The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA. (lookformedical.com)
Proteins3
Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. (tu-darmstadt.de)
Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins required to establish new replication forks. (mdpi.com)
Chromosome replication2
Histone acetylation controls the inactive X chromosome replication dynamics. (tu-darmstadt.de)
Obviously, the initiation of chromosome replication is essential to bacterial reproduction, but this process is not inhibited by any of the currently-used antimicrobial agents. (mdpi.com)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
Genome2
Developmental differences in genome replication program and origin activation. (tu-darmstadt.de)
Genome instability and aberrant alterations of transcriptional programs both play important roles in cancer. (pklab.org)
Correlates1
therefore, the time of replication completion correlates with the band length. (sdbonline.org)
PCNA2
By a PCNA immunostaining assay, the replication timetable was obtained for all the bands mapped. (sdbonline.org)
PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. (lookformedical.com)
When DNA damage was induced at higher levels by γ irradiation, there was an increase in TOPBP1/BRCA1 at sites away from replication forks. (wikipedia.org)
In contrast, when replication forks were stalled by hydroxyurea to generate DNA replication stress, TOPBP1/BRCA1 were found at sites of replication forks. (wikipedia.org)
Recombination1
Dr. Xiong research encompasses a wide range of subjects that include virus diversity, recombination, RNAi suppression, host resistance and resistance-breaking, replication and movement of RNA viruses, and how all these are related to the control and management of viral diseases. (bio5.org)
The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)
Inhibition1
This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF-MEK-ERK1/2 pathway inhibition. (babraham.ac.uk)
Viral1
However, other initiation mechanism can be used, especially in viral mRNAs. (cnrs.fr)
Ligase1
In animals, 5mC is maintained during DNA replication by DNMT1 together with UHRF1, which directly recognizes hemimethylated cytosine via the SRA domain and stimulates activity of DNMT1 in a manner dependent on its ubiquitin-ligase activity ( Nishiyama and Nakanishi, 2021 ). (elifesciences.org)
Progression2
Dysregulated mitochondrial dynamics respond rapidly to metabolic cues, and are linked to the initiation and progression of diverse human cancers. (biomed.news)
We identify genetic subpopulations with transcriptional signatures relevant to tumor progression and therapy resistance. (pklab.org)
Nucleus1
Modifications in SLC35C1 degrades the tensile nucleus of replication development 2C( CDG2C glycosylation tetrasaccharide product study stem II, LAD2), an ciliary Phylogenetic guanylate determined by concerted to autosomal phosphorylated disease, large erythrocyte and diverse RUNX1 lipoprotein( Lubke et al. (evakoch.com)
Machinery1
Some viruses hijack cellular machinery to translate some of their mRNAs through a noncanonical initiation pathway using internal ribosome entry site (IRES), a highly structured RNAs which can directly recruit the ribosome with a restricted set of initiation factors, and in some cases even without cap and initiator tRNA. (cnrs.fr)
Recruitment1
This showed a DNA damage specific role for TOPBP1 recruitment at both replication sites and non-replication sites. (wikipedia.org)
Mechanisms1
The ex vivo infection model closely reflects the situation in vivo and can be used to study the infection and replication mechanisms of PRV, as well as the antiviral immune responses of salmonid erythrocytes. (biomedcentral.com)
Translation1
Translation initiation, in both eukaryotes and bacteria, requires essential elements such as mRNA, ribosome, initiator tRNA, and a set of initiation factors. (cnrs.fr)
To mediate these aspects of DNA repair, TOPBP1 was found to associate with Rad9, which forms a complex with Rad1 and Hus1, hereby termed the 9-1-1 DNA repair clamp. (wikipedia.org)
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation. (tu-darmstadt.de)
Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. (tu-darmstadt.de)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
Function1
null alleles are strict maternal effect mutations, and the phenotype of inappropriate DNA replication is the consequence of loss-of-gene function. (sdbonline.org)
however, mRNAs encoding a subset of factors important for error-free replication and chromosome segregation, including TIPIN, PLK2 and PLK3, remain at low abundance. (babraham.ac.uk)
Events1
In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. (pklab.org)
Sites1
Maintenance DNMTs (directly or indirectly) recognize hemimethylated CpGs and restore symmetric methylation at these sites to prevent the passive loss of 5mC upon DNA replication. (elifesciences.org)
Measurements of oxygen consumption, mitochondrial membrane potential, and patch-clamp electrophysiology show BT2 increases proton conductance across the mitochondrial inner membrane independently of its inhibitory effect on BCKDK. (biomed.news)
Study1
The study of PRV replication and pathogenesis of the infection has been impeded by the inability to propagate PRV in vitro. (biomedcentral.com)