US patent 5955478, Gray NM, Young JW, "Methods for treating gastrointestinal motility dysfunction using optically pre (+) cisapride", issued 1999-Sep-21 Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE (April 2010). (wikipedia.org)
4-Amino-5-chloro-substituted benzamides have been shown to increase gastric motility in-vivo and enhance field-stimulated and peristaltic contractions in-vitro. (nih.gov)
Higher acetylcholine levels increase gastrointestinal peristalsis and further increase pressure on the lower esophageal sphincter, thereby stimulating gastrointestinal motility, accelerating gastric emptying, and improving gastro-duodenal coordination. (wikipedia.org)
It stimulates smooth muscle contraction, which aids in emptying of the stomach and promoting motility of the small and large intestine. (github.io)
Even brisk walking may help stimulate bowel motility and, certainly, is unlikely to hurt most patients. (medscape.com)
Metoclopramide3
Cisapride is also commonly used to treat GI stasis in rabbits, sometimes in conjunction with metoclopramide (Reglan). (wikipedia.org)
Prokinetic drugs like metoclopramide and cisapride are used in conjunction with other measures in patients who are suffering from nausea or bloating in addition to heartburn. (web-gerd.com)
Colonic1
Prucalopride , a first in class benzofuran , is a selective, high affinity serotonin (5-HT 4 ) receptor agonist that stimulates colonic mass movements, which provide the main propulsive force to defecation . (wikipedia.org)
Erythromycin1
However, Cisapride can cause life threatening cardiac arrhythmias, especially in patients with cardiac or renal diseases, those with prolonged QT interval on their EKG, patients who are on anti-fungal, anti-viral and Mycin types of antibiotics like erythromycin and clarithromycin. (web-gerd.com)
Receptor1
Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M 1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which metabolizes acetylcholine. (wikipedia.org)
Reglan1
Cisapride (Propulsid) causes less diarrhea and extra-pyramidal side effects than Metoclopropamide (Reglan). (web-gerd.com)
Transit time1
The positive effects seen from cisapride in cats include accelerated gastric emptying of both liquids and solids, and a decrease in transit time. (github.io)
Megacolon2
Cisapride is still available in the United States and Canada for use in animals, and is commonly prescribed by veterinarians to treat megacolon in cats. (wikipedia.org)
This page is a mishmash - hodgepodge of information on Megacolon and the En spotting breeds. (vgr1.com)
Benzamides2
The present experiments examined the contractile response to a series of benzamides in the guinea-pig non-stimulated ileum. (nih.gov)
Some of these prokinetic agents, such as mosapride and cisapride , classic benzamides , have only moderate affinity for 5HT 4 receptors. (wikipedia.org)
Bowel2
Second it stimulates bowel movement, which aids in the emptying of the bowels and the relief of constipation. (asterisklabs.in)
Cisapride is a prokinetic that helps the intestines flow more freely, resulting in more bowel movements, softer stools, and less stomach pain and discomfort. (asterisklabs.in)
Constipation2
Cisapride also relieves constipation-like symptoms by indirectly stimulating the release of acetylcholine, which acts on muscarinic receptors. (wikipedia.org)
It stimulates movement inthe pyloric section of the stomach and in the small intestines.2it may be prescribed if your cat suffers from: Cat constipation is a treatable condition that can usually be remedied within 48 hours. (github.io)
Release1
PPIs block final pathway of acid release and prevent stimulated acid secretion. (web-gerd.com)
Human3
As such, the relatively poor selectivity profile of cisapride versus other receptors (especially hERG [human ether-a-go-go K + ] channels) contributes to its potential to cause cardiac arrhythmias . (wikipedia.org)
Since cisapride has been discontinued in human medicine, the pharmaceutical company that used to market it under the trade name "propulsid" has decided to stop making it available. (github.io)
A novel oligosaccharide compound AVR-25 selectively binds to the TLR4 protein (IC 50 = 0.15 µM) in human peripheral blood monocytes and stimulates IL-10 production. (nature.com)
Smooth1
the exact mechanism by which cGMP stimulates relaxation of smooth muscles has not been determined. (empowerpharmacy.com)
Cisapride treatment for gastro-oesophageal reflux in children" (PDF). (wikipedia.org)
Increase1
The drug is designed to increase blood flow, helping to stimulate erection and to maintain it. (infomedly.com)
Market1
The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, and cisapride was voluntarily removed from the U.S. market on July 14, 2000. (wikipedia.org)
Patients2
The withdrawal of cisapride leaves medical professionals with the task of prescribing a ppropriate alternative therapy for patients. (github.io)
Chemical pathways in the brain appear to be stimulated by this organic compound, so early research demonstrates the possibility for pepper to benefit Alzheimer's patients and those that are suffering from dementia and other age-related or free radical-related malfunctions in cognition. (nutrawiki.org)
Side1
Beacause of this side-effect, Cisapride is no longer availabe in the US. (web-gerd.com)
Domperidone2
Two additional promotility agents that have shown promise for functional dyspepsia are cisapride and domperidone. (medscape.com)
Cisapride was voluntarily withdrawn from the market due to concerns about QT c prolongation and serious cardiac side effects, and domperidone has not been approved by the Food and Drug Administration for use in this country. (medscape.com)
US patent 5955478, Gray NM, Young JW, "Methods for treating gastrointestinal motility dysfunction using optically pre (+) cisapride", issued 1999-Sep-21 Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE (April 2010). (wikipedia.org)
Prokinetics are the drugs which stimulate the movement of the gastrointestinal tract by increasing the frequency or strength of contractions and help move the contents in the upper GI tract still forwards. (mutalikpharmacology.com)
Voluntarily1
The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, and cisapride was voluntarily removed from the U.S. market on July 14, 2000. (wikipedia.org)
Endogenous2
In normal volunteers, fluconazole administration (doses ranging from 200 mg to 400 mg once daily for up to 14 days) was associated with small and inconsistent effects on testosterone concentrations, endogenous corticosteroid concentrations, and the adrenocorticotropic hormone (ACTH)-stimulated cortisol response. (nih.gov)
No clinically significant effect was observed on endogenous steroid levels or on the ACTH-stimulated response in healthy male volunteers taking fluconazole 200-400 mg daily. (grandbazaregypt.biz)
Symptoms3
Cisapride also relieves constipation-like symptoms by indirectly stimulating the release of acetylcholine, which acts on muscarinic receptors. (wikipedia.org)
Cisapride 20 mg b.d. for preventing symptoms of GERD induced by a provocative meal. (nih.gov)
This multicentre, randomized, double-blind, placebo-controlled trial was undertaken to determine the efficacy and safety of cisapride 20 mg b.d. dosing in reducing or preventing heartburn and other meal-related symptoms after challenge with a provocative fatty meal. (nih.gov)
Promote1
Dasatinib inhibits the action of proteins called tyrosine kinases, which promote and stimulate blood vessel formation and cancer growth and spread. (nih.gov)
Action1
This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. (netmeds.com)
Agents1
Clinical trials of other promotility agents, such as motilin agonists and partial 5HT 4 agonists (tegaserod) that do not have the potential cardiac effects of cisapride, are under way and have shown some promise for patients with functional dyspepsia. (medscape.com)
Children1
Cisapride treatment for gastro-oesophageal reflux in children" (PDF). (wikipedia.org)