somewhat similar sequences of about 110 amino acids each. (wikipedia.org)
Ribonucleic3
Ribonucleic acid (RNA) is a nucleic acid present in all living cells. (rodefshalom613.org)
Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by biochemical methods. (biomedcentral.com)
The molecular functions of ribonucleic acid (RNA) are diverse and essential in all organisms. (biomedcentral.com)
Sequences1
Oligonucleotide library is created containing single-stranded nucleic acids having random sequences flanked by binding sites. (conversationpoint.com)
Bind2
Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. (mdpi.com)
Target molecule is incubated along with the oligonucleotide library allowing for nucleic acids to bind to them resulting in the formation of Aptamers. (conversationpoint.com)
Functional2
Since the native signal protein peptide of S. aureus protein A was not able to deliver hGH to the extracellular space, it was modified using bioinformatics tools and fused to the n-terminal region of hGh to show that the redesigned signal peptide was functional. (biomedcentral.com)
Other noteworthy developments in modifications of Aptamers, include the addition of functional units of non-nucleic origin and nucleotide modifications, which further improves aptamer performance. (conversationpoint.com)
Diagnostic1
This has led to rapid developments in the domain which can be attributed to various factors, such as number in the number of clinical trials, increased awareness about advantages offered by Aptamers as compared to antibodies, rise in the investment in the pharmaceutical research and development, along with rise in prevalence of chronic and rare diseases have contributed to the increase in the demand for Aptamers-based therapeutics and diagnostic solutions. (conversationpoint.com)
Hormone2
Glucagon-like peptide-1 (GLP-1) is a peptide hormone synthesized and released by enteroendocrine L-cells in the ileum and large intestine following oral food intake. (justia.com)
Since the natural growth hormone signal peptide is of eukaryotic origin and is not detectable by any of the Escherichia coli secretory systems, including Sec and Tat, and is therefore unable to secrete hGH in the prokaryotic systems, designing a new and efficient signal peptide is essential to direct hGh to the extracellular space. (biomedcentral.com)
Protein2
Wilson, D. S., Keefe, A. D. & Szostak, J. W. The use of mRNA display to select high-affinity protein-binding peptides. (nature.com)
In this study, using a combination of the bioinformatics design and molecular genetics, the protein A signal peptide from Staphylococcus aureus was modified, redesigned and then fused to the mature hGH coding region. (biomedcentral.com)
Small4
They include coding mRNAs and non-coding (nc) RNAs among them antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), micro-RNAs (miRNAs), small activating RNAs (saRNAs), RNA aptamers and RNA guides. (frontiersin.org)
There are currently several products containing RNA on the market, and many are under development, among them mRNA, antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), small activating RNAs (saRNAs), micro-RNAs (mi-RNAs), RNA aptamers and RNA guides. (frontiersin.org)
Flexibility of Aptamers offer wider applications as they can be developed against molecules as small as 60 Daltons this means Aptamers can target molecules that are ten times smaller than antibody targets. (conversationpoint.com)
Currently, Aptamers for small molecule drugs, peptides, dyes and viral particles have been developed successfully. (conversationpoint.com)
Select1
Aptamer development process does not involve animals or living cells thus, making it possible to select Aptamers for toxic compounds such as zootoxins and pathogenic bacteria. (conversationpoint.com)
Applications1
While antibodies are highly effective for a wide range of applications, there are unique aptamer advantages that can overcome some difficult scientific challenges. (conversationpoint.com)
Present1
The present disclosure relates to glucagon-like peptide-1 receptor (GLP-1R) agonists and methods of treating or preventing allergic inflammation and/or methods of treating or preventing respiratory syncytial virus (RSV) infection. (justia.com)
Development2
Who are the key players engaged in the development of aptamer-based therapeutics and technologies? (conversationpoint.com)
What are the different initiatives undertaken by start-up players for the development of aptamer-based technologies in the recent past? (conversationpoint.com)
Signal3
17. The apparatus of claim 15, wherein the at least one signal generator, when energized, is configured to provide up to approximately 20 dBm of power. (patentsencyclopedia.com)
18. The apparatus of claim 15, wherein the at least one signal generator is disposed on the substrate proximate to the at least one electromagnetic field generator. (patentsencyclopedia.com)
19. The apparatus of claim 18, wherein the at least one signal generator is coupled to the at least one electromagnetic field generator via a flip-chip pressure connector. (patentsencyclopedia.com)
Cells1
Some Aptamers are able to enter cells without external assistance. (conversationpoint.com)
Region4
3. The apparatus of claim 1, wherein the thin region has a dimension of up to approximately 100 micrometers from and normal to a surface of the substrate. (patentsencyclopedia.com)
5. The apparatus of claim 1, wherein the at least one electromagnetic field generator is configured to deliver power to the thin region in an area parallel to a surface of the substrate having dimensions of approximately 8 millimeters by 8 millimeters. (patentsencyclopedia.com)
13. The apparatus of claim 12, wherein the array of conductors comprises a periodic array of equally spaced electrodes, and wherein an extent of the thin region from and normal to a surface of the substrate is based at least in part on a spacing between adjacent electrodes of the periodic array. (patentsencyclopedia.com)
24. The apparatus of claim 1, wherein the power is delivered to the thin region via a magnetic field above the electrodes, and wherein the at least one electromagnetic field generator comprises a length of wire arranged in a serpentine pattern. (patentsencyclopedia.com)
Methods1
Disclosed herein are methods of treating allergic disorders and respiratory syncytial virus (RSV) infections with a glucagon-like peptide-1 receptor (GLP-1R) agonist. (justia.com)
Benefit2
24, 2014, which designates the U.S., and which claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 61/838,488 filed Jun. (google.com)
This application is a national stage application filed under 35 U.S.C. § 371 of PCT/US2018/018136 filed Feb. 14, 2018, which claims the benefit of U.S. Provisional Patent Application Serial No. 62/458,744 filed Feb. 14, 2017, which are is expressly incorporated herein by reference in their its entirety. (justia.com)