AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
ClaudinsClaudin-3Claudin-4Tight JunctionsClaudin-1OccludinClaudin-5Membrane ProteinsZonula Occludens-2 ProteinClaudin-2MARVEL Domain Containing 2 ProteinZonula Occludens-1 ProteinZonula Occludens ProteinsClostridium perfringensPermeabilityEpithelial CellsTight Junction ProteinsNephronsLoop of HenleDogsMadin Darby Canine Kidney CellsElectric ImpedanceCell Membrane PermeabilityJunctional Adhesion MoleculesKeratosis, ActinicFreeze Fracturing
Certain claudinsTransmembraneIntegral membraneBarrierProteinsClaudin expressionTight junctionRenal epithelialReabsorptionExpressionGroupStructureStudyFoundClaudinMultiple claudinsTightParacellularCLDN1ExtracellularOccludinsTricellulinCancersECL1PhosphorylationEpithelialCancerProteinStrandsInteractTumorsBelongsStructuresRoleFamilyDataFindingsCellsFormTherapy
Certain claudins2
  • In patients with inflammatory bowel disease (IBD), disease activity-dependent changes in expression of certain claudins have been noted, thus making certain claudin family members potential therapy targets. (figshare.com)
  • 1 In several cancers, this family of proteins is abnormally regulated, but certain claudins, like Claudin-4, are more frequently overexpressed in neoplasias. (biocare.net)
Transmembrane3
  • Claudins are transmembrane proteins constituting one of three tight junction protein families. (figshare.com)
  • Claudins are transmembrane proteins with four membrane-spanning regions that serve as the major cell-adhesion molecules of tight junctions. (rndsystems.com)
  • Claudins are a group of transmembrane tight junction (TJ) proteins that are vital to the regulation of paracellular transport. (ku.edu)
Integral membrane2
Barrier7
  • Tight junctions restrict the flow of ions and aqueous molecules between cells, and their permeability is determined by the profile of claudin expression and arrangement of claudins with other proteins at the paracellular barrier. (biocare.net)
  • Claudins and barrier dysfunction in intestinal inflammation: Cause or consequence? (uea.ac.uk)
  • Gong, Y & Hou, J 2017, ' Claudins in barrier and transport function-the kidney ', Pflugers Archiv European Journal of Physiology , vol. 469, no. 1, pp. 105-113. (wustl.edu)
  • Tight junctions (TJs) function primarily as a barrier against paracellular transport between epithelial cells and are composed mainly of occludin (OLD) and claudins (CLDs). (elsevierpure.com)
  • Prof. Dorothee GÜNZEL's presented her recent advances on the structure, function and localisation of a family of proteins that form the continuous intercellular barrier between epithelial cells, the claudins. (unige.ch)
  • DE caused upregulation (3 to 5-fold) of mRNA transcripts for matrix metalloproteinase 9 (Mmp9), claudins (Cldn1 and Cldn2), and Gfap (1.6-fold) in the OB, suggestive of altered blood-brain barrier integrity and reactive gliosis. (cdc.gov)
  • Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. (leibniz-fmp.de)
Proteins2
  • Objective: The aim of this study was to investigate the malignant potential of endometrial polyps (EP) by assessing the immunoexpressions of both estrogen receptor (ER) and progesterone receptor (PR), Ki-67 cell proliferation index, neovascularization network (endoglin - CD105), cellular adhesion molecules (claudins 3 and 4), and extracellular matrix proteins (MMP-2 and -9) in both EP and endometrioid adenocarcinoma (type I) in comparison with the normal endometrium. (unesp.br)
  • Cerebral microvascular endothelial cells are linked together through the interactions among multiple tight junction proteins including claudins, occludin and ZO-1 [ 5 ]. (researchsquare.com)
Claudin expression1
  • First, I examined the patterns of claudin expression in the proximal nephron and found that claudins-2 and -10a are expressed throughout the PT, in both convoluted and straight segments. (ku.edu)
Tight junction2
  • The lessons learned on claudins from the kidney will have a broader impact on tight junction biology in other epithelia and endothelia. (wustl.edu)
  • The BBB structure encompasses occludins, claudins, and junctional adhesion molecules to support specialized endothelial cells, forming the tight junction to prevent molecules larger than 400 Da from entering the brain 1 . (nature.com)
Renal epithelial2
  • Claudins are discovered to be key players in renal epithelial physiology. (wustl.edu)
