Circadian liver. Medical search. Frequent questions

Bailey says that new research shows that liver metabolism changes quite dramatically during the day. (wrvo.org)
The liver is the primary site for the metabolism of drugs, converting them into water-soluble compounds that can be excreted in body fluids. (europa.eu)
This novel platform provides the first device that recapitulates circadian rhythms and can accurately predict the metabolism, clearance and toxicity of pharmaceuticals. (europa.eu)
The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. (europa.eu)
These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. (europa.eu)
In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. (europa.eu)
Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. (europa.eu)
Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes, orchestrating metabolism and physiology. (mpg.de)
Due to technical limitations in large-scale, quantitative protein measurements, it remains unresolved to what extent the circadian clock regulates metabolism by driving rhythms of protein abundance. (mpg.de)
Our large-scale proteomic analysis reveals thus that circadian post-transcriptional and post-translational mechanisms play a key role in the temporal orchestration of liver metabolism and physiology. (mpg.de)
A study in Nature Communications delves into how the liver's circadian clock responds to meal timing, impacting fat metabolism and other bodily processes. (news-medical.net)
Our results suggest that suppression of blue light at night effectively maintains circadian rhythms and metabolism. (nih.gov)
Therefore, interactions between the host and a reductionist microbiota are non-uniform over the circadian cycle, revealing a promising tool to identify key microbiota species/functions that modify host metabolism. (biorxiv.org)
and thermal variations that characterize tissue metabolism are circadian ("about 24 hours") in periodicity. (sanevax.org)
By tending to flatten the circadian variation of metabolism, high iron in tissues may also interfere with the normal day to night fluctuations associated with a healthy metabolic system. (sciencedaily.com)
DALLAS - Dec. 5, 2017 - Circadian rhythms affect some of the most crucial functions in the human body, from sleep and mental health to metabolism and defending against deadly diseases such as cancer. (utsouthwestern.edu)
For shift workers with metabolic issues who have no choice (which is, sadly, most of them) but to work those hours, the lab group is looking into whether timing the administration of drugs according to normal circadian liver metabolism would help. (marksdailyapple.com)
The metabolism of most animals follows a circadian rhythm that differs between the day and night. (scienceblogs.com)
After 3 weeks, we compared body weight, food intake, plasma levels of lipids and glucose, and the expression patterns of the clock genes and the genes involved in lipid metabolism in the liver and WAT. (researchgate.net)
LL eliminated the circadian rhythms of the expression of the clock genes as well as most of the genes involved in lipid metabolism in both liver and WAT. (researchgate.net)
In addition to the small sample size being a limitation, some of the methodologies used, including a "forced desynchrony design" to evaluate metabolism outside of normal circadian patterns, could limit generalizability to other environments. (medscape.com)

