Cisplatin kidney tubules proximal. Medical search. Frequent questions

Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. (gaa-science.com)
The 2 critical factors in the development of acute kidney injury (AKI) secondary to aminoglycoside nephrotoxicity are dosing and duration of therapy. (medscape.com)
The therapeutic efficacy of the antineoplastic drug cisplatin is limited by its nephrotoxicity, which affects particularly to proximal tubular cells (PTC). (uah.es)
Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. (frontiersin.org)

Given their importance in massive nutrient and electrolyte reabsorption, the proximal tubule and medullary thick ascending limb require significant ATP and are most susceptible to ischemic damage. (wikipedia.org)
1.Describe the process of water, nutrient and electrolyte reabsorption in the nephron of the kidney. (essayworldwide.com)

Approximately 40%-50% of the filtered urea undergoes passive reabsorption in the proximal tubule. (medscape.com)
In states of intravascular volume depletion, proximal sodium and water reabsorption increases, coupled with a parallel increase in the reabsorption of urea. (medscape.com)
2.Describe the hormonal regulation of water and electrolyte reabsorption in the kidneys. (essayworldwide.com)
Thus the filtrate passes through the following structure in their order: proximal convoluted tubules-they perform the nutrient reabsorption, loop of henle-controls urine concentration, distal convoluted tubules- regulation of sodium, pH and potassium and finally collecting gland- regulation of water and sodium. (essayworldwide.com)
One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)

Examination of USAG-1 expression in developing kidney indicated that a mosaic of proximal and distal tubule marker-positive cells reside side by side in the immature nephron. (ox.ac.uk)
This suggests that each cell controls its own fate for becoming a proximal or distal tubule cell. (ox.ac.uk)

Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. (scienceopen.com)
Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2-mediated mitophagy protects against cisplatin-induced renal tubular epithelial cell ferroptosis through the ROS/HO1/GPX4 axis. (ijbs.com)

Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys. (wikipedia.org)
These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes. (medscape.com)
The mechanism of cisplatin-induced acute kidney injury includes oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress, which result in apoptosis, necrosis and ferroptosis of renal tubular epithelial cells, causing rapid loss of kidney function [ 8 - 11 ]. (ijbs.com)

Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)
Proximal tubular cells isolated from the knockout mice were more sensitive to cisplatin-induced apoptosis than cells from wild-type mice. (elsevierpure.com)
Objective In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. (thieme-connect.com)
This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. (thieme-connect.com)
Pre-treatment with curcumin significantly ameliorated inflammation and apoptosis induced by cisplatin. (thieme-connect.com)
Conclusions These data indicate that curcumin has nephroprotective properties against cisplatin-induced kidney damage in rats and this effect is associated with its anti-inflammatory and anti-apoptosis profiles, in addition to its antioxidant. (thieme-connect.com)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
9 ] reported curcumin administration provided protection against cisplatin-induced renal tubular cell apoptosis. (thieme-connect.com)
Apoptosis and cell proliferation in proximal tubular cells exposed to apoptotic bodies. (uah.es)
Cisplatin-induced cytotoxicity appears to be multifactorial and involves inflammation, oxidative stress as well as apoptosis. (uah.es)
Since iPGE2 also mediates both cisplatin-induced HK-2 cell apoptosis, intervention in the COX-2/iPGE2/EP receptor pathway might provide us with new therapeutic avenues in patients with cisplatin-induced acute kidney injury. (uah.es)

There are approximately one million nephrons in the kidneys of the adult human. (drprincetta.com)
The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)

Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
acute and chronic kidney disease-their statistical data, and the conventional drugs used for treatment. (biomedcentral.com)
Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries. (hindawi.com)
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was developed as a follow-up to the MDRD equation in an attempt to be as accurate in describing renal function at lower GFR (less than 60 mL/min/1.73 m 2 ), but more accurate at a higher GFR . (clincalc.com)
Hyperfiltration of the glomerulus is associated with chronic kidney disease. (drprincetta.com)
Recovery from a decreased GFR and chronic kidney disease can be limited due to fibrosis of kidney tissue. (drprincetta.com)
Dr. Henderson further describes kidney supplements that may be beneficial for urinary tract infections or UTI's, kidney stones, and chronic kidney disease. (drprincetta.com)

Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
MATE transporters efflux organic cations in exchange with protons across the luminal membrane of renal proximal tubule cells and the canalicular membrane of hepatocytes, thereby enabling excretion of organic cations into urine and bile. (proteasepathway.com)
Cisplatin is excreted primarily in the urine, resulting in concentrated drug levels, which encourage uptake into the cells by passive diffusion or active uptake. (medscape.com)
The blood is constantly filtered by the kidneys to make urine. (ox.ac.uk)
Formaldehyde and perhaps other food derived toxins in the urine then damage the DNA in the kidney cells, driving the secretion of GDF15 into the blood. (ox.ac.uk)
An unexpected decrease in urine output followed by a rise in serum creatinine concentration, including an inability to excrete waste, keep-up electrolytes, and maintain water balance, is termed acute kidney injury (AKI) or acute renal failure. (biomedcentral.com)
For analysis, we excluded subjects who had missing data on serum Mg or urine albumin or urine creatinine (n = 5), those who had urinary tract infection, glomerulonephritis, nephritic syndrome, or kidney cancer (n = 17), and those who had UACR �� 300mg/g (n = 21). (trpv-antagonist.com)
This means that, for instance, in the liver (where its abundance is relatively low) it effluxes its substrates into the bloodstream, whilst in the kidney (where it is one of the dominating ABC transporters [7]) it effluxes into the urine. (solvobiotech.com)

Mechanistically, these knockout mice had heightened activation of p53 and c-Jun N terminal kinase, the signaling pathways contributing to cisplatin acute kidney injury. (elsevierpure.com)
They then asked why these mice developed kidney failure and severe weight loss. (ox.ac.uk)
The researchers also report that when mice are treated with the chemotherapeutic agent Cis-Platin, the kidney cells are activated to secrete the same hormone. (ox.ac.uk)
In G0 marker mice, almost all proximal tubular cells remained in the G0 phase under physiological conditions. (asn-online.org)
We also isolated primary proximal tubular cells from G0 marker mice and induced senescence. (asn-online.org)
Our data suggest that G0 marker mice can be a useful tool for identifying senescent proximal tubular cells both in vivo and in vitro, in combination with cyclin D1 expression. (asn-online.org)
The results showed that cisplatin induced mitochondrial injury, ROS release, intracellular iron accumulation, lipid peroxidation and ferroptosis in the kidney, which were aggravated in Bnip3 knockout , Pink1 knockout or Park2 knockout cisplatin-treated mice. (ijbs.com)

On the sixth day, the cats were killed to determine the histological renal damage, renal function, the accumulation of arsenic, and antioxidant activities in the kidney. (springer.com)
Extensive necrosis and debris accumulation were observed in the tubules, particularly in the proximal tubules, within the CCl4-applied group. (medscidiscovery.com)

Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. (biomedcentral.com)
Heart performance and kidney function are closely interconnected and communication between these organs occurs through a variety of bidirectional pathways. (biomedcentral.com)

Chronic Mg deficiency has also been shown to increase copper absorption and concentrations in plasma, muscle, kidney, and liver. (drsircus.com)
Chen CJ, Chen CW, Wu MM, Kuo TL (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. (springer.com)
Therefore, the BUN level may reflect functioning of the liver and/or kidneys. (medscape.com)
Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
It is expressed in the kidney, blood-brain barrier (BBB), liver, and other tissues, and its localization to the basolateral or apical membranes is tissue-dependent. (solvobiotech.com)
MRP4 (recently reviewed in [1] is found in a variety of human tissues, with high levels of mRNA expression in the kidney and prostate, and lower levels in the liver, testis, ovary, lung, parotid gland, adrenal gland, and in various neurons and blood cells. (solvobiotech.com)
In the liver, choroid plexus, prostatic acinar cells, and the GIT, MRP4 is expressed at the basolateral membrane, while in the brain capillary endothelium and renal proximal tubule cells it is expressed at the apical membrane [2-6]. (solvobiotech.com)

Glomerular filtration rate (GFR) is the most accessible guide for normal kidney function, which rises to the aggregate sum of fluid filtered through the entirety of the working nephrons per unit of time [ 4 ]. (biomedcentral.com)
Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)

Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)

In this review, we discuss the induction protocols for kidney organoids and tubuloids, as well as their potential applications in understanding kidney development, renal pathogenesis, and drug screening. (j-organoid.org)

We have recently shown that the cyclo-oxygenase-2 (COX2)/intracellular prostaglandin E2 (iPGE2)/EP receptor pathway mediates the apoptotic effect of cisplatin on human proximal tubular HK-2 cells. (uah.es)

Nephrotoxic drugs, such as antibiotics (gentamicin), diuretics (furosemide), chemotherapeutic drugs (cisplatin) and calcineurin inhibitors (tacrolimus), induce acute kidney injury [ 1 ]. (ijbs.com)

