Loading...
  • patients
  • Respiratory failure requiring orotracheal intubation (OTI) and mechanical ventilation (MV) is almost always a fatal complication in patients who undergo hematopoietic progenitor transplantation (HPT). (ebscohost.com)
  • Trials
  • As part of the internationally recognized University of Chicago Comprehensive Cancer Center (UCCCC), we participate in national clinical trials testing new and emerging therapies. (uchospitals.edu)
  • A primary site for early-phase clinical trials, we offer our patients access to more new treatment protocols than any other hospital in the region. (uchospitals.edu)
  • Intracoronary transplantation of peripheral blood- or bone marrow-derived cells, as tested in several recent trials, is associated with moderate increases in left ventricular (LV) ejection fraction (EF) and a small reduction of LV end-systolic volumes. (onlinejacc.org)
  • Many of the early landmark trials demonstrated convincing benefit in terms of clinical end points ( 1-4 ). (onlinejacc.org)
  • In the majority of clinical trials investigating the effects of intracoronary cell transplantation, the primary end point comprises changes in LV volumes and EF in comparison with a control group over time ( 5-7 ). (onlinejacc.org)
  • Table 1 ( 8-20 ) summarizes LV ejection fraction (EF) at baseline and latest available follow-up in the control group and transplantation group in 13 trials of intracoronary transplantation performed in AMI ( 8-20 ). (onlinejacc.org)
  • In 2 trials (n = 126), peripheral blood cells were used for intracoronary infusion and in 8 investigations bone marrow-derived cells were used. (onlinejacc.org)
  • z.o.o. with respect to its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) development work, clinical trials and ultimately, commercialization in the European market. (bio-medicine.org)
  • Pavletic leads a number of clinical trials on chronic GVHD at the National Cancer Institute at NIH. (wikipedia.org)
  • Six articles on a 2005 international consensus project for clinical trials in chronic GVHD were referenced more than 1600 times in peer-reviewed literature. (wikipedia.org)
  • In October 2006 Pavletic received the National Cancer Institute (NCI) Director's Individual Merit Award for his achievements in developing national and international consensus guidelines for clinical trials in chronic GVHD, which enabled research to be conducted on one of the most serious late effect cancer treatment complications in already cured patients. (wikipedia.org)
  • National Cancer Institute Center for Cancer Research - Search CCR Clinical Trials by Selected Physician. (wikipedia.org)
  • https://bethesdatrials.cancer.gov/clinical-trials-search-physician?field_investigator_name_value=Pavletic Scopus search. (wikipedia.org)
  • From 2000-2004 he was Senior Vice-President for Medical Affairs at Antigenics Inc., in New York where he was responsible for design, implementation and analysis of clinical trials of cancer vaccines. (wikipedia.org)
  • His activities include development and execution of clinical trials in blood and bone marrow cancers, transplantation and immune disorders. (wikipedia.org)
  • Her focus in this time was on adaptive clinical trials as a way to make progress through the high-dimensional space of treatment combinations more quickly than by comparing pairs of points in this space one comparison at a time, with each comparison taking five years to make. (wikipedia.org)
  • Transplant Unit
  • He initiated and maintained a successful cooperation with the bone marrow transplant unit of the Fred Hutchinson Cancer Research Center since the early 70s and participated in the design of protocols related to stem cell transplantation for patients with SCID, Wiskott-Aldrich syndrome, Chronic Granulomatous Disease, and X-linked hyper-immunoglobulin M syndrome. (wikipedia.org)
  • transplants
  • From 1980-1997, Gale was Chairman of the Scientific Advisory Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), an organization of more than 400 transplant centers in over 60 countries worldwide working together to analyze and advance knowledge about blood cell and bone marrow transplants. (wikipedia.org)
  • During the 1980s, he conducted some of the first bone marrow transplants in Europe, and also developed precise molecular tests to detect residual leukaemia cells in the blood of patients. (wikipedia.org)
  • therapies
  • While they share common clinical and pathologic manifestations, they have quite different and unique etiologies, presentations, pathogenesis, and therapies [1- (springer.com)
  • disorders
  • They can differentiate into many cell types including bone, fat, and muscle which allow them to treat a large range of disorders. (wikipedia.org)
  • cells
  • 89 Zr-labeled bone marrow cells (2 × 10 7 cells, 16.6 kBq/10 6 cells) were transferred intravenously, and serial microPET images were obtained ( n = 5). (aacrjournals.org)
  • 89 Zr-oxine-labeled bone marrow cells showed delayed proliferation, but differentiated normally. (aacrjournals.org)
  • Mobilization of approximately 0.64% of pretransplanted bone marrow cells induced a 3.8-fold increase of circulating bone marrow cells. (aacrjournals.org)
  • 89 Zr-oxine complex ex vivo cell labeling combined with PET imaging has shown promise as a sensitive method of tracking transferred bone marrow cells. (aacrjournals.org)
  • The donated tissue repopulated the marrow and restored production of the blood cells. (uchospitals.edu)
  • It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. (wikipedia.org)
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • In the following discussion, the effects of intracoronary transplantation of bone marrow- and blood-derived stem cells in AMI on functional and morphometric LV parameters are put into the context of established therapy, such as reperfusion therapy and adjunctive pharmacotherapy. (onlinejacc.org)
