Sample pack is a cost efficient option to profile all 4 cleavable linkers. (vectorlabs.com)
As a leading service provider of ADC conjugation, BOC Sciences ' linker development services include enzymatically cleavable linkers , chemically labile linkers , and non-cleavable linkers that have been proven to improve the efficacy and stability of antibody drugs. (bocsci.com)
The β-glucuronidases abundance in lysosomes and tumor interstitium associated with the hydrophilicity of its substrates are the reasons of interest for designing safe and efficient cleavable ADC linkers . (bocsci.com)
BOC Sciences has experts in small molecule drug development and developed a variety of β-glucuronidases cleavable linkers for specific antibodies based on customers' new drug development. (bocsci.com)
11 The 4,5-dimethoxy-2-nitrobenzyl (DMNB)-containing linkers used in our previous study allowed optical MO uncaging, but cyclic cMOs could accommodate enzyme-cleavable linkers as well. (cdc.gov)
Linker7
displaystyle \longrightarrow } + {\displaystyle +} RapiGest SF, the brand-name for sodium 3-[(2-methyl-2-undecyl-1,3-dioxolan-4-yl)methoxy]-1-propanesulfonate, is an acid-cleavable anionic detergent marketed by Waters Corporation and AOBIOUS INC. MALDI matrix compounds such as α-cyano-4-hydroxycinnamic acid have been linked through a linker consisting of an unsymmetric formaldehyde acetals to dodecanol. (wikipedia.org)
Even though all 4 cleavable moieties undergo efficient cleavage, the recovery of biopolymer or digests might vary from application to application requiring a preliminary testing of biotin probes to determine a best performing linker for a given application. (vectorlabs.com)
Apart from using auristatin and doxorubicin, BOC Sciences provides β-glucuronidases cleavable linker customized-design services targeting special cytotoxic agents such as anthracyclines, camptothecin derivatives , taxanes, hedgehog inhibitors, nitrogen mustards, and histone deacetylase inhibitors. (bocsci.com)
The introduction of a glycosidase cleavable linker featuring a hydrophilic sugar moiety also helps overcome aggregation issues. (bocsci.com)
BF-30 derivatives were designed by fusing heptapeptide-palmitic tags to native BF-30 via a protease-cleavable linker and prepared by F-moc solid-phase synthesis. (jcancer.org)
Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release. (bachem.com)
18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)
Protease Cleavable1
Highly Site Specific, Protease Cleavable, Hydrophobic Peptide-Polymer Nanoparticles. (mpg.de)
Peptide2
Applications for cleavable detergents include protease digestion of proteins such as in-gel digestion with trypsin after SDS PAGE and peptide extractions from electrophoresis gels. (wikipedia.org)
Enzyme cleavable nanoparticles from peptide based triblock copolymers. (mpg.de)
Surfactants2
Cleavable detergents, also known as cleavable surfactants, are special surfactants (detergents) that are used in biochemistry and especially in proteomics to enhance protein denaturation and solubility. (wikipedia.org)
UV light- or fluoride-cleavable surfactants have also been developed but are not in current use. (wikipedia.org)
Chemically1
This has been enabled by introduction of chemically modified nucleotides with cleavable terminator groups and fluorescent dyes attached to them. (helsinki.fi)
Signal2
which contain an N-terminal cleavable signal sequence. (elifesciences.org)
8. alm2: score of ALOM program after excluding putative cleavable signal regions from the sequence. (githubusercontent.com)
Research1
Human tPA Purified Non-Cleavable from Innovative Research has been recombinantly produced in insect cells and purified using affinity chromatography. (innov-research.com)
Analysis1
This type of cleavable detergent is inherently compatible with MALDI and does not have to be removed prior to analysis. (wikipedia.org)
Specific1
Small cleavable adapters enhance the specific cytotoxicity o. (rwth-aachen.de)
Mass2
Cleavable detergents are mainly used in sample preparations for mass spectrometry. (wikipedia.org)
This cleavable detergent is sensitive to heat and acid and is degraded during a typical trypsin digestion into the uncharged lipophilic compound 1-(furan-2-yl)undecan-1-ol and the zwitterionic 3-aminopropane-1-sulfonic acid (homotaurine), which can be removed by C18 solid phase extraction during sample work-up. (wikipedia.org)
The sample pack contains 4 most often used alkyne-activated, cleavable biotin probes, Diazo, Dde, PC and DADPS Biotin Alkyne. (vectorlabs.com)
Photo-cleavable2
Dual Stimuli-Responsive Poly(2-hydroxyethyl methacrylate-co-methacrylic acid) Microgels Based on Photo-Cleavable Cross-Linkers: pH-Dependent Swelling and Light-Induced Degradation. (mpg.de)
During this project, a new class of protein photo cleavable crosslinking reagents was designed and synthesised. (bl.uk)
Antibody-Drug Conjugate1
Mirvetuximab soravtansine is an antibody-drug conjugate comprised of a FRα-binding antibody, a cleavable linker, and a potent tubulin-targeting agent. (empr.com)
Mass Spectrometry2
Cleavable detergents are mainly used in sample preparations for mass spectrometry. (wikipedia.org)
Subsequently, we used disuccinimidyl sulfoxide (DSSO), a new mass spectrometry cleavable cross-linker, and the known position of disulfide bonds to experimentally validate each model. (nih.gov)
Cross-linker1
2. A membrane-impermeant, cleavable cross-linker. (nih.gov)
Selectively1
The second was a method of iterative multiplex imaging using selectively chemically cleavable immunoprobes. (nih.gov)
Proteins3
Brzhozovskiy A, Kononikhin A, Bugrova AE, Kovalev GI, Schmit PO, Kruppa G, Nikolaev EN, Borchers CH . The Parallel Reaction Monitoring-Parallel Accumulation-Serial Fragmentation (prm-PASEF) Approach for Multiplexed Absolute Quantitation of Proteins in Human Plasma. (mcgill.ca)
However, many mitochondrial precursor proteins are not synthesized with cleavable presequences but possess internal targeting signals. (rupress.org)
Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. (nih.gov)
Order1
In order to perform isotopic tagging, the kit provides two cleavable IsoTaG probes encoded by zero [M] and two [M + 2] deuterium atoms. (vectorlabs.com)