• The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. (wikipedia.org)
  • The largest class of nuclear transport receptors is the superfamily of importin -like factors (also named karyopherins) that PCI-32765 distributor can be classified as importins (import karyopherin) and exportins (export karyopherin) depending on the direction in which they transport the cargo (reviewed PCI-32765 distributor in references 25, 32, 43, 72, and 80). (irjs.info)
  • Proteins bearing a classical nuclear localization signal (cNLS) are imported into the nucleus by the importin / heterodimer (26, 49, 55). (irjs.info)
  • In this work, we recharacterized the importin-α binding nuclear localization signal (NLS) of rat ChREBP, identifying it as an extended classical bipartite NLS encompassing minimally residues 158-190. (elsevierpure.com)
  • Each of these subunits are part of the karyopherin family of proteins. (wikipedia.org)
  • In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
  • Despite the current availability of selective inhibitors for the classical nuclear export pathway, no inhibitor for the classical nuclear import pathway has been developed. (elsevierpure.com)
  • In glutathione S-transferase pull-down assays, TDP-43 bound to karyopherin-alphas, thereby confirming the classical nuclear import pathway for the import of TDP-43. (crick.ac.uk)
  • The detail's customersWrite leads coefficient karyopherins new as study in superhydrophobic family application changes, and in peripheral infrared clusters: several states, central motions, Native new dynamics, seconds of poly(ethylene and AF relationships, and 2a1 review rewards. (enchantlegacy.org)
  • Nuclear localization signals for four distinct karyopherin-β nuclear import systems. (nih.gov)
  • Here we demonstrate that THOV NP contains a motif (KRxxxxxxxxxKTKK) at amino acid positions 179-193 that represents a classical bipartite nuclear localization signal (NLS). (nih.gov)
  • Accordingly, THOV NP failed to interact in coprecipitation assays with the cellular NPI-1/3 transport factors of the karyopherin alpha family. (nih.gov)
  • karyopherin subunit alpha 2 [Source:HGNC. (gsea-msigdb.org)
  • In order to gain insights into the role of Net in hypoxia, we have analysed in parallel the genes regulated by HIF-1alpha, the classical factor involved in the response to hypoxia. (gsea-msigdb.org)