Class ii susceptibility alleles class hla dr7 antigen. Medical search. Frequent questions

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (musc.edu)
In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)

Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. (musc.edu)
RESULTS: The distribution frequencies of the minor alleles of nucleotides 16304C (p = .037), 16311C (p = .027), and 152C (p = .034) were remarkably higher in AS patients than in healthy controls, which indicated that the16304C, 16311C, and 152C alleles were correlated with an increased risk of AS. (bvsalud.org)
D′ can therefore take on values between 0 and 1, and it is a measure of linkage disequilibrium that is normalized for variations in allele frequencies at the two loci. (musculoskeletalkey.com)

Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)

HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)

Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)

The syndrome was subsequently shown to be caused by an antibody response against antigens present in the alveolar and glomerular basement membranes. (medscape.com)
The diagnosis of CD also has changed as a result of the availability of CD-specific antibody tests, based mainly on tissue transgluta- minase type 2 (TG2) antibodies. (vdocuments.net)
Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)

This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)

In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)

The similarity between antigens of Streptococcus pyogenes and multiple cardiac proteins can cause a life-threatening type II hypersensitivity reaction. (wikipedia.org)

Because the antigenic epitope is hidden within the triple helix of the collagen, an environmental factor (eg, smoking, hydrocarbon exposure) presumably is required to unmask the cryptic antigen to the immune system. (medscape.com)

When bound to the specific antigens in the kidneys and lungs, the antibodies initiate an inflammatory destruction of tissues by complement activation and recruitment of proinflammatory cells, leading to rapidly proliferative glomerulonephritis, often accompanied by pulmonary hemorrhage. (medscape.com)
The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)

An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. (musc.edu)

In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)

During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)

children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). (vdocuments.net)

The disease typically develops two to four weeks after a streptococcal throat infection. (wikipedia.org)
In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. (bvsalud.org)

Once the anti-GBM antibodies bind to the specific GBM antigen, complement is activated. (medscape.com)
Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)

During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)

In group 2, the diagnosis of CD is based on positive serology and histology. (vdocuments.net)

This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)

CONCLUSION: In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. (bvsalud.org)

OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)

HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects. (cdc.gov)
Molecular genetic testing of first-degree relatives of a proband (including young children) to monitor those with known celiac disease-susceptibility alleles for early evidence of celiac disease in order to institute gluten-free diet early in the disease course. (nih.gov)
Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)

Major histocompatibility complex (MHC)-class II HLA-DR genotyping and serotyping were performed by software analysis. (nih.gov)
9. Histocompatibility antigens in polymyalgia rheumatica and giant cell arteritis. (nih.gov)

To find an association between human leukocyte antigen (HLA) class II DRB1, DRB3, DRB4, and DRB5 alleles frequencies in a sample of Iraqi patients with Guillain-Barre syndrome (GBS) and compare with a healthy control group. (nih.gov)
Human leukocyte antigen genotyping for HLA DRB1, DRB3, DRB4, and DRB5 was performed using the polymerase chain reaction-sequence-specific primers method. (nih.gov)
Our results suggest an association between HLA-DRB1*03:01, DRB1*07:01, DRB4*01:01, and HLA DR3, DR7 and a susceptibility to GBS. (nih.gov)
We determined HLA alleles B , DRB1 , DQA1, and DQB1 , by sequence-based typing. (nih.gov)
Further molecular genetics studies of HLA-DR2 reveal that the association of anti-GBM nephritis is with HLA-DRB1 alleles (HLA-DRB1 1501 and 1502 alleles), HLA-DQA1 01 alleles, and HLA-DQB1 06 alleles. (medscape.com)

HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. (cdc.gov)
HLA-DQ2/DQ8 and HLA-DQB1*02 homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population. (cdc.gov)
Frequency of HLA-DQB1*0201/02 and DQB1*0302 alleles and tissue transglutaminase antibody seropositivity in children with type 1 diabetes mellitus. (cdc.gov)
Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)

11. Unusual functional and biochemical properties of DR molecules from the HLA-DR1, B14 haplotype. (nih.gov)
12. Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency. (nih.gov)
14. HLA-B14 subtyping by semi-nested PCR-SSP and haplotype distribution in a Spanish population. (nih.gov)

7. Molecular genetic analysis of nonclassic steroid 21-hydroxylase deficiency associated with HLA-B14,DR1. (nih.gov)
Targeting the immunogenetic diseases with the appropriate HLA molecular typing: critical appraisal on 2666 patients typed in one single centre. (cdc.gov)

Susceptibility to AS is determined largely by genetic factors, with B27 comprising less than one-half of the genetic component. (clinicalgate.com)

When bound to the specific antigens in the kidneys and lungs, the antibodies initiate an inflammatory destruction of tissues by complement activation and recruitment of proinflammatory cells, leading to rapidly proliferative glomerulonephritis, often accompanied by pulmonary hemorrhage. (medscape.com)
Once the anti-GBM antibodies bind to the specific GBM antigen, complement is activated. (medscape.com)
Coexistence of ANCAs (mostly myeloperoxidase [MPO-ANCAs]) with anti-GBM antibodies is thought to occur when the renal involvement in ANCA vasculitis leads to the exposure of antigens from the basement membrane and the formation of anti-GBM antibodies. (medscape.com)
The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. (wjgnet.com)
The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. (wjgnet.com)

Genetic susceptibility for celiac disease is highly prevalent in the Saudi population. (cdc.gov)

The disease typically develops two to four weeks after a streptococcal throat infection. (wikipedia.org)
Both genetic susceptibility and environmental features are typically involved. (medscape.com)

Individuals who carry alleles con- for disease prevention. (nih.gov)
10. Mixed lymphocyte reactions for individuals with phenotypic identity for specific HLA-B,DR determinants: the role of linkage disequilibrium and of specific DR and other class II determinants. (nih.gov)

During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. (nih.gov)

15. HLA-A, -B, and -DR antigens in North African patients with nasopharyngeal carcinoma. (nih.gov)

p -Values were corrected for comparisons of multiple HLA alleles. (nih.gov)

5. HLA antigens in 88 cases of rheumatic fever observed in Martinique. (nih.gov)

1. New evidence for the existence of HLA-B14 subtypes. (nih.gov)
4. Further evidence for the partition of HLA-B14. (nih.gov)

1, 2, 3] In the kidneys, binding of these autoantibodies with the GBM results in activation of the complement cascade and can lead to rapidly progressive glomerulonephritis. (medscape.com)

The process took place in three rounds: two using a personalized and anonymous online voting platform and one face-to-face. (bvsalud.org)

Anatomy24

Organisms12

Diseases13

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes63

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups2

Health Care8

Systemic lupus erythem2

Frequencies3

Peptides3

Polymorphism1

Molecules6

Antibody3

Genes1

Genetics1

Proteins1

Immune1

Bound2

CHAINS1

Psoriasis1

Human1

Risk1

Disease2

Specific2

Cells2

Group1

Major1

Presence1

Association1

Celiac disease susceptibility3

Histocompatibility2

DRB15

DQB14

Haplotype3

Molecular2

Genetic factors1

Antibodies5

Population1

Typically2

Individuals2

Present2

Patients1

Multiple1

Cases1

Evidence2

Results1

Process1