Citation gene expression regulation developmental. Medical search. Frequent questions

Some of these modifications that regulate gene expression are inheritable and are referred to as epigenetic regulation. (wikipedia.org)
Peña, CJ , Neugut, YD & Champagne, FA 2013, ' Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats ', Endocrinology , vol. 154, no. 11, pp. 4340-4351. (elsevierpure.com)
Histone lysine methylation plays a fundamental role in the epigenetic regulation of gene expression in multicellular eukaryotes, including plants. (upenn.edu)
We found that mothers' trauma history was associated with epigenetic regulation of BDNF in their newborns. (syr.edu)
For example, maternal behavior toward pups can alter epigenetic regulation of ERα mRNA expression. (uky.edu)
The epigenetic regulation of spatiotemporal gene expression is crucial for human development. (researchgate.net)
Finally, Mag and Mbp expression correlated with DNA methylation, highlighting epigenetic regulation as a potential mechanism for developmental fluoxetine-induced changes in myelination. (rug.nl)

Methylation of DNA is a common method of gene silencing. (wikipedia.org)
Often, DNA methylation and histone deacetylation work together in gene silencing. (wikipedia.org)
Reduced DNA methylation and histone 3 lysine 9 trimethylation and increased histone 3 lysine 4 tri-methylation at the ERα gene promoter (Esr1) were detected at PN21 in high LG female offspring. (elsevierpure.com)
Recent studies have expanded our knowledge regarding the biological roles and dynamic regulation of histone methylation. (upenn.edu)
In this review, we will discuss recent advances in understanding the regulation and roles of histone methylation in plants and animals. (upenn.edu)
DNA methylation and gene expression are involved in our developmental adaptations to our experiences and can be influenced by social interventions. (syr.edu)
Patterns of DNA methylation and expression of a gene involved in neurodevelopment and psychiatric risk (BDNF) have been linked with childhood trauma. (syr.edu)
Given the intergenerational patterns of health and behavior, and previous links between childhood trauma and BDNF methylation and expression, this study investigated the potential for maternal history of traumatic experiences to influence development in her newborn, via changes in her newborn's BDNF methylation and expression. (syr.edu)
Moreover, the association between maternal trauma and BDNF methylation and expression patterns were moderated by newborn sex. (syr.edu)
Male newborns showed increased BDNF expression with maternal exposure to child abuse (p = .001), and increased BDNF methylation with greater maternal fear (p = .001). (syr.edu)
Future research should consider the potential for maternal historical trauma experiences to influence offspring DNA methylation and gene expression in a manner that could alter development and inform novel prevention strategies. (syr.edu)
Gene expression can be suppressed by the epigenetic modification of the promoter regions by DNA methylation that results in gene silencing. (uky.edu)
Indeed, the decrease in ERα mRNA expression in the cortex during development is accompanied by an increase in promoter methylation. (uky.edu)
Numerous environmental stimuli can alter the DNA methylation that occurs for ERα, glucocorticoid receptors, as well as many other critical genes involved in neuronal development. (uky.edu)
Additionally perinatal stress and exposure to environmental estrogens can also have lasting effects on gene expression by modifying DNA methylation of these important genes. (uky.edu)
They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A, occurring either at or close to key residues marked by methylation for regulation of transcription - K27 and G34. (aacrjournals.org)
We used a mouse model to investigate DNA methylation in developmental programming of type-2 diabetes. (usda.gov)
DNA methylation differences were validated using quantitative bisulfite pyrosequencing, and associations with expression were assessed by RT-PCR. (usda.gov)

In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
These proteins all contain two zinc fingers and four homeodomains, suggesting that they function as regulators of gene expression. (uky.edu)
Gene repression often depends on the recruitment of Polycomb group (PcG) proteins, although the sequences that underlie the recruitment of PcG proteins, also known as Polycomb response elements (PREs), remain poorly understood in vertebrates. (imperial.ac.uk)

This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)