In conclusion, a combination of the proposed smartphones and smart eyeglasses applications could support users in synchronising their circadian clock to the external clocks, thus living a healthier lifestyle. (kobv.de)
But because people who are awake all night may be eating at night, these people are fighting against their circadian clocks, they are out of sync with the environment, says Bailey. (wrvo.org)
Over the last decades, a better knowledge of the molecular machinery supervising the regulation of circadian clocks has been achieved, and numerous findings have helped in unravelling the outstanding significance of the molecular clock for the proper regulation of our physiologic and metabolic homeostasis. (uniba.it)
A new study found chronic alcohol use may interfere with the genetic clocks in liver cells to accelerate liver damage. (uab.edu)
We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring. (nature.com)
Taken together, the present findings indicate that age-related circadian disorganization in entrainment to light, stress, and exercise is due to sympathetic dysfunctions in peripheral organs, while meal timing produces effective entrainment of aged peripheral circadian clocks. (nature.com)
23 Despite these apparent relationships between circadian rhythm and peripheral clock function in aged mice, no study to date has examined changes in the coordination of the SCN with peripheral clocks in aging. (nature.com)
In fact, we now know that our bodies contain innumerable cellular circadian clocks, the local actions of which give rise to daily rhythms of tissue function. (cas.cz)
Disrupted circadian clocks, researchers believe, are the reason that shift workers experience higher incidents of type 2 diabetes, obesity and cancer. (sciencedaily.com)
But other body tissues also have circadian clocks, including the liver, which regulates blood glucose levels. (sciencedaily.com)
Each of the body's circadian clocks operates on its own schedule to perform its necessary functions. (sciencedaily.com)
But, as anyone who has ever been on a graveyard or swing shift knows, working off-hours can cause one's circadian clocks to get out of synch and disrupt sleeping and eating patterns. (sciencedaily.com)
Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)
For example, being awake during the day and asleep at night is a circadian rhythm that arises from biological clocks responding to changes in light levels in the organism's environment. (medicalnewstoday.com)
Could Discovery of Circadian Clocks in Bacteria Have Implications for Drug Delivery Timing, Industrial Biotech? (genengnews.com)
Reporting on their research in Science Advances (" A circadian clock in a non-photosynthetic prokaryote "), Merrow and an international team of colleagues concluded, "Our work opens the field of circadian clocks in the free-living, nonphotosynthetic prokaryotes, bringing considerable potential for impact upon biomedicine, ecology, and industrial processes. (genengnews.com)
Biological clocks, or circadian rhythms, are internal timing mechanisms that are widespread across nature, enabling living organisms to cope with the major changes that occur from day to night, even across seasons. (genengnews.com)
Circadian clocks create a 24-hour temporal structure, which allows organisms to occupy a niche formed by time rather than space," the authors wrote. (genengnews.com)
So while circadian clocks are "… pervasive throughout nature," the authors wrote, "… they remain largely unknown in the nonphotosynthetic bacteria, despite bacteria representing about 15% of the living matter on Earth. (genengnews.com)
Here, we identify in Bacillus subtilis circadian rhythms sharing the canonical properties of circadian clocks: free-running period, entrainment, and temperature compensation," the team noted. (genengnews.com)
Biological clocks or "circadian clocks" help time our sleep patterns, alertness, mood, physical strength, blood pressure and much more. (theconversation.com)
An understanding of how circadian clocks work and the central role they play in our biology has led to advances in many areas, not least an appreciation that when circadian rhythms are disrupted our overall health and well-being can be severely affected. (theconversation.com)
Unlike the decision systems, the circadian clocks show strong cooperative binding and negative regulation, which achieves tight temporal control of gene expression. (lu.se)

Circadian melatonin disruption can be used as an indicator of delirium. (greenmedinfo.com)
Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores. (greenmedinfo.com)
Such knowledge also offers important opportunities to mitigate the consequences of circadian disruption, so prevalent in modern societies, that arise from shiftwork, ageing and neurodegenerative disease. (cas.cz)
Short-term circadian rhythm disruption can have a big negative impact on memory , problem solving , emotional responses and attention . (theconversation.com)
Airline pilots and flight attendants are exposed occupationally to certain known cancer risk factors (e.g., cosmic radiation, ultraviolet radiation, and circadian rhythm disruption). (cdc.gov)
Combined with lifestyle and genetic factors, numerous occupational exposures in aviation might contribute to heart disease risk (e.g., circadian rhythm disruption, fatigue, shift work, chronic stress). (cdc.gov)
Interestingly," said Dr. Friedman, some of the differentially expressed genes were related to circadian-clock genes, which suggests disruption of the circadian system in association with e-cigarette and Western diet exposure. (medscape.com)
However it is based on a theory that light at night (LAN) would disrupt circadian rhythms and that this disruption might increase cancer risk. (who.int)
There is convincing evidence that circadian disruption mediated by exposure to light at night promotes mammary carcinogenesis in rodents. (cdc.gov)
In 2010, the International Agency for Research on Cancer (IARC) classified "shiftwork that involves circadian disruption" as a probable human carcinogen (Group 2A). (cdc.gov)

What are the imbalances that occur after you shift back to a normal circadian rhythm? (apple.com)

New research presented at Physiological Bionergetics: From Bench to Bedside reports that the damage occurs because of the effects of chronic alcohol consumption on the liver's circadian clock. (sleepreviewmag.com)
The liver's circadian clock is set by food intake. (sciencedaily.com)

