OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth CareGeographicals
AmodiaquineAntimalarialsSulfadoxineArtemisininsPyrimethamineChloroquineDrug CombinationsMalaria, FalciparumPlasmodium falciparumFluorenesDrug ResistanceSesquiterpenesParasitic Sensitivity TestsSenegalDrug Therapy, CombinationEthanolaminesCameroonBetazoleHistamine N-MethyltransferaseParasitemiaMalariaGhanaAngolaGabonBurkina FasoProtozoan ProteinsChlorpheniramineMaliQuinineMembrane Transport ProteinsSierra LeoneMefloquineProguanilTreatment FailureTanzaniaChemistry Techniques, AnalyticalTreatment OutcomeDapsoneColombiaMultidrug Resistance-Associated ProteinsInhibitory Concentration 50RwandaQuinolinesKenyaUgandaPapua New GuineaPlasmodium vivaxNaphthyridinesMalaria, VivaxAfghanistanNigeria
ChloroquineMefloquineArtemether-lumefantrineFalciparum malariaASAQCombined with artesunate or amodiaquineArtesunate plus amodiaquine combinationPyrimethamineEfficacyPharmacology and TherapeuticsAntimalarial drugsAnti-malarialArtemisininBURKINA FASODihydroartemisinin-piperaquineAdequateVersusCYP2C8DosesDoseTreatmentCentreTreatmentsPatientsResistanceRandomised clinical trialPreclinicalSubjectsDrugsInfectious diseasesManifestationsDaysMalaria casesCliniciansInitiationStudiesMedicationsEvidenceChildrenData
Chloroquine15
  • To examine the kinetics of the disposition of Plasmodium falciparum during treatment with amodiaquine, a Mannich base derivative of chloroquine and chloroquine. (medscape.com)
  • Additional aims were to compare P. falciparum kinetics in children in whom initial treatment with chloroquine failed and following re-treatment with amodiaquine, and in siblings in whom there was household clustering of falciparum infections. (medscape.com)
  • An important aim was to validate the kinetic method of evaluating therapeutic efficacy in a randomised trial involving the antimalarial drugs amodiaquine and chloroquine. (medscape.com)
  • Children were randomised to receive amodiaquine 30 mg/kg given over 3 days (n = 104) or chloroquine base 30 mg/kg given over 3 days (n = 106). (medscape.com)
  • Following treatment, the areas under the parasite density versus time curve (AUC pd· ) and the half-life of parasitaemia (t 1 / 2,pd were significantly lower with amodiaquine than with chloroquine [518.7 ± 47.5 (standard error) vs 810.7 ± 101.3 asexual forms/µl · h, p = 0.01, and 3.5 ± 0.1 (class IIb) vs 4.5 ± 0.3h (class IV), p = 0.001, respectively]. (medscape.com)
  • The volume of blood completely cleared of parasites per unit time (CLB pd ) was higher (not significant) with amodiaquine than with chloroquine. (medscape.com)
  • 0.98 ± 0.001 vs 0.93 ± 0.02, p = 0.02, respectively) and the t 1 / 2,pd index was significantly lower (1.9 ± 0.05 vs 2.5 ± 0.2, p = 0.0035) with amodiaquine than with chloroquine. (medscape.com)
  • These findings indicate that amodiaquine produces more favourable P. falciparum disposition kinetic profiles than chloroquine, indicating a better efficacy, and may be used as an alternative to chloroquine in chloroquine-resistant infections in endemic areas. (medscape.com)
  • In many parts of Africa, one of the effective alternatives to chloroquine is amodiaquine, a Mannich base derivative of chloroquine. (medscape.com)
  • Here we report for the first time that amodiaquine (AQ), a clinical 4-aminoquinoline antimalarial with unexplored cancer-directed chemotherapeutic potential, causes autophagic-lysosomal and proliferative blockade in melanoma cells that surpasses that of its parent compound chloroquine. (nih.gov)
  • The antimalarials most widely known to trigger dyschromia are chloroquine, hydroxychloroquine, amodiaquine, and quinacrine. (medscape.com)
  • They were high for amodiaquine-artesunate, variable for sulfadoxine/pyrimethamine-artesunate, and poor for chloroquine-artesunate. (ox.ac.uk)
  • Other derivatives, which equally are good but not as effective as chloroquine, are amodiaquine, mefloquine and primaquine. (ispub.com)
  • Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine. (blogspot.com)
  • Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. (blogspot.com)