Using a false discovery rate of 0.05, a total of 1,497 differentially expressed genes were identified. (biomedcentral.com)
The present study was conducted to determine whether corneal cells differentially express genes for T4 regulation, keratan sulfate proteoglycan (KSPG) synthesis, crystallins, and endothelial cell ion transporters during transparency development and whether these expressions are altered when E9 embryos are treated with T4. (unboundmedicine.com)
These genes crossregulate each other but are differentially required during distinct developmental periods, first in the preotic placode and later in the otic vesicle. (tamu.edu)
ChIP-Seq for the activating K36 trimethylation mark (H3K36me3) mark of G34V mutant KNS42 pGBM cells identified 156 genes differentially bound and expressed compared to wild-type pGBM control. (aacrjournals.org)
By transcript profiling with oligo-microarrays we have begun to identify genes that are differentially regulated in cultures established with auxin and gibberellin compared to cultures where the phytohormones are absent. (usda.gov)

abstract = "Developmental regulation of somatostatin (SRIF) gene expression was studied in five regions of rat brain and in rat stomach. (northwestern.edu)
abstract = "This chapter discusses the relative merits of the basic approaches to assay tissue-specific gene expression. (princeton.edu)
abstract = "As is the case with many eukaryotic genes, regulation of the chick ovalbumin (Ov) gene involves both positive and negative modulation. (umn.edu)

Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. (wikipedia.org)
Detlef Weigel received his PhD in 1988 from the Max Planck Institute for Developmental Biology. (elifesciences.org)
Since 2002, he has been director of the Department of Molecular Biology at the Max Planck Institute for Developmental Biology. (elifesciences.org)
He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. (elifesciences.org)
She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
Since most of the genes examined here have orthologs in other vertebrates, the results of this study will contribute to the body of knowledge concerning reproduction in vertebrates as well as to an improved understanding of eel biology. (biomedcentral.com)
We thus provide the mechanistic explanation for how the first histone gene mutation in human disease biology acts to deliver MYCN, a potent tumorigenic initiator, into a stem cell compartment of the developing forebrain, selectively giving rise to incurable cerebral hemispheric glioblastoma. (aacrjournals.org)
Sensenbaugh, KR & Sanders, MM 1999, ' Multiple promoter elements including a novel repressor site modulate expression of the chick ovalbumin gene ', DNA and Cell Biology , vol. 18, no. 2, pp. 147-156. (umn.edu)

Hence, developmentally regulated, lineage-specific transcription of the lck gene is mediated by distinct promoter sequences that appear to be capable of functioning independently. (rupress.org)
Any step of gene expression may be modulated, from signaling to transcription to post-translational modification of a protein. (wikipedia.org)
citation needed] Transcription of DNA is dictated by its structure. (wikipedia.org)
citation needed] Regulation of transcription thus controls when transcription occurs and how much RNA is created. (wikipedia.org)
Transcription of a gene by RNA polymerase can be regulated by several mechanisms. (wikipedia.org)
Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb silencing systems to regulate the expression of genes involved in pluripotency and early developmental transcription programs. (nih.gov)
We have identified a large group of regulated genes with putative binding sites for the FOXO transcription factor, DAF-16. (biomedcentral.com)
Genes with DAF-16 sites upstream of the transcription start site tend to be upregulated, whereas genes with DAF-16 sites downstream of the coding region tend to be downregulated. (biomedcentral.com)
Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. (imperial.ac.uk)
Real-time quantitative PCR (RT-qPCR) analysis and sfGFP (superfolder green fluorescent protein) analysis reveal that AmtR directly and negatively regulates the transcription and expression of crn A, cre T, csh A, and hyu B. A growth test shows that C. glutamicum ATCC 14067 can use creatine or creatinine as a sole nitrogen source. (frontiersin.org)
Abscisic acid in combination with auxin is very effective in increasing transcript abundance of CesA genes as measured by quantitative, reverse transcription PCR. (usda.gov)

We also suggest that this mechanism may be playing a significant role in the repression of genes in undifferentiated stem cells. (duke.edu)
The Zhx2 gene was originally characterized in our lab based on its ability to control the developmental repression of several hepatic genes, including AFP (PNAS, 102:401). (uky.edu)
Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. (nih.gov)
These results demonstrate that the Ov NRE contains not only sites responsible for the repression of the gene but also a positive element that is required for responsiveness to steroid hormones. (umn.edu)

Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)

The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
The CHD7 protein regulates the activity (expression) of several other genes through a process known as chromatin remodeling. (medlineplus.gov)
Shortage of this protein is thought to disrupt chromatin remodeling and the regulation of gene expression. (medlineplus.gov)

Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)
I describe the temporal and spatial expression patterns of these genes through embryonic development. (rice.edu)
Changes in gene expression during embryonic development likely cause the signs and symptoms of CHARGE syndrome. (medlineplus.gov)

MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
These results link metabolism and epigenetic control, which may be relevant to the developmental and disease processes regulated by these two enzymes. (zfin.org)
Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
Unlike in adults, most genes with putative DAF-16 binding sites are upregulated during dauer entry, suggesting that DAF-16 has different activity in dauer versus adult metabolism and aging. (biomedcentral.com)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
The insulin signaling pathway (ISP) has a key role in major physiological events like carbohydrate metabolism and growth regulation. (biomedcentral.com)

Mutations in three genes, boxer, dackel and pinscher, disrupt the sorting of axons in the optic tract but do not affect mapping on the tectum. (zfin.org)
Mutations in two genes, nevermind and who-cares, affect the dorsoventral patterning of the projection. (zfin.org)
Critically, H3F3A G34 mutations cause profound upregulation of MYCN, a potent oncogene which is causative of glioblastomas when expressed in the correct developmental context. (aacrjournals.org)
Mutations in the CHD7 gene cause CHARGE syndrome, a disorder that affects many areas of the body. (medlineplus.gov)
More than 600 mutations that can cause CHARGE syndrome have been identified, and they occur throughout the CHD7 gene. (medlineplus.gov)
More than 50 mutations in the CHD7 gene have been identified in people with Kallmann syndrome, a disorder characterized by the combination of hypogonadotropic hypogonadism (a condition affecting the production of hormones that direct sexual development) and an impaired sense of smell. (medlineplus.gov)
Mutations in this gene account for 5 to 10 percent of all cases of Kallmann syndrome. (medlineplus.gov)
Most of the CHD7 gene mutations that cause Kallmann syndrome alter single protein building blocks (amino acids) in the CHD7 protein. (medlineplus.gov)
Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. (cdc.gov)
Emergence can result from mutations in housekeeping structural or regulatory genes or from acquiring foreign genetic information. (cdc.gov)

Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types of cancer and other diseases. (biomedcentral.com)
The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. (biomedcentral.com)

This is due to the assemblage of a rar-corepressor-histone deacetylase complex on retinoic acid response elements (RAREs) in regulatory regions of a subset of genes. (duke.edu)

Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
And recent genome-wide analyses showed that major transcriptional regulators governing development are under the regulation of PcG complexes. (karger.com)
Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, et al: Polycomb complexes repress developmental regulators in murine embryonic stem cells. (karger.com)
Using a sensitive method to monitor the transcripts of thousands of genes, we are comparing cultures containing two plant hormones with cultures that are missing these two growth regulators. (usda.gov)

The set of up-regulated genes includes genes involved in neuroendocrine processes, cell-cell signaling, neurogenesis and development. (biomedcentral.com)
Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
There was an age-related upregulation in expression of genes involved in synaptogenesis, axonogenesis and neuroprotection suggesting preservation of neuronal processes with age. (nature.com)

However, the developmental timing of these effects, which provide insight into the cellular and molecular pathways through which early experience alters later behavior, had not been explored. (elsevierpure.com)
Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
What gene expression programs do these pathways regulate, and how do they control complex downstream events? (biomedcentral.com)

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. (research.com)

The G34 mutation is specific to tumours of the cerebral hemispheres and is associated with a distinct age of incidence (16 yrs) and gene expression signature compared to K27 and wild-type tumours. (aacrjournals.org)
Au WY, Fung AT, Ma ES, Liang RH, Kwong YL: Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocytic leukemia and myelodysplastic syndrome. (karger.com)
Many people with Kallmann syndrome caused by a CHD7 gene mutation have some of the features of CHARGE syndrome (described above), such as abnormally shaped ears and hearing loss. (medlineplus.gov)
Researchers suspect that Kallmann syndrome resulting from a CHD7 gene mutation may actually represent a mild form of CHARGE syndrome. (medlineplus.gov)