Relative effects of arsenate on sodium, phosphate, and glucose transport by the rabbit proximal tubule. (springer.com)
Distal convoluted tubules- sodium chloride, hydrogen and potassium ions, and water bicarbonates (Malnic et al. (essayworldwide.com)

These include the major components of the glomerulus, proximal and distal tubules, loop of Henle, and collecting duct [ 1 ]. (j-organoid.org)

Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. (scienceopen.com)
Recently, to diagnose UTI noninvasively, several studies have reported that some urinary biomarkers of acute kidney injury (AKI) may be associated with UTI. (e-cep.org)
Urinary NGAL (uNGAL) is secreted predominantly by the injured epithelial cells of the kidney. (e-cep.org)

Necrotic cells fall into the tubule lumen, obturating it, and determining acute kidney failure. (wikipedia.org)
In situ hybridization and immunohistochemistry revealed that KIM-1 is expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules. (scienceopen.com)
In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
Aminoglycosides preferentially affect the proximal tubular cells. (medscape.com)
Although cyclophosphamide is not nephrotoxic, ifosfamide, by virtue of its metabolite chloroacetaldehyde, is toxic to the tubular cells, with preferential involvement of the proximal tubule leading to Fanconi syndrome. (medscape.com)
Here, we studied the effects on HK-2 cells of apoptotic bodies (ABs) generated after treatment of HK-2 cells with cisplatin. (uah.es)
So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
Using this mouse line, we analyzed cell cycle of proximal tubular cells after DNA damage caused by aristolochic acid and cisplatin nephropathy models. (asn-online.org)
In the chronic phase of kidney injury, most proximal tubular cells were G0 marker-positive, but some G0 marker-positive cells exhibited nuclear abnormalities, such as nuclear enlargement. (asn-online.org)
Various anionic drugs have been indicated to be taken up into the proximal tubular cells by the classic p -aminohippurate (PAH) transporter. (aspetjournals.org)
CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem  Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney  Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB  Type IV HSN Rx *ADH hormone 2nd messenger  adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)
Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)

Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
A poor short- and mid-term outcome was also observed in patients with sub-clinical AKI (defined by positive biomarkers of kidney injury but not meeting the current definition of AKI) [ 16 ]. (springeropen.com)
Interestingly, even patients who apparently recovered from AKI at ICU discharge (based on serum creatinine) but with positive biomarkers of kidney injury had a higher risk of death during the year following ICU discharge. (springeropen.com)
Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
β 2 -microglobulin (β 2 -MG) and N -acetyl-β-D-glucosaminidase (NAG) are the dominant biomarkers employed routinely in environmental toxicology research, while kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are also emerging as effective markers to identify mycotoxin induced nephropathy. (frontiersin.org)

On histopathology, there is usually tubulorrhexis, that is, localized necrosis of the epithelial lining in renal tubules, with focal rupture or loss of basement membrane. (wikipedia.org)
Histopathology: Toxic ATN is characterized by proximal tubular epithelium necrosis (no nuclei, intense eosinophilic homogeneous cytoplasm, but preserved shape) due to a toxic substance (poisons, organic solvents, drugs, heavy metals). (wikipedia.org)
Results Cisplatin challenged rats demonstrated kidney injury as shown by reduced creatinine clearance, increased of plasma BUN, plasma creatinine, and kidney MDA, decreased of kidney GSH levels, and kidney histopathology alterations. (thieme-connect.com)

Cisplatin has been used as a standard agent of combination chemotherapy in several cancers, such as nasopharyngeal, lung, and ovarian cancer. (thieme-connect.com)
In fact, the prevalence of cisplatin-induced kidney damage was 34% after fourth cycles and 52% after six cycles of cisplatin chemotherapy in adult cancer patients treated with cisplatin at a dose of ≥60 mg/m 2 at Dharmais National Cancer Hospital, Jakarta, Indonesia [ 6 ]. (thieme-connect.com)
have reported that the continued administration of PEM as a maintenance therapy significantly extended progression-free survival in patients who have efficaciously been treated with PEM + cisplatin induction chemotherapy in the PARAMOUNT trial [ 4 ]. (biomedcentral.com)

In addition, curcumin downregulated Ctr1 and OCT2 drug transporters as compared to cisplatin group. (thieme-connect.com)

