• Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this could be a reflection of vascular dysfunction and damage. (wikipedia.org)
  • The resulting increase in reactive oxygen species leads to decreased bioavailability of the endothelium-derived signaling molecule nitric oxide via oxidative inactivation and thereby induces endothelial dysfunction. (uni-muenchen.de)
  • Hyperhomocysteinemia not only leads to endothelial dysfunction but also promotes the development and propagation of atherosclerotic lesion in atherosclerosis-prone animal models. (uni-muenchen.de)
  • SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
  • The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
  • We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
  • A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
  • Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
  • Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
  • SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
  • Decreased number of peripheral blood EPCs has been associated with endothelial dysfunction and high cardiovascular risk. (nutriforce.cn)
  • Aims: Endothelial microvascular dysfunction is a known mechanism of vascular pathology in cardiac amyloidosis (CA). Scientific evidence regarding the possible protective role of the amyloid transthyretin (ATTR) stabilizer, tafamidis, is lacking. (tau.ac.il)
  • Preeclampsia is a pregnancy-specific disorder involving widespread endothelial dysfunction and vasospasm that usually occurs after 20 weeks of gestation and can present as late as 4-6 weeks postpartum. (medscape.com)
  • MetS is associated with endothelial dysfunction, decreased circulating endothelial progenitor cells (EPCs), and a pro-inflammatory state. (sbir.gov)
  • Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation. (open.ac.uk)
  • Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
  • However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
  • Adverse stimuli such as pro-fibrotic and pro-inflammatory cytokines or reactive oxygen species, induce endothelial injury and dysfunction. (rug.nl)
  • When persistent, this dysfunction can result in endothelial-to-mesenchymal transition (EndMT) which contributes to fibro-proliferative disease. (rug.nl)
  • Dr. Solomon's research interests include endothelial cell dysfunction and inflammation in pulmonary arterial hypertension, methods of detection of cardiac allograft cellular rejection, and organizational structures and outcomes in the delivery of critical care cardiology. (nih.gov)
  • The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
  • Activation of the clotting cascade and increased sensitivity to pressors are compatible with endothelial cell dysfunction. (health.am)
  • Interleukin-6, IL-6) in AF with particular reference to circulating progenitor cells (CPCs) as a novel marker of endothelial health/angiogenesis. (bham.ac.uk)
  • The contributions of circulating EPCs to angiogenesis in tumours, ischaemic injury and other diseases as well as their usefulness in the repair of wounded hearts and limbs remain under intense investigation. (nutriforce.cn)
  • Bone marrow-derived endothelial progenitor cells (EPCs) contribute to tumour angiogenesis. (nutriforce.cn)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
  • Secondary objectives were to determine toxicity, enumerate circulating endothelial cells as an angiogenesis biomarker and analyze the effect of treatment on CYP3A4-metabolized steroids. (medscape.com)
  • TIMP-1 also protects against apoptosis in B cells, stimulates erythropoiesis and BFU-E expansion, both stimulates and inhibits tumor growth, inhibits angiogenesis, and stimulates gonadal steroidogenesis in conjuction with Cathepsin L. (rndsystems.com)
  • It acts by inducing angiogenesis and endothelial cell migration. (bvsalud.org)
  • Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are capable of maintaining, generating, and replacing terminally differentiated cells within their own specific tissue as a consequence of physiological cell turnover or tissue damage due to injury. (nutriforce.cn)
  • There are many factors involved in the process of creating CECs, including: reduced interaction between the endothelial cells and basement membrane proteins, damaged endothelial cellular adhesion molecules, mechanical injury, decreased survival of cytoskeletal proteins, and inflammation. (wikipedia.org)
  • Inflammation and endothelial injury were assessed in selected samples by immunostaining for CD8 T cells, activated cytotoxic T lymphocytes, and vascular endothelial cells. (nih.gov)
  • The ability of factor VIIa to cleave other clotting factors depends on binding to its cofactor tissue factor (TF), which is expressed on the surface of endothelial cells and monocytes in response to injury or inflammation. (medscape.com)
  • Endothelial progenitor cells (EPCs) are cells derived from the bone marrow which differentiate into endothelial cells to help support the vascular endothelium and create new blood vessels. (wikipedia.org)
  • Recent evidence indicates that circulating endothelial progenitor cells (EPCs), a population of bone marrow-derived cells, have an important role in the process of vascular repair, by promoting re-endothelialization following vascular injury [1]. (nutriforce.cn)