Mefloquine3
  • The DeTACT trials will compare two existing combinations (artemether-lumefantrine and artesunate-piperaquine) against two TACTs constituted of one additional drug added to each of these combinations (amodiaquine and mefloquine, respectively). (tropmedres.ac)
  • A total of 3428 pregnant women in the second or third trimester who had falciparum malaria (at any parasite density and regardless of symptoms) were treated with artemether-lumefantrine, amodiaquine-artesunate, mefloquine-artesunate, or dihydroartemisinin-piperaquine. (lshtm.ac.uk)
  • There was no significant difference among the amodiaquine-artesunate group, dihydroartemisinin-piperaquine group, and the mefloquine-artesunate group. (lshtm.ac.uk)
Artemether-lumefantrine6
  • Given the frequent use of antimalarial medications in EVD treatment and the limited data on clinical impact, this study evaluated the association between early treatment with the oral antimalarial agent combination artemether-lumefantrine on mortality in patients with EVD using the multinational IMC database. (springer.com)
  • Assessment of cardiac safety following artemether-lumefantrine (AL) or artesunate-amodiaquine (ASAQ) treatment of acute uncomplicated falciparum malaria in children from Ibadan Southwest Nigeria. (edu.ng)
  • The risk of bias in included studies was evaluated based on study design, methodology and missing data.In total, 29,493 patients from 84 clinical trials were included in the analysis, treated with artemether-lumefantrine (n = 13,664), artesunate-amodiaquine (n = 11,337) and dihydroartemisinin-piperaquine (n = 4,492). (ox.ac.uk)
  • Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso. (ined.fr)
  • Effectiveness and safety of artemether-lumefantrine versus artesunate-amodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial. (ined.fr)
  • Effectiveness of artesunate-amodiaquine vs. artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Nanoro, Burkina Faso: a non-inferiority randomised trial. (ined.fr)
Falciparum malaria2
  • Drug resistant falciparum malaria and the use of artesunate-based combinations: focus on clinical trials sponsored by TDR. (ox.ac.uk)
  • Comment on "A. annua and A. afra infusions vs. Artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial" Munyangi et al. (univ-amu.fr)
ASAQ5
  • The widespread use of artesunate-amodiaquine (ASAQ) for treating uncomplicated malaria makes it important to gather and analyse information on its tolerability. (nih.gov)
  • An individual-patient tolerability analysis was conducted using data from eight randomized controlled clinical trials conducted at 17 sites in nine sub-Saharan countries comparing ASAQ to other anti-malarial treatments. (nih.gov)
  • Reduced effects of ACT partner drugs have been reported but with little information regarding widely used artesunate/amodiaquine (ASAQ). (cdc.gov)
  • Molecular findings showed no artemisinin resistance-associated genotypes and major increases in genotypes associated with high sensitivity/efficacy for amodiaquine than before ASAQ was introduced. (cdc.gov)
  • The first-line ACT in Zanzibar has been artesunate/amodiaquine (ASAQ) since 2003, plus recently added single, low-dose primaquine. (cdc.gov)
Combined with artesunate or amodiaquine1
  • A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria. (ajtmh.org)
Artesunate plus amodiaquine combination1
  • The Committee reviewed the evidence and added the artesunate plus amodiaquine combination tablet for the treatment of malaria in adults and children, in line with current WHO treatment guidelines. (who.int)
Pyrimethamine7
  • This intervention is delivered to all children aged 3-59 months in the community, regardless of malaria status, as a single dose of sulfadoxine-pyrimethamine and three daily doses of amodiaquine, monthly for up to 5 months during the short transmission season. (beryl.tv)
  • We sought detailed molecular studies of resistance to sulfadoxine-pyrimethamine and amodiaquine in Plasmodium falciparum in populations implementing seasonal malaria chemoprevention. (beryl.tv)