ATN presents with acute kidney injury (AKI) and is one of the most common causes of AKI. (wikipedia.org)
Acute tubular necrosis is classified as a "renal" (i.e. not pre-renal or post-renal) cause of acute kidney injury. (wikipedia.org)
We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. (elsevierpure.com)
Chloroquine, a pharmacological inhibitor of autophagy, blocked autophagic flux and enhanced acute kidney injury in both models. (elsevierpure.com)
Rapamycin, however, activated autophagy and protected against cisplatin-induced acute kidney injury. (elsevierpure.com)
Thus, our results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms. (elsevierpure.com)
In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
it is named kidney injury molecule-1 (KIM-1). (scienceopen.com)
Outcome of acute kidney injury: how to make a difference? (springeropen.com)
Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. (springeropen.com)
Cyclosporine and tacrolimus cause acute kidney injury (AKI) by inducing afferent and efferent arteriolar vasoconstriction. (medscape.com)
While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)
Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. (ox.ac.uk)
In kidney injury models, the ratio of USAG-1 to BMP-7 expression decreased with kidney damage but increased after subsequent kidney regeneration. (ox.ac.uk)
Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. (ijbs.com)
Here, we investigated the mechanism underlying both BNIP3-mediated and PINK1-PARK2-mediated mitophagy-induced attenuation of ferroptosis in cisplatin-induced acute kidney injury. (ijbs.com)
Drug-induced acute kidney injury is the second most common cause of acute kidney injury in hospitalized patients, especially in the intensive care unit[ 1 , 2 ]. (ijbs.com)
Among all types of acute kidney injury, drug-induced acute kidney injury accounts for 14-37.5% in several studies [ 3 , 2 ]. (ijbs.com)
During cisplatin treatment, approximately 20%-30% of patients develop acute kidney injury [ 7 ]. (ijbs.com)
Elucidating the precise molecular mechanisms underlying cisplatin-induced acute kidney injury will provide evidence for future treatment. (ijbs.com)
Along with the kidney injury, diabetic patients often suffer from multiple complications, such as retinopathy, neuropathy, and cardiovascular diseases. (hindawi.com)
The objective of this work is to investigate the histological and biochemical consequences of administering Dexmedetomidine (DEX), an alpha-2 adrenergic receptor agonist with notable sedative qualities as well as antioxidant and anti-inflammatory characteristics, in the context of Carbon tetrachloride (CCl4)-induced kidney injury. (medscidiscovery.com)
Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)

Review the essentials of nephrology and explore the latest clinical updates with the Kidney Self-Assessment Program (KSAP). (asn-online.org)

Histopathological examination furthers confirmed the kidney damage protection effect of curcumin. (thieme-connect.com)
The GFR examination and albuminuria, a marker of kidney damage, are both used by nephrologists to categorise kidney conditions into two categories: acute and chronic kidney disorders. (biomedcentral.com)

However, the molecular mechanisms behind the anti-inflammatory and anti-apoptotic effects of curcumin in the cisplatin-induced kidney damage have not been explored. (thieme-connect.com)
Therefore, in this study, we aimed to investigate the possible molecular mechanisms of anti-inflammatory and anti-apoptotic effects of curcumin in cisplatin-induced kidney damage. (thieme-connect.com)

In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
The aging kidneys undergo a wide range of macrostructural changes, such as decreased cortical volume, increased surface roughness, and augmented numbers and sizes of cysts [ 11 ], which correspond to the typical microstructural features of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and nephron loss [ 12 ]. (hindawi.com)

We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)

However, the role of mitophagy in ferroptosis in kidney disease is unclear. (ijbs.com)

It is present in both the central nervous system and peripheral organs including the kidney. (degruyter.com)
Kidneys are an overly sensitive organ with restricted regenerative efficiency with respect to other vital organs. (biomedcentral.com)
The kidneys are a pair of bean-shaped organs that are normally found in the right and left of retroperitoneal space in the abdomen. (drprincetta.com)
The CRS classification system includes a vast array of acute or chronic conditions in these two important organs, where the primary failing organ can be either the heart or the kidneys. (biomedcentral.com)

Also, cisplatin increased ERK1/2 phosphorylation and NF-κB expression, which subsequently increased mRNA expression of TNF-α, IL-6, KIM-1, NGAL, and Bax/Bcl-2 ratio as well as decreased mRNA expression of IL-10 in kidney tissues. (thieme-connect.com)
10 11) NGAL is expressed in various tissues including the kidney. (e-cep.org)

A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
Because hOAT1 has been suggested to show rather limited capacity for organic anion transport, hOAT3 might play a large role in the human kidney. (aspetjournals.org)
In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)

