Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). (neobiotechnologies.com)
C) Commonly a nuclear stain (blue) is used in combination with cytokeratin markers (green) and CD45 (red) to distinguish tumor cells from white blood cells. (utwente.nl)
Chromogranin2
MCC express both neuroendocrine (neuron-specific enolase, synaptophysin, chromogranin) and cytokeratin markers (cytokeratin 20, as a paranuclear dot, CAM 5.2) and is negative for S100 and the common leukocyte antigen ( 2 ). (ispub.com)
The neoplastic cells routinely express pan-cytokeratin and neuroendocrine markers chromogranin and synaptophysin (focal to diffuse staining). (pbpath.org)
Anti-Cytokeratin2
This Mouse Monoclonal Anti-Cytokeratin 18 Antibody Clone DC-10 is used to qualitatively detect Cytokeratin 18 in normal and neoplastic formalin fixed paraffin embedded (FFPE) tissue sections in immunohistochemical detection methodology. (eaglebio.com)
The Mouse Monoclonal Anti-Cytokeratin 18 Antibody Clone DC-10 is for research use only and not intended for use in diagnostic or clinical procedures. (eaglebio.com)
Mouse Monoclonal Antibody1
SDS-PAGE Analysis Purified Cytokeratin 8/18 Mouse Monoclonal Antibody (rKRT8.18/1346).Confirmation of Integrity and Purity of Antibody. (neobiotechnologies.com)
Markers2
Staining of these cells with cytokeratin markers revealed that these populations correspond to non-epithelial, myoepithelial/basal and luminal epithelial cells, respectively. (cardiff.ac.uk)
Furthermore, some markers, such as cytokeratin (CK) 20 and the asymmetric unit membrane, are related to terminal urothelial differentiation, their expression limited to superficial and occasional intermediate cells. (york.ac.uk)
Neoplastic3
The neoplastic cells displayed variable clear cell change and only expressed cytokeratin 7. (qxmd.com)
The biopsy showed infiltrating neoplastic cells characterized by cytologically bland nuclei and abundant finely vacuolated, clear cytoplasm embedded in a collagenized/fibrotic stroma [Figure 1A/B]. No necrosis or mitotic figures were identified. (pbpath.org)
Immunohistochemical6
The immunohistochemical study was negative for Thyroid Transcription Factor 1 (TTF-1), although it was not valued for vimentin, cytokeratin 8 and CD10 because of the small size of the lesion that did not allow an adequate study ( Figure 3 ). (scirp.org)
Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. (dermnetnz.org)
Immunohistochemical study revealed that the tissue was positive for cytokeratin 7 (CK7), cytokeratin 20 (CK20), but negative for gross cystic disease fluid protein 15 (GCDFP15), CDX2, and PAX8. (karger.com)
Immunohistochemical stains reveal that the tumor cells, exhibit membranous carbonic anhydrase 9 (Figure 3) staining and in contrast to the majority of other clear cell renal cell carcinomas are diffusely positive for CK7 (Figure 4). (mayocliniclabs.com)
Immunohistochemical study using antibody for cytokeratin, revealed diffuse and intense positivity. (jnsbm.org)
The argument that this represents a reactive inflammatory dermatosis is supported by studies that used immunohistochemical staining to show that these lesions express cytokeratins similar to those seen in other inflammatory dermatoses, such as psoriasis. (statpearls.com)
Carcinoma19
In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
Go to Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma for more complete information on these topics. (medscape.com)
Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, with a previously known bone metastasis of renal origin and symptomatic goiter containing a nodule that was found to be a metastasic lesion. (scirp.org)
Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, thyroid metastasis with a previously known bone metastasis of renal origin and large goiter with compressive symptoms. (scirp.org)
Sternal biopsy was compatible with metastases from clear cell renal carcinoma ( Figure 1 ). (scirp.org)
The anatomopathological analysis of the surgical specimen described micrometastasis by clear cell renal carcinoma. (scirp.org)
AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, livercarcinoma, breast cancer, and esophageal cancer. (neobiotechnologies.com)
Trichilemmal carcinoma shows many histologic features reminiscent of follicular ORS-notably, its glycogen-rich clear cells, trichilemmal keratinization, and similar immunostaining profile. (jcadonline.com)
3 While the clinical differential diagnosis commonly includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and keratoacanthoma, the histopathological differential also includes trichilemmoma, trichoepithelioma, clear cell SCC, clear cell porocarcinoma, and clear cell hidradenocarcinoma. (jcadonline.com)
Metastasis of clear cell renal cell carcinoma (ccRCC) to the thyroid gland is rare, and simultaneous occurrence of ccRCC and papillary thyroid carcinoma (PTC) is even rarer. (spandidos-publications.com)
After the operation, the pathological examination results suggested the following: Renal clear cell carcinoma, pT1aN0M0, the tumor sized ~4.0×4×3.5 cm 3 , with no lymph node cancer metastases or distant metastasis. (spandidos-publications.com)
The Challenge of 'Monomorphic' Mucoepidermoid Carcinoma-Report of a Rare Case with Pure Spindle-Clear Cell Morphology. (qxmd.com)
His work deals with themes such as Epithelial-mesenchymal transition, Cytokeratin, Clear cell carcinoma and PTEN, which intersect with Cancer research. (research.com)
described a case of squamous cell carcinoma in situ occurring within a clear cell acanthoma. (statpearls.com)
Decreased SATB2 expression is associated with metastasis and poor prognosis in human clear cell renal cell carcinoma. (ac.ir)
Antibody stains1
This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas. (neobiotechnologies.com)
Marker1
During TGF- β 1-induced transition and EGF-induced reversion, hepatic oval cells sustained their progenitor cell marker expression, including α -fetoprotein, albumin, and cytokeratin-19. (hindawi.com)
Cytoplasm6
A Toker cell is an epithelial cell with clear cytoplasm in the nipple of some women. (wikipedia.org)
at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)
As seen on H/E, the above mass forming lesion is comprised of cells with clear cytoplasm arranged in alveolar/ acinar patterns with intersecting bands of fibromyomatous stroma (Figure 1). (mayocliniclabs.com)
Some parts are low grade clear cell (inset top right), but most (main photo) is high grade with eosinophilic cytoplasm, as were the metastases. (biomedcentral.com)
The tumor cells demonstrated clear/foamy vacuolated cytoplasm and small uniform nuclei with finely dispersed chromatin [Figure 4]. (pbpath.org)
Mixed neoplasia pattern including small round cells with scarce eosinophilic to clear cytoplasm. (auanews.net)
Renal2
Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. (gersteinlab.org)
Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
Epithelia2
It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. (neobiotechnologies.com)
Cytokeratin 18 is expressed in simple nonstratified epithelia. (eaglebio.com)
Positivity1
Loss of SATB2 expression correlates with cytokeratin 7 and PD-L1 tumor cell positivity and aggressiveness in colorectal cancer. (ac.ir)
Proliferation4
A tissue specimen examination, collected by incisional skinbiopsy from the lesion at right inguinal area, showed epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer lying between clear cell neoplasm and the underlying epidermis (Fig. 2 ). (karger.com)
Epidermal proliferation with nests of clear cell neoplasm with pagetoid spreading through the epidermis with flattened basal cell layer. (karger.com)
Cytokeratin staining (panker) demonstrates bile ductular proliferation. (librepathology.org)
Malignant proliferation showing large monomorphic cells with some epithelioid (A1E/AE3) or angiocentric aspects without clear vascular differentiation. (medscape.com)
Paraffin-embedded1
Formalin-fixed, paraffin-embedded human colon stained with Cytokeratin 8/18 Mouse Recombinant Monoclonal Antibody (rKRT8.18/1346). (neobiotechnologies.com)
Lesions1
