HypertensionDyslipidemiaAbdominal obesityPolycystic ovary syDiagnosisDisordersMetSABSTRACTObeseAdiposityEndocrineOverweight and obesityGlucoseDiabeticComorbiditiesAdolescentsAssessmentWaistGeneticGlycemic controlSevereAdipose tissueDiseasesIncidenceIncreases with ageT2DMChildhood obesityAtherosclerosisComponents of metabolic syndromeContribute to metabolic syndromePostoperative complicationsPrevalence of obesityDysmetabolicDysfunctionPrecision obesity managementInsulin resistanPatientsRisk factorPathwaysSymptomsCardiovascular risk factorsTriglyceridesAcanthosis nigricansPreventionOutcomesDisorder characterizedChronic diseaseAffects1970s2022PrediabetesPeople with obesityDevelopment of obesitySuggestsCoupled with insulin resistance
Hypertension19
- PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
- Metabolic syndrome is defined as a group of coexisting metabolic risk factors, such as central obesity, lipid disorders, carbohydrate disorders, and arterial hypertension. (hindawi.com)
- The aim of our study was to demonstrate a correlation between waist circumference (WC) and body mass index (BMI) in patients with metabolic syndrome in relation with hypertension, lipid disorders, and carbohydrate disorders. (hindawi.com)
- The aim of our study was to demonstrate a correlation between waist circumference (WC) and body mass index (BMI) in patients with metabolic syndrome in relation to hypertension, lipid disorders, such as atherogenic dyslipidaemia, and carbohydrate disorders, such as impaired fasting glucose or diabetes mellitus type 2. (hindawi.com)
- These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. (mdpi.com)
- Multivariate analysis (after correction for sex, age, family history of type 2 diabetes mellitus, obesity, cardiovascular disease, hypertension and dyslipidaemia) showed that waist circumference/height ratio and IGF-I SDS were the only variables independently correlated with the presence of retinopathy. (biomedcentral.com)
- Family history of type 2 diabetes mellitus, obesity, cardiovascular diseases, hypertension or dyslipidaemia in first- and second-degree relatives was also investigated (positive/negative). (biomedcentral.com)
- The remaining two missense variants, p.Arg252His and p.Lys68Gln, were found in two unrelated individuals manifesting symptoms suggestive of AOMS3, such as childhood-onset abdominal obesity, type 2 diabetes, hypertriglyceridemia, and arterial hypertension. (biomedcentral.com)
- NASH is comparable to alcoholic cirrhosis/hepatitis, as it can follow the same sequelae of complications (portal hypertension [HTN], esophageal varices, increased bleeding times, decreased albumin, causing ascites, fluid shifts, malnutrition), but the risk factors for these diseases are different. (nursingcenter.com)
- Metabolic syndrome is a cluster of conditions, which includes elevated blood pressure (hypertension), elevated blood glucose (diabetes), elevated triglycerides and low high-density lipoprotein (HDL) levels (hypercholesterolemia) 1 . (optixanthin.com)
- Physical inactivity is associated with numerous adverse health conditions, including obesity, hypertension, type 2 diabetes and atherosclerotic cardiovascular disease, and it contributes annually to 250,000 premature deaths (Booth et al. (acefitness.org)
- For example, insulin resistance is likely to be associated with obesity, hypertension, dyslipidemia and other metabolic disorders. (acefitness.org)
- Metabolic syndrome (MetS) is defined as a panel of endocrine disorders, including central adiposity, dyslipidemia, hyperglycemia and hypertension ( Kaur, 2014 ). (frontiersin.org)
- filled out a questionnaire referring to major cardiovascular risk factors: smoking, obesity, hypertension, and dyslipidemia. (pharmaceuticalintelligence.com)
- the most frequent correlation was found for obesity and hypertension. (pharmaceuticalintelligence.com)
- Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal fat), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (merckmanuals.com)
- Ce syndrome se caractérise par l'association d'anomalies incluant une résistance à l'insuline, un hyper-insulinisme, une intolérance au glucose ou un diabète de type 2, une hypertension artérielle et des troubles du métabolisme lipidique et de la coagulation. (erudit.org)
- It is characterized by a cluster of risk factors of atherosclerosis including insulin resistance, hyperinsulinemia, impaired glucose tolerance or type 2 diabetes, hypertension, dyslipidemia, and coagulation abnormalities. (erudit.org)
- These studies are of great importance at the national level, since obesity in Brazil is already of great importance in the Public Health of Children and Adolescents and presents severe complications, that mainly include type 2 diabetes, hypertension, hyperlipidemia, bone maturation and accelerated growth, ovarian hyperandrogenism, cholecystitis, pancreatitis and pseudo-brain tumor. (bvsalud.org)
Dyslipidemia1
- Ensuring a certain intake level of dietary polyunsaturated fatty acids (PUFAs) might help improve the clinical manifestations of dyslipidemia, impaired vascular endothelial function, and IR in PCOS patients ( 11 ). (frontiersin.org)
Abdominal obesity9
- Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
- Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). (wikipedia.org)
- HPA-axis dysfunction may explain the reported risk indication of abdominal obesity to cardiovascular disease (CVD), type 2 diabetes and stroke. (wikipedia.org)
