Clinical and stem cell. Medical search. Frequent questions

In addition, there is a risk of tumorigenesis after stem cell transplantation due to the ability of stem cells to proliferate and resist apoptosis. (wikipedia.org)
Data from preclinical transplantation studies suggested that stromal cell infusions not only prevent the occurrence of graft failure, but they have an immunomodulatory effect. (nih.gov)
Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation. (nih.gov)
Introduction To observe the short-term and long-term effects of extensive fascial resection combined with autologous limbal stem cell sharing transplantation for pterygium. (researchsquare.com)
Methods A retrospective case series analysis was performed with 403 patients (420 eyes) who underwent extensive fascial resection combined with autologous limbal stem cell sharing transplantation in the Department of Ophthalmology, Second People's Hospital of Yunnan Province from January 2017 to June 2018. (researchsquare.com)
Discussion and conclusion Extensive fascial resection combined with autologous limbal stem cell sharing transplantation for the treatment of pterygium, the patient's appearance satisfaction is higher, and the recurrence probability is lower than the average recurrence rate of limbal stem cell transplantation. (researchsquare.com)
Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. (biomedcentral.com)
Stem cell transplantation is a valuable supplementary therapy for CD. (biomedcentral.com)
MILAN - Studies are exploring hematopoietic stem cell transplantation (HSCT) as a rescue therapy in early-stage multiple sclerosis (MS), researchers told colleagues at the 9th Joint ECTRIMS-ACTRIMS meeting. (medscape.com)
The researchers noted that the patients who underwent stem cell transplantation had numerous adverse effects. (medscape.com)
Stem cells have been used to treat illness in limited ways for decades, including transplantation from bone marrow. (sciencedaily.com)
Hematopoietic stem cell transplantation (HSCT) is increasingly used effectively to treat various hematological diseases. (bvsalud.org)
Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease but not applicable in total bilateral disease. (liverpool.ac.uk)
Some clinical work popped up but it was mainly related to bone marrow loss after hematopoietic stem cell transplantation such as during treatment for blood cancers. (ipscell.com)
Our limited understanding of the complex cellular composition, anatomy, and function of this tissue has slowed the establishment of effective tissue regenerative (repair) and/or cell replacement (transplantation) therapies. (ohsu.edu)
Treatment of limbal stem cell deficiency (LSCD) has been achieved with transplantation of ex vivo expanded LSCs taken from a small biopsy of limbus. (ncl.ac.uk)
05). This study demonstrates that transplantation of autologous limbal epithelial stem cells cultured on HAM without the use of non-human animal cells or products is a safe and effective method of reconstructing the corneal surface and restoring useful vision in patients with unilateral total LSCD. (ncl.ac.uk)
ReNeuron Receives Notice Of Allowance From US Patent Office For Neural Stem Cell Transplantation Patent Application. (biospace.com)
The primary outcome of the STEM-PD trial is to assess safety and tolerability of the transplanted product at 1-year post-transplantation, while secondary endpoints will assess survival and function of the transplanted cells by brain imaging, as well as measure effects on Parkinson's symptoms. (lu.se)
Patients who undergo hematopoietic stem - cell transplantation (HSCT) are more susceptible to developing severe forms of COVID-19 with an increased risk of mortality . (bvsalud.org)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Non-low-risk patients are evaluated for stem cell transplantation in first remission. (medscape.com)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
The use of human stem cell-based models, including human brain organoids and cell transplantation, will further the efforts of the scientific community to unravel the complexity of dopamine neurons, driving advancements in stem cell-based treatments in Parkinson´s disease," revealed Alessandro. (lu.se)
Dr CHAUHAN (India)1 welcomed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation. (who.int)
The determination of the Director-General to continue examining ethical, clinical and epidemiological issues related to human organ transplantation was greatly appreciated. (who.int)
Stem cell transplantation may be an option in cases of severe recalcitrant ALPS. (medscape.com)

Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
The thrust of research in this area is focused on mesenchymal stem/stromal cells or MSCs, but several of these trials are not interventional studies using cells at all. (ipscell.com)
Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)