  • Then I generated renal epithelial cell lines with inducible expression of PT claudins, claudin-2 and either claudin-3 or claudin-10a. (ku.edu)
Reabsorption2
  • New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption Aronson PS . (yale.edu)
  • New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption Journal Of The American Society Of Nephrology 2022, 33: 659-661. (yale.edu)
Expression2
  • A study was undertaken with the aim of exploring expression of claudins in human disease and two different animal models of IBD: dextrane sulfate sodium-induced colitis and adoptive transfer model of colitis. (figshare.com)
  • The results of calcium permeability assays show that calcium transport was reduced with co-expression of claudins-2 and -10a but unchanged with co-expression of claudins-2 and -3. (ku.edu)
Group1
Structure1
Study1
  • and 3) both IBD animal models that were analyzed can be used for investigating claudins as a therapy target, respecting their similarities and differences highlighted in this study. (figshare.com)
Found1
  • Claudins were expressed by epithelial and cells of mesodermal origin and were found to be situated at the membrane, within the cytoplasm, or within the nuclei. (figshare.com)
Claudin8
  • Phylogenetic woods analyses of human claudin protein also showed sequence similarities between some claudins, such as claudin-22 and claudin-24, claudin-6 and claudin-9, and claudin-3 and claudin-4, whereas other claudins show relatively distant Vatalanib associations [2]. (tam-receptor.com)
  • The carboxy-terminal tails of claudins, which mostly differ in size and sequence between different claudin protein, contain a PDZ-domain-binding motif that allows claudins to interact directly with cytoplasmic TJ-associated protein such as ZO-1, ZO-2, ZO-3, and MUPP1. (tam-receptor.com)
  • Claudins play a essential function in the control of the selectivity of paracellular permeability, with claudin-15 and claudin-2 known to function in cation stations/skin pores, whereas claudin-4, -10a and -7 Vatalanib contribute to the function of anion stations/pores [22]. (tam-receptor.com)
  • Consistent with the interruption of TJs during tumorigenesis [1], specific claudins including claudin-7 and claudin-1 are downregulated in intrusive breasts, prostate, and esophageal malignancies (Desk 2). (tam-receptor.com)
  • On the various other hands, the upregulation of claudins, claudin-3 and claudin-4 particularly, provides been associated with tumorigenesis also. (tam-receptor.com)
  • We have previously described the presence of two claudin isoforms, claudins 6 and 9, in the neonatal proximal tubule and subsequent reduction of these claudins during postnatal maturation. (elsevierpure.com)
  • At present, 27 members of the Claudin family have been discovered, and with the deepening of research, members of the Claudins family will continue to grow, 24 of which are expressed in mammals. (biochempeg.com)
  • The position and charge of amino acids in the ECL1 region of different claudins are very different, and the difference of C-terminal sequence is another difference point that distinguishes the members of claudin. (biochempeg.com)
Multiple claudins1
  • The manifestation design of claudins varies among tissues types, and most cell or tissue types exhibit multiple claudins [32,33]. (tam-receptor.com)
Tight2
  • 19. Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation. (nih.gov)
  • The endothelial contains adherens junctions that depend on vascular endothelial cell cadherin, and tight junctions involving claudins and occludins. (readabstracts.com)
Paracellular2
  • Previously, the roles of Claudins during organ development have exclusively been related to their canonical functions in determining paracellular permeability. (zfin.org)
  • As TJ protein, Claudins are important for the maintenance of mobile polarity and paracellular transport of substances. (scienceexhibitions.org)
CLDN11
  • DE caused upregulation (3 to 5-fold) of mRNA transcripts for matrix metalloproteinase 9 (Mmp9), claudins (Cldn1 and Cldn2), and Gfap (1.6-fold) in the OB, suggestive of altered blood-brain barrier integrity and reactive gliosis. (cdc.gov)
Extracellular1
  • [ 4 ] The structure of claudins consists of intracellular amino and carboxy termini, 4 transmembrane domains, and 2 extracellular loops mediating interactions between claudins on adjacent cells. (medscape.com)
Occludins1
