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  • Caspase
  • Using quantitative Western blot analysis, we studied the levels of nonactivated (uncleaved) caspase 2 and 3 in peripheral blood low-density cells from 185 patients with newly diagnosed AML. (bloodjournal.org)
  • Taken together, caspase 2 and caspase 3 protein levels obtained at diagnosis may constitute a reliable prognostic factor in AML. (bloodjournal.org)
  • 13 14 Caspase 2 is activated by cleavage into three fragments that are then further processed into 18- and 12-kD active subunits. (bloodjournal.org)
  • Upregulated interleukin (IL)-1β maturation, IL-18 secretion, and caspase-1 cleavage were observed in MDMs from type 2 diabetic patients after stimulation with various danger molecules (ATP, high-mobility group protein B1, free fatty acids, islet amyloid polypeptide, and monosodium uric acid crystals). (diabetesjournals.org)
  • Caspase 3 (Apopain or Cysteine Protease CPP32 or Protein Yama or SREBP Cleavage Activity 1 or CASP3 or EC 3.4.22.56) pipeline Target constitutes close to 16 molecules. (reportsnreports.com)
  • The latest report Caspase 3 - Pipeline Review, H2 2017, outlays comprehensive information on the Caspase 3 (Apopain or Cysteine Protease CPP32 or Protein Yama or SREBP Cleavage Activity 1 or CASP3 or EC 3.4.22.56) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportsnreports.com)
  • Furthermore, this report also reviews key players involved in Caspase 3 (Apopain or Cysteine Protease CPP32 or Protein Yama or SREBP Cleavage Activity 1 or CASP3 or EC 3.4.22.56) targeted therapeutics development with respective active and dormant or discontinued projects. (reportsnreports.com)
  • Calpain cleavage may indicate activation of necrosis, while caspase cleavage may indicate apoptosis. (wikipedia.org)
  • Xkr8 was activated directly by caspases and required a caspase-3 cleavage site for its function. (wikipedia.org)
  • report that CED-8, a Caenorhabditis elegans protein implicated in controlling the kinetics of apoptosis and a homologue of the XK family proteins, is a substrate of the CED-3 caspase. (wikipedia.org)
  • occur
  • In order to activate VEGF-C, a second cleavage has to occur between the N-terminal propeptide and the VHD. (wikipedia.org)
  • Signs and symptoms only occur after severe narrowing or closure impedes blood flow to different organs enough to induce symptoms. (wikipedia.org)
  • Acrosin regulation has been found to occur through Protein C inhibitor (PCI). (wikipedia.org)
  • macrophages
  • Some cells release TF in response to blood vessel damage (see next paragraph) and some do only in response to inflammatory mediators (endothelial cells/macrophages). (wikipedia.org)
  • But significant amounts are also produced by tissue macrophages , blood monocytes , and epithelial cells of the genitourinary system and gastrointestinal tract . (wikipedia.org)
  • Typically, atherosclerosis begins in childhood, as a thin layer of white-yellowish streaks with the inner layers of the artery walls (an accumulation of white blood cells, mostly monocytes/macrophages) and progresses from there. (wikipedia.org)
  • chimeric
  • This information can be exploited to generate transgenic humanized rodent P. berghei parasites expressing chimeric P. berghei / P. falciparum proteins on the surface of rodent irbc, thereby opening new avenues for in vivo screening adjunct therapies that block sequestration. (mcponline.org)
  • constitutively
  • EPR-HV3HSA elicited less blood loss than constitutively active HV3HSA in murine liver laceration or tail transection but extended bleeding time to the same extent. (springer.com)
  • citation needed] vWF is a large multimeric glycoprotein present in blood plasma and produced constitutively as ultra-large vWF in endothelium (in the Weibel-Palade bodies), megakaryocytes (α-granules of platelets), and subendothelial connective tissue. (wikipedia.org)
  • This protein is constitutively expressed and secreted in mononuclear cells. (wikipedia.org)
  • mRNA
  • The KX blood group antigen mRNA expression pattern correlates with McLeod syndrome. (wikipedia.org)
  • For example, a deletion within the mRNA that encodes part of the transmembrane domain of the protein effectively leads to non-translation of the intracellular domain due to the presence of a stop codon. (wikipedia.org)
  • cell
  • M. J. (1967) "Fine structural localization of a blood-brain barrier to exogenous peroxidase", J. Cell. (springer.com)
  • Malaria parasites actively remodel the infected red blood cell (irbc) by exporting proteins into the host cell cytoplasm. (mcponline.org)
  • Malaria parasites invade and develop inside red blood cells, and extensive remodeling of the host cell is required in order for the parasite to take up nutrients and grow ( 1 ). (mcponline.org)
  • She and her team looked only at soldiers whose sickle cell status was confirmed by blood tests taken during their years of service, instead of from self-reported sickle cell status or past medical history, as had been done in the other studies. (scinfo.org)