- According to the 2005 IDF criteria, subsequently revised in 2009, abdominal obesity is identified as the waist circumference of ≥80 cm in women and ≥94 cm in men. (hindawi.com)
- Abdominal obesity is the major disorder constituting a base for the development of metabolic syndrome. (hindawi.com)
- Evidence from the conducted studies has revealed that abdominal obesity (assessed based on the waist circumference) plays a very important role in the development of metabolic disorders and in the assessment of cardiovascular risk. (hindawi.com)
- Due to the limitations of BMI methodology, current reports by the World Health Organization and other organizations suggest combining the measurements of BMI and abdominal obesity [ 11 ]. (hindawi.com)
- We investigated pathogenic DYRK1B variants causative of abdominal obesity-metabolic syndrome 3 (AOMS3) in a group of patients originally diagnosed with type 2 diabetes. (biomedcentral.com)
- describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. (tomwademd.net)
Polycystic ovary sy5
- Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
- Polycystic ovary syndrome is a clinical syndrome typically characterized by anovulation or oligo-ovulation, signs of androgen excess (eg, hirsutism, acne), and multiple ovarian cysts in the ovaries. (merckmanuals.com)
- Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. (merckmanuals.com)
- Polycystic ovary syndrome has several significant potential complications. (merckmanuals.com)
- Though limited data exist, Dr. Dunfaif believes there's are indications of cardiovascular risk in patients of all ages with polycystic ovary syndrome. (hcplive.com)
Diagnosis12
- Diagnosis is based on clinical findings corroborated with laboratory tests. (medscape.com)
- The recommendation applies to asymptomatic women with no previous diagnosis of type 1 or type 2 diabetes mellitus. (medscape.com)
- Once the diagnosis of diabetes is established in a pregnant woman, continued testing for glycemic control and diabetic complications is indicated for the remainder of the pregnancy. (medscape.com)
- Timely diagnosis would help in delaying its complications and co-morbidities. (biomedcentral.com)
- In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
- Your health care provider who is familiar with metabolic syndrome will make the diagnosis by obtaining the necessary tests, including blood pressure monitoring, waist circumference monitoring, blood glucose, serum insulin, and lipid profile (triglycerides and HDL). (lowcarbneurologist.com)
- Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)
- Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
- Autonomic neuropathy increases the risk of complications , which calls for an early diagnosis. (pharmaceuticalintelligence.com)
- Diagnosis is by clinical criteria, hormone measurement, and imaging to exclude a virilizing tumor. (merckmanuals.com)
- In a clinical setting BMI is a useful tool in assessing children's weight status, but additional clinical information is useful in making the diagnosis of obesity. (txpeds.org)
- From the abstract: 'This international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). (cdc.gov)
Disorders9
- All of the above-mentioned disorders contribute to metabolic syndrome and are related to the development of type 2 diabetes and ischaemic heart disease. (hindawi.com)
- Children with overweight/obesity secondary to genetic syndromes or hormonal disorders were excluded. (biomedcentral.com)
- 25% body fat in men) may foretell the presence of metabolic disorders, or downstream precipitation of incident diabetes, cardiovascular disease, and other inflammatory-driven conditions. (dimensionsofdentalhygiene.com)
- Exosomes have previously been associated with a number of endocrine disorders, including obesity, type 2 diabetes mellitus, disorders of the reproductive system and cancer. (spandidos-publications.com)
- Complications include cardiovascular disorders (particularly in people with excess abdominal fat). (merckmanuals.com)
- Acquired or inherited defects associated to environmental factors in any part of this system can lead to metabolic disorders such as the syndrome X which is presently a frequent syndrome in industrialized countries. (erudit.org)
- In addition, if necessary, specific treatment of the metabolic disorders is required. (erudit.org)
- A metabolic syndrome is a group of interrelated common clinical disorders. (naturalayurvedictreatment.com)
- The symptoms of metabolic disorders vary widely depending upon the metabolic problem present. (naturalayurvedictreatment.com)
MetS4
- Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. (biomedcentral.com)
- Explain the relationship between metabolic syndrome (MetS) and periodontal disease, and a potential assessment tool for MetS risk. (dimensionsofdentalhygiene.com)
- Background: Worldwide, the prevalence of the metabolic syndrome (MetS) is estimated to be 70% among those with type 2 diabetes mellitus (T2DM). (researcher.life)
- When all three criteria were entered for multivariate risk analysis, only the NCEP ATP III (+) was found to be associated independently with raised all three liver enzymes.Conclusion: Central obesity and MetS following NCEPATP III criteria were independently associated with elevated ALT, AST and GGT in our diabetic population. (researcher.life)
ABSTRACT3
- ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)
- From the abstract: ' In this Review, we discuss advances in the genetics of obesity from the past decade-with emphasis on developments from the past 5 years-with a focus on metabolic consequences, and their potential implications for precision management of the disease. (cdc.gov)
