Citation carcinoma small cell. Medical search. Frequent questions

Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. (medlineplus.gov)
The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. (biomedcentral.com)
EGFR immunoreactivity was present in 36/43 (83.7%) of anal canal and in 20/24 (83.3%) of tonsil squamous cell carcinomas. (biomedcentral.com)

Background: Our aims were to investigate the treatment and clinicopathological variables in relation to prognosis in small cell neuroendocrine cervical carcinoma (SCNECC). (ncku.edu.tw)

Hepatocellular carcinoma is among the eight leading causes of cancer deaths worldwide with a clear tendency to increase further. (who.int)
Reticulin stain was done to confirm the HA and to see whether it has progressed up to the hepatocellular carcinoma (HCC). (who.int)

Recent data suggest that the tumour, node, metastasis classification traditionally reserved for the staging of nonsmall cell lung cancer (NSCLC) can also be applied for the staging of SCLC 3 . (ersjournals.com)
in small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). (ersjournals.com)
The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active EGFR mutations, as well as those who have developed acquired resistance to the first-generation of EGFR-TKIs due to the T790M mutation. (biomedcentral.com)
There are small cell and non-small cell lung cancers (NSCLC). (biomedcentral.com)
NSCLC are subdivided into adenocarcinomas (about 50%), squamous cell (about 20%), large cell (about 10%), and otherwise not defined carcinomas [ 1 ]. (biomedcentral.com)
METHODS: Discovery utilised Taqman Low Density Arrays (754 miRNAs) in 20 non-small cell lung cancer (NSCLC) tumour/normal pairs. (edgehill.ac.uk)
Here we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management.METHODS: Discovery utilised Taqman Low Density Arrays (754 miRNAs) in 20 non-small cell lung cancer (NSCLC) tumour/normal pairs. (edgehill.ac.uk)
The aim of the present study was to study the presence of pre-cachexia and cachexia in patients with stage III nonsmall-cell lung carcinoma (NSCLC) by using a cancer-specific framework and a general framework for cachexia, and to explore the prognostic value of pre-cachexia and cachexia. (edu.au)
In conclusion, pre-cachexia and cachexia are prevalent in this small population of patients at diagnosis of stage III NSCLC. (edu.au)
2 trials were carried out in patients with melanoma, 8 in non-small cell lung cancer (NSCLC), 2 in head and neck squamous cell carcinoma, 2 in gastric cancer, and 1 trial each was conducted in patients with renal and urothelial cancers. (esmo.org)
In the 4 NSCLC trials and one small cell lung cancer study analysed, the OS benefit in all 5 trials was significantly in favour of the women. (esmo.org)
Epidermal growth factor receptor (EGFR) has been validated as a therapeutic target in several human tumours, including colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (HNSCC). (biomedcentral.com)
Monoclonal antibodies directed against the extracellular domain of EGFR and small molecule inhibitors of the tyrosine kinase domain of the receptor have been evaluated in the treatment of several solid tumours including CRC, NSCLC and HNSCC [ 3 ]. (biomedcentral.com)
In NSCLC, approximately 85% of patients who responded favourably to gefitinib or erlotinib, two FDA-approved small-molecule EGFR-tyrosine-kinase inhibitors, were shown to have somatic mutations in the EGFR gene. (biomedcentral.com)

A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. (jci.org)
Human parathyroid hormone-related protein in ovarian small cell carcinoma. (ejgo.net)
SMARCA4 (BRG1) loss of expression is a useful marker for the diagnosis of ovarian small cell carcinoma of the hypercalcemic type (ovarian rhabdoid tumor): a comprehensive analysis of 116 rare gynecologic tumors, 9 soft tissue tumors, and 9 melanomas. (ejgo.net)

citation needed] Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for surgery in this disease since the 1970s. (wikipedia.org)
Jeremy J.W. Chen, Ph.D., of National Chung-Hsing University, Pan-Chyr Yang, M.D., Ph.D., of National Taiwan University in Taiwan, and colleagues increased or blocked the expression of HLJ1 in lung carcinoma cells in the lab and examined the gene's expression in tumor and surrounding tissue cells of 71 patients with non-small-cell lung cancer. (eurekalert.org)
The authors conclude that HLJ1 expression is a novel tumor suppressor in non-small-cell lung cancer. (eurekalert.org)
A New Tumor Suppressor DnaJ-Like Heat Shock Protein, HLJ1, and Survival of Patients With Non-Small-Cell Lung Carcinoma. (eurekalert.org)
Tumor volumes prior to initial therapy for 33 patients with small cell carcinoma of the lung were determined from serially measurable roentgenographic lesions. (johnshopkins.edu)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor . (medlineplus.gov)
These changes allow cells to grow and divide uncontrollably to form a tumor . (medlineplus.gov)

Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)

Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases. (wikipedia.org)
In ES-SCLC, platinum-based combination chemotherapy is the standard of care, with radiotherapy added only to palliate symptoms such as dyspnea, pain from liver or bone metastases, or for treatment of brain metastases, which, in small-cell lung carcinoma, typically have a rapid, if temporary, response to whole brain radiotherapy. (wikipedia.org)
The pancreas is an uncommon but recognizable site for metastases from renal cell carcinoma (RCC). (scirp.org)
K. Chiu, A. Razack and A. Maraveyas, "Targeted Therapy in the Management of Elderly Patients with Pancreatic Metastases from Renal Cell Carcinoma," Journal of Cancer Therapy , Vol. 4 No. 9B, 2013, pp. 15-21. (scirp.org)
He presented with paraplegia due to spinal metastases of the bronchial carcinoma. (biomedcentral.com)
Here, we report the case of a 16-year-old boy with a non-small cell, squamous cell bronchial carcinoma T4N2M1 initially presenting with paraplegia due to spinal metastases. (biomedcentral.com)

Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma. (doximity.com)

Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. (biomedcentral.com)
The associations of SOX2 and/or high-risk (HR)-HPV RNA in situ hybridization (RISH) levels with clinicopathological characteristics and prognostic outcomes for 88 neuroendocrine carcinoma (NEC) cases were analyzed. (biomedcentral.com)

Prospective Randomized Trial of Interferon Alfa-2a Plus Vinblastine versus Vinblastine Alone in Patients with Advanced Renal Cell Cancer," Journal of Clinical Oncology, Vol. 17, No. 9, 1999, pp. 2859-2867. (scirp.org)
Phase III Trial of Interferon Alfa-2a with or without 13-Cis-Retinoic Acid for Patients with Advanced Renal Cell Carcinoma," Journal of Clinical Oncology, Vol. 18, No. 16, 2000, pp. 2972-2980. (scirp.org)
R. I. Fisher, S. A. Rosenberg and G. Fyfe, "Long-Term Survival Update for High-Dose Recombinant Interleukin-2 in Patients with Renal Cell Carcinoma," The Cancer Journal From Scientific American, Vol. 6, Suppl. (scirp.org)
Randomized Phase III Trial of High-Dose Interleukin-2 versus Subcutaneous Interleukin-2 and Interferon in Patients with Metastatic Renal Cell Carcinoma," Journal of Clinical Oncology, Vol. 23, No. 1, 2005, pp. 133-141. (scirp.org)
Recombinant Human Interleukin-2, Recombinant Human Interferon Alfa-2a, or Both in Metastatic Renal-Cell Carcinoma," The New England Journal of Medicine, Vol. 338, No. 18, 1998, pp. 1272-1278. (scirp.org)
Objectives Renal cell carcinoma (RCC) is often found incidentally in asymptomatic individuals undergoing abdominal computed tomography (CT) examinations. (elsevierpure.com)

In recent years, the advent of targeted therapy has transformed the outcomes of patients with metastatic RCC although little evidence is available on its effectiveness on this subset of patients. (scirp.org)

Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. (wikipedia.org)
Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
The therapeutic mechanism for radiation is based on the intrinsic ability of cells to repair damage and the ability of the radiation oncologist to take advantage of any geometric separation between malignant and nonmalignant tissues. (medscape.com)
characterized by alterations in blood production and Mothers typically assume most responsibility the rapid proliferation of malignant cells throughout for taking care of these needs6,7. (bvsalud.org)