The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
Recent data from in vitro models demonstrating the essential role of stromal support in hematopoiesis shaped the view that cell-cell interactions in the marrow microenvironment are critical for normal hematopoietic function and differentiation. (nih.gov)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
The 85 qPCR and 11 control assays have been experimentally optimized and validated to fit the needs of researchers interested in differentiation, proliferation, development, and homeostasis of stem cells. (genomeweb.com)
Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use. (prnewswire.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

They can then induce the release of bioactive agents and the formation of progenitor cells in response to these changes. (wikipedia.org)
Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis of pancreatic cancer. (ohsu.edu)
Stem/progenitor cells offer the promise that transplantable beta cells may be generated in the laboratory. (ohsu.edu)
To deliver on that promise, our laboratory is collaborating with the laboratories of Markus Grompe, M.D., OHSU, and Gordon Keller, Ph.D., University Health Network, Toronto, Canada, in the development and characterization of monoclonal antibodies directed against cell surface molecules expressed by pancreatic cell subsets as well as pancreatic progenitor cells derived from pluripotent stem cells. (ohsu.edu)
This project focuses on the compelling need to generate cell-surface marker specific reagents useful for identification, study, and isolation of pulmonary stem/progenitor cells. (ohsu.edu)

The focus of this webinar is on the Lessons Learned from IND/Phase I trials including overcoming the challenges, and addressing the regulatory issues, as stem cell based therapies move towards the clinic. (ca.gov)
Together, we'll continue to focus on accelerating innovative stem cell and gene therapies to patients while meeting the basic health care needs of underserved communities. (uclahealth.org)
Our goal is to help accelerate those trials, clear the path for more therapies to reach clinical trials and ensure people throughout California can access these innovative treatments. (uclahealth.org)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
Stem cell therapies are regulated differently in various countries around the world, with some countries offering stem cell therapies that are not available elsewhere. (nationalacademies.org)
In the United States, stem cell therapies are regulated as biologics and are subject to premarket approval under the risk-based approach to approving cellular and tissue-based products. (nationalacademies.org)
The Japanese government has made innovation, including innovation in stem cell research, a national priority, and new laws regarding regenerative medicine products are expected to provide a more efficient path to the translation of these therapies to the clinic. (nationalacademies.org)
While stem cell therapies offered in China must be registered, there are not yet approved quality control guidelines available. (nationalacademies.org)
If regulations for stem cell therapies were only just now being developed in the United States, they would look much different than the ones that exist today, said Margaret Foster Riley, professor of law at the University of Virginia School of Law. (nationalacademies.org)
Personalized Stem Cell was founded in 2018 to advance human regenerative medicine by securing FDA approval for autologous stem cell therapies for serious diseases with limited treatment options. (personalizedstemcells.com)
The clinical trial presentation will explore cutting-edge research results that have unveiled promising connections between stem cell therapies, cognitive rejuvenation and ADRI (Alzheimer's Disease Risk Index). (newswire.com)
Some clinics may falsely advertise that it is not necessary for FDA to review and approve their stem cell therapies. (cdc.gov)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
and 3) facilitate the purification of cell culture expanded cell populations for cell-based therapies. (ohsu.edu)

One of the most extensively studied stem cell types are embryonic stem cells, which possess many of the same therapeutic properties as mesenchymal stem cells, including the ability to self-regenerate and differentiate into a number of cell lineages. (wikipedia.org)
Injected embryonic stem cells have been shown to increase the risk for tumor formation in the host patient. (wikipedia.org)
Also, the host's immune system may reject injected embryonic stem cells and thus eliminate their therapeutic effects. (wikipedia.org)
Exiqon this week launched Stem Cell Focus microRNA PCR panels for embryonic and induced pluripotent stem cell research. (genomeweb.com)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
The non-embryonic stem cells like adult stem cells are in clinical use for many years and embryonic stem cells are now emerging as an alternative source for the same purpose with huge potentials in drug discovery and toxicological studies. (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Traditionally, scientists have worked with both embryonic and adult stem cells for research tools, as well as for cellular therapy. (prnewswire.com)
While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use. (prnewswire.com)
Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics. (prnewswire.com)
Clinical research had demonstrated the therapeutic benefits of interventions using adult stem cells rather than embryonic cells, a direction that guaranteed respect for human dignity, even at the embryonic stage. (who.int)