- From the abstract: 'The greatest change in the treatment of people living with type 1 diabetes in the last decade has been the explosion of technology assisting in all aspects of diabetes therapy, from glucose monitoring to insulin delivery and decision making. (cdc.gov)
Obese14
- The obesity epidemic has resulted in more overweight/obese women before and during pregnancy. (karger.com)
- The current obesity epidemic has resulted in an increasing number of overweight and obese women entering pregnancy [ 1 ]. (karger.com)
- 38 In a multicentered, randomized controlled trial that studied the effects of periodontal treatment on secondary prevention of cardiovascular disease, Offenbacher et al 39 demonstrated that obesity may exert such a dominant influence that when obese individuals undergo periodontal therapy, its presence may nullify the effects of periodontal treatment on high-sensitivity C-reactive protein (hs-CRP), a sensitive marker of systemic inflammation. (dimensionsofdentalhygiene.com)
- Immunohistochemical Analysis of Intestinal and Central Nervous System Morphology in an Obese Animal Model (Danio rerio) Treated with 3,5-T2: A Possible Farm Management Practice? (ac.ir)
- These results indicate for the first time that KYN and indole TRP metabolic pathways are concomitantly altered in obese subjects and highlight their respective associations with obesity-related systemic inflammation. (frontiersin.org)
- Alterations in TRP metabolism in obese subjects may also arise from the gut microbiota, which has been shown to be disrupted both at compositional and functional levels in obesity ( 20 - 22 ). (frontiersin.org)
- Thus, reports based on the survey-specific BMI percentiles would always designate 5 percent of children as obese and would fail to detect any true increasing prevalence of obesity across surveys. (nationalacademies.org)
- Malaysia has the highest rate of obesity among Asian countries, with 64% of male and 65% of female population being either obese or overweight 2 . (optixanthin.com)
- The World Health Organisation (WHO) describes obesity as something that has "reached epidemic proportions globally" and currently states the fact that there are more than 1 billion overweight adults and 300 million obese people worldwide. (bodybuilding.com)
- His father was obese and had type I diabetes mellitus. (endocrine-abstracts.org)
- Obesity is the most prevalent nutritional disease in public health in children and adolescents in the United States, with approximately 21-24% of children being overweight and another 16-18% being obese, and the prevalence is higher among specific ethnic groups. (bvsalud.org)
- Obese children are at risk for developing numerous obesity-related conditions and medical problems during childhood ( Table 3 ). (txpeds.org)
- Included in the list of obesity-related conditions are the psychological and social effects on overweight and obese children. (txpeds.org)
- The researchers suggested based on data that dislocations were an uncommon complication, but were clearly associated with overweight and obese patients, worse health, and increased liner size (the part of the prosthetic was large). (caringmedical.com)
Adiposity5
- The key sign of metabolic syndrome is central obesity, also known as visceral, male-pattern or apple-shaped adiposity. (wikipedia.org)
- Rather than total adiposity, the core clinical component of the syndrome is visceral and/or ectopic fat (i.e., fat in organs not designed for fat storage) whereas the principal metabolic abnormality is insulin resistance. (wikipedia.org)
- Central obesity is a key feature of the syndrome, as both a sign and a cause, in that the increasing adiposity often reflected in high waist circumference may both result from and contribute to insulin resistance. (wikipedia.org)
- The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
- Brown and Scherer critically review the evidence linking adiposity with 13 types of cancer, discussing several possible mechanisms for the connection. (tomwademd.net)
Endocrine5
- Simple measures of gestational weight gain provide insufficient detail of the underlying physiological and metabolic adaptations occurring in pregnancy, and should be complemented by measures of body composition, metabolic and endocrine responses. (karger.com)
- However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
- Today I link to the web page, An Endocrine Society Thematic Issue: Obesity 2023 . (tomwademd.net)
- In Endocrine Reviews , Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. (tomwademd.net)
- Endocrine etiologies for obesity are rare and usually are accompanied by attenuated growth patterns. (medscape.com)
Overweight and obesity7
- Retinal vascular changes may become evident as an early complication of overweight and obesity, even during childhood and adolescence. (biomedcentral.com)
- In the last three decades, overweight and obesity have become a relevant health issue for a significant proportion of children and adolescents. (biomedcentral.com)
- A notable feature of the global obesity epidemic is the appearance of overweight and obesity in childhood and early adulthood. (nature.com)
- We calculated the racial/ethnic-specific percentages of gestational diabetes mellitus (GDM) attributable to overweight and obesity. (cdc.gov)
