AnatomyDiseasesChemicals and Drugs
CarbimazoleAntithyroid AgentsThyrotoxicosisHyperthyroidismGraves DiseaseMethimazolePropylthiouracilThyroxineErythema NodosumThyroid Gland
MethimazoleHyperthyroidismGravesPropylthiouracilThyrotoxicosisAgranulocytosisAntithyroid drugsThyroidectomyPropranololPatient'sHypothyroidismDiagnosisAnti-thyroidRadioiodine treatmentPharmacologySensitivitySymptomsTreatmentThyroxineEndocrinologyAssessmentPresentationPatientPracticeDosesFindingsTherapyAcuteOccursExaminationPregnancyComplicationsThyrotropinInvolvesMonths
Methimazole17
  • Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. (wikipedia.org)
  • If doses greater than 30 mg of methimazole are required, switching to propylthiouracil to control hyperthyroidism can be tried (doses up to 450 mg/day while breastfeeding have shown to be safe), or continuing with methimazole but with clinical and analytical monitoring (T4 and TSH) of the infant every 2 weeks at first. (e-lactancia.org)
  • In December 2018, based on the assessment of epidemiological studies and case reports, the European Medicines Agency (EMA) has concluded that there is a strong association of carbimazole or methimazole (also known as thiamazole, the active form of carbimazole) with congenital malformation when administered during pregnancy, particularly at high doses and during the first trimester of pregnancy. (npra.gov.my)
  • EMA requested the product registration holders of carbimazole and methimazole to update the product information to include further advice for women of childbearing potential to use effective contraception during treatment. (npra.gov.my)
  • Recent data demonstrates the association of carbimazole and methimazole with pancreatitis. (npra.gov.my)
  • Based on all available evidence, EMA is requiring all product package inserts of carbimazole and methimazole to be updated with a new contraindication in patients with a history of acute pancreatitis after administration of carbimazole or methimazole. (npra.gov.my)
  • NPRA has received 332 reports with 593 adverse events suspected to be related to carbimazole and four (4) reports with five (5) adverse events with methimazole. (npra.gov.my)
  • Based on available evidence, carbimazole and methimazole may cause congenital malformations when administered during pregnancy, particularly in the first trimester of pregnancy and at high doses. (npra.gov.my)
  • Careful benefit/risk assessment should be carried out prior to treatment with carbimazole or methimazole during pregnancy. (npra.gov.my)
  • If a patient develops acute pancreatitis after the administration of carbimazole or methimazole, these drugs should be discontinued immediately. (npra.gov.my)
  • Report any adverse drug reactions related to carbimazole or methimazole to NPRA. (npra.gov.my)
  • Longhofer S, Martin-Jimenez T, Soni-Gupta J: Serum concentrations of methimazole in cats after a single oral dose of controlled-release carbimazole or sugar-coated methimazole (thiamazole), Vet Ther 11:E1, 2010. (everycat.org)
  • Carbimazole is rapidly metabolized to methimazole in vivo. (everycat.org)
  • This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. (everycat.org)
  • Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. (everycat.org)
  • The administration of antithyroid drugs such as carbimazole and methimazole is extremely effective. (differencebetween.com)
  • Do not use in cats with hypersensitivity to methimazole, carbimazole or the excipient, polyethylene glycol. (petsupplies4less.com)
Hyperthyroidism11
  • Carbimazole (brand names Neo-Mercazole, Anti-Thyrox, etc.) is used to treat hyperthyroidism. (wikipedia.org)
  • Be wary of diagnosing hyperthyroidism on the basis of a T4 determination in the absence of supportive clinical findings. (vin.com)
  • The clinical picture of hyperthyroidism can be correlated with diabetes, kidney failure, inflammatory bowel disease etc. (thefastreport.com)
  • Carbimazole is an antithyroid agent commonly used in clinical practice by dr to treat patients with hyperthyroidism and thyrotoxicosis symptoms. (ezhmag.com)
  • Ophthalmopathy may also occur before the onset of hyperthyroidism or as late as 20 years afterward and frequently worsens or abates independently of the clinical course of hyperthyroidism. (msdmanuals.com)
  • Although the diagnosis of Graves disease is generally easy, based on the clinical triad: hyperthyroidism, goitre, exophthalmosand confirmed by the positivity of anti-TSH receptor antibodies, the thyroid tuberculosis remains difficult outside of guidance by Clinical or biological factors (TB disease, history of tuberculosis, cutaneous fistula on clinical examination, fever, inflammatory syndrome). (juniperpublishers.com)
  • Frenais R, Rosenberg D, Burgaud S et al: Clinical efficacy and safety of a once-daily formulation of carbimazole in cats with hyperthyroidism, J Small Anim Pract 50:510, 2009. (everycat.org)
  • Hypothyroidism and hyperthyroidism are commonly encountered in clinical practice. (racgp.org.au)