  • EPCs are primarily identified by the expression of cell-surface antigenic markers, including CD133, CD34 and vascular endothelial growth factor receptor 2 (VEGFR-2), and have the ability to differentiate into mature cells with an endothelial phenotype [2]. (nutriforce.cn)
  • Circulating, bone marrow-derived endothelial progenitor cells (EPCs) were first described 8 years ago, yet the exact nature of these endothelial precursor cells remains unclear. (nutriforce.cn)
  • In response to tumor-secreted cytokines, EPCs mobilize from the bone marrow to the peripheral blood, home to the tumor site, and differentiate to mature endothelial cells and secrete proangiogenic factors to facilitate vascularization of tumors. (nutriforce.cn)
  • Endothelium maintenance and restoration of normal endothelial cell function is guaranteed by a complex physiological procedure in which EPCs play a significant role. (nutriforce.cn)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Flow cytometry with quantification of three EPC markers in peripheral blood samples was used to assess the number of circulating EPCs. (tmu.edu.tw)
  • Among heart failure patients, patients with New York Heart Association functional class (FC) IV had fewer circulating EPCs compared to those with FC II and FC III (p = 0.053). (tmu.edu.tw)
  • Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
  • The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
  • Our previous study also showed decreased and dysfunctional circulating EPCs in patients with COPD [ 9 ]. (hindawi.com)
  • In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
  • Endothelial progenitor cells (EPC) are a subtype of stem cells with high proliferative potential that are capable of differentiating into mature endothelial cells, thus contributing to neovascularization in tumors. (nutriforce.cn)
  • 48: 1538-1547 Bouvier, C.A., Gaynor, E., Clintron, J.R. et al (1970) Circulating endothelium as an indicator of vascular injury. (wikipedia.org)
  • The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently co-exist with the arrhythmia, with similar disruption to endothelial repair (normally effected by endothelial progenitor cells). (bham.ac.uk)
  • The vascular endothelium, the innermost layer of blood vessels, provides a dynamic interface between the circulating blood and various tissues/organs and thereby maintaining tissue homeostasis. (nature.com)
  • This approach applies serum from exposed animals to cultured primary endothelial cells, as this is the component in direct contact with the vascular endothelium. (cdc.gov)
  • Endothelium is the inner lining of the blood vessel wall that is in direct contact with circulating blood. (mayo.edu)
  • Dr. Katusic's studies are focused on understanding mechanisms responsible for normal endothelial function and repair of injured endothelium. (mayo.edu)
  • The recognition of endothelium in brain blood vessels as a major therapeutic target significantly advanced efforts to develop pharmacological therapies, as well as gene- and cell-based therapies. (mayo.edu)
  • The vascular endothelium produces a number of important substances including endothelial-derived relaxing factor or nitric oxide, endothelin-1, prostacyclin, and tissue plasminogen activator. (health.am)
  • Hypoxic vascular endothelial cells activate white blood cells, which bind to the endothelium and release directly damaging substances (eg, reactive oxygen species, proteolytic enzymes) and inflammatory mediators (eg, cytokines, leukotrienes, tumor necrosis factor). (msdmanuals.com)
  • Objectives: The purpose of this study was to explore the relationship between endothelial progenitor cell (EPC) levels, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). (tmu.edu.tw)
  • We have shown that chronic inflammatory disease impacts endothelial progenitor cell (EPC) biology, through reducing their circulating numbers and by impairing their function. (rug.nl)
  • [ 4 ] Most circulating TFPI is bound to lipoproteins, but on the surface of endothelial cells, a second pool of TFPI is bound to heparan sulfates. (medscape.com)
  • After endocardial cushion formation, the endothelial mesenchymal transformation (EMT), which are specified endothelial cells, differentiate and migrate into the cardiac jelly. (medscape.com)
  • Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
  • Background: Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
  • Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
  • Microparticles are plasma membrane vesicle fragments (between 0.1 and 1 μm in size) released from various cell types during activation by agonists or physical or chemical stress, including apoptosis [ 6 , 7 ]. (ersjournals.com)
  • After entering the circulation via the gastrointestinal mucosa, the toxin preferentially localizes to the kidneys, inhibiting protein synthesis and eventually leading to cell necrosis or apoptosis. (medscape.com)
  • In other cells, apoptosis may be augmented, increasing cell death and thus worsening organ function. (msdmanuals.com)
  • Among aPL, anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) have been shown to induce NF-kappaB nuclear translocation leading to a pro-inflammatory endothelial cell phenotype and thereby inducing acute phase proteins, such as serum amyloid A (SAA). (europa.eu)
  • Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study. (ersjournals.com)
  • In accordance, inhibition of NF-kB translocation by a synthetic inhibitor Bay 11-7082 significantly diminished homocysteine-induced ICAM-1 expression and adhesion of monocytes to endothelial cells. (uni-muenchen.de)
  • These cells are induced to leave the bone marrow and enter the vasculature by circulating angiogenic factors such as vascular endothelial growth factor (VEGF). (nutriforce.cn)
  • Once in the circulation, these cells can arrest at sites of ischaemia or growth factor release (such as VEGF release), such as in the tumour periphery. (nutriforce.cn)
  • Methods and Results: Study population included patients with ATTR-CA. cEPCs were assessed using flow cytometry by the expression of CD34 (+) /CD133 (+) and vascular endothelial growth factor receptor (VEGFR)-2 (+) and by the formation of colony-forming units (CFUs) and production of VEGF. (tau.ac.il)
  • Research suggests that the vascular endothelial growth factor (VEGF), a pleiotropic factor, is responsible for signaling the development of the endocardial cushion. (medscape.com)
  • ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
  • RÉSUMÉ Nous avons évalué la valeur pronostique de l'endostatine et du facteur de croissance endothéliale vasculaire (VEGF) dans le sérum pour le diagnostic de la prééclampsie. (who.int)
  • It is actually a splice variant of the better known vascular endothelial growth factor receptor 1 (VEGF-R1). (medscape.com)
  • sFlt-1 freely circulates and reduces the level of both VEGF and placental growth factor (PIGF). (medscape.com)
  • Prior to a myocardial infarction (MI or heart attack), plaque may accumulate in the coronary arteries, Some plaque formations may rupture, causing a mechanical dislodgment of endothelial cells creating CEC. (wikipedia.org)
  • During early development, the myocardial cushion begins as a matrix of endothelial cells and an outer mitochondrial layer separated by cardiac jelly. (medscape.com)
  • Mechanisms may involve decreased circulating volume, decreased cardiac output, and vasodilation, sometimes with shunting of blood to bypass capillary exchange beds. (msdmanuals.com)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • Elevated levels of homocysteine lead to increased generation of superoxide anion in endothelial cells by a biochemical mechanism involving nitric oxide synthase, and, to a lesser extent, by an increase in the chemical oxidation rate of homocysteine and other aminothiols in the circulation. (uni-muenchen.de)
  • Some of these mediators bind to cell surface receptors and activate nuclear factor kappa B (NF κ B), which leads to production of additional cytokines and nitric oxide (NO), a potent vasodilator. (msdmanuals.com)
  • Endothelial cell damage subsequently potentiates renal microvascular thrombosis by promoting activation of the blood coagulation cascade. (medscape.com)
  • The findings are published in this week's online issue of the Journal of Cell Biology . (science20.com)
  • The relatively new theory of endothelial injury explains many of the clinical findings in preeclampsia. (health.am)
  • Several findings suggest endothelial injury in preeclampsia. (health.am)
  • To determine the effectiveness of using next-generation sequencing (NGS) to identify DNA-repair pathway gene defects in tumor samples and circulating DNA and identify patients with non-prostate GU cancer suitable for PARP inhibition. (bcan.org)
  • Preclinical data have demonstrated that the combination of the aromatase inhibitor letrozole and sorafenib on breast cancer cells produced a synergistic inhibition of cell proliferation associated with a downregulation of the cell cycle regulatory proteins c-myc, cyclin D1 and phospho-Rb and possibly preventing the acquisition of resistance towards letrozole. (medscape.com)
  • Our studies show that pharmacological or genetic inhibition of the endothelial protein focal adhesion kinase, or FAK, prevents tumor spread by enhancing the vessel barrier function. (science20.com)
  • The researchers found that selective FAK inhibition within endothelial cells prevented spontaneous tumor metastasis without alterations in tumor size. (science20.com)
  • In comparison, 0.4 cells/ ml were found in healthy individuals The High-Definition Circulating Endothelial Cell (HD-CEC) assay is a novel fluid biopsy test which detects endothelial cells in the blood of patients who have recently suffered a heart attack. (wikipedia.org)
  • Circulating endothelial cells (CEC) were shown to be elevated in patients with active antineutrophil cytoplasmic antibody-associated vasculitis. (bmj.com)
  • 400 cells/ml in most of the patients) and significantly higher than in healthy and disease controls (p≤0.01 for each group). (bmj.com)
  • Of translational relevance, several candidate drugs which are endothelial protective have been shown to improve clinical manifestations of COVID-19 patients. (nature.com)
  • Objectives: To detect the relation between the circulating endothelial progenitor cells (CEPCs) and stages of breast cancer patients. (journalcra.com)