  • It triggers cell adhesion in sympathetic neurons through RET cleavage. (reportsnreports.com)
  • This became known as a red blood cell "ghost" (spectre), and so the major protein of the ghost was named spectrin. (wikipedia.org)
  • Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. (wikipedia.org)
  • Bves is a highly conserved, transmembrane protein that is involved in cell adhesion, cell motility, and most recently has been shown to play a role in vesicular transport. (wikipedia.org)
  • Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes and ependymal cells. (wikipedia.org)
  • It is involved in many important CNS processes, including cell communication and the functioning of the blood brain barrier. (wikipedia.org)
  • Recently, we found that coagulins are cross-linked on hemocyte cell surface proteins called proxins. (wikipedia.org)
  • Under these physiological conditions, a transient and localized influx of calcium into the cell activates a small local population of calpains (for example, those close to Ca2+ channels), which then advance the signal transduction pathway by catalyzing the controlled proteolysis of its target proteins. (wikipedia.org)
  • activates
  • In all three pathways, C3-convertase cleaves and activates component C3, creating C3a and C3b, and causes a cascade of further cleavage and activation events. (wikipedia.org)
  • Cleavage of CED-8 by CED-3 activates its proapoptotic function and generates a carboxyl-terminal cleavage product, acCED-8, that promotes PS externalization in apoptotic cells and can induce ectopic PS exposure in living cells. (wikipedia.org)
  • physiological
  • Their utility as molecular wires has also led to their incorporation into redox reactions in higher‐order organisms, where they participate in numerous physiological processes, including blood coagulation. (intechopen.com)
  • Rhodnius prolixus is an important blood-feeding model organism that is extensively used for physiological and endocrinological research. (biologists.org)
  • Blood feeding initiates endocrinological and physiological changes that lead to a timed, and predictable, growth and development to the next instar or adult. (biologists.org)
  • activation
  • Finally, 2 months of therapy with the antidiabetic drug metformin significantly inhibited the maturation of IL-1β in MDMs from patients with type 2 diabetes through AMP-activated protein kinase (AMPK) activation. (diabetesjournals.org)
  • interactions
  • When secreted from degranulating cells, it can interact with a variety of circulating antipeptidases, but is mostly captured by α 2 -macroglobulin, which sequesters peptidases in a cage-like structure that precludes interactions with large protein substrates and inhibitors, like serpins. (jimmunol.org)
  • Nonetheless, not all human ADAMs have a functional protease domain, which indicates that their biological function mainly depends on protein-protein interactions. (wikipedia.org)
  • This structural feature is consistent with the secondary binding protein hypothesis, as charge-charge interactions would stabilize a protein-zona pellucida "tethering" complex. (wikipedia.org)
  • therapeutic
  • The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, as well as to methods of making these isolated blood proteins and to therapeutic compositions comprising them. (patentsencyclopedia.com)
  • From a biotechnological perspective, attempts have been made to emulate this approach, to produce novel proteins with potential therapeutic applications. (springer.com)
  • inactive
  • However, the resulting protein is still held together by disulfide bonds and remains inactive (although it can bind already VEGFR-3). (wikipedia.org)
  • monocytes
  • In the April 24 JAMA Neurology, researchers led by Stanley Appel at Houston Methodist Neurological Institute in Texas reported that blood monocytes ramp up expression of a bevy of inflammatory genes in people with ALS, and this occurs most dramatically in those with a rapidly progressing form of the disease. (alzforum.org)
  • Sequencing RNA from monocytes taken from the blood of 23 ALS patients and 10 healthy controls, they found more than 200 genes differentially expressed between the groups. (alzforum.org)
  • The top 10 upregulated (red) genes in blood monocytes from people with ALS compared to healthy controls are primarily involved in inflammation. (alzforum.org)
  • They travel back and forth across the blood-brain barrier, and both respond to and activate monocytes and microglia, and hence may serve as a go-between between the two compartments. (alzforum.org)
  • functional
  • Frey, A. (1993) "Gamma-Glutamyl Transpeptidase: Molecular Cloning and Structural and Functional Features of a Blood-Brain Barrier Marker Protein" in: The Blood-Brain Barrier: Cellular and Molecular Biology (ed. (springer.com)
  • Studies have also shown that GFAP knockout mice undergo multiple degenerative processes including abnormal myelination, white matter structure deterioration, and functional/structural impairment of the blood-brain barrier. (wikipedia.org)