These lines of evidence suggest that the transcriptional-translational feedback loop mediated by the clock genes, and the post-translational modification of their products, are indispensable to the circadian clock machinery. (elifesciences.org)
We now know that the morning and evening preferences of individuals who describe themselves as either "larks" or "owls" also appear to be related to small changes in some of these clock genes that either speed up or slow down our circadian rhythms. (theconversation.com)
More notably, LL markedly decreased not only the amplitude but also the average levels of the expression of the genes in the liver, but not in the WAT, suggesting that transcription in the liver is sensitive to constant light exposure. (researchgate.net)
Time-restricted feeding restored the circadian rhythms of most of the genes to various degrees in both liver and WAT. (researchgate.net)
Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy balance, and (3) circadian expression of hepatic clock and metabolic genes. (researchgate.net)
NIH's National Center on Sleep Disorders Research has supported the discovery of sleep and circadian rhythm regulating genes. (medlineplus.gov)
Hepatic RNA sequence analysis revealed changes in 433 genes associated with fatty liver development and progression in the mice exposed to e-cigarettes and the Western diet compared with saline exposed mice. (medscape.com)
Research has shown that circadian-clock genes play a key role in fatty liver disease, Dr. Friedman noted. (medscape.com)

Circadian rhythm is a 24-hour internal clock that regulates how awake and/or how tired we feel during the course of a day. (amymdwellness.com)
The results show that responses are far stronger in both areas following exercise in the morning and that this is likely to be controlled by a central mechanism involving the protein HIF1-alfa, which directly regulates the body's circadian clock. (sleepreviewmag.com)
The body's primary circadian clock, which regulates sleep and eating, is in the brain. (sciencedaily.com)

After decades of research that helped scientists understand these vast biological functions, the field of circadian rhythms is being recognized with a Nobel Prize this year for the discovery of a fruit fly gene controlling the biological clock. (utsouthwestern.edu)

Pineal calcification may contribute to melatonin deficiency and circadian timing irregularities. (greenmedinfo.com)

But researchers are still making new discoveries confirming that the body's circadian clock affects our health. (sleepreviewmag.com)
There appears to be rather significant differences between the effect of exercise performed in the morning and evening, and these differences are probably controlled by the body's circadian clock. (sleepreviewmag.com)

Physiological events that show day-night fluctuations in mammals are controlled by an internal circadian clock system. (nature.com)
The SCN, in turn, is synchronised to the light/ dark cycle, so that internal circadian time maps on to external solar time and thereby ensures our temporal adaptation to the world. (cas.cz)

Circadian rhythm disorders can cause overweight and obesity. (nih.gov)
Home Mood Bipolar Disorder Do Circadian-Modifying Treatments Work for Bipolar Disorders? (cet.org)
Disturbances in circadian rhythm-the approximately 24-hour cycles that are endogenously generated by an organism-can be categorized into 2 main groups: transient disorders (eg, jet lag or a changed sleep schedule due to work, social responsibilities, or illness) and chronic disorders (eg, delayed sleep-phase syndrome [DSPS], advanced sleep-phase syndrome [ASPS], and irregular sleep-wake cycle). (medscape.com)
The diagnosis of circadian rhythm disorders is primarily based on a thorough history. (medscape.com)
Lack of sleep and sleep disorders can also create problems in people's personal lives, especially within their families, Dr. Twery says. (medlineplus.gov)
Circadian rhythm sleep disorders occur when people's internal sleep-wake schedule (clock) does not align with the earth's cycle of darkness (night) and light (day). (msdmanuals.com)
Causes of circadian rhythm sleep disorders may be internal or external. (msdmanuals.com)
There are several types of circadian rhythm disorders. (msdmanuals.com)
With treatment, most people with mood disorders can lead productive lives. (medlineplus.gov)