  • This study provides a comprehensive, high-throughput assessment of P falciparum genotype variation at all four parasite genes known to contribute to resistance to the seasonal malaria chemoprevention drugs (amodiaquine and sulfadoxine-pyrimethamine) across seven countries implementing seasonal malaria chemoprevention in the African Sahel at the outset of scale-up in 2015-16. (beryl.tv)
  • This study, and previous smaller studies in the region, provide substantial evidence that seasonal malaria chemoprevention with sulfadoxine-pyrimethamine and amodiaquine is not currently under a serious threat from drug-resistant parasites in these implementation areas. (beryl.tv)
  • Dispersible sulfadoxine-pyrimethamine and amodiaquine and matching placebos ended up donated by Guilin Pharmaceutical. (besthealthideas.com)
  • Small children in the chemoprevention-by yourself group and the mixture team acquired four courses of sulfadoxine-pyrimethamine and amodiaquine at every month intervals each yr small children in the vaccine-by yourself group gained four courses of sulfadoxine-pyrimethamine and amodiaquine placebos on that very same plan. (besthealthideas.com)
  • Administration of each dose of sulfadoxine-pyrimethamine and amodiaquine or placebo was specifically noticed by demo staff at distribution factors in trial villages. (besthealthideas.com)
Efficacy6
  • The objective of this study was to assess the safety and efficacy of two MB-based malaria combination therapies, MB-artesunate (AS) and MB-amodiaquine (AQ), compared to the local standard of care, AS-AQ, in Burkina Faso. (uni-muenchen.de)
  • In Senegal, therapeutic trials supervised the in vivo efficacy of artesunate plus amodiaquine from 1999 to 2005 at the M'lomp village dispensary. (biomedcentral.com)
  • METHODS: The study assessed the clinical and parasitological efficacy of AL, CQ, and DHA/PPQ in four arms. (cdc.gov)
  • METHODS AND ANALYSIS: A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). (bvsalud.org)
  • The proportion of patients with early treatment failure, late clinical failure, late parasitological failure, or an adequate clinical and parasitological response as indicators of efficacy. (who.int)
  • Clinical and parasitological parameters will be monitored over a 42-day follow-up period to evaluate drug efficacy. (who.int)
Pharmacology and Therapeutics2
  • I had my basic medical degree training at the University of Ibadan College of Medicine and also did my residency training in Internal Medicne, with subspeacialization in Clinical Pharmacology and Therapeutics at the University College Hospital Ibadan. (edu.ng)
  • I am also currently the Chairman of the Clinical Pharmacology and Therapeutics subspecialty of the National Postgraduate Medical College of Nigeria and the Secretary of the Nigerian Society of Clinical pharmacology and Therapeutics. (edu.ng)
Antimalarial drugs1
  • Clinical trials conducted in African children have attested to the good tolerability of oral artesunate when combined with standard antimalarial drugs. (ox.ac.uk)
Anti-malarial1
  • Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate (e.g. amodiaquine, an anti-malarial drug) could increase the plasma concentrations of the substrate. (wikipedia.org)
Artemisinin5
  • In addition, selection of resistance/tolerance to the slowly eliminated long-acting partner drugs in ACT (e.g., amodiaquine) is expected, especially in highly malaria-endemic areas of Africa ( 8 - 10 ), which could result in relatively reduced ACT cure rates and reduced protection against artemisinin resistance ( 11 ). (cdc.gov)
  • Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. (ajtmh.org)
  • Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. (blogspot.com)
  • Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. (ox.ac.uk)
  • This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs).A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. (ox.ac.uk)
BURKINA FASO1
  • Prise en charge du VIH/sida et migrations internationales dans le district rural de Nanoro, Burkina Faso. (ined.fr)
Dihydroartemisinin-piperaquine1