- Using logistic regression, we estimated the magnitude of the association between prepregnancy body mass index and GDM and calculated the percentages of GDM attributable to overweight and obesity overall and by race/ethnicity. (cdc.gov)
- The adjusted percentages of GDM deliveries attributable to overweight and obesity were 17.8% among Asians/Pacific Islander, 41.2% among White, 44.2% among Hispanic, 51.2% among Black, and 57.8% among American Indian women. (cdc.gov)
- Elevated prepregnancy body mass index contributed to GDM in all racial/ethnic groups, which suggests that decreasing overweight and obesity among women of reproductive age could reduce GDM, associated delivery complications, and future risk of diabetes in both the mother and offspring. (cdc.gov)
Glucose9
- Other signs of metabolic syndrome include high blood pressure, decreased fasting serum HDL cholesterol, elevated fasting serum triglyceride level, impaired fasting glucose, insulin resistance, or prediabetes. (wikipedia.org)
- The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. (medscape.com)
- failure of the signals or of the B cells to adapt adequately in relation to insulin sensitivity results in inappropriate insulin levels, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes. (medscape.com)
- serum fasting glucose starting from 5.5 mmol/l or Diabetes Mellitus of Type II, diagnosed earlier. (lomr.org)
- In short, clinical studies revealed that natural astaxanthin helps manage blood glucose levels and lowers risks of diabetes-related complication after 6 to 12 weeks of consumption. (optixanthin.com)
- In addition, there is evidence that fatty acids interfere with very early stages of Glucose Transporter Type 4 (GLUT4) and hexokinase II activity [8]. (heraldopenaccess.us)
- Now you see why central obesity is regarded as one of the highest risk factors for diabetes as it is a disease related to insulin and glucose function. (bodybuilding.com)
- Since diabetes is associated with cardiovascular and kidney complications, we investigated the influence of SBE on blood glucose, blood pressure and renal function in some experimental animal paradigms. (endocrine-abstracts.org)
- Though select diabetes guidelines suggest the use of continuous glucose monitoring on patients with diabetic patients on intensive therapy, the potential benefits on type 2 patients without insulin and pre-diabetes patients has yet to be fully explored. (hcplive.com)
Diabetic3
- Assessment of metabolic syndrome was done by International Diabetic Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. (biomedcentral.com)
- Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
- Less than a generation ago, type 2 DM was seen almost strictly as an adult disease, with less than 2% of new diabetic cases in children diagnosed as type 2 DM. (txpeds.org)
Comorbidities2
- Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. (mdpi.com)
- screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
Adolescents8
- Obesity in Adolescents Obesity is now twice as common among adolescents than it was 30 years ago and is one of the most common reasons for visits to adolescent clinics. (msdmanuals.com)
- The screening for retinopathy should be proposed to all children and adolescents with overweight/obesity. (biomedcentral.com)
- A cohort of children and adolescents with overweight or obesity underwent clinical and metabolic assessment and fundus oculi examination, in order to identify clinical and hormonal risk factors for early retinopathy. (biomedcentral.com)
- A single-centre cross-sectional study was performed on a cohort of consecutive Caucasian Italian children and adolescents with overweight (BMI between + 1.75 and + 2 SDS) or obesity (BMI ≥ + 2 SDS). (biomedcentral.com)
- A systematic review done among the young in 2020 showed that globally, about 3% of children and 5% of adolescents had Metabolic Syndrome , with some variation across countries and regions. (lowcarbneurologist.com)
- In this CPR, we discuss the management of obesity and metabolic syndrome (O&MS) in children and adolescents with CKD stages 2-5 and on dialysis, as well as after kidney transplantation, focusing on non-pharmacological treatment (diet, physical activity and behavior modification). (springer.com)
- Pediatric obesity remains an ongoing serious international health concern affecting ~17% of US children and adolescents, threatening their adult health and longevity. (medscape.com)
- Adolescents undergoing lifestyle therapy, medication regimens, or bariatric surgery for obesity will need cohesive planning to help them effectively transition to adult care, with continued necessary monitoring, support, and intervention. (medscape.com)
Assessment4
- There is a strong rationale for implementing a risk assessment model that considers patients' cumulative inflammatory burden, which may be amplified by obesity and chronic infection from periodontal disease. (dimensionsofdentalhygiene.com)
- Baseline assessment and screening will also help identify central problems that can prove useful in recognizing your client's limitations. (acefitness.org)
- If you have, then the following clinical vignette and discussion should prove to be a useful stimulus for learning more about obesity, its assessment, and its treatment. (psychiatrist.com)
- To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity. (medscape.com)
Waist2
- Two common methods to assess the degree of obesity are measuring waist circumference, a surrogate for abdominal fat, and calculating the body mass index (BMI). (psychiatrist.com)