citation needed] In August 2018, the FDA approved nivolumab to treat patients with metastatic small cell lung cancer (SCLC) who failed to respond to platinum-based chemotherapy and at least one other line of treatment. (wikipedia.org)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
Recently, prophylactic cranial irradiation (PCI) has been shown to improve outcome in patients with ES-SCLC 4 , but only small advances have been made otherwise. (ersjournals.com)
The authors write, "These findings may identify a subgroup of non-small-cell lung cancer patients who may benefit from adjuvant therapy and facilitate the design of individualized therapies for lung cancer. (eurekalert.org)
RESULTS:Sixty-nine samples from patients with non-small-cell lung cancer were sent for molecular testing for epidermal growth factor receptor. (edu.lb)
Long-term Outcomes of Local and Metastatic Small Cell Carcinoma of the Urinary Bladder and Genomic Analysis of Patients Treated With Neoadjuvant Chemotherapy. (doximity.com)
Purpose: The combination of cisplatin, ifosfamide, and oral etoposide (PlEo) given concurrently with accelerated hyperfractionated thoracic radiation was studied in patients with limited small-cell lung cancer in a phase II trial to assess response, survival, and toxicity. (psu.edu)
To describe ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) to increase awareness of this condition when treating patients with gynecological small cell carcinoma (SmCC). (umn.edu)
All 6 patients had a primary RCC of clear cell type. (scirp.org)
Response and survival in our 16-year-old patient were similar to adult patients with stage IV non-small cell lung carcinoma. (biomedcentral.com)
Lung carcinomas in patients below 20 years of age are extremely rare. (biomedcentral.com)
We reviewed the medical records of neuroendocrine bladder carcinoma patients treated at the University of Nebraska Medical Center between 1996 and 2011. (nebraska.edu)
Eighteen patients with histologically documented small cell carcinoma of the lung who had failed initial combination chemotherapy regimens were treated with single-agent cisplatin in a dose of 100 mg/m 2 every 3 weeks, with mannitol and fluid diuresis. (elsevierpure.com)
The antitumor efficacy of high-dose cisplatin in heavily pretreated patients with small cell carcinoma of the lung appears to be marginal. (elsevierpure.com)
Results of a prospective dose-intensive regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type. (ejgo.net)

Summary Small cell carcinoma (SmCC) of the prostate is a rare and aggressive histologic subtype of the prostate cancer. (johnshopkins.edu)

RESULTS: Despite sustained transmission of imported VDPV2 in NYS involving potentially thousands of individuals (depending on seasonality, population structure and mixing assumptions) in 2022, the expected number of additional paralytic cases in years 2023 and beyond is small (less than 0.5). (cdc.gov)

Large cell carcinoma arises from epithelial cells that line the lungs. (medlineplus.gov)

Here, we demonstrated that chaetocin dramatically inhibited the proliferation in ESCC cells by causing cycle arrest in the M phase and activating the caspase-dependent apoptosis signaling pathway in vitro , and we also found that chaetocin induced the accumulation cellular reactive oxygen species (ROS). (aging-us.com)

The risk factors, the optimal therapy and prognostic factors contributing to poor outcomes of neuroendocrine urinary bladder carcinoma are not fully elucidated because of its rarity. (nebraska.edu)

Atezolizumab was associated with a significant improvement in overall survival (HR for death = 0.70) Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. (wikipedia.org)
In contrast, little progress has been made in the treatment of extensive-stage SCLC (ES-SCLC), apart from the recently documented survival gain by the addition of prophylactic cranial irradiation. (ersjournals.com)
Cell survival after exposure can be expressed in terms of a logarithmic curve of survival versus dose. (medscape.com)
Cell survival, single fraction. (medscape.com)
Besides being related to intrinsic cellular radiosensitivity, cell survival is also related to oxygen tension, the position of the cell in the mitotic cycle, and dose rate. (medscape.com)
Several models have been used to conceptualize radiation-induced cell death and to explain the cell survival curve. (medscape.com)
The cell survival curve can be interpreted to follow a linear-quadratic model, according to which the surviving fraction is equivalent to e (αD - βD2) , where α and β represent the alpha and beta components, respectively (see the image below). (medscape.com)
Composition of cell survival curve. (medscape.com)
The linear alpha component is responsible for the initial shoulder on the cell survival curve and is caused by repairable damage to the target. (medscape.com)

Benign thyroid nodules were more frequent than thyroid carcinoma. (bvsalud.org)
Evidence also shows that thyroid nodules and carcinoma prevalence increase with age (8). (who.int)

