Cell AgingErythrocyte AgingFibroblastsMetabolic Clearance RateAnion Exchange Protein 1, ErythrocyteCyclin-Dependent Kinase Inhibitor p16beta-GalactosidaseCells, CulturedAgingCyclin-Dependent Kinase Inhibitor p21TelomereDiploidyTumor Suppressor Protein p53DNA DamageMucociliary ClearanceHeterochromatinCell LineCell CycleTelomeraseCell Cycle CheckpointsOxidative StressCell DivisionGene Expression RegulationCaveolinsCaveolin 1Erythrocyte MembraneApoptosisCell NucleusSignal TransductionCell Line, TumorRetinoblastoma ProteinLongevityTime FactorsCell ProliferationTumor Suppressor ProteinsCell Cycle ProteinsUp-RegulationReactive Oxygen SpeciesPhenotypeRNA, MessengerTransfectionNeoplasmsHistonesHalf-LifeModels, BiologicalBlotting, WesternErythrocytesHydrogen PeroxideRNA InterferenceBiological MarkersCyclin-Dependent KinasesRNA, Small InterferingNuclear ProteinsDNACyclinsDNA-Binding ProteinsDown-RegulationGene ExpressionProtein-Serine-Threonine KinasesMolecular Sequence DataProtein BindingDNA ReplicationCreatinineCell Transformation, NeoplasticBase SequenceFlow CytometryTranscription, GeneticTranscription FactorsKidneyPromoter Regions, GeneticPhosphorylationTechnetium Tc 99m PentetatePeptide FragmentsInjections, IntravenousLiverTissue DistributionArea Under CurveLungGlomerular Filtration RateInulinPhagocytosisKidney Function TestsMononuclear Phagocyte SystemAntipyrineMice, Inbred C57BLTechnetium Tc 99m MertiatideAdministration, OralInfusions, IntravenousUreaPharmacokineticsKineticsBiological AvailabilityIodine RadioisotopesDrug InteractionsMucusMice, KnockoutIodohippuric AcidKidney DiseasesDose-Response Relationship, DrugRats, Sprague-Dawley