As previously reported, transgenic mice bearing functional proximal promoter sequence juxtaposed with the SV40 large T antigen gene invariably develop lymphoid tumors confined to the thymus. (rupress.org)
In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs. (rupress.org)
In three separate lines of transgenic mice, expression in fetal livers was high, and this level persisted into adulthood. (princeton.edu)
Developmental expression and function of DKKL1/Dkkl1 in humans and mice. (nih.gov)
Microarray and real-time PCR analyses of the laser-captured hair matrix cells show a strong decrease in expression of Cdk inhibitor p27(Kip1) and increased expression of selected cyclins in TG vs. WT mice. (brad.ac.uk)
Primary epidermal keratinocytes (KC) from TG mice exhibit significantly increased proliferation and decreased p27(Kip1) expression, compared with WT KC. (brad.ac.uk)

Most of these genes can be markers of communication deficits. (bvsalud.org)

Fe-deficiency induces a complex series of responses in plants, involving physiological and developmental changes, to increase Fe uptake from soil. (biomedcentral.com)
Duplication of actn3 in the zebrafish indicates that variation in actn3 expression may promote physiological diversity in muscle function among vertebrates. (rice.edu)

In multicellular organisms, gene regulation drives cellular differentiation and morphogenesis in the embryo, leading to the creation of different cell types that possess different gene expression profiles from the same genome sequence. (wikipedia.org)
Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. (nih.gov)
Genome-wide transcriptional profiling has revealed similar gene expression signatures in several tumor types and early developmental stages of their tissue of origin. (jax.org)
Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)

These data suggest that there is differential expression of the SRIF gene in different regions of the brain and in the stomach during development. (northwestern.edu)
Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. (plos.org)
Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)

Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)
The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. (nature.com)
The Exon Junction Complex (EJC) plays a central role in post-transcriptional gene expression control. (nature.com)
Insulin-like growth factor-II (IGF-II) mRNA-binding protein-2 (IMP2) is one of the three homologues (IMP1-3) that play important roles in the post-transcriptional regulation of gene expression in several tissues. (pcom.edu)

However, based on the systematic review (discussed in Appendix C) of the limited epidemiological studies and the high-quality animal studies, ATSDR concluded that hepatic and developmental effects are presumed health effects in humans. (cdc.gov)

The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)

The preliminary experiments reported at this conference are encouraging that this experimental plan is revealing the most important genes in the process of fiber initiation. (usda.gov)

Many insulin/IGF pathway and other known dauer regulatory genes have changes in expression that suggest strong positive feedback by the TGFβ pathway. (biomedcentral.com)
Finally, we also see strong regulation of many novel hedgehog- and patched-related genes, hormone biosynthetic genes, cell cycle genes, and other regulatory genes. (biomedcentral.com)
We see evidence of TGFβ-mediated regulation of several other classes of regulatory genes, and we discuss possible functions of these genes in dauer formation. (biomedcentral.com)

Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. (biomedcentral.com)
In addition, many insulin-like ligand and novel genes with similarity to the extracellular domain of insulin/IGF receptors have altered expression. (biomedcentral.com)
Up and down regulation of insulin-like ligands and novel genes with similarity to the extracellular domain of insulin/IGF receptors suggests opposing roles for several members of these large gene families. (biomedcentral.com)

Specifically, we have been focusing on Polycomb-group (PcG) genes, which play an important role in supporting self-renewal. (karger.com)

The goal of this study was to identify genes that may be involved in sexual maturation in experimentally matured eels. (biomedcentral.com)

Some findings showed critical genes, which modulate several aspects of verbal communication. (bvsalud.org)

Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). (wikipedia.org)
Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. (wikipedia.org)
Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. (wikipedia.org)
Protein Isl-1 RNA interference and over expression in early chicken embryo dorsal root ganglia (DRG) were used to investigate t. (nel.edu)
In the rodent cerebral cortex, estrogen receptor mRNA and protein expression are high early in postnatal life and declines dramatically as the animal approaches puberty. (uky.edu)
I found that pollywog encodes the zebrafish mitogen activated protein kinase kinase kinase 4 ( map3k4 ) gene and that it acts upstream of p38a MAPK in the YSL. (rice.edu)
This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. (nih.gov)
However, the function of IMP2 is least understood, largely because an isoform-specific antibody is not available, which makes the conventional techniques to locate protein expression not feasible. (pcom.edu)
Bone morphogenetic protein signaling regulates size of hair follicles and modulates the expression of cell cycle-associated genes. (brad.ac.uk)
Bone morphogenetic protein (BMP) signaling is involved in the regulation of a large variety of developmental programs, including those controlling organ sizes. (brad.ac.uk)
SSRI exposure and maternal adversity interacted to affect expression of genes such as myelin-associated glycoprotein (Mag) and myelin basic protein (Mbp). (rug.nl)
The CHD7 gene provides instructions for making a protein called chromodomain helicase DNA binding protein 7. (medlineplus.gov)
Researchers are working to determine which genes the CHD7 protein regulates. (medlineplus.gov)