- Obesity involved in this is central obesity ( fat over the abdomen and waist). (naturalayurvedictreatment.com)
Genetic9
- The mechanisms responsible for insulin resistance syndromes include genetic or primary target cell defects, autoantibodies to insulin, and accelerated insulin degradation. (medscape.com)
- Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
- Metabolic syndrome (MS) is a complex disease caused by a combination of genetic factors with a person's life-style (nutrition characterized by a high content of carbohydrates, hypodynamia and hypokinesia, alcohol, smoking, mental and physical strain). (lomr.org)
- This article discusses an overview of the risk factors, cellular and genetic levels of the process, immune response, complications, and treatment of NASH. (nursingcenter.com)
- Evidence from genome-wide association studies highlight the importance of genetic and epigenetic factors in the development of obesity and how they in turn affect the transcriptome, metabolites, microbiomes, and proteomes. (springermedizin.at)
- Obesity is commonly characterized as the accumulation of body fat that results when energy intake exceeds energy expenditure, although individuals respond differently to this imbalance due to genetic predisposition. (springermedizin.at)
- Pediatric obesity has its basis in genetic susceptibilities influenced by a permissive environment starting in utero and extending through childhood and adolescence. (medscape.com)
- Genetic screening for rare syndromes is indicated only in the presence of specific historical or physical features. (medscape.com)
- Despite a significant increase in research on pediatric obesity since the initial publication of these guidelines 8 years ago, further study is needed of the genetic and biological factors that increase the risk of weight gain and influence the response to therapeutic interventions. (medscape.com)
Glycemic control1
- Given the involvement of melanocortin pathways in regulating blood pressure, obesity, and glycemic control, the proposed research has the potential to guide the development of novel and effective therapies devoid of side effects that improve both the quality of life and overall health of these patients. (grantome.com)
Severe5
- In moderate-to-severe obstructive sleep apnoea/hypopnoea syndrome, treatment with continuous positive airway pressure has been shown to be effective. (ersjournals.com)
- Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
- Ms A, a 49-year-old woman with a history of severe obesity, bipolar disorder, anxiety, and multiple medical problems, was admitted to the hospital with severe anasarca and a chronic pleural effusion. (psychiatrist.com)
- Another apparent challenge is the traditionally simplistic calculation of severe obesity. (springermedizin.at)
- The importance of clinically identifying children with severe obesity is increasing, as these children are at particularly high risk for medical and probably psychological complications and may need to be specifically targeted for treatment. (txpeds.org)
Adipose tissue6
- The pathogenic role played in the syndrome by the excessive expansion of adipose tissue occurring under sustained overeating, and its resulting lipotoxicity was reviewed by Vidal-Puig. (wikipedia.org)
- Systemic inflammation in obesity originates primarily from the adipose tissue, in which adipocytes and infiltrated immune cells accumulate and secrete inflammatory factors ( 2 - 5 ). (frontiersin.org)
- report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue. (tomwademd.net)
- In JCEM , Kalavalapalli and associates report that the insulin resistance of adipose tissue predicts the severity of liver fibrosis in patients with type 2 diabetes and non-alcoholic fatty liver disease. (tomwademd.net)
- CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). (endocrine-abstracts.org)
- Its pathophysiology is likely to involve insulin resistance at the level of both skeletal muscle and visceral adipose tissue and altered fluxes of metabolic substrates between these tissues that in turn impair liver metabolism. (erudit.org)
Diseases17
- Metabolic syndrome can lead to several serious and chronic complications, including type-2 diabetes, cardiovascular diseases, stroke, kidney disease and nonalcoholic fatty liver disease. (wikipedia.org)
- This is especially true of patients who may be at high risk for additional complications, e.g. those with metabolic syndrome, diabetes, or cardiac, cerebrovascular or other neurological diseases. (ersjournals.com)
- These syndromes may also be associated with immunological diseases and may exhibit distinct phenotypic characteristics. (medscape.com)
- Introduction of primary prophylaxis in those people to limit the development of diabetes mellitus type 2 and cardiovascular diseases should be considered. (hindawi.com)
- Those factors increase the risk of developing cardiovascular diseases of atherosclerotic etiology and diabetes mellitus type 2 [ 1 , 5 - 9 ], which are the main cause of premature deaths among most of the European and US population [ 10 ]. (hindawi.com)
- A three-point scale was used to assess the manifestation degree of a disease being the part of metabolic syndrome ( DM-II, hypertony, atherosclerosis, obesity, concomitant diseases). (lomr.org)
- Discuss the prevalence of obesity and risk of inflammatory-driven diseases, including comorbid conditions and periodontitis. (dimensionsofdentalhygiene.com)