  • manifestations
  • The clinical manifestations of central nervous system fungal infections commonly seen in children in clinical practice include a chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome and rarely, a fungal ventriculitis. (springer.com)
  • Clinical manifestations of rickets often appear at this time. (wikipedia.org)
  • correlates
  • Some of the initial studies were accompanied by parallel analyses in which functional and morphometric parameters were used as correlates for clinical end points. (onlinejacc.org)
  • tissue
  • Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, leading to rickets or osteomalacia. (wikipedia.org)
  • Journal
  • In 1982, Eddy published a seminal paper in the New England Journal of Medicine that described the role clinical policies and guidelines play in medical decision-making, noted their importance in determining the quality of care, and advocated explicit analysis of evidence and estimation of outcomes. (wikipedia.org)
  • heterogeneous
  • Clinical symptoms are heterogeneous, ranging from the rapidly fatal, perinatal variant, with profound skeletal hypomineralization and respiratory compromise, to a milder, progressive osteomalacia later in life. (wikipedia.org)
  • Medicine
  • For example, Michael Bishop, MD, director of stem cell transplantation at the University of Chicago Medicine, is a leader of the International Post-Transplant Research Consortium. (uchospitals.edu)
  • Bone Marrow Transplantation is abstracted and indexed in BIOBASE/Current Awareness in Biological Sciences, BIOSIS, Current Contents/Clinical Medicine, Current Contents/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, and Science Citation Index. (wikipedia.org)
  • David M. Eddy is an American physician, mathematician, and healthcare analyst who has done seminal work in mathematical modeling of diseases, clinical practice guidelines, and evidence-based medicine. (wikipedia.org)
  • Eddy was the first to introduce Markov models to clinical medicine. (wikipedia.org)
  • Diseases
  • However Professor Hobbs had founded the COrrection of GEnetic diseases by Transplantation or COGENT movement, with a charitable trust which attracted £13 million 1971-2007. (wikipedia.org)
  • cell
  • The effect of 89 Zr-oxine labeling on bone marrow cell viability and differentiation was evaluated in vitro . (aacrjournals.org)
  • APOP ), a developer of a novel stem cell production technology, today announced a collaboration with Washington University , a leading academic institution based in St. Louis, MO , aimed at determining the safety and tolerability in a U.S. Phase I/II study using ApoGraft™ for bone marrow transplantations. (prnewswire.com)
  • gene
  • Clinical and radiologic correlations are also fundamental to the diagnostic process, with additional gene testing being confirmatory. (wikipedia.org)
  • malignant
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as (Erlenmeyer flask deformity) Alternating radiolucent femoral metaphyseal bands Pathologic fractures The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. (wikipedia.org)
  • laboratory
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • research
  • The Division has a tradition of excellence in basic, clinical and translational research as well as clinical programs. (pittsource.com)
  • The Department of Pediatrics of the University of Pittsburgh School of Medicine is seeking faculty for clinical programs, biomedical and health science research programs. (pittsource.com)
  • The mother may consent to donate the blood for research and/or clinical use and the cord blood bank will make the blood available for use as appropriate. (stemcellcordblood.net)
  • Dmitry Rogachev National Research Center is the most advanced center in Russia in the area of pediatric hematology/oncology and immunology with scientific, clinical and educational expertise. (fnkc.ru)
  • Today we collaborate with the most advanced research and clinical centers worldwide, our employees are the members of the various professional societies (EBMT, SIOP, EHA, SIOP Asia, ESID, etc. (fnkc.ru)
  • excessive citations] The term "guided meditation" is most commonly used in clinical practice, scholarly research, and scientific investigation to signify an aggregate of integrated techniques. (wikipedia.org)
  • Master of Social Work Clinical Research Papers. (wikipedia.org)
  • The Clinical Working Party supports clinical research among ESPID members. (wikipedia.org)
  • hematology
  • The Center provides educational resources including internship, residency and post doctoral programs as well as disseminating current knowledge to the Russian pediatric hematology/oncology professional community in more than 80 clinical centers throughout the country. (fnkc.ru)
  • Clinical hematology: theory and procedures. (wikipedia.org)
  • extensive
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • model
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • increase
  • The generalized increase in bone density has a special predilection to involve the medullary portion with relative sparing of the cortices. (wikipedia.org)
  • The generalized increase in bone density of the medullary portion predominates with relative sparing of the cortices. (wikipedia.org)
  • purpose
  • while a numbers of key growth factors that regulates hematopoiesis have been identified and some of them are currently used for clinical purpose, how bone marrow microenvironment that presents those signals to the hematopoietic progenitors is constructed remains totally obscure. (nii.ac.jp)