  • and treatment with the loose formulation of artesunate-amodiaquine (AOR = 2.27 (95 % CI: 1.14-4.51), P = 0.020, compared to dihydroartemisinin-piperaquine).The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. (ox.ac.uk)
Adequate3
  • By day 14, the rates of adequate clinical and parasitological response after PCR-based correction for recrudescence were 87% for MB-AS, 100% for MB-AQ (p = 0.004), and 100% for AS-AQ (p = 0.003). (uni-muenchen.de)
  • High PCR-corrected adequate clinical and parasitological response (ACPR) rates were observed at the primary end points of 28days for AL and CQ and 42days for DHA/PPQ. (cdc.gov)
  • The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population. (bvsalud.org)
Versus1
  • Amodiaquine attained 100parasitological clearance rate versus 70in CQ-treated volunteers. (bvsalud.org)
CYP2C81
  • Amodiaquine (AQ) and pioglitazone (PGZ) are both metabolized by CYP2C8, an enzyme also inhibited by PGZ. (ox.ac.uk)
Doses1
  • These analyses enabled us to predict the potential of these cannabinoids to produce drug interactions in vivo at clinical or recreational doses. (aspetjournals.org)
Dose2
  • In making its decision, the Committee reviewed the latest clinical evidence and the information about licensing in several countries of the fixed-dose combination tablet. (who.int)
  • Eligible patients were treated with a daily dose of 1 tablet containing 135mg amodiaquine 'AQ' and 50mg artesunate 'AS' for the patients with 8-17 kg body weight over 3 days, 1 tablet containing 270mg amodiaquine 'AQ' and 100mg artesunate 'AS' for the patients with 17-35 kg body weight and 2 tablets for the patients above 35 kg body weight over 3 days. (who.int)
Treatment3
  • Empiric antimalarial treatment is a component of protocol-based management of Ebola virus disease (EVD), yet this approach has limited clinical evidence for patient-centered benefits. (springer.com)
  • This surveillance study is a one-arm prospective evaluation of clinical and parasitological responses to directly observed treatment for uncomplicated malaria. (who.int)
  • Two endocrinologists independently made the final diagnosis of AVP deficiency or primary polydipsia with use of clinical information, treatment response, and the hypertonic-saline test results. (journalfilter.com)
Centre1
  • Clinical profile, knowledge, and beliefs about diabetes among patients attending a Tertiary Health Centre in Lagos: A cross-sectional survey. (edu.ng)
Treatments1
  • The most effective drug identified, called amodiaquine, is now part of a clinical trial of treatments for COVID-19. (nih.gov)
Patients2
  • While there is no Ebola virus-specific therapy proven to be effective in clinical trials, mortality has been dramatically lower among EVD patients managed with supportive intensive care in highly resourced settings, allowing for the avoidance of hypovolemia, correction of electrolyte and metabolic abnormalities, and the provision of oxygen, ventilation, vasopressors, and dialysis when indicated. (biomedcentral.com)
  • This study will collect clinical and laboratory data with the aim to compare clinical characteristics and immune responses in AD patients in Sub-Saharan Africa and Central Europe. (inclinicaltrials.com)
Resistance2
  • Identification of a drug that could be used safely and effectively for IPTi instead of SP in areas, such as north eastern Tanzania, where there is a high level of resistance to SP and amodiaquine. (druglib.com)
  • Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. (blogspot.com)
Randomised clinical trial1
  • We conducted a hospital based open-label randomised clinical trial in 40 indigenous semi-immune healthy adult male volunteers with and without malaria parasites. (bvsalud.org)
Preclinical1
  • However, no reviews were focused following various preclinical and clinical studies published since the MMV initiation (2000) to till date. (biomedcentral.com)
Subjects2
  • Bidirectional Pharmacokinetic Interaction Between Amodiaquine and Pioglitazone in Healthy Subjects. (ox.ac.uk)