- 3,4 Research has provided an understanding of how genetics can modify inflammatory response and the clinical expression of a number of diseases, including coronary artery disease, Alzheimer's disease, and periodontitis. (dimensionsofdentalhygiene.com)
- Monogenic forms of metabolic diseases could be misdiagnosed and should be suspected in families with several affected members and early-onset metabolic phenotypes that are difficult to control. (biomedcentral.com)
- However, families with rare monogenic forms of metabolic diseases could be misdiagnosed or even overlooked if causative variants are not directly explored, especially in populations with a high prevalence of these entities. (biomedcentral.com)
- These conditions are normally caused by central obesity and physical inactivity, which further increases the risk of cardiovascular diseases (CVD), particularly heart failure. (optixanthin.com)
- Integrating multi-omics approaches will enable a paradigm shift from the one size fits all approach towards precision obesity management, i.e. (1) precision prevention of the onset of obesity, (2) precision medicine and tailored treatment of obesity, and (3) precision risk reduction and prevention of secondary diseases related to obesity. (springermedizin.at)
- The Pediatric Renal Nutrition Taskforce (PRNT) is an international team of pediatric renal dietitians and pediatric nephrologists who develop clinical practice recommendations (CPRs) for the nutritional management of children with kidney diseases. (springer.com)
- Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
- In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
- It was evidenced the importance of research in the investigation of better ways to obtain the public health of a given community, bringing discussion of themes that involve aspects of human growth and development such as nutritional aspects, sexuality, motor development, covering situations and diseases as obesity, cerebral palsy, dyslexia and violence. (bvsalud.org)
- Metabolic syndrome is a collection of heart diseases causing factors that increase the chance of getting Heart disease, Stroke, and Type 2 Diabetes. (naturalayurvedictreatment.com)
Incidence3
- Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease. (biomedcentral.com)
- In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. (frontiersin.org)
- Introduction: Pulmonary embolism is one of the complications of COVID-19, with reported incidence ranging from 3 to 33 % in non-ICU patients to as high as 40% among ICU patients. (bvsalud.org)
Increases with age2
- The number of patients with metabolic syndrome increases with age. (hindawi.com)
- T2D increases with age and is associated with multiple organ complications. (biomedcentral.com)
T2DM1
- Clinicians may consider hepatic complication as a negligible component in T2DM. (researcher.life)
Childhood obesity6
- Childhood obesity has been correlated with coronary heart disease, but the correlation with microvascular disease remains unclear. (biomedcentral.com)
- 2000) (see Chapter 3 for a more extensive discussion about the use of terms for childhood overweight and childhood obesity). (nationalacademies.org)
- This characterization clearly appears to apply to childhood obesity. (nationalacademies.org)
- Intervention and prevention of childhood obesity should begin as early in life as possible. (txpeds.org)
- Early intervention is critical for the prevention of childhood obesity. (txpeds.org)
- Additionally, childhood obesity may be an independent risk factor for adult morbidity and mortality, regardless of the persistence of childhood obesity ( 2 ). (txpeds.org)
Atherosclerosis1
- The retinal microcirculation is affected early in the process of atherosclerosis and it offers the opportunity to indirectly study the effects of obesity on small brain vessels. (biomedcentral.com)
Components of metabolic syndrome1
- Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
Contribute to metabolic syndrome1
- citation needed] Recent research indicates prolonged chronic stress can contribute to metabolic syndrome by disrupting the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). (wikipedia.org)
Postoperative complications2
- In this paper 21.6% of patients followed post-surgery (8 out of 37 patients) required a second surgery for postoperative complications. (caringmedical.com)
- Overall, 54% of patients (20 out of 37) suffered from intra- or postoperative complications. (caringmedical.com)
Prevalence of obesity1
- Because direct measures of body fat are neither feasible nor available for nationwide assessments of the prevalence of obesity, the National Health and Nutrition Examination Surveys (NHANES), 1 conducted by the National Center for Health Statistics, have been using body mass index (BMI) as a surrogate measure for body fatness. (nationalacademies.org)
Dysmetabolic2
- Other names given to this condition include insulin resistance syndrome, dysmetabolic syndrome, and Syndrome X. According to a US national health survey (NHANES 1988-2012), more than 1 in 5 Americans have Metabolic Syndrome. (lowcarbneurologist.com)
- This syndrome is also known as Syndrome X, Insulin resistance syndrome, and Dysmetabolic syndrome. (naturalayurvedictreatment.com)
Dysfunction3
- [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
- Erectile dysfunction (ED) is a frequent complication of type 2 diabetes that impairs quality of life for up to 75% of men with diabetes. (grantome.com)
- This syndrome involves anovulation or ovulatory dysfunction and androgen excess of unclear etiology. (merckmanuals.com)
Precision obesity management2
