Metabolic Clearance RateAndrostanes17-KetosteroidsIodine IsotopesHalf-LifeGlucose Clamp TechniqueBlood GlucoseInsulinInfusions, ParenteralInjections, IntravenousTritiumInfusions, IntravenousRadioimmunoassayKineticsGlucoseTestosteroneLiverGlucagonDogsCarbon IsotopesGrowth HormoneInsulin ResistanceTime FactorsPregnancyMicrosomes, LiverMucociliary ClearancePharmaceutical PreparationsKidneyGlucuronidesHepatocytesAldehyde OxidaseTechnetium Tc 99m PentetateCytochrome P-450 Enzyme SystemGlucuronatesBiotransformationDealkylationCytochrome P-450 CYP3AAntipyrineDrug InteractionsArea Under CurveTissue DistributionPharmacokineticsAdministration, OralThyroxineC-PeptideFatty Acids, NonesterifiedRats, Sprague-DawleyModels, BiologicalMononuclear Phagocyte SystemMidazolamBiological AvailabilityDose-Response Relationship, DrugChromatography, High Pressure LiquidRats, Inbred StrainsHormonesHydrocortisoneIodine RadioisotopesGlucuronosyltransferaseHydroxylationCytochrome P-450 CYP2D6