potential to transform clinical research through increased innovation, better implementation and broader benefits for participants and communities. (avac.org)
PLOS Medicine publishes research and commentary of general interest with clear implications for patient care, public policy or clinical research agendas. (plos.org)

Here, we found that a large proportion of clinical isolates were intrinsically tolerant to fluconazole, and/or could be induced by high temperature (37°C) to become tolerant (conditionally tolerant). (microbiologyresearch.org)

The inhibition of one of these steps by small molecules, such as antimicrobial peptides, or their action on specific targets will leave pathogens armless against classical antibiotics. (intechopen.com)

Any items that expire and are not immediately updated in VC will result in removal from the clinical site. (charlotte.edu)

Clinical agencies require students to comply with select health and training requirements for the privilege of using the agency and for the safety of the public. (charlotte.edu)

Closed-loop therapy with system feedback to monitor and redirect patient state based on conditional probability and reduced order techniques. (blogspot.com)

The conditional KO line has been subsequently backcrossed to C57BL/6NTac animals for at least 2 generations and the Cre-transgene was removed by segregation. (taconic.com)

Anatomy15

Organisms82

Diseases45

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes53

Disciplines and Occupations4

Technology, Industry, Agriculture7

Information Science4

Health Care9

Trials10

Bacterial3

Toxins1

Patients8

Mice3

Respiratory4

Knockout1

Infections1

Meningitis1

Recommendation4

Coronavirus2

Manifestations3

Practice6

Infection4

Typhimurium1

Immune4

Rigorous1

Stability1

20192

Diseases3

Admission4

Characteristics1

Cognitive1

Species1

Regulatory2

Widely1

Approval3

Outbreak1

Genes1

Laboratory2

Drug3

Trial2

Prevalence1

Important1

Mouse1

Examination2

Medical3

Center2

Research2

High1

Specific1

Removal1

Health1

Patient1

Line1