- The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management. (springermedizin.at)
- Finally, we propose a vision for the future of precision obesity management. (cdc.gov)
Insulin resistan1
- In clinical practice, no single laboratory test is used to diagnose insulin resistance syndrome. (medscape.com)
Patients18
- Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
- Lifestyle intervention can effectively alleviate the pathological manifestations of abnormal reproduction and metabolism in patients with PCOS, and dietary intervention may also exert important effects on the prevention and control of PCOS and its complications ( 11 , 12 ). (frontiersin.org)
- We carried out a cross-sectional study of 195 patients with metabolic syndrome. (who.int)
- Nous avons mené une étude transversale sur 195 patients atteints du syndrome métabolique. (who.int)
- In most patients, the presentation of obesity is straightforward, with the patient indicating problems with weight or repeated failure in achieving sustained weight loss. (medscape.com)
- In the clinical examination, measure anthropometric parameters and perform the standard, detailed examination required in evaluating patients with any chronic, multisystem disorder, such as obesity. (medscape.com)
- A subset of these patients has concurrent symptoms of excessive daytime sleepiness attributable to their nocturnal breathing disorder and is classified as having obstructive sleep apnoea/hypopnoea syndrome (4-5% of the middle-aged population). (ersjournals.com)
- Numerous reports throughout the 19th century and the early part of the 20th century AD gave way to systematically conducted studies on patients with OSAHS and related syndromes 1 . (ersjournals.com)
- The study group consisted of 839 patients with diagnosed metabolic syndrome: 345 men (41.1%) and 494 women (58.9%) aged 32-80. (hindawi.com)
- The aim of the work is to study biochemical characteristics in the blood of patients with metabolic syndrome under the influence of ozone in low doses and to comparу the results in parallel groups. (lomr.org)
- This system allows to make a clinical evaluation of examined patients in accordance with the accepted classifications taking into consideration the stage of the disease being the part of metabolic syndrome complex. (lomr.org)
- The examined group consisted of 111 patients, average age being 50 - 70, with different nosologic forms of metabolic syndrome manifestations. (lomr.org)
- We have examined 90 subjects, classified into three groups, with 30 patients each: those with type 1 diabetes, type 2 diabetes and control group of healthy subjects. (pharmaceuticalintelligence.com)
- Patients having complications due to avarana should be treated with Anabhishyandi (unctuous), Snigdha, vaatanuloman, and Kapha Pitta avirudha drugs. (naturalayurvedictreatment.com)
- Patients with type 2 diabetes treated with triple therapy had less hepatic steatosis and fibrosis and significantly improved insulin sensitivity versus conventional therapy. (hcplive.com)
- The paper concluded that shoulder replacement improved function in many patients, but with a high rate of complications and reoperations. (caringmedical.com)
- And apply health equity considerations to clinical care, activity management and reconditioning of long COVID patients. (cdc.gov)
- Today I'll present an overview of post-COVID conditions as an introduction of the main presentation on evaluating and supporting patients with cardiovascular symptoms and complications following COVID-19. (cdc.gov)
Risk factor6
- Over the past decade, mounting evidence suggests obesity is also a risk factor for periodontal disease, 28-37 independent of other factors, such as age, gender, race, and ethnicity. (dimensionsofdentalhygiene.com)
- Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. (biomedcentral.com)
- Obesity is a prominent risk factor for Non-insulin Dependent Diabetes Mellitus, (NIDDM), which is also called diabetes mellitus type II. (heraldopenaccess.us)
- Central obesity means that you store fat around the abdomen, and it is "the most relevant risk factor" for metabolic syndrome (3). (bodybuilding.com)
- With obesity being a major risk factor for type 2 DM, pediatric care providers must now view type 2 DM as a pediatric illness ( 3 ). (txpeds.org)
- Complications from shoulder replacement surgery are a risk factor of the surgery. (caringmedical.com)
Pathways3
- The mechanisms of the complex pathways of metabolic syndrome are under investigation. (wikipedia.org)
- HsIL-6 and hsCRP were increased in obesity and were overall associated with TRP metabolic pathways alterations. (frontiersin.org)
- In the second aim, the applicants will then determine whether reactivating hypothalamic leptin and insulin pathways restores normal sexual function and offers a potential treatment strategy in cases of central insulin and leptin resistance caused by diet-induced obesity. (grantome.com)
Symptoms7
- Early diagnostic strategies and medical interventions, even before symptoms or complications appear, could be useful. (biomedcentral.com)
- The identification of carriers of pathogenic variants in genes such as DYRK1B could be useful for establishing early diagnostic strategies and medical interventions in a reasonable number of affected individuals even before symptoms or complications appear. (biomedcentral.com)
- There are usually no immediate physical symptoms in metabolic syndrome. (lowcarbneurologist.com)