More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
The company has been working to develop its HuCNS-SC ® (purified human neural stem cells) platform technology as a treatment for multiple disorders of the central nervous system. (genengnews.com)

Adult mesenchymal stem cells are being used by researchers in the fields of regenerative medicine and tissue engineering to artificially reconstruct human tissue which has been previously damaged. (wikipedia.org)
Several different forms of stem cells have been identified and studied in the field of regenerative medicine. (wikipedia.org)
A five-year, $8 million grant from the California Institute for Regenerative Medicine will enable UCLA stem cell scientists to include a wider cross-section of Los Angeles' diverse population in potentially lifesaving medical research. (uclahealth.org)
Established in 2014 with Dr. John Adams as its first director, and under the umbrella of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, the Alpha clinic provides resources to help UCLA researchers overcome common roadblocks to launching clinical trials and supports their efforts to enroll Californians in need, regardless of their race, gender, age, socioeconomic status or geographic location. (uclahealth.org)
The cells are known to be among the most promising type in regenerative medicine. (ucdavis.edu)
The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
In recent years, developments in stem cell (SC) biology and regenerative medicine have revealed that SCs unexpectedly can be used to treat autoimmune diseases. (biomedcentral.com)
First stem cell clinical trial landscape is revolutionized by Beauty-Stem Biomedical and Taiwan Tzu Chi Hospital, unveiling the progress of stem cell nutritional benefit on cognitive and regenerative healthcare. (newswire.com)
LOS ANGELES, August 18, 2023 (Newswire.com) - Beauty-Stem Biomedical , a natural food supplement researcher and supplier, and Taiwan's Tzu Chi Hospital will host a preliminary CD34 clinical trial presentation and provide updates to a groundbreaking announcement centered around the world's first-ever human trial for a stem cell nutritional product, promising to challenge conventional understandings of nutrition's role in cognitive and regenerative healthcare. (newswire.com)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
A better understanding of changes to intestinal cell populations during mucosal repair will facilitate future efforts directed at regenerative medicine. (ivis.org)
Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)

Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
The public clinical trials database http://clinicaltrials.gov shows 123 clinical trials using MSCs for a very wide range of therapeutic applications (Figure 1 ), the majority of which are in Phase I (safety studies), Phase II (proof of concept for efficacy in human patients), or a mixture of PhaseI/II studies (Figure 2 ). (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been shown to counter rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis [ 8 ]. (biomedcentral.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)

