• Our hypothesis is pretreatment of OS cells with calcitriol would sensitize them for cisplatin therapy leading to decrease in concentration for IC50. (ku.edu)
  • Results: Calcitriol does not sensitize the 143B-P and 143B-MM OS cells for cisplatin therapy. (ku.edu)
  • The dose response of cisplatin with and without calcitriol (100nM) pretreatment was studied in osteosarcoma cell lines 143B-MM, 143-P and control murine osteoblast MC3T3-E1. (ku.edu)
  • The response to intraarterial chemothera py (IAC) comprising 100 mg/m(2) of cisplatin (CDDP) and 40 mg/m2 of pirarub icin (THP) and the prognosis were assessed in 23 patients (the mean follow- up period was 19 months). (unibo.it)
  • NEW YORK (Reuters Health) Feb 01 - In patients with unresectable hepatocellular carcinoma (HCC) confined to the liver, repeated cisplatin-based chemoembolization and a single dose of intrahepatic arterial yttrium 90 (90Y) microspheres produce equivalent median survival times, U.S. researchers conclude in a report published online on January 11 in the journal Cancer. (ynjr.net)
  • Plasma cisplatin pharmacokinetics were determined in 6 patients enrolled in a phase I trial of combined high-dose cisplatin and Interleukin-2 (IL-2) therapy. (elsevier.com)
  • These data demonstrate no significant effects of IL-2 on the plasma pharmacokinetics of cisplatin in the dose schedule given and support the feasibility of this combined modality therapy. (elsevier.com)
  • The effects on the growth of subcutaneously implanted HCT-116 xenografts in mice following intraperitoneal administration of a single dose of 4 mgkg -1 cisplatin and intravenous administration of 1 mgkg -1 auristatin PYE were evaluated compared to the effect of each agent administered alone. (elsevier.com)
  • The study compared outcomes in 691 patients who received cisplatin-based chemoembolization between 1992 and 2000 and 99 patients treated with 90Y microspheres between 2000 and 2005. (ynjr.net)
  • Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. (uib.no)
  • The gemzar doesn't seem to be as bad as the cisplatin was, and Dr. D thinks that the decadron they gave me as a premed was causing a large part of my stomach distress. (moondoggie.com)
  • This is great news, because the drug we're talking about is cisplatin, which is a platinum drug that's used to treat cancer. (geminianeyes.com)
  • The most common of them in clinical practice is cisplatin that contains a heavy metal complex with a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. (communalnews.com)
  • effect cisplatin on collagen protein in mollusca research work need for the referencess. (medschat.com)
  • Some recent research out of the U.K. suggests that aspirin can help prevent permanent hearing loss as a side effect of the cancer drug cisplatin, but further research is necessary. (southbayhearing.com)
  • Although adprt2- cells are sensitive to cisplatin, ADP-ribosylation is evident in these cells owing to redundant signalling by the double-strand break (DSB)-responsive ART Adprt1a, promoting NHEJ-mediated repair. (ed.ac.uk)