Cisplatin usually affects the proximal tubules primarily with some secondary effect on the glomeruli and distal tubules. (medscape.com)

Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
This analysis led them to discover that DNA damage in a particular cell type in the kidney (proximal tubule cell), causes it to secrete a factor called GDF15 into the blood stream that signals to the brain to suppress appetite. (ox.ac.uk)
Active cell division can promote kidney recovery. (drprincetta.com)

Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
Production of guanidinoacetic acid, a precursor of creatinine is known to be reduced by metabolic disturbance when kidney function is damaged, and thus it may be a sensitive marker of renal damage. (gaa-science.com)
I have become particularly interested in variations of creatinine and glomerular filtration rate and declining levels of function at the stage 2 and stage 3 kidney disease. (drprincetta.com)
I have evaluated kidney function based on serum creatinine levels and estimated glomerular filtration rate (eGFR). (drprincetta.com)

KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. (scienceopen.com)
Northern blot analysis revealed that hOAT3 mRNA is expressed in the kidney, brain, and skeletal muscle. (aspetjournals.org)

The Kidney Week 2023 mobile app features interactive maps, complete program, personalized scheduler, social media integration, and m. (asn-online.org)

The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world. (asn-online.org)

For more than 30 years, guanidinoacetic acid (GAA), together with other guanidino compounds, has been proposed as an important marker for renal failure, in kidney transplantation, and for renal metabolism, especially for the metabolic activity of the renal proximal tubules. (gaa-science.com)
Water helps remove metabolic waste by the kidneys, which is impossible in the absence of a quantity of water acting as a conductor. (articlesfactory.com)

New experimental data have emerged in recent years focusing on the interactive effects of kidney and lung dysfunction, and providing evidence that kidney-lung crosstalk occurs and can be bidirectionally deleterious. (biomedcentral.com)

Hence, curcumin may be useful for preventing kidney damage against cisplatin administration. (thieme-connect.com)
However, it has many severe side effects that limit the therapeutic use of cisplatin, one of them is kidney damage [ 1 ] [ 2 ]. (thieme-connect.com)
Even though various treatment strategies namely saline hydration and diuresis have been suggested for prevention of cisplatin-induced kidney damage, but its prevalence is still high. (thieme-connect.com)
Cadenas S, Barja G (1999) Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO 3 . (springer.com)
Like the canary in the coal that is sent down into mine shafts to sniff out toxins before the miners are sent in, finding ways to improve kidney function before irreversible kidney damage occurs can be indemnifying. (drprincetta.com)

Due to several reasons, the proximal portion of the renal tubule is most commonly injured in ATN. (wikipedia.org)
All of these isoforms are commonly expressed in the kidney, and their potential roles in renal handling of organic anions have been indicated. (aspetjournals.org)

KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney. (scienceopen.com)
Improving kidney function can be difficult and exasperating. (drprincetta.com)
True to the tenets of do no harm, treat the whole patient, and stress preventative medicine, I am looking for ways to improve kidney function in my patients. (drprincetta.com)
I have been fortunate to practice chelation therapy, and I have monitored kidney function in hundreds of patients. (drprincetta.com)
Through continuity of care I have compared lab values over time for many patients and tried to figure out what improves kidney function and what causes its decline. (drprincetta.com)
She also suggests the use of dietary supplements that have been shown in some studies to improve kidney function. (drprincetta.com)
However, I am interested in how to improve kidney function in early kidney decline such as with stage 2 and 3 kidney disease on an outpatient basis. (drprincetta.com)
I decided to do a literature search on PubMed about natural ways to improve kidney function. (drprincetta.com)
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. (pfizermedicalinformation.com)
Hence, maintaining kidney function during PEM treatment by reducing the use of combination drugs and the risk of other renal dysfunctions, such as dehydration, may help patients continue therapy and contribute to their long-term survival. (biomedcentral.com)

Stage 2 kidney disease is defined as an eGFR between 60 to 89 milliliters per minute, and stage 3 kidney disease is defined as an eGFR between 30 and 59 milliliters per minute. (drprincetta.com)
I discovered that a good place to begin in understanding kidney disease is a thorough review of basic renal physiology. (drprincetta.com)

The hOAT3 protein was shown to be localized in the basolateral membrane of renal proximal tubules and the hOAT3 gene was determined to be located on the human chromosome 11q12-q13.3 by fluorescent in situ hybridization analysis. (aspetjournals.org)

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