Also, transplanted mesenchymal stem cells pose little risk for rejection as they are derived from the patients own tissue, so are genetically identical, however graft versus host disease is a possibility, where the cells change enough while outside the patient's body that the immune system recognizes them as foreign and can attempt to reject them. (wikipedia.org)
Genetic mutations in stem cells as well as conditions at target tissue may result in formation of a cancerous tumor. (wikipedia.org)
WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
Farmer and Wang's team has generated the stem cells for the study from placental tissue. (ucdavis.edu)
The loose connective tissue under the epithelium contains a large number of fibroblasts and abundant capillaries, which indicates that the pterygium epithelial cells have a strong ability to proliferate and migrate. (researchsquare.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
Clinical data, blood, and tissue samples will be collected to establish a biorepository to facilitate the study of the natural history of MDS. (nih.gov)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
The results show that the enzyme aminopeptidase in the stem cell niche -- in this case, the area where stem cells are found in the testicular tissue in fruit flies -- plays a role in both of these functions. (sciencedaily.com)
That's because there's a delicate balance to be struck in managing the proliferation of undifferentiated stem cells in tissue, Chen said. (sciencedaily.com)
The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more. (prnewswire.com)
Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
An allogeneic source of transplantable cells for use in total bilateral disease can be obtained from culture of donated cadaveric corneal tissue. (liverpool.ac.uk)
Our laboratory, in collaboration with the laboratory of Jeffrey Whitsett, M.D., at the Cincinnati Children's Hospital, is generating and characterizing a panel of monoclonal antibodies targeting cell-surface markers on different subsets of pulmonary cells involved in the process of pulmonary tissue regeneration. (ohsu.edu)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow Mesenchymal stem cells can be obtained via a procedure called bone marrow aspiration. (wikipedia.org)
Human mesenchymal stem cell therapy is limited due to variation in individual response to treatment and the high number of cells needed for treatment. (wikipedia.org)
This is the first of several planned trials that will allow qualified PSC-enrolled physicians to provide FDA compliant, quality cell therapy to patients suffering from OA. (orthoworld.com)
PSC works within FDA's cell therapy regulations to provide stem cell therapy for patients that follows the rules FDA has created in order to assure consistent manufacturing, quality tested cells and clinical trial and manufacturing oversite for safety and efficacy. (orthoworld.com)
There are a variety of different gene therapy approaches for sickle cell disease being developed and tested in clinical trials at UCLA and elsewhere," Schiller said. (uclahealth.org)
The clinical trial, known formally as the " CuRe Trial: Cellular Therapy for In Utero Repair of Myelomeningocele," is funded by the state's stem cell agency, CIRM . (ucdavis.edu)
In some cases, offering a particular stem cell therapy can have a positive economic impact for the country in which it is offered because patients are willing to travel in hopes of finding effective therapeutic options. (nationalacademies.org)
however, regulations for treating patients with cells and tissues that are based on evidence could help to address challenges relating to therapy, safety, and efficacy. (nationalacademies.org)
Platelet counts and clinical and parasitologic characteristics during fumagillin therapy and a 1-month follow-up of 2 allogeneic hematopoietic stem cell recipients with Enterocytozoon bieneusi microsporidiosis. (cdc.gov)
We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD). (biomedcentral.com)
Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
Patients who have had stem cell or exosome therapy should discuss any concerns and abnormal reactions with their healthcare provider. (cdc.gov)
This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
The interplay between stem cell and tumor biology offers an exceptional opportunity to advance our knowledge about cancer, one of the leading causes of death worldwide, with potential impacts in cancer diagnosis and therapy. (hindawi.com)
Recent months have seen the first iPSC clinical trial in humans, creation of the world's largest iPSC biobank, major funding awards, a historic challenge to the "Yamanaka Patent", a Supreme Court ruling affecting industry patent rights, announcement of an iPSC cellular therapy clinic scheduled to open in 2019, and much more. (prnewswire.com)
Could stem cell therapy help reduce the severity of osteoporosis? (ipscell.com)
However, the supply of donor-derived islets will never meet the needs of the large number of patients who could potentially benefit from this cell-based therapy. (ohsu.edu)
In addition, for the first time, a strictly defined uniform group of patients with total unilateral LSCD and no other significant ocular conditions has been used to allow the success or failure of treating LSCD to be attributable directly to the proposed stem cell therapy. (ncl.ac.uk)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
An investigational stem cell-based therapy for the treatment of Parkinson's Disease, STEM-PD, has been given regulatory approval for a Phase I/IIa clinical trial. (lu.se)
WCMM members Agnete Kirkeby and Gesine Paul-Visse are part of the team behind STEM-PD - a new kind of dopaminergic nerve cell therapy designed to replace cells lost in Parkinson's disease, the first of its kind in Europe! (lu.se)
The funding received from the Swedish Research Council will go towards his research, 'mapping human dopamine neuron diversity at single-cell resolution for improved stem cell therapy in Parkinson's disease. (lu.se)

We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. (cdc.gov)
We report 2 cases of E. bieneusi microsporidiosis in allogeneic hematopoietic stem cell transplant (HSCT) recipients who were treated with fumagillin and experienced thrombocytopenia. (cdc.gov)
COVID-19 in hematopoietic stem-cell transplant recipients: A systematic review and meta-analysis of clinical characteristics and outcomes. (bvsalud.org)

