AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
AtracuriumNeuromuscular Blocking AgentsNeuromuscular Nondepolarizing AgentsAndrostanolsNeuromuscular BlockadeOpiumAnesthesia Recovery PeriodVecuronium BromideAnesthesia, IntravenousNeostigmineMonitoring, IntraoperativeEdrophoniumDiphenhydramineNitrous OxideAnesthesia, GeneralThiopentalNeuromuscular JunctionFentanylAnesthetics, IntravenousStereoisomerismDose-Response Relationship, DrugNicotinic AntagonistsIsoquinolinesAnesthetics, InhalationPropofolChromatography, High Pressure LiquidDrug InteractionsDouble-Blind MethodProspective StudiesAge FactorsClonazepamAnxiety DisordersEconomics, NursingPanic DisorderLactationSeizuresAlgorithms
Besylate InjectionAtracuriumNeuromuscular blockPropofolNimbexIntubationAnesthesiaPancuroniumBronchospasmPatientsIntravenousActionPatientShortBesylate injectionRocuroniumDetermine if cisatracuriumBlockadeVecuroniumMechanically ventilatedDrugsAssays10mgParalyticParalysisFentanylVitroClinicalDateHospitalProductStatusPlasmaEffectsDataMuscleAdditionalStudiesHighly
Besylate Injection2
  • The approval by the US Food and Drug Administration is for single dose vials of Cisatracurium Besylate Injection USP with strengths of 10 mg/5 ml and 200 mg/20 ml. (indiatimes.com)
  • Meitheal Pharmaceuticals, Inc. issues voluntary nationwide recall of Cisatracurium Besylate Injection, USP 10mg per 5mL due to mislabeling. (ahrq.gov)
Atracurium6
  • Cisatracurium is one of the ten isomers of the parent molecule, atracurium. (wikipedia.org)
  • Moreover, cisatracurium represents approximately 15% of the atracurium mixture. (wikipedia.org)
  • The generic name cisatracurium was conceived by scientists at Burroughs Wellcome Co. (now part of GlaxoSmithKline) by combining the name "atracurium" with "cis" [hence cisatracurium] because the molecule is one of the three cis-cis isomers comprising the ten isomers of the parent, atracurium. (wikipedia.org)
  • As is evident with the parent molecule, atracurium, cisatracurium is also susceptible to degradation by Hofmann elimination and ester hydrolysis as components of the in vivo metabolic processes. (wikipedia.org)
  • One of the metabolites of cisatracurium via Hofmann elimination is laudanosine - see the atracurium page for further discussion of the issue regarding this metabolite. (wikipedia.org)
  • The two reverse ester linkages in the bridge between the two isoquinolinium groups make atracurium and cisatracurium poor targets for plasma cholinesterase, unlike mivacurium which has two conventional ester linkages. (wikipedia.org)
Neuromuscular block2
  • Influence of Gender on the Plasma-Effect site equilibration time of propofol anesthetic and Cisatracurium Besylate neuromuscular blocking agent. (clinicaltrialsregister.eu)
  • Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. (absource.de)
Propofol1
  • In the operating room patient was monitored with ECG, HR, NIBP and SpO2 and was submitted to total intravenous anesthesia with propofol, alfentanil and cisatracurium. (scielo.br)
Nimbex1
  • By the time of its approval for human use, in 1995, by the US Food and Drug Administration, Burroughs Wellcome Co. had merged with Glaxo Inc., and cisatracurium was approved to be marketed as Nimbex by GlaxoWellcome Inc. The trade name "Nimbex" was derived from inserting an "i" to the original proposal "Nmbex," which stood for excellent Neuromuscular blocker. (wikipedia.org)
Intubation1
  • Neonates were administered cisatracurium 0.2 mg/kg followed by adjustment of inspired sevoflurane to target end-tidal concentration based on intubation condition of the preceding subject. (medscimonit.com)
Anesthesia1
  • The pharmacological research of cisatracurium and the other individual isomers was then developed further primarily by R. Brandt Maehr and William B. Wastila, PhD (both of whom were pharmacologists within the Division of Pharmacology at Burroughs Wellcome Co.) in collaboration with John J. Savarese MD (who at the time was an anesthesiologist in the Dept. of Anesthesia, Harvard Medical School at the Massachusetts General Hospital, Boston, MA). (wikipedia.org)
Pancuronium1
  • Its shorter duration of action, unique organ-independent elimination, and low incidence of adverse effects have made cisatracurium an appealing alternative to older agents such as pancuronium and vecuronium. (medscape.com)
Bronchospasm1
  • To date, cisatracurium has not been reported to elicit bronchospasm at doses that are clinically prescribed. (wikipedia.org)