An understanding of the molecular mechanisms driving this developmental regulation of gene expression is critical for understanding the complex events that determine lasting brain physiology and prime the plasticity of neurons. (uky.edu)
Neuroanatomy, published in 1984, that has received over 1500 citations over the years, and one in volume 4 of Handbook of Physiology in 1986. (lu.se)

Here, we have defined a set of genes that help to understand the molecular mechanisms controlling reproduction in eels. (biomedcentral.com)
AB - Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms. (imperial.ac.uk)
Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)
Epigenetics is the study of the fundamental molecular mechanisms that restrict the gene expression potential of differentiated cell types - for example, what makes a liver cell different from a neuron, even though both cell types contain the same DNA. (usda.gov)

Their ability to maintain cell and tissue homeostasis is critical, with many miRNA genes implicated in human diseases such as metabolic, inflammatory, and neurodegenerative diseases ( Vishnoi and Rani, 2017 ). (frontiersin.org)
Gene, 2017 Jan 20. (nih.gov)

The proximal promoter lies just 5' to the coding region for the gene and is active only in thymocytes. (rupress.org)
Repressors bind to the Operator, coding sequences on the DNA strand that are close to or overlapping the promoter region, impeding RNA polymerase's progress along the strand, thus impeding the expression of the gene. (wikipedia.org)
Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse. (nih.gov)
A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). (uky.edu)
Alternatively, activation of BMP signaling in HaCaT KC induces growth arrest, stimulates p27(Kip1) expression, and positively regulates p27(Kip1) promoter activity, thus further supporting a role of p27(Kip1) in mediating the effects of BMP signaling on HF size. (brad.ac.uk)
In contrast, in the case of ''true'' bivalency, virtually all cells in the population carry both marks simultaneously at the promoter in question, leading to low, if any, expression for that gene in all cells. (researchgate.net)
Sanders, Michel M. / Multiple promoter elements including a novel repressor site modulate expression of the chick ovalbumin gene . (umn.edu)

CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. (nih.gov)

Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. (jax.org)
This study provides the first evidence that different EJCs can have distinct functions, illuminating EJC-dependent gene regulation. (nature.com)
Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
A distinct set of cellulose synthase or '-glucan synthase (CesA) genes are up-regulated during secondary wall biogenesis. (usda.gov)

MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)

The switch from maternal to zygotic developmental programs is associated with large-scale modification of chromosomes. (biomedcentral.com)
Maternal to zygotic transition (MZT) is the key event during embryogenesis marked by the switch of control from the maternal and possibly paternal transcripts to the newly synthesized embryonic gene products [ 9 - 11 ]. (biomedcentral.com)
Female newborns showed reduced BDNF expression with greater maternal fear (p = .004). (syr.edu)
In addition, most animal research into developmental SSRI exposure neglects the influence of maternal adversity. (rug.nl)

Some of these genes have previously described functions while many others have roles that have yet to be characterized in a reproductive context. (biomedcentral.com)
Members of this family have numerous roles, including regulation of cell adhesion, cell differentiation, directed cell motility, intracellular signaling and stabilization of f-actin at the sarcomeric Z-line in muscle. (rice.edu)

Hence these modifications may up or down regulate the expression of a gene. (wikipedia.org)

My study shows that Zhx2 regulates Elovl3 expression in female liver. (uky.edu)

Using this IMP2-specific antibody, I examined IMP2 expression in the mouse nervous system as well as the developmental patterns by Western blot and immunostaining. (pcom.edu)
Ongoing experiments are aimed at further understanding of IMP2 expression patterns during injury and assessment of its role to facilitate mRNA localization during axon regeneration in the adult nervous system. (pcom.edu)

These data suggest that BMP signaling plays an important role in regulating cell proliferation and controls the size of anagen HFs by modulating the expression of cell-cycle-associated genes in hair matrix KC. (brad.ac.uk)

We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFβ mutants at similar developmental stages undergoing dauer formation. (biomedcentral.com)