Purpose: To compare the clinical outcomes of MSC injection and arthroscopic marrow stimulation treatment with those of arthroscopic marrow stimulation treatment alone for the treatment of OLTs in older patients. (researchgate.net)
Patients were divided into 2 groups: 35 patients (37 ankles) treated with arthroscopic marrow stimulation treatment alone (group A) and 30 patients (31 ankles) who underwent MSC injection along with arthroscopic marrow stimulation treatment (group B). Clinical outcomes were evaluated according to the visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, and the Roles and Maudsley score. (researchgate.net)
Large lesion size (≥109 mm(2)) and the existence of subchondral cysts were significant predictors of unsatisfactory clinical outcomes in group A (P = .04 and .03, respectively). (researchgate.net)
StemCells also reported positive outcomes in an earlier Phase I/II study in thoracic SCI. (genengnews.com)
AMLs in which the most primitive cells displayed more mature phenotypes were associated with better outcomes. (johnshopkins.edu)
The aim of this study was to analyze, by performing a systematic review and meta-analysis , all studies that evaluated COVID-19 in HSCT adult recipients and present clinical characteristics and outcomes. (bvsalud.org)
In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life. (cdc.gov)

Patients were randomized to receive corneal epithelial stem cells cultured on amniotic membrane (AM): investigational medicinal product (IMP) or control AM only. (liverpool.ac.uk)

At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)

abstract = "The failure of complete remissions to reliably translate into cures in acute myeloid leukemia (AML) can be explained by the leukemia stem cell (LSC) paradigm, which hypothesizes that rare leukemia cells with stem cell features, including self-renewal capacity and drug resistance, are primarily responsible for both disease maintenance and relapses. (johnshopkins.edu)

The corneal epithelium is maintained by a population of stem cells known as limbal stem cells (LSCs) due to their location in the basal layer of the outer border of the cornea known as the limbus. (ncl.ac.uk)

A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)

Only those rare AML cells characterized by a hematopoietic stem cell (HSC) CD34 + CD38 − phenotype were believed capable of generating leukemia in immunocompromised mice, but more recently, significant heterogeneity in the phenotypes of engrafting AML cells has been demonstrated. (johnshopkins.edu)

In the research process of expanding the therapeutic uses of mesenchymal stem cells, they are grown in laboratories or grown using medication to stimulate new cell growth within the human body. (wikipedia.org)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)

Mesenchymal stem cells are able to differentiate, or mature from a less specialized cell to a more specialized cell type, to replace damaged tissues in various organs. (wikipedia.org)
Mesenchymal stem cells can also be isolated from birth-associated tissues such as the umbilical cord without the need for an invasive surgical procedure. (wikipedia.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
The "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project, was founded at the Dental School of Universidade Federal de Minas Gerais (UFMG) in March 2001 and is responsible for providing dental care to patients who have undergone and will undergo HSCT, in addition to those from the UFMG Clinical Hospitalwho are only undergoing hematological treatment. (bvsalud.org)
This study aimed to present the various activities of the "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project, which provides dental care to eligible patients during pre- and post-HSCT. (bvsalud.org)
Thus, the "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project plays an important role in teaching, research, and extension activities within the UFMG Dental School, especially concerning HSCT. (bvsalud.org)

The number of fully differentiated cells and their phenotype can be influenced in three ways. (wikipedia.org)
Patients with AML cells expressing a primitive HSC phenotype (CD34 + CD38 − with high aldehyde dehydrogenase activity) manifested significantly lower complete remission rates, as well as poorer event-free and overall survivals. (johnshopkins.edu)
The strong clinical correlations suggest that the most immature phenotype detectable within a patient's AML might serve as a biomarker for "clinically relevant" LSCs. (johnshopkins.edu)
Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)

However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
Stem cells are removed from another person, called a donor. (medlineplus.gov)
Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
The red blood cells are returned to the donor. (medlineplus.gov)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)