Although most commonly located on the lower extremities, clear cell acanthomas can also appear on the trunk, forearm, face, inguinal area, and few cases of nipple and areola lesions have been reported. (statpearls.com)
Cell21
Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
It is a nondendritic, nonkeratizing, "clear" cell present in the basal cell layer of the epidermis, free in the dermis, and around hair follicles as the hair disk of Pinkus. (ispub.com)
Histologically, most of them are serous or mucinous, but endometrioid, clear cell, Brenner (transitional cell) or mixed histotypes can be also seen. (intechopen.com)
RCC comprises different subtypes with specific histopathological and genetic characteristics, of which clear cell RCC (ccRCC) is the predominant pathological type, accounting for nearly 80% of all RCC cases ( 2 ). (spandidos-publications.com)
The stem/progenitor potential of these cell populations was assessed in vivo by cleared mammary fat pad transplantation. (cardiff.ac.uk)
Cleared mammary fat pad transplantation of these cell populations revealed that extensive mammary fat pad repopulation capacity segregates with the CD24Low cells, whilst CD24High cells have limited repopulation capacity. (cardiff.ac.uk)
The establishment of ERα + luminal breast cancer cell lines has turned out to be a challenging task for reasons not entirely clear. (nature.com)
Hepatic progenitors obtain the myofibroblast phenotype after EMT and lose this phenotype after MET, yet the variation of progenitor cell characteristics is still not clear during the EMT/MET process. (hindawi.com)
Clear cell acanthoma (CCA), also known as "Degos acanthoma" and "acanthome cellules Claires of Degos and Civatte," was first described by Degos et al. (statpearls.com)
however, there are reports of rare cases of multiple disseminated clear cell acanthomas. (statpearls.com)
The exact etiology of clear cell acanthoma is unknown. (statpearls.com)
It is unclear whether clear cell acanthoma represents a benign neoplasm or a reactive inflammatory dermatosis. (statpearls.com)
Most experts maintain that clear cell acanthoma is an epidermal tumor, as originally described. (statpearls.com)
[4] [5] There have also been reports of clear cell acanthomas developing on top of pre-existing psoriatic plaques, which further supports this argument. (statpearls.com)
[6] Research has described an association between clear cell acanthomas and other conditions including stasis dermatitis, varicose veins, viral infections, and arthropod bites, among others. (statpearls.com)
Clear cell acanthomas occur equally in both sexes. (statpearls.com)
Clear cell acanthoma does not appear to occur in children. (statpearls.com)
The pigmented clear cell acanthoma or melanoacanthoma histologically, as well as clinically varies from a typical clear cell acanthoma in that it shows a higher number of melanocytes and increased levels of melanin within the lesion. (statpearls.com)
[2] To date, three case reports exist detailing "atypical clear cell acanthoma. (statpearls.com)
A clear cell acanthoma presents as a solitary, red or red-brown, dome-shaped papule or nodule. (statpearls.com)
Broad spectrum1
Pagetoid SCCIS will be broad spectrum Cytokeratin positive while typically negative for CK7. (dermnetnz.org)
Epidermal1
This entity was first identified and documented by Headington 9 in 1976, who described an epidermal-based tumor composed of atypical clear cells derived from adnexal keratinocytes. (jcadonline.com)
Cells1
Vacuolated, or clear cells are common. (wikipedia.org)
The lu-5 antibody recognizes an epitope on the surface of cytokeratin filaments which is present in a wide range of cytokeratins, except in intermediate-size filament proteins. (biogenex.com)
Detection1
The current standard for CTC detection is the FDA-cleared CellSearch (CS) and this will be used as the "golden standard" in CANCER-ID. (utwente.nl)
Negative1
Cytokeratin 10-negative nested pattern enables sure distinction of clonal seborrheic keratosis from pagetoid Bowen's disease. (dermnetnz.org)
Surgical1
Although surgical treatment with clear margins is the golden standard, local recurrence rates remain high. (jcimcr.org)