Patients3
  • citation needed] Since Hofmann elimination is an organ-independent chemodegradative mechanism, there is little or no risk to the use of cisatracurium in patients with liver or renal disease when compared with other neuromuscular-blocking agents. (wikipedia.org)
  • Patients received 0.15 mg/kg cisatracurium and were randomized to receive 0.07 mg/kg neostigmine on reappearance of the first (group I), second (group II), third (group III), or fourth (group IV) tactile TOF response (16 patients per group). (silverchair.com)
  • In this multicenter, double-blind trial, 340 patients presenting to the intensive care unit (ICU) with an onset of severe ARDS within the previous 48 hours were randomly assigned to receive, for 48 hours, either cisatracurium besylate (178 patients) or placebo (162 patients). (nih.gov)
Intravenous1
  • Patient received intravenous midazolam and fentanyl and was paralyzed with cisatracurium. (hindawi.com)
Action1
  • Administration of anticholinesterase agents (neostigmine, pyridostigmine) may be used to antagonize the action of cisatracurium once the patient has demonstrated some spontaneous recovery from neuromuscular block. (drugguide.com)
Patient2
  • [ 1 , 2 ] Cisatracurium, introduced in the United States in 1995, has become one of the most widely used neuromuscular blocking agents in the pediatric patient population. (medscape.com)
  • While there, a nurse allegedly gave Lombardi Cisatracurium meant for another patient on a ventilator. (wabi.tv)
Short1
  • Thereafter, the entire clinical development of cisatracurium was completed in a record short period from 1992 to 1994: the team of scientists was led by J. Neal Weakly PhD, Martha M. Abou-Donia PhD, and Steve Quessy PhD, in the Division of Clinical Neurosciences at Burroughs Wellcome Co., Research Triangle Park, NC. (wikipedia.org)
Besylate injection9
  • These highlights do not include all the information needed to use CISATRACURIUM BESYLATE INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for CISATRACURIUM BESYLATE INJECTION. (nih.gov)
  • May potentiate or prolong neuromuscular blockade action of cisatracurium besylate injection. (nih.gov)
  • Cisatracurium Besylate Injection is contraindicated in patients with known hypersensitivity to cisatracurium. (pfizermedicalinformation.com)
  • Severe anaphylactic reactions to Cisatracurium Besylate Injection have been reported. (pfizermedicalinformation.com)
  • Cisatracurium Besylate Injection has been associated with residual paralysis. (pfizermedicalinformation.com)
  • Chicago, Illinois - January 27, 2021, Meitheal Pharmaceuticals, Inc. ("Meitheal"), announced today that it is voluntarily recalling one (1) lot of Cisatracurium Besylate Injection, USP 10mg per 5mL to the user level. (meithealpharma.com)
  • The decision to recall the product was made after a product complaint revealed that a portion of Lot C11507A of cartons labeled as Cisatracurium Besylate Injection, USP 10mg per 5mL, containing 10-vials per carton, contained 10-vials mis-labeled as Phenylephrine Hydrochloride Injection, USP 100mg per 10mL. (meithealpharma.com)
  • The affected Cisatracurium Besylate Injection lot being recalled is C11507A, EXP. (meithealpharma.com)
Rocuronium2
  • Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecur" by Kristen G. Dinsmore, Bethany Campbell et al. (etsu.edu)
  • The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. (etsu.edu)
Determine if cisatracurium2
  • The authors conducted this study to determine if cisatracurium is associated with benefits when compared with other common pharmacologic paralyzing agents. (medscape.com)
  • Studies to determine if cisatracurium besylate impacts fertility have not been completed. (pfizermedicalinformation.com)
Blockade1
  • 37. [Neuromuscular blockade with cisatracurium in infants andchildren. (nih.gov)
Vecuronium4
  • They queried a nationally representative administrative dataset using ICD codes to identify mechanically ventilated patients, use of the paralytic agents cisatracurium or vecuronium for at least 2 days, and the respective clinical outcomes. (medscape.com)
  • and thus the conclusions show a simple association between cisatracurium use and time on the ventilator when compared with vecuronium. (medscape.com)
  • Is it possible that cisatracurium (a short-acting agent) use results in a shorter duration of mechanical ventilation compared with vecuronium (a longer-acting agent)? (medscape.com)