  • Immunocytochemistry and RT-PCR have been widely used for the detection of circulating endothelial progenitor cells (CEPCs) in patients with breast cancer but their specificity is limited. (journalcra.com)
  • From bone marrow to skin: The transient increase in circulating endothelial progenitor cells in patients with superficial and full thickness burns correlates with surface area and depth of injury and circulating chemokine levels. (ox.ac.uk)
  • Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
  • Of all patients with malignancies, 58% had CD276+ CEC counts above the ULN (8 cell per 4 ml). (researchgate.net)
  • Results: HFpEF and HFrEF patients had significantly decreased circulating EPC levels compared to controls. (tmu.edu.tw)
  • Conclusions: HFpEF and HFrEF patients have decreased circulating EPC numbers, which is an indication of impaired endothelial turnover. (tmu.edu.tw)
  • We investigated eight patients with acute GVHD and ten with chronic GVHD for signs of endothelial injury and microvessel loss by measurement of von Willebrand factor (vWF) in plasma and blood vessel density in biopsy samples taken from lesional skin. (nih.gov)
  • Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
  • To correlate levels of baseline circulating tumor cells (CTCs) with survival in untreated patients. (bcan.org)
  • Barcode sequencing identifies resistant mechanisms to EGFR-inhibitors in circulating tumor DNA of lung cancer patients. (cdc.gov)
  • miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery. (cdc.gov)
  • PARP inhibitors, such as olaparib, can keep PARP from working, so tumor cells can't repair themselves, and they may stop growing. (bcan.org)
  • Schlaepfer, with colleagues at the UC San Diego Moores Cancer Center, is exploring whether inhibiting targets like FAK, which has important regulatory functions in both tumor cells and blood vessels, might provide a dual mechanism for preventing both cancer growth and spread. (science20.com)
  • Inactivating FAK within endothelial cells prevented this unwanted permeability and helped block the ability of tumor cells to pass through endothelial cell barriers. (science20.com)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • By integrating advanced molecular, imaging, single cell transcriptomics, and statistical approaches, we study how molecules work together to control the timing and the spatial pattern of cell differentiation in developing tissues and stem cell systems. (usc.edu)
  • Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
  • Endothelial cell (EC) monolayers located in the inner lining of blood vessels serve as a semipermeable barrier between circulating blood and surrounding tissues. (rsc.org)
  • A circulating angiopoietin-like protein that is expressed in a variety of tissues in response to HYPOXIA. (bvsalud.org)
  • FAK modifies the function of other cellular proteins, and researchers identified a previously unknown FAK target: a protein called vascular endothelial cadherin (VE-cadherin) that helps endothelial cells fasten tightly together. (science20.com)
  • Characterization of circulating endothelial cells in acute myocardial infarction. (wikipedia.org)
  • On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
  • A hydrogel model of the human blood-brain barrier using differentiated stem cells. (open.ac.uk)
  • Blood vessels are tightly lined with endothelial cells, which form a permeability barrier to circulating cells and molecules. (science20.com)
  • And so during these viral infections (such as Lassa fever), you disturb that endothelial barrier and it becomes porous for various reasons. (cdc.gov)
  • Endothelial progenitor cells (purple circles) arise in the bone marrow as CD34+CD133+VEGFR2+ cells. (nutriforce.cn)
  • Exposure of endothelial monolayers to D,L- and L-homocysteine resulted in a time- and dose-dependent increase in adherent THP-1 cells by upregulating ICAM-1 expression on endothelial cells. (uni-muenchen.de)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • CECs are known to express endothelial markers such as the blood glycoprotein von Willebrand factor (vWF) which is involved in platelet aggregation and adhesion, CECs also express the cell surface protein CD146 which is the most commonly known endothelial marker found in CECs and plays an important role in permeability, cell-cell cohesion and signalling. (wikipedia.org)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
  • The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
  • Sorafenib is US FDA approved for the treatment of advanced renal cell carcinoma and unresectable hepatocellular carcinoma. (medscape.com)
  • Molecular profiling of hepatocellular carcinoma using circulating cell-free DNA. (cdc.gov)
  • A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream. (science20.com)
  • The tyrosine kinase receptors Tyro3, Axl and Mer (TAMs) and their ligands protein S and Gas6 are involved in the uptake of PS-exposing apoptotic cells in macrophages and dendritic cells. (lu.se)
  • The method of stimulating isolated cells with CSE in vitro has been explored and frequently applied to determine the direct causes in the relationships between cigarette smoking and cellular functions [ 15 ]. (hindawi.com)