In this study, researchers at the University of Alabama at Birmingham observed that the levels of proteins involved in mitochondrial function and energy production changed cyclically in the livers of healthy mice. (sleepreviewmag.com)
C57BL/6J mice were exposed to 10-lux light for 30 minutes at Zeitgeber time 14 for light pulse with blue light or blue-light cut light to induce phase shift of circadian rhythms. (nih.gov)
However, each group of mice have a distinctive circadian metabolic profile. (biorxiv.org)
In the course of investigating metabolic defects in Sik3 -deficient mice ( Sik3 -/- ), we observed that circadian rhythmicity of the metabolisms was phase-delayed. (elifesciences.org)
Sik3 -/- mice also exhibited other circadian abnormalities, including lengthening of the period, impaired entrainment to the light-dark cycle, phase variation in locomotor activities, and aberrant physiological rhythms. (elifesciences.org)
They reported, for the first time in a published study, that the attacks on the intruder mice showed a circadian pattern of aggression - that is, their intensity and frequency depended on the time of day. (medicalnewstoday.com)
They found that when they stopped the master clock neurons from being able to make a specific chemical messenger, or neurotransmitter, the mice lost their circadian pattern of aggression. (medicalnewstoday.com)
Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. (researchgate.net)
NEW YORK (Reuters Health) - Use of electronic cigarettes combined with a Western diet may raise the risk of fatty liver disease, suggests new research in mice. (medscape.com)
To investigate, Dr. Friedman and his colleagues studied mice missing the gene for apolipoprotein E, which makes them more prone to heart disease and fat in the liver. (medscape.com)
Because of the extra fat in the liver that we found in the mice exposed to e-cigarettes, I don't think it's reasonable to conclude that e-cigarettes are safe," Dr. Friedman concluded. (medscape.com)

Discovering a factor, such as iron, that sets the circadian rhythm of the liver may have broad implications for people who do shift work. (sciencedaily.com)
Skrlec I, Talapko J. Hepatitis B and circadian rhythm of the liver. (wjgnet.com)

A direct pathway from the eyes to the suprachiasmatic nucleus, where the circadian clock resides, is used to synchronise the circadian clock to external light-dark cycles. (kobv.de)
Here, we report that blue light disturbs circadian rhythms by interfering with the clock gene in the suprachiasmatic nucleus (SCN) and that suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms. (nih.gov)
Circadian rhythms in mammals are governed by the master oscillator located in the hypothalamic suprachiasmatic nucleus (SCN). (elifesciences.org)

Here, we attempted to determine whether the effects of LL are different between various peripheral tissues and whether time-restricted feeding restores the circadian rhythms especially in white adipose tissue (WAT). (researchgate.net)
Time-restricted feeding restored the circadian rhythms in both tissues. (researchgate.net)

This presentation will therefore consider the molecular, cellular and physiological basis of the circadian clock of mammals, with a focus on the SCN as our primary pacemaker. (cas.cz)
But a series of more recent advancements - notably the first circadian gene in mammals discovered by UT Southwestern's Dr. Joseph S. Takahashi - has elevated the research beyond flies and positioned scientists to unlock many of the mysteries of human health and behavior. (utsouthwestern.edu)
However, the molecular mechanisms underlying the determination or stabilization of the circadian period and phase remain to be investigated in mammals. (elifesciences.org)

Circadian time therefore pervades every level of biological organisation, from molecules to society. (cas.cz)
Under normal conditions, we experience a 24-hour pattern of light and dark, and our circadian clock uses this signal to align biological time to the day and night. (theconversation.com)
A circadian clock also stops everything happening at the same time, ensuring that biological processes occur in the appropriate sequence. (theconversation.com)

Workers punching in for the graveyard shift may be better off not eating high-iron foods at night so they don't disrupt the circadian clock in their livers. (sciencedaily.com)
Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. (researchgate.net)
This innovative metric provides a new tool for investigating shift and personal factors that most strongly disrupt circadian rhythms and thereby, perhaps, risk of two of the most common cancers in people, breast and prostate. (who.int)

Entrainment or phase adaptation is an important function of the circadian clock system that allows the adjustment of circadian dynamics in response to external stimuli. (nature.com)

Much of that success will stem from a cascade of findings related to the CLOCK gene, the first mammalian gene controlling circadian rhythms that Dr. Takahashi discovered and cloned in the 1990s. (utsouthwestern.edu)