Antibodies against the vascular-endothelial growth factor receptor (VEGFR) are efficient in non-squamous cell tumors [ 1 ]. (biomedcentral.com)
MCPyV was reported in 2008 and was identified in Merkel cell tumors, a rare form of skin cancer ( 8 ). (cdc.gov)

carcinoma and metastasis if not adequately treated and in a timely manner1. (bvsalud.org)

The authors observed that HLJ1 stopped proliferation of lung cancer cells, slowed the cell division cycle's progression, and inhibited the cells' ability to move and invade other tissues. (eurekalert.org)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
When these proteins are turned on (activated) by binding to other molecules, signaling pathways are triggered within cells that promote cell proliferation. (medlineplus.gov)
The altered protein cannot regulate cell proliferation effectively and allows DNA damage to accumulate in cells. (medlineplus.gov)
Moreover, the MST1/2 inhibitor XMU-MP-1 not only partially rescued the inhibitory effect chaetocin-induced proliferation, but also rescued the chaetocin-induced apoptosis in ESCC cells. (aging-us.com)

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. (ejgo.net)
Small cell carcinama of the ovary, hypercalcemic type. (ejgo.net)
The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. (ejgo.net)
Small cell of the ovary, hypercalcemic type -analysis of combined experience and recommendation for management. (ejgo.net)
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. (ejgo.net)
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines. (ejgo.net)

Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. (biomedcentral.com)

late-responding tissues have smaller α/β ratios. (medscape.com)
Subsequent development of in situ hybridization (ISH) techniques to detect EBV-encoded small RNAs (EBERs) facilitated the detection of EBV in cancer tissues ( 4 , 5 ). (spandidos-publications.com)
Formalin fixed, paraffin-embedded tissues from anal and tonsil carcinoma were used. (biomedcentral.com)

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. (spandidos-publications.com)
In 1990, Burke et al ( 3 ), first reported the association between EBV and gastric carcinoma with characteristic lymphoepithelioma-like histology based on polymerase chain reaction (PCR) techniques. (spandidos-publications.com)
In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)
The reason for this is that Helicobacter Pylori ( H. pylori ), discovered in 1983 by Marshall and Warren, and classified as a definite carcinogen by World Health Organization in 1994, has been regarded as the major factor in almost all gastric carcinomas worldwide ( 7 - 9 ). (spandidos-publications.com)
In addition to accumulating more case series of EBV-associated gastric carcinoma (EBVaGC), the development of comprehensive molecular analyses has provided evidence that EBVaGC is a distinct subset both in terms of its clinicopathological and molecular features. (spandidos-publications.com)

Merkel cell polyomavirus (MCPyV), associated with Merkel cell carcinoma, was detected in 27 of 635 nasopharyngeal aspirate samples by real-time PCR. (cdc.gov)

Small cell carcinoma of the ovary with hypercalcemia: a report of eleven cases. (ejgo.net)
4] Estel R, Hackethal A, Kalder M, Münstedt K. Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature. (ejgo.net)
7] Jamy O, Yaghmour G, Hare F, Martin MG. Population- based analysis of the clinical features of primary small cell carcinoma of the ovary. (ejgo.net)

Extensive stage small cell lung cancer (SCLC) is classified as a rare disorder. (wikipedia.org)
The small infiltrating cancer nests surrounding CIN 3 margins or the CIN 3-like SCC with deep invasion generally display a decreased SOX2 level locally, and this indicates reduced SOX2 expression during invasive growth [ 13 ]. (biomedcentral.com)
Scholars@Duke publication: Extent of Surgery for Stage IA Non-Small-Cell Lung Cancer. (duke.edu)
nium-214, deliver to target cells in the respiratory epithelium the energy that is considered to cause radon-associated lung-cancer (NRC 1991). (nationalacademies.org)
Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. (medlineplus.gov)
Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent. (medlineplus.gov)
In nearly all cases of lung cancer, these genetic changes are acquired during a person's lifetime and are present only in certain cells in the lung. (medlineplus.gov)
Somatic mutations in many different genes have been found in lung cancer cells. (medlineplus.gov)
Surgical Approach to a Penile cancer, squamous cell carcinoma, erythroplasia of Queyrat. (bvsalud.org)
Previous studies of breast cancer progression have focused on tamoxifen users, or have been limited by their small sample size and methodology. (medscape.com)

A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (nih.gov)

Small-cell lung carcinoma has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). (wikipedia.org)