The clinic's first use of the Community Engagement Alliance model will focus on connecting people with sickle cell disease to health care resources and clinical trials of potential treatments for the condition. (uclahealth.org)
Several of those are now considered applicable for patient treatments beyond the need for regulated clinical trials. (biomedcentral.com)
However, a lack of regulations concerning stem cell treatments or a lack of enforcement of such regulations could cause patients harm and damage the industry. (nationalacademies.org)
As a result, human cells, with the exception of those deemed minimally manipulated and used for autologous treatments, would be subject to FDA premarket approval as biologics. (nationalacademies.org)
In contrast to previous treatments that did not result in parasitologic clearance or clinical remission, fumagillin showed a cure rate of 100%, even for severely immunocompromised patients ( 2 , 4 - 10 ). (cdc.gov)
While all medical treatments have benefits and risks, unapproved stem cell and exosome products expose patients to potential risks without a clear benefit. (cdc.gov)
Currently, the only stem cell treatments approved by the Food and Drug Administration (FDA) are products that treat certain cancers and disorders of the blood and immune system. (cdc.gov)
If you are considering stem cell treatments, check to make sure the product you are considering is on the FDA's approved list of stem cell treatments external icon . (cdc.gov)
Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. (prunderground.com)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)

and Dr. Gary Schiller, a UCLA professor of hematology oncology who is one of the leaders of UCLA's new sickle cell disease center which opened in Fall 2022. (uclahealth.org)

Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)

Herein, we gave a brief introduction to MSC-EVs and focused on their mechanisms and clinical application in periodontal regeneration. (biomedcentral.com)
and stem cell regeneration. (lu.se)

Mesenchymal stem cells possess many properties that are ideal for the treatment of inflammatory and degenerative diseases. (wikipedia.org)
However, there have been some cases where there were both improvement and toxicity inflicted on the targeted organ, as well as cases where treatment of mesenchymal stem cells did not show improvement of function at all. (wikipedia.org)
Personalized Stem Cells (PSC) treated the first patients in an FDA-approved clinical trial for stem cell treatment of knee osteoarthritis (OA). (orthoworld.com)
Farmer, stem cell bioengineer Aijun Wang , and the clinical fetal treatment team led by Shinjiro Hirose , plan to treat six patients. (ucdavis.edu)
It also showed that the stem cell treatment was safe in animals. (ucdavis.edu)
After surgical treatment of pterygium, there will still be a small number of mutant epithelial stem cells remaining. (researchsquare.com)
Surgical excision is the main treatment of pterygium, but the postoperative recurrence rate is high, the appearance of the eye is not ideal, postoperative foreign body feeling has been a difficult problem of clinical treatment. (researchsquare.com)
In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. (biomedcentral.com)
Be sure to get all of the facts if you are considering any stem cell treatment. (cdc.gov)
Ask for this information before getting treatment-even if the stem cells or exosomes are your own. (cdc.gov)
Also this year, Philips Research began a clinical study involving a prototype of its Platform for Personalized Analytics Applications - software for oncologists to analyze, interpret, and interactively present data from NGS instruments in order to prioritize treatment for cancer patients. (genomeweb.com)
The registry will also help connect patients with DBA to research and clinical studies, and possible treatment options. (nih.gov)
A research team reports progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment. (sciencedaily.com)
We performed a controlled multicenter study to examine the feasibility, safety, and efficacy of allogeneic corneal epithelial stem cells in the treatment of bilateral LSCD. (liverpool.ac.uk)
Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)

Eight researchers from Lund Stem Cell Center at Lund University have been awarded 41.4 million SEK in the latest announcements from the Swedish Research Council. (lu.se)
In their latest grant announcements, eight researchers from Lund Stem Cell Center at Lund University were awarded 41.4 million SEK, giving significant funding support to ground-breaking research in the areas of medicine and health, and natural and engineering sciences. (lu.se)