  • His thyroid function tests were still consistent with hyperthyroidism while he had been receiving carbimazole 40 mg/d for 6 weeks. (medscape.com)
  • On clinical evaluation cats with hyperthyroidism and chronic kidney disease may have a poor hair coat, skin tent, generalized muscle wasting, tacky mucous membranes, tachycardia, a heart murmur, hypertension, and weakness. (dvm360.com)
  • The diagnosis of hyperthyroidism is typically made based on the historical, physical and clinical findings mentioned previously in addition to evaluation of serum total thyroxine (TT4) levels. (dvm360.com)
Graves5
  • Clinical assessment showed no stigmata of Graves disease, but nodularity of the thyroid gland was noted. (cmaj.ca)
  • On examination, the patient had no clinical features of Graves disease. (cmaj.ca)
  • I have been diagnosed with Graves Disease and have been on 30mg Carbimazole a day, for about two weeks. (patient.info)
  • RÉSUMÉ La première description des pathologies thyroïdiennes, telles qu'on les connaît aujourd'hui, a été celle de la maladie de Graves par Caleb Parry en 1786, mais la pathogenèse de l'affection thyroïdienne n'a pas été découverte avant 1882-1886. (who.int)
  • We are reporting this case since the clinical association of Graves' disease in GS has never been reported before and is a rare association of the syndrome. (iap-kpj.org)
Propylthiouracil1
Thyrotoxicosis2
Agranulocytosis1
  • 4] F. Joseph, N. Younis and D. Bowen Jones: "Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor", Int. J. Clin. (edu.pl)
Antithyroid drugs1
Thyroidectomy1
  • After a curative subtotal thyroidectomy and discontinuation of the carbimazole, the patient's white cell count remained normal. (edu.pl)
Propranolol2
Patient's1
  • Carbimazole was restarted and the patient's symptoms improved rapidly. (cmaj.ca)
Hypothyroidism2
  • We describe the clinical case of two childbearing age women with thyroid dysfunction, hypocalcemia, hyperphosphatemia, and high levels of PTH.Case 1: A 34-year-old woman with infertility for 3 years, microprolactinoma treated with low-dose dopamine agonists, autoimmune primary hypothyroidism and obesity. (endocrine-abstracts.org)
  • The exact prevalence of primary hypothyroidism in Australia is unknown, but it is probably similar to that found in the USA, where hypothyroidism has been documented in 4.6% of the population, with 0.3% being clinical and 4.3% being subclinical. (racgp.org.au)
Diagnosis5
  • A clinical diagnosis of toxic multinodular goitre was made. (cmaj.ca)
  • Diagnosis is clinical and with thyroid function tests. (msdmanuals.com)
  • The diagnosis is made by a combination of clinical features and detection of thyroid autoantibodies. (brainkart.com)
  • the well-informed clinician keeps the diagnosis in mind, and if the initial thyroid hormone tests are not definitive, employs additional tests that are cost-effective in the individual clinical situation. (curehunter.com)
  • Zaider E, Bickers DR. Clinical laboratory methods for diagnosis of the porphyrias. (medscape.com)
Anti-thyroid1
  • The onset of anti-thyroid effect is rapid but the onset of clinical effects on thyroid hormone levels in the blood is much slower. (wikipedia.org)
Radioiodine treatment1
  • Carbimazole was stopped 2 weeks after radioiodine treatment. (cmaj.ca)
Pharmacology1
  • This assessment task is designed to help you develop the application of your pathophysiology and pharmacology knowledge to assessment and clinical decision making skills so that you may apply these to your professional role. (excellentassignmenthelp.com)
Sensitivity1
Symptoms2
  • Now off thyroxine and just on Carbimazole, symptoms have also included weight gain but I'm sure that will get back to normal when I'm sorted. (patient.info)
  • In addition to these symptoms, the patient can have the following clinical features because of the increased thyroid hormone levels. (differencebetween.com)
Treatment7
  • Treatment with carbimazole was started and the patient soon became euthyroïd. (pediatriconcall.com)
  • TSH measurements were repeated 14-28 days after starting treatment with carbimazole (11 cats) or radioactive iodine (11 cats). (avmi.net)
  • He/she can suggest you the best treatment plan according to the current clinical presentation of your cat. (thefastreport.com)
  • With this situation, the patient was put on medical treatment with carbimazole 40mg/d and propanolol 80mg/d. (juniperpublishers.com)
  • Brown-Séquard the clinical features of thyroid disease since demonstrated that in animals death from the dawn of the 20th century, the methods adrenalectomy could be delayed by infu- of investigation and treatment advanced sion of blood from healthy animals. (who.int)
  • Most patients begin treatment with ATDs, and clinical guidelines suggest that the appropriate treatment period is 12 to 18 months. (e-jyms.org)
  • Following 3 weeks of treatment, the dose should be titrated to effect based on individual serum total T4 (TT4) levels and clinical response. (petsupplies4less.com)