  • In the DeTACT clinical trial, the majority of subjects recruited from African countries will be children. (tropmedres.ac)
Drugs7
  • Although clinical trials only revealed an increased risk of insomnia, post-marketing surveillance showed that the drugs are associated with a possible increase in suicidal behavior and other side effects such as agitation, aggression, anxiousness, dream abnormalities, hallucinations, depression, irritability, restlessness, and tremor. (wikipedia.org)
  • Such repurposing of existing drugs can greatly speed the time required for human clinical trials. (nih.gov)
  • Pivoting their efforts to COVID-19, the researchers then used the chips to identify three approved drugs-amodiaquine, toremifene, and clomiphene-that could reduce SARS-CoV-2 entry into human lung cells. (nih.gov)
  • Based in part on these results, amodiaquine has been incorporated into the ongoing ANTICOV clinical trial, which is testing drugs to treat COVID-19 in 13 African countries. (nih.gov)
  • We discuss different clinical studies focusing on the evaluation of novel drugs against malaria in different human trials over the past five years. (biomedcentral.com)
  • 5Sigma-Tau Industrie Farmaceutiche Riunite SpA, Rome, Italy within endemic regions and the anorexic effects of malaria infection, these results are unlikely to impact on the clinical utility of these drugs. (compoundlibraries.com)
  • a more comprehensive understanding of the factors contributing to pharmacokinetic variability is critical in order to optimize the use of these drugs in clinical practice. (compoundlibraries.com)
Infectious diseases1
Manifestations1
Days1
  • History and epidemiology inhalant abuse carry a poor risk-to-benefit ratio to a maximum of 7 to 3 days amodiaquine not used as antihypertensive therapy. (oaksofwellington.com)
Malaria cases1
  • These researchers ultimately conclude that, "While the use of RDTs in all suspected cases has been shown to be cost-saving when parasite prevalence among clinically diagnosed malaria cases is low to moderate, findings show that targeting RDTs at the group older than six years and treating children less than six years on the basis of clinical diagnosis is even more cost-saving. (malariamatters.org)
Clinicians1
  • This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. (edu.au)
Initiation1
  • 2) Four publications (3) Initiation of a Clinical Trial Unit (CTC) at one of the major hospitals in Zimbabwe, Chitungwiza General Hospital, for the conduct of Phase I Clinical Studies. (edctpalumninetwork.org)
Studies4
  • There are about 36 clinical studies being (or have been) conducted in Madagascar. (inclinicaltrials.com)
  • However, clinical studies on AD in Sub-Saharan Africa are rare and there is a lack of knowledge about possible differences in pathogenesis between European and African AD. (inclinicaltrials.com)
  • The work has also resulted in secondary of achievements such as: (1) Establishment of a Clinical Trial Research Group whose purpose is to critically discuss the design and execution of clinical studies in African settings. (edctpalumninetwork.org)
  • Inhibition data is used in determining the requirement and scope of clinical DDI studies. (labcorp.com)
Medications1
  • These medications tend to be associated with distinct clinical and histological patterns largely dependent on their underlying pathogenesis. (medscape.com)
Evidence1
  • The Committee reviewed the available evidence on analogue insulins compared to recombinant human insulin and concluded that analogue insulins currently offer no significant clinical advantage over recombinant human insulin and there is still concern about possible long-term adverse effects. (who.int)
Children1
  • 4. Assessment of the effect of IPTi on the development of clinical immunity in children in low and high transmission areas. (druglib.com)
Data1
  • Meta-analysis of clinical trial data provides an estimated mean decrease in clinical malaria episodes per child per year of 75% with seasonal malaria chemoprevention compared with placebo, and a modest beneficial effect on the prevalence of anaemia. (beryl.tv)