  • During the development of EMT, restricted junction (TJ) protein, such as Occludins and Claudins, and buy 75438-58-3 buy 75438-58-3 adherens junction protein, such as E-Cadherin, are down-regulated [12]C[17] usually. (scienceexhibitions.org)
Tricellulin1
  • 18. Angulin-1 seals tricellular contacts independently of tricellulin and claudins. (nih.gov)
Cancers3
  • A better understanding of the emerging role of claudins in CSC/TICs and chemoresistance may help to develop therapies against recurrent cancers. (tam-receptor.com)
  • 4. Dysregulation of Claudins in Individual Cancers 4.1. (tam-receptor.com)
  • Since our initial findings, other research groups have found that claudins are dysregulated in many other cancers. (nih.gov)
ECL11
  • These sequences bound to different claudins their ECL1 and peptides with nanomolar binding constants. (biodiversityhotspot.org)
Phosphorylation2
  • [ 8 ] Recent studies have shown that the barrier function of claudins can be modulated also through phosphorylation of the serine and/or threonine phosphorylation sites at the carboxy tail by various kinases such as WNK4 [ 9 ] and cyclic adenosine monophosphate dependent protein kinase. (medscape.com)
  • Moreover, this tail region is usually the site of post-translational modifications such as FLT1 phosphorylation, which can impact the localization and functions of claudins. (tam-receptor.com)
Epithelial2
  • Claudins are discovered to be key players in renal epithelial physiology. (nih.gov)
  • A large number of studies have confirmed that the Claudins family is an essential skeleton protein of TJs, mainly expressed in a tissue-specific manner in endothelial cells or epithelial cells. (biochempeg.com)
Cancer4
  • Although the function of claudins in cancer cells is not clear, recent findings suggest their involvement in cancer cell survival [ 16 ] and invasion [ 20 ] mechanisms. (medscape.com)
  • When claudins become altered or disrupted, cancer and other diseases may develop. (syr.edu)
  • Claudins are aberrantly expressed in aggressive breast cancer. (oncotarget.com)
  • In the field of cancer immunotherapy, CLDN18.2 , an isomer of Claudins family member CLDN18, has become a hot target for competition by pharmaceutical companies. (biochempeg.com)
Protein1
  • The Claudins (CLDNs) protein family was first cloned and named from chicken liver by Furuse Mikio et al. (biochempeg.com)
Strands1
  • Second: One in two claudins are unable to polymerize into strands. (leibniz-fmp.de)
Interact1
  • Third: Claudins interact with each other in five organization principles. (leibniz-fmp.de)
Tumors1
  • The role of claudins in the differential diagnosis of serosal tumors is limited to 1 study to date. (medscape.com)
Belongs1
Structures2
  • It is critical to understand the structures of claudins to help develop drug delivery methods with the mechanistic elements in mind. (syr.edu)
  • Claudins members have similar structures. (biochempeg.com)
Role3
  • We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). (medscape.com)
  • Zeb1 and twist were inversely associated with several claudins, indicating a role in their down-regulation. (bmj.com)
  • This is because mutations in claudins play a role in a number of hereditary diseases, the most obvious one being the HELIX syndrome - a rare condition causing reduced sweat production. (leibniz-fmp.de)
Family1
  • Now, CLDN6 is a potential target of the Claudins family, and the development of tumor-targeted drugs is also in full swing. (biochempeg.com)
Data1
  • Our current data suggest that claudins may be important for cell motility and invasion. (nih.gov)
Findings1
  • These findings constitute the first characterization of the permeability characteristics of claudins 6 and 9 in a cell model and may explain why the neonatal proximal tubule has lower permeability to chloride and higher resistance than the adult proximal tubule. (elsevierpure.com)
Cells2
  • 001). Reactive mesothelial cells rarely expressed claudins. (medscape.com)
  • We transfected claudins 6 and 9 into Madin-Darby canine kidney II (MDCK II) cells and performed electrophysiological studies to determine the resultant changes in physiological characteristics of the cells. (elsevierpure.com)
Form1
  • Depending on the cell, claudins are organized in various constellations to form semi-permeable meshworks up to several hundred nanometers wide. (leibniz-fmp.de)
Therapy1
  • the possible application of epigenetic therapy to target claudins. (tam-receptor.com)