Dehydrogenases and a subset of cytochrome p450 genes (cyp26a1, cyp26b1, and cyp26c1) play the major role in providing the retinoic acid and limiting its access. (duke.edu)
In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. (plos.org)
In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. (plos.org)

Fgf3 and Fgf8 are upstream activators of atoh1 genes during both phases, and foxi1, pax8 and dlx genes regulate atoh1b in the preplacode. (tamu.edu)

We are proposing that this is a basic, early embryonic switch that can cause the initiation of cascades of gene expression that are responsible for at least some early, diversification of cell phenotypes. (duke.edu)
His Cancer research research is multidisciplinary, incorporating perspectives in Carcinogenesis, Cyclin A, Cell cycle, PTEN and Cyclin D. His work carried out in the field of Internal medicine brings together such families of science as Gene expression and Oncology. (research.com)
mRNA expressions were determined by real-time PCR using cDNA synthesized from whole-cell RNA, cells expressing T4 receptor mRNAs assessed by in situ hybridization, and KS disaccharide sulfation measured by electrospray ionization tandem mass spectrometry (ESI-MS/MS). (unboundmedicine.com)
In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
A model is presented in which zebrafish atoh1 genes operate in a complex network leading to hair cell development. (tamu.edu)
The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma. (nih.gov)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a 'window of opportunity' for cell-fate specification. (researchgate.net)
Transcript abundance of the genes causing the increase in cell wall thickness was measured in cultures established under different plant hormone compositions. (usda.gov)
Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)

However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)

Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. (nih.gov)

In addition, selective and precise allocation of retinoic acid during early development through the interaction of Phase I enzymes throws the switch 'ON' in a predictable, developmental manner. (duke.edu)
When SRIF mRNA levels from each stage of development were quantified and normalized by the amount of poly (A) + RNA present at that stage of development, a unique pattern of SRIF gene expression was seen in each region. (northwestern.edu)
However, it remains unclear whether such a relationship is a universal feature of malignancy, whether heterogeneities exist in the developmental component of different tumor types and to which degree the resemblance between cancer and development is a tissue-specific phenomenon. (jax.org)
Finally, we identify a set of genes that are upregulated in most cancers and we show that this signature is active in early development. (jax.org)
Taken together, there appears to be a critical window during development where, outside factors that alter epigenetic programming can have lasting effects on neuronal gene expression. (uky.edu)
Phytohormone regulation of cotton fiber development in vitro. (usda.gov)
This approach will identify specific genes that are critical for initiating fiber development. (usda.gov)
Our team is interested in the regulation of two time points in cotton fiber development: initiation of fiber growth from ovule epidermal cells and the transition from fiber elongation to secondary wall biogenesis. (usda.gov)

Analysis of gene expression in a developmental context emphasizes dist" by K Naxerova, C J. Bult et al. (jax.org)

Finally, we show that disrupting the TET1-OGT interaction in mouse embryonic stem cells changes the abundance of TET2 and 5-methylcytosine, which is accompanied by alterations in gene expression. (zfin.org)
This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
It is generally thought that such 'developmental programming' of diabetes risk is mediated, at least in part, by induced alterations in developmental epigenetics. (usda.gov)

Anatomy10

Organisms6

Diseases3

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology5

Phenomena and Processes64

Disciplines and Occupations21

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture3

Humanities6

Information Science77

Named Groups1

Health Care19

Geographicals3

Epigenetic regulation7

Methylation18

Proteins4

Genetics1

Differentially5

Abstract3

Biology8

Transcription11

Repression4

Phenotype1

Chromatin6

Embryonic development4

Metabolism6

Mutations10

Range of developmental processes2

Histone1

Regulators7

Processes3

Pathways3

Metrics1

Mutation4

Mice6

Markers1

Physiological2

Genome4

Differential expression3

Post-transcriptional5

Hepatic1

Transcriptional regulation1

Important genes1

Regulatory genes3

Receptors3

Polycomb1

Identify genes1

Critical genes1

Protein13

Physiology2

Mechanisms4

20172

Promoter7

Promoters1

Distinct4

MicroRNAs2

Maternal4

Roles2

Regulate the expression1

Regulates1

Patterns2

Proliferation1

Stages1

Subset3

Upstream1

Cell10

Poorly understood1

Murine1

Development8

Context1

Alterations3