Loading...
  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. (springer.com)
  • Haplotype
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • gene
  • Statistically significantly gene ontology (GO) function and biological process differentially expressed in essential hypertension were MHC class II receptor activity and immune response respectively. (medsci.org)
  • DQA1
  • The data available on DQ2-negative CD patients indicate that they almost invariably are HLA-DQ8 positive (DQA1 ∗ 0301/DQB1 ∗ 0302). (biomedcentral.com)
  • fetal
  • It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
  • These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth. (springer.com)
  • Recently, another group of TAAs was described that include antigens overexpressed by neoplastic and fetal cells, and was weakly expressed in a phase-specific way in a few normal cells ( 14 , 15 ). (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • autologous
  • Stimulation of peripheral blood mononuclear cells from two dengue virus type 4 (D4V)-immune donors with live D4V or noninfectious D4V antigen generated 17 HLA class II-restricted CD4+ CTL capable of specific lysis of dengue virus antigen-treated autologous lymphoblastoid cell lines. (umassmed.edu)
  • genotypes
  • In this report, we studied chemokine receptors (CCR2, CCR5), chemokine (SDF1), and HLA class I and II genotypes in LT-NP and attempted to find out whether any particular pattern of host genetics could be implicated in the LT-NP phenotype. (bloodjournal.org)
  • HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skåne (DiPiS) study. (springer.com)
  • proteins
  • In fact, practically all the trials of immunotherapy of cancer (by and large of vaccination) conducted during the last 10 years were based on the use of TAAs encompassing normal proteins or peptides, to generate antitumor T cells mostly restricted by class I HLA ( 4 ). (aacrjournals.org)
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • disease
  • The D8/17 non-HLA B-cell antigen has not been studied in Australia, where Aboriginal people have among the world's highest prevalence of rheumatic heart disease (RHD). (mja.com.au)
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • Combination of HLA class I (HLA-A1, HLA-A2, HLA-B14, HLA-B17, HLA-B27) and class II antigens (HLA-DR5 and HLA-DR6) have been correlated with low rates of disease progression. (bloodjournal.org)
  • association
  • P = 0.000003), this association remains one of the strongest HLA - cancer associations ever reported. (dorak.info)
  • and (3) gestational infections affect the association between HLA and HrBW. (springer.com)
  • and (3) infections aggravated the association between HLA-DQ2/8 and HrBW. (springer.com)
  • accurately
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • recognition
  • Antigen recognition by six D4V-specific clones and three D2V- and D4V-cross-reactive clones was restricted by HLA-DR7. (umassmed.edu)
  • Of note, TcRαβ intraepithelial lymphocytes, responsible of the villous atrophy observed in CD patients' small intestine, are restricted to MHC class I recognition. (biomedcentral.com)