Over a course of two or three weeks, the cells will multiply and differentiate into specialized cells. (wikipedia.org)
During long-term culture, mesenchymal stem cells age, lose their ability to differentiate, and have a higher chance to undergo malignant transformation. (wikipedia.org)
They can differentiate into many cell types including bone, fat, and muscle which allow them to treat a large range of disorders. (wikipedia.org)
One question now is whether the activity of the niche and of the enzyme reported in this research can be harnessed to manipulate stem cells to differentiate in useful ways. (sciencedaily.com)
In addition, their "unspecialized" nature allows them to differentiate into a wide variety of specialized cell types. (prnewswire.com)
Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)

Stem Cell Transplants for Early MS: Who Benefits Most? (medscape.com)
The researchers tracked 103 patients after stem cell transplants (median, 45 months), 204 patients on alemtuzumab (median, 45 months), and 314 patients on ocrelizumab (median, 35 months). (medscape.com)
Compared with ocrelizumab, patients who received stem cell transplants had a 60% lower risk of relapse but the same risk of MS activity detected via MRI. (medscape.com)
Mason endured more than 9 months of chemotherapy and stem cell transplants. (cdc.gov)

The project will build on Oxfords established strength in iPS cell technology to deliver a robust platform for research and to support drug discovery in the areas of Alzheimer's, Parkinson's, Autism, Schizophrenia, Bipolar, Migraine, Pain and Diabetes. (ox.ac.uk)
The clinical trial presentation on Sept. 9 stands as a testament to their unwavering commitment to pushing stem cell medical research boundaries. (newswire.com)
If the stem cell product is not on the approved list or if you are considering an exosome product, ask the provider to show you documentation from the FDA and that they have FDA's permission to research the product. (cdc.gov)
Biologic specimens will be collected at specified intervals, with some tests performed in local clinical laboratories and others performed by centralized research centers or banked in the Biospecimen Repository. (nih.gov)
The aim of this research was to characterise the constituents of the stem cell niche in normal and strangulated equine intestine using biomarkers validated in other animal models. (ivis.org)
In a research paper to be published in the journal Cell Reports on Oct. 13, Xin Chen, an associate professor of biology in the university's Krieger School of Arts and Sciences, and six co-authors report on how stem cells are affected by their immediate surroundings. (sciencedaily.com)
We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. (prnewswire.com)
Induced pluripotent stem cells represent one of the most promising research advances within the past decade, making this a valuable report for both executives and investors to use to optimally position themselves to sell iPSC products. (prnewswire.com)
A distinctive feature of this report is an end-user survey of 273 researchers (131 U.S. / 143 International) that identify as having induced pluripotent stem cells as a research focus. (prnewswire.com)
In 2003 he became Director of the OHSU Hematopoietic Cell Processing Laboratory, and in 2004 he became a member of the Oregon Stem Cell Center, where he is Director of the Center's monoclonal antibody and flow cytometry core facilities and conducts independent research. (ohsu.edu)

American Journal of Respiratory Cell and Molecular Biology. (lu.se)

Qiagen has already unveiled plans to bundle the CLC Genomics Workbench with its new Gene Reader sequencer and to launch a new variant analysis product next year to support NGS-based clinical testing and reporting. (genomeweb.com)

StemCells said today it will shrink its workforce by about 25% by January 31, 2016, as part of a restructuring that will include selling off assets and refocusing clinical efforts away from retinal disorders and toward chronic spinal cord injury (SCI). (genengnews.com)
Instead, StemCells said, it will seek a partner to fund continued development of its platform in retinal disorders. (genengnews.com)

Multipotent stem cells normally reside within intestinal crypts and are the source of mucosal renewal that maintains barrier function. (ivis.org)

Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)

Are you considering a blood stem cell transplant? (nih.gov)
This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
Have you received a stem cell transplant? (nih.gov)
Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
The stem cells are frozen and stored until they are needed for a transplant. (medlineplus.gov)
A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)

A clinicaltrials.gov search for stem cells for osteoporosis identified a dozen trials. (ipscell.com)

Stem Cells Translational Medicine 2019;8:323-331. (liverpool.ac.uk)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)

Their application could be much wider, however, if there were reliable techniques to control how they take on specialized functions, how they can revert to their stem state and, in some instances, how they proliferate in their original state to form potentially dangerous tumors. (sciencedaily.com)