- However, medical problems associated with the insulin resistance of this syndrome and its corresponding complications may develop over time and themselves present with clinical symptoms. (lowcarbneurologist.com)
- In this article, we will delve into the different types of sleep apnea, their symptoms, causes, and available treatment options. (drjcsuri.com)
- Describe cardiovascular symptoms and complications associated with post-COVID conditions. (cdc.gov)
- Determine which clinical assessments and tests are needed for a patient with cardiovascular symptoms. (cdc.gov)
Cardiovascular risk factors1
- On the contrary, the correlations between obesity, cardiovascular risk factors and early signs of microvascular disease in children remain to be elucidated. (biomedcentral.com)
Triglycerides1
- Ectopic obesity is defined as the accumulation of triglycerides in non-adipose tissues [6]. (heraldopenaccess.us)
Acanthosis nigricans1
- Clinical features of insulin resistance involve skin changes (Acanthosis nigricans). (naturalayurvedictreatment.com)
Prevention4
- When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity. (springermedizin.at)
- Secondly, even those public health initiatives that are directed towards obesity prevention and management show little evidence of success and efficacy at the population level. (springermedizin.at)
- The prevention of pediatric obesity by promoting healthful diet, activity, and environment should be a primary goal, as achieving effective, long-lasting results with lifestyle modification once obesity occurs is difficult. (medscape.com)
- Future research should include trials commencing preconception and provide results disaggregated by a priori defined participant characteristics including social and environmental factors, clinical traits, and other novel risk factors to predict GDM prevention through interventions. (cdc.gov)
Outcomes2
- Dr. Green discusses the potential of combination therapy to reduce cardiovascular and kidney outcomes in people with type 2 diabetes. (hcplive.com)
- They do note: "Revision of anatomical to reverse arthroplasty shows better clinical outcomes and lower complication rates than anatomical revision. (caringmedical.com)
Disorder characterized2
- Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
- Obesity is a metabolic disorder characterized by a chronic low-grade inflammatory state, as reflected in increased levels of circulating inflammatory markers, including pro-inflammatory cytokines and the acute phase protein C-reactive protein (CRP) ( 1 - 4 ). (frontiersin.org)
Chronic disease3
- Despite professional society guidelines recommending that obesity be treated as a chronic disease by emphasizing the use of lifestyle modification in conjunction with pharmacotherapy, antiobesity medications are uncommonly prescribed in most clinical practices. (tomwademd.net)
- Type 2 diabetes mellitus is a common chronic disease which develops insidiously over time, and is associated with obesity, nutritional imbalance (high fructose beverages, high starch and processed foods, carbohydrate excess intake, and an imbalance of proinflammatory to anti-inflammatory polyunsaturated fatty acids), which makes it an acquired and manageable disease. (pharmaceuticalintelligence.com)
- Obesity is a multifactorial chronic disease that cannot be addressed by simply promoting better diets and more physical activity. (springermedizin.at)
Affects1
- Obesity and metabolic syndrome (O&MS) due to the worldwide obesity epidemic affects children at all stages of chronic kidney disease (CKD) including dialysis and after kidney transplantation. (springer.com)
1970s2
- In 2000, obesity was two to three times more common in children and youth than in a reference period in the early 1970s. (nationalacademies.org)
- Before the development of purified insulin in the 1970s, lipoatrophy was a common complication of insulin therapy (1 2). (endocrine-abstracts.org)
20222
- 2. The State of Obesity 2022 . (msdmanuals.com)
- Read our special collection of journal articles, published in 2022-2023, focused on obesity! (tomwademd.net)
Prediabetes2
- Insulin resistance, metabolic syndrome, and prediabetes are closely related to one another and have overlapping aspects. (wikipedia.org)
- Under the first aim, novel cell type-specific tools will be used to allow acute neuronal manipulation to examine the role of POMC-specific insulin and leptin resistance in ED in a unique mouse model of prediabetes. (grantome.com)
People with obesity1
- A survey of people with obesity in the US shows that 35% of men and 40.4% of women are suffering from obesity [2]. (heraldopenaccess.us)
Development of obesity1
- There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
Suggests2
- Work on the United Kingdom population-based Cognitive Function and Ageing Study (CFAS) neuropathology cohort suggests that up to a third of AD cases are attributable to modifiable risk factors, including T2D/MS and midlife obesity, with attributable risks for AD in the United Kingdom of 1.9% and 6.6%, respectively [ 43 ]. (biomedcentral.com)
- Mongraw-Chaffin and coauthors find a strong graded association of body mass index and diabetes with self-reported COVID-19 that suggests obesity and diabetes might play a role in risk for symptomatic SARS-CoV-2 infection, beyond their co-occurrence with socioeconomic factors. (tomwademd.net)
Coupled with insulin resistance1
- They come together as a symbiotic relationship, such as obesity coupled with insulin resistance, and with these come HTN and hyperlipidemia. (nursingcenter.com)