• The bacterial pathogen Vibrio cholerae can occupy both the human gut and aquatic reservoirs, where it may colonize chitinous surfaces that induce the expression of factors for three phenotypes: chitin utilization, DNA uptake by natural transformation, and contact-dependent bacterial killing via a type VI secretion system (T6SS). (nih.gov)
  • Therefore, antibodies raised by these antigens could induce complement-mediated killing of other meningococcal groups, including the endemic MenW cc11 strain. (cdc.gov)
  • Lung abscess - has a similar clinical presentation, although an abscess is more likely to occur in children with neurologic abnormalities and be related to an aspiration event. (clinicaladvisor.com)
  • Due to the lack of thorough quantification, however, it is unclear whether and to what extent the bacterial growth rate can predict the lysis rate upon β-lactam treatment under diverse conditions. (pnas.org)
  • The aims of this analysis were (i) to apply a whole-body physiologically based pharmacokinetic (WPBPK) model structure to describe the pharmacokinetics (PK) of CMS and colistin in critically ill patients and (ii) to predict colistin concentration-time courses and bacterial killing in target tissues combining the WBPBPK model with a semi-mechanistic pharmacokinetic-pharmacodynamic (PKPD) model. (diva-portal.org)
  • The model was used to predict tissue concentrations in lungs, skin, blood and kidneys to drive a semi-mechanistic PKPD model on a wild-type (ATCC 27853) or a meropenem-resistant (AUR552) clinical strain P. aeruginosa to predict bacterial killing following the original dosing regimen and by replacing the original initial dose with a loading dose of 9MU. (diva-portal.org)
  • The targets of quinolone activity are the bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. (cdc.gov)
  • Without a clinical diagnostic test, suspected cases of SARS must be confirmed in the laboratory, using RT-PCR or slower methods of detection-involving serology or viral culture, isolation, and identification by electron microscopy-thereby causing a significant increase in the time required for an accurate diagnosis. (nap.edu)
  • The fluoroquinolone susceptibility profile for each clinical isolate is determined by the number and location of mutational changes in specific enzyme target sites, porin proteins, and efflux mechanisms. (cdc.gov)
  • Primary component in turmeric kicks off cancer-killing mechanisms in hu. (bio-medicine.org)
  • Killing does not depend on the secretion of S. marcescens chitinases, as mutants in which all three chitinase genes were deleted retained wild-type killing abilities. (nih.gov)
  • These other causes for pleural effusions are distinguished from parapneumonic effusion and empyema based on clinical history and physical findings. (clinicaladvisor.com)
  • The UI team, including Pezzulo and co-lead author Xiao Xiao Tang, Ph.D., a Howard Hughes Medical Institute postdoctoral research associate at the UI, developed a simple experiment to study bacterial killing by the ASL. (scienceblog.com)
  • In the case of the Dutch Bacterial Meningitis Cohort, written informed consent was obtained from all participating patients or their legally authorized representatives prior to study inclusion (9). (deepdyve.com)
  • The study appears Sept. 15 in Clinical Cancer Research a peer. (bio-medicine.org)
  • The study appears Sept. 15 in Clinical Cancer Research, a peer-reviewed journal of the American Association of Cancer Research. (bio-medicine.org)
  • Although turmeric is used in cooking, the amount of curcumin needed to produce a clinical response is much larger. (bio-medicine.org)
  • Finally, after establishing a CBP, VetCAST will promulgate expert comments and/or recommendations associated with CBPs to facilitate their sound implementation in a clinical setting. (frontiersin.org)
  • This notion serves as the foundation for the concept of bacterial persistence: dormant bacterial cells that do not grow are phenotypically tolerant against β-lactam treatment. (pnas.org)
  • We measured TH concentrations in cerebrospinal fluid (CSF) from patients with bacterial meningitis and controls. (deepdyve.com)
  • OBJECTIVE: To characterize the population pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitis (ABECB), with particular attention to the speed of bacterial killing. (hindawi.com)
  • The amphipathic structure of HDPs plays an important role in the process of endotoxin removal as well as in bacterial killing through hydrophobic and electrostatic interaction with toxic lipid A. This interaction occurs when the positively charged fragments within HDPs attract negatively charged phosphates of lipids A, and the hydrophobic fragments of HDPs bind with lipid A fatty acid moieties. (springer.com)
  • Human subjects Cerebrospinal fluid (CSF) samples were derived from the Dutch Bacterial Meningitis Cohort, which includes adults with community-acquired bacterial meningitis with positive CSF cultures. (deepdyve.com)
  • Using a unique animal model of CF, a team of scientists from the University of Iowa has discovered a surprising difference between healthy airways and airways affected by CF that leads to reduced bacterial killing in CF airways. (scienceblog.com)
  • We found that the lysis rate of a bacterial population linearly depends on the instantaneous growth rate of the population, regardless of how the latter is modulated. (pnas.org)
  • Interpretation of in vitro effects is usually based on bacterial growth after 24h in time-kill and checkerboard experiments. (diva-portal.org)
  • We propose that the early dynamics of bacterial killing and growth, which may be of great clinical importance, should be considered in future in vitro combination studies. (diva-portal.org)
  • Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis. (wikipedia.org)
  • The 2010 revision included a neonatal management algorithm for secondary prevention of GBS EOD that was widely adopted by neonatal physicians as a means of managing risk of all bacterial causes of early-onset sepsis (EOS). (aappublications.org)