By shedding light on the role of stem cells in mitigating the impacts of neurodegenerative diseases, Beauty-Stem Biomedical and Tzu Chi Hospital aim to ignite hope and possibilities for those affected by these conditions. (newswire.com)
These results have medical implications because if this cell fate change could happen randomly, it may lead to diseases such as cancers. (sciencedaily.com)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
Stem cells are the building blocks of modern medicine and hold the key to tackling some of the most complex diseases of our time - from lung disease to neurological disorders to cancer. (lu.se)

The FDA regulates stem cell and exosome products in the United States. (cdc.gov)
Thus, it may refer to the "exosome complex ," being a proteic (enzymatic) macromolecular machinery, present in archaea and eukaryotic cells, being involved in RNA degradation. (frontiersin.org)
On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)

Mesenchymal stem cells have also been shown to travel to sites of inflammation far from the injection site. (wikipedia.org)

Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)

In part, the grant will fund the UCLA Alpha Stem Cell Clinic's continued collaboration with the UCLA Clinical and Translational Science Institute, which supports more than 350 clinical trials at medical centers and community clinics throughout the region. (uclahealth.org)

Recent efforts demonstrated that the multiple mesenchymal lineages can be clonally derived from a single mesenchymal stem cell, supporting the proposed paradigm. (nih.gov)

Given the strength of our clinical findings for the safety and preliminary efficacy of our HuCNS-SC platform technology in treating chronic spinal cord injury, we have decided that now is the time to narrow our focus," StemCells' CEO Martin McGlynn said in a statement. (genengnews.com)
Clinical trials are of the utmost importance in the development and continued monitoring of new drugs entering the market, to ensure their safety and efficacy in improving human health. (sagepub.com)

Our data shows that the STEM-PD product is safe and highly efficacious in reverting motor deficits in preclinical models of Parkinson's disease" says Agnete Kirkeby, who has led the preclinical development of the product. (lu.se)

A UC Davis Health team today announced the launch of the world's first, FDA-approved human clinical trial using stem cells before birth to treat the most serious form of spina bifida . (ucdavis.edu)
They're introducing the first-ever human trial involving a nutritional supplement made from stem cells , specifically for dementia. (newswire.com)
Although extensive experimentation in the lab and in animal models of human disease takes place prior to clinical trials, trials on human patients are a necessity to determine whether the new approach will work well in humans, and often in what group of people and in what combination with other drugs (if any). (sagepub.com)
The human body is made up of about 220 different kinds of specialized cells such as nerve cells, muscle cells, fat cells and skin cells. (benthamscience.com)
In conclusion, acetone and methanol extracts from C. odontophyllum stem bark exhibited promising cytotoxic activity against human colorectal cancer cell line HCT 116 and paves way for further investigation in view of its mode of cancer cell death. (scirp.org)
One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)

That the enzyme in that spot promotes more specialized cells to become like stem cells "suggests that this change of cell fate needs cues from where stem cell normally reside, but not randomly," said Chen, the principal investigator. (sciencedaily.com)

Anatomy57

Organisms16

Diseases12

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care1

Transplantation33

Stromal Cells4

Differentiation11

Progenitor8

Therapies15

Embryonic13

Neural Stem2

Regenerative13

MSCs10

Tissue17

Therapy22

Hematopoietic stem cell3

Outcomes7

Epithelial stem cells cultured1

Pluripotent cells1

Abstract1

Limbal stem cells1

Bone marrow stem cells1

Heterogeneity1

Therapeutic3

Tissues3

HSCT5

Phenotype4

Donor7

Treatments10

20221

Tumor1

Regeneration2

Treatment16

Lund-stem-cell-center2

Differentiate6

Transplants4

Research11

Biology1

Genomics1

Retinal2

Multipotent1

Adipose1

Transplant6

Clinicaltrials.gov1

20191

Chemotherapy1

Proliferate1

Diseases5

Exosome4

Injection1

Biological Properties1

Centers1

Lineages1

Efficacy2

Preclinical1

Human6

Normally reside1