Thyroxine2
  • This applied also to athyreotic subjects on thyroxine and to subjects on thyroxine plus carbimazole, suggesting that the mechanism is independent of thyroid tissue, uninfluenced by carbimazole, and probably operates via the peripheral metabolism of T4. (lu.se)
  • Functional thyroid tissue may elaborate increased amounts of thyroxine (T4) and T3, producing clinical signs including a loud and fast heart, a prominent precordial impulse, a strong pulse, weight loss with good appetite, heat intolerance, behavioural changes and polydipsia/polyuria. (vin.com)
Endocrinology1
Assessment1
  • Role of two nutritional hepatic markers (insulin-like growth factor 1 and transthyretin) in the clinical assessment and follow-up of acute intermittent porphyria patients. (medscape.com)
Presentation1
  • Because of significant overlap in the clinical presentation it can be difficult to differentiate between the two. (dvm360.com)
Patient5
  • Carbimazole was stopped 6 months later, and the patient remained well with normal thyroid indices. (cmaj.ca)
  • Clinical examination revealed a severely ill patient, a silent abdomen which was distended with painful percussion and palpation of the epigastrium. (endocrine-abstracts.org)
  • Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. (endocrine-abstracts.org)
  • For each patient and visit, both a TRAb and TSI were performed, and a clinical activity score (CAS) recorded. (ekjo.org)
  • For aminoglycoside and courses with patients to address and will increasingly enable clinical trials to comment robert lakin nice piece, but our patient engagement strategy includes interviews with low income plays pay out. (dtbfirmware.com)
Practice1
  • We are looking at information informing current clinical practice and your choice of references must reflect this. (excellentassignmenthelp.com)
Doses2
  • Given that a small, but detectable, amount of both PTU and MMI are transferred into breast milk, the lowest effective doses of MMI/CM (carbimazole) or PTU should always be administered. (medscape.com)
  • She received four doses of filgrastim (Granulocyte-colony stimulating factor) which maintained the neutrophil count within a reasonable level while she continued to receive carbimazole to prepare her for surgery. (edu.pl)
Findings1
  • This case should encourage physicians to ask their patients about possible biotin intake, especially when laboratory results are not compatible with clinical findings. (medscape.com)
Therapy4
  • Even after stopping carbimazole, this took a while to settle and eventually I found Borage therapy cream which helped immensely however I feel as though the medication triggered something that very faintly still simmers. (patient.info)
  • Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy. (pneumotox.com)
  • Carbimazole should always be discontinued if neutropenia occurs but this case demonstrates that in exceptional circumstances filgrastim can be an effective therapy while continuing carbimazole in the short term. (edu.pl)
  • Several clinical factors, such as male sex, young age, high thyrotropin receptor antibody (TRAb) levels, ophthalmopathy, and smoking, have been proposed as indicators of poor prognosis after ATD therapy [ 5 - 8 ]. (e-jyms.org)
Acute1
  • Bylesjo I, Wikberg A, Andersson C. Clinical aspects of acute intermittent porphyria in northern Sweden: A population-based study. (medscape.com)
Occurs1
  • This is because the large store of pre-formed T3 and T4 in the thyroid gland and bound to thyroid binding globulin (99% bound) has to be depleted before any beneficial clinical effect occurs. (wikipedia.org)
Examination2
  • Clinical examination, chest radiography and echocardiography confirmed worsening of congestive cardiac failure. (cmaj.ca)
  • The clinical examination revealed a tachycardia at 120batt/min and the cervical palpation showed a homogeneous goitre characterized by an elastic consistency and a very clear vascular character. (juniperpublishers.com)
Pregnancy2
  • verification needed] Carbimazole should be used judiciously in pregnancy as it crosses the placenta. (wikipedia.org)
  • For the above reasons, it is preferable to use PTU in pregnancy, especially in the first trimester, with the possibility of changing to carbimazole for the second and third trimesters. (wikipedia.org)
Complications1
  • Such intervention was considered heavy iodine load which may exacerbate the hemodynamic and clinical complications of TS. (heartviews.org)
Thyrotropin1
  • To determine the clinical and biochemical relationships between a second-generation thyrotropin receptor-binding inhibition antibody (TRAb) immunoassay, detecting stimulatory and blocking antibodies, with the thyroid stimulating immunoglobulin (TSI) bridging immunoassay detecting the stimulatory component only. (ekjo.org)
Involves1
  • When your child takes part in a clinical trial it usually involves some visits to a hospital clinic, GP surgery or research unit. (healthtalk.org)
Months1