  • These well-regulated processes to transfer information between cells occur through direct cell-cell contact, various soluble bioactive factors and through cellular microparticles [ 6 , 7 ]. (ersjournals.com)
  • Biochemical evidence includes an imbalance in the prostacyclin:thromboxane ratio and high circulating concentrations of von Willebrand factor, endothelin, and cellular fibronectin. (health.am)
  • Cellular function declines, and if shock persists, irreversible cell damage and death occur. (msdmanuals.com)
  • The characteristic renal lesion of preeclampsia "glomeruloendotheliosis" is manifested primarily by swelling of the glomerular capillary endothelial cells. (health.am)
  • Endothelial cells as biosensors to assess the vascular inflammatory potential of serum following nanomaterial exposure. (cdc.gov)
  • Serum collected from 19 d inhalation exposures to 0.5 or 5.0 mg/m3 MWCNT was also assayed for endothelial activation. (cdc.gov)
  • Serum from exposed mice induced an up-regulation of endothelial cell surface VCAM and ICAM expression, along with elevations in mRNA at the 4 h time point. (cdc.gov)
  • Serum from preeclamptic women, when applied to human umbilical vein endothelial cell cultures, produces no morphologic abnormalities in the cells but releases procoagulants, vasoconstrictors, and mitogens. (health.am)
  • V. To correlate levels of circulating endothelial cells with clinical outcome. (bcan.org)
  • Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. (cdc.gov)
  • Antiphospholipid syndrome (APS) is an autoimmune disease, characterized by recurrent thrombosis in presence of circulating antiphospholipid antibodies (aPL). (europa.eu)
  • This also suggests that the defect leading to preeclampsia also represents more than just endothelial injury and the podocyte might be involved as well. (medscape.com)
  • Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
  • These cells then can participate in new vessel formation by differentiating into branching blood vessels. (nutriforce.cn)
  • Though not yet approved by the FDA, this test has demonstrated better specificity than the FDA approved CellSearch test used to detect circulating tumour cells. (wikipedia.org)
  • PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
  • Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer. (cdc.gov)
  • aPL activate endothelial cells (ECs) by up-regulating adhesion molecules, IL-6 production and modulating prostaglandin metabolism. (europa.eu)
  • If the heart muscles have prolonged ischemia this may lead to the detachment of endocardial endothelial cells which can also create CEC. (wikipedia.org)
  • The aortic and pulmonic valves develop from the outflow tract of the endocardial cushion, also believed to have neural crest cell migration from the brachial crest during development. (medscape.com)
  • Blood cell counts role was assessed by culture and detection of the organism and other blood chemistry values were normal. (cdc.gov)
  • The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)
  • Indeed, impaired endothelial function has a major detrimental effect on blood flow and cognitive function. (mayo.edu)
  • They took samples of their blood and isolated the cells that were coming from inside their artery - cells known as circulating endothelial cells (CEC). (foxnews.com)
  • It's digitizing the cells in the blood to diagnose a heart attack in the making. (foxnews.com)
  • The abnormal perfusion stimulates the production of substances in the blood that activate or injure endothelial cells. (health.am)
  • Microangiopathic hemolytic anemia results from mechanical damage to red blood cells circulating through partially occluded microcirculation. (medscape.com)
  • Once perfusion declines and oxygen delivery to cells is inadequate for aerobic metabolism, cells shift to anaerobic metabolism with increased production of carbon dioxide and elevated blood lactate levels. (msdmanuals.com)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • Preliminary correlative analysis suggested that a decrease in circulating endothelial cells from baseline to 1 week after treatment appeared to predict a positive response. (medscape.com)
  • Thus, endothelial cells modify the contractile response of the underlying smooth muscle cells, prevent intravascular coagulation, and maintain the integrity of the intravascular compartment. (health.am)
  • The shiga-like toxin affects endothelial cells and initiates intravascular thrombogenesis. (medscape.com)
  • We will use primary ECs and endothelial cell lines to determine the molecular events by which anti-beta2-GPI antibodies and SAA i n presence and absence of LXA4 affect the transcriptional regulation of target genes (such as IL-6, IL-8, tissue factor). (europa.eu)
  • We are taking an interdisciplinary approach to studying primordial germ cell (PGC) development in the context of gastrulating embryos by combining the power of molecular genetics with advanced optical imaging within living embryos. (usc.edu)
  • Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey. (cdc.gov)
  • Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration Front Cell Dev Biol. (usc.edu)
  • In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia Dev Biol. (usc.edu)
  • Disruption of endothelial homeostasis (damage vs. repair) is thought to be central to this process. (bham.ac.uk)