  • Cisatracurium Versus Vecuronium for Acute Respiratory Distress Syndrome - Medscape - Jan 10, 2018. (medscape.com)
Mechanically ventilated1
  • While the conclusion of this study may be correct-that cisatracurium use in mechanically ventilated patients is associated with a shorter time on the ventilator without improvements in mortality-there are several caveats to this study. (medscape.com)
Drugs2
  • Moreover, Cisatracurium besylate significantly inhibited the expansion of intracellular Mycobacterium tuberculosis both in vitro and in vivo, which also displayed a strong auxiliary bacteriostatic effect to support the therapeutic efficacy of isoniazid and rifampicin , the first-line anti-tubercular drugs . (bvsalud.org)
  • Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration. (stabilis.org)
Assays1
10mg1
  • Normal supplies of Cisatracurium Juno 10mg/5mL are expected to return in the third week of October 2021. (hps.com.au)
Paralytic2
  • However, the original study suggesting benefit to paralytic use compared cisatracurium versus placebo, [ 1 ] whereas this study compared two active paralytic agents. (medscape.com)
  • An alternative four-drug method adds the paralytic cisatracurium as the third drug in the sequence. (deathpenaltyinfo.org)
Paralysis1
  • There is a reasonable probability that a patient who requires phenylephrine to increase their blood pressure, such as patients with severely low blood pressure, especially resulting from septic shock who is administered cisatracurium instead could result in a fast onset of muscle paralysis and decrease in oxygen. (meithealpharma.com)
Fentanyl2
  • Patient received intravenous midazolam and fentanyl and was paralyzed with cisatracurium. (hindawi.com)
  • In 2017, as Scott Dozier attempted to rush his execution by waiving his appeal rights, the state hurriedly adopted an untried three-drug protocol of diazepam, fentanyl, and cisatracurium. (deathpenaltyinfo.org)
Vitro2
  • citation needed] In vitro studies using human plasma indicated that cisatracurium spontaneously degrades at physiological pH via Hofmann elimination to yield laudanosine and the quaternary monoacrylate. (wikipedia.org)
  • Evaluation of cisatracurium besylate in the in vitro mouse lymphoma forward gene mutation assay resulted in mutations in the presence and absence of exogenous metabolic activation. (pfizermedicalinformation.com)
Clinical1
  • Thereafter, the entire clinical development of cisatracurium was completed in a record short period from 1992 to 1994: the team of scientists was led by J. Neal Weakly PhD, Martha M. Abou-Donia PhD, and Steve Quessy PhD, in the Division of Clinical Neurosciences at Burroughs Wellcome Co., Research Triangle Park, NC. (wikipedia.org)
Date1
  • To date, cisatracurium has not been reported to elicit bronchospasm at doses that are clinically prescribed. (wikipedia.org)
Hospital1
  • Cisatracurium Besylate 10 mg/mL Solution Compounded in a Hospital Pharmacy to Prevent Drug Shortages : A Stability Study Involving Four Degradation Products. (stabilis.org)
Product1
  • Consider using a cisatracurium product that has no benzyl alcohol preservative. (nih.gov)
Status1
  • Assess respiratory status continuously throughout therapy with cisatracurium. (drugguide.com)
Plasma1
  • In rat plasma, cisatracurium is also metabolized by non-specific carboxylesterases (a rate-limiting step) to the monoquaternary alcohol and the monoquaternary acid. (wikipedia.org)
Effects1
  • paromomycin increases effects of cisatracurium by pharmacodynamic synergism. (medscape.com)
Data1
  • Based on the LC-MS/MS data, the BUD for cisatracurium diluted to 10x and 100x is 96 hours. (etsu.edu)
Muscle1
  • Experts predict a fivefold jump in demand for midazolam, a common sedative, and a tenfold increase in the use of cisatracurium, a muscle relaxant, STAT reported. (beckershospitalreview.com)
Additional1
  • Additional supplies of Cisatracurium Juno 150mg/30mL are expected to arrive in early October 2021. (hps.com.au)
Studies1
  • Long-term animal studies to evaluate the carcinogenic potential of cisatracurium besylate have not been performed. (pfizermedicalinformation.com)
Highly1
  • Cisatracurium besylate was identified to be highly protective for the viability of macrophages during Mycobacterium tuberculosis infection via inhibiting necroptosis . (bvsalud.org)