A few studies have reported that SOX2 is overexpressed in cervical squamous cell carcinoma (SCC), and plays an important role in the progression from squamous dysplasia to SCC. (biomedcentral.com)

While PVC exposurecausesliver toxicity and increases the risk of liver cancers, including angiosarcomas and hepatocellular carcinomas, the carcinogenic effects of work-related exposure to other MPs, such as polystyrene and polyethylene, are not well understood. (cdc.gov)

In rare cases, the genetic change is inherited and is present in all the body's cells (germline mutations). (medlineplus.gov)
EGFR mutations were absent from squamous cell carcinoma of the anus and tonsils, but EGFR protein expression was detected in the majority of the cases. (biomedcentral.com)

Fluorescence-activated cell sorting (FACS) and fluorescence in situ hybridization (FISH) analysis indicated the induction of polyploidy in all staurosporine and in two out of four stauprimide-treated SCLC cell lines. (uni-luebeck.de)
Erythroplasia of Queyrat (EQ) is a squa- nant degeneration increases by 30 % if treat- mous cell carcinoma in situ arising from the ment is not received in a timely manner1. (bvsalud.org)
EQ is one of the three most frequent vari- ence these conditions must be counseled ants of carcinoma in situ of the penis. (bvsalud.org)

The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) showed stronger growth suppression in H1975-OR cells than in H1975-P cells, but vorinostat, another HDAC inhibitor, showed equal inhibitory efficacy in both cell types. (biomedcentral.com)

Radiation can also affect the processes of the cell cycle necessary for cell growth, cell senescence, and apoptosis (programmed cell death). (medscape.com)
When DNA becomes damaged, p53 helps determine whether the DNA will be repaired or the cell will self-destruct ( undergo apoptosis ). (medlineplus.gov)

Primary small cell carcinoma of the hepatobiliary tract is rare. (springer.com)
In 1879, Harting and Hesse (1879) described autopsy findings that documented pulmonary malignancy in miners in that region and by early in the 20th century the malignancy was shown to be primary carcinoma of the lung (Arnstein 1913). (nationalacademies.org)

citation needed] Combination chemotherapy consists of a wide variety of agents, including cisplatin, cyclophosphamide, vincristine and carboplatin. (wikipedia.org)
To our knowledge, this is the first reported case of small cell carcinoma of the CBD in which a radical resection was performed after successful neoadjuvant chemotherapy. (springer.com)

The TP53 gene provides instructions for making a protein, called p53, that is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (medlineplus.gov)
The protein regulates cell growth and division by monitoring DNA damage. (medlineplus.gov)
The EGFR and KRAS genes each provide instructions for making a protein that is embedded within the cell membrane. (medlineplus.gov)

His interests are in Non-small cell lung carcinoma, radiation induced lung injury and idiopathic pulmonary fibrosis. (jefferson.edu)
The exact mechanism of cell death due to radiation is still an area of active investigation. (medscape.com)
Repeated small doses of radiation are less damaging to a sensitive cell than a single fraction containing an equivalent total dose (see the image below). (medscape.com)

Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon CT (Kd = approximately 0.44 nM) and for human CT (Kd = approximately 5.4 nM). (jci.org)

We have recently shown that staurosporine mediates the conversion of small cell lung carcinoma (SCLC) cells into a neuron-like process-bearing phenotype. (uni-luebeck.de)
Here, we have extended these studies to the staurosporine analogs K252a, lestaurtinib, PKC412, stauprimide, and UCN-01 and analyzed their influence on process extension, cell cycle distribution, and induction of polyploidy in four SCLC cell lines. (uni-luebeck.de)
In GLC-36 and SCLC-24H cells, only cell flattening was detectable. (uni-luebeck.de)
These data demonstrate that in SCLC cells, albeit a higher substrate specificity, staurosporine analogs can induce staurosporine-comparable effects. (uni-luebeck.de)

Anatomy6

Organisms2

Diseases74

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology4

Phenomena and Processes19

Disciplines and Occupations13

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture2

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Squamous cell carcinomas3

Prognosis in small cell neuroendocrine1

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NSCLC14

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Tumor8

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Metastases6

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Neuroendocrine carcinoma2

Renal6

Targeted Therapy1

Malignant4

Patients15

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20221

Epithelial Cells1

Reactive Oxygen1

Urinary Bladder1

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SCLC4