Research shows, says Bailey, that people who work the night shift are at greater risk for many conditions like diabetes, liver-related and metabolic diseases. (wrvo.org)
When the clock in the liver gets out of synch with the one in the brain, it may contribute to metabolic diseases, according to Donald A. McClain, M.D., Ph.D., University of Utah professor of medicine (endocrinology) and biochemistry and senior author on the study. (sciencedaily.com)
Disturbance of circadian rhythms underlies various metabolic diseases. (researchgate.net)
E-cigarettes contain nicotine and it's been shown that nicotine is associated with insulin resistance and metabolic diseases like non-alcoholic fatty liver disease (NAFLD). (medscape.com)

Jennifer Valcin, MS, doctoral researcher at the University of Alabama at Birmingham, presented "The liver molecular circadian clock in chronic alcohol-induced mitochondrial dysfunction" as part of the symposium "Mitochondria on the Move: Networking in Health and Disease" on Sept 10 and at the poster session later that evening. (sleepreviewmag.com)
Recent evidence indicates that post-transcriptional and post-translational mechanisms play essential roles in modulating temporal gene expression for proper circadian function, particularly for the molecular mechanism of the clock. (mpg.de)

LL disrupted this pattern, causing disruptions in circadian rhythms of plasma levels of triglycerides (TG) and glucose. (researchgate.net)

Among the 3000 proteins accurately quantified across two consecutive cycles, 6% showed circadian oscillations with a defined phase of expression. (mpg.de)
Russell Foster is a circadian neuroscientist: He studies the sleep cycles of the brain. (ted.com)
People who are obese burn calories in daily circadian cycles that are altered compared with those who are not obese, with the lowest point of energy expenditure occurring during their awake hours, as opposed to the typical lowest expenditures during sleeping hours observed among those of healthy weight. (medscape.com)
Cite this: Circadian Calorie-Burning Cycles Altered in Obesity - Medscape - Nov 21, 2023. (medscape.com)

New research is revealing exactly why shift workers and other chronically sleep deprived members of mankind tend to have problems with obesity , insulin resistance, diabetes, heart disease, and all the other popular features of metabolic syndrome: their livers aren't processing fat efficiently, instead allowing fat to accumulate. (marksdailyapple.com)
Furthermore, those with obesity showed greater glucose intolerance during the circadian day, with lower insulin production during the circadian night. (medscape.com)

This paper reviews the evidence for a connection between disturbances of circadian rhythms and breast cancer. (sanevax.org)

Circadian clock phase is influenced primarily through exposure to light. (kobv.de)
In liver samples, they observed that e-cigarette exposure led to hepatic lipid accumulation and oxidative stress, as well as a significant increase in hepatic expression of p53, a known inducer of insulin resistance and NAFLD. (medscape.com)
An increased risk was found for women living in areas with the highest quintile of outdoor light at night exposure estimates (HR=1.12 [95% CI=1.00 - 1.26], test for trend, P=0.06). (cdc.gov)

Our internal clock, the circadian clock, determines at which time we have our best cognitive abilities, are physically strongest, and when we are tired. (kobv.de)
Living against our circadian clock makes us less efficient and poses serious health impact, especially when exercised over a long period of time, e.g. in shift workers. (kobv.de)
Time series genome-wide map of BMAL1 binding in mouse liver. (expasy.org)
Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. (europa.eu)
This 2001 study ties in with my concerns over vaccinating adolescent girls at the most fragile time of their lives - puberty, menarche - a time when the endocrine system is striving to develop its own rhythm/balance. (sanevax.org)
But if this happens at a time that is out of synch with the circadian clock, such as during a graveyard shift, it could result in abnormal blood glucose levels. (sciencedaily.com)
Mexican cavefish living in constant darkness, lost this circadian rhythm some time ago. (scienceblogs.com)
They then work during the night at a time when the circadian system has prepared the body for sleep, and alertness and performance are low. (theconversation.com)
How shift work and long hours are linked to a wide range of health and safety risks by reducing time for sleep, disturbing circadian rhythms, and disrupting family and non-work responsibilities. (cdc.gov)

Interestingly, daily rhythms of one fifth of the liver proteins were not accompanied by changes at the transcript level. (mpg.de)

Circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers. (greenmedinfo.com)
Shift workers try to sleep during the day, but sleep is usually shorter and of poorer quality than when sleep occurs at night because, although desperately tired, the circadian system is instructing the body that it should be awake. (theconversation.com)

Circadian patterns of glucose regulation are also altered among those who are obese, with key implications of the findings being potential clues in optimizing weight management approaches and reducing adverse effects of sleep regimens that counter the metabolic circadian patterns. (medscape.com)

They found that when heme binds to a circadian protein-a substance whose function Simcox likens to that of a cog in a mechanical clock-the protein's activity increases and causes the liver to optimally control blood glucose levels. (sciencedaily.com)

Our circadian rhythm is controlled by an area in our brain called the hypothalamus , which is super sensitive to light. (amymdwellness.com)

To address this issue, the EU-funded CircaCHIP project has developed a microfluidics-based liver-on-a-chip device that captures metabolic dynamics and oscillations of temperature and hormones of the native tissue. (europa.eu)

This virtual workshop aims to apply developing advances in circadian science to priorities in lung biology, disease and therapeutics research by stimulating multi-disciplinary discussions between exceptional pulmonary and circadian investigators. (nih.gov)
Apply developing advances in circadian science to priorities in lung biology, disease and therapeutics, including (a) normal lung cell biology (b) lung pathophysiology, and (c) targets and pathways for lung therapeutics. (nih.gov)

We found it was possible to monitor circadian phase shift from light estimation based on smartphone sensor and weather information with a weekly error of 32±17min, which outperformed wrist measurements in 11 out of 12 participants. (kobv.de)

Non-alcoholic fatty liver disease (NAFLD) is currently considered as one of the emerging liver pathologies in the Western countries due to the modification of eating habits and lifestyle. (uniba.it)

Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. (expasy.org)

Circadian variations in microbiota function adds an extra layer of complexity to metabolic interactions between the host and the microbiota. (biorxiv.org)

however, their energy expenditure metrics were similar across circadian phases, without the adjustment of energy utilization during rest observed among those with healthy weight during the circadian night. (medscape.com)

Since the liver is involved in how the body responds to food intake, the liver can be reset or altered by things in our diet -- food and alcohol. (wrvo.org)

In this light, the aim of this review is to give a comprehensive description of how our circadian machinery is regulated and to describe to what extent our internal clock is involved in the regulation of hormonal and metabolic homeostasis, and by extension in the development and progression of NAFLD/NASH and eventually in the onset of HCC. (uniba.it)
The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. (nature.com)

Apart from liver specific metabolic pathways, we identified many other essential cellular processes in which protein levels are under circadian control, for instance vesicle trafficking and protein folding. (mpg.de)
Increased activity of a circadian protein is healthy when it occurs in the liver's natural clock cycle. (sciencedaily.com)

Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. (europa.eu)
When a shift worker eats foods high in iron at night it could exacerbate the lack of synchronization between the clock in the liver and the main one in the brain," says McClain, who's also the University Health Sciences' associate vice president for clinical research and director of the Center for Clinical and Translational Science. (sciencedaily.com)

The study involved 30 volunteers in healthy and obese weight ranges, who took part in a rigorous circadian protocol involving designated times of being awake and asleep and eating throughout each day for 5 days. (medscape.com)

Living organisms need to regulate their gene expression in response to environmental signals and internal cues. (lu.se)

Chronic alcohol consumption disrupts the clock and makes the mitochondria less flexible and prone to dysfunction, contributing to the development of alcoholic liver disease. (sleepreviewmag.com)
All in all, this is further evidence that many (if not most) of our metabolic issues stem from liver dysfunction. (marksdailyapple.com)

Well, unfortunately, Bailey says the signs and symptoms that indicate underlying liver disease are quite vague - things like abdominal pain and swelling, swelling of legs and ankles, chronic fatigue, nausea vomiting - which could be caused by many other things. (wrvo.org)
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is hosting a three-day virtual workshop titled "Circadian Clock at the Interface of Lung Health and Disease" on Thursday, September 14th 12:00 p.m. - 4:00 p.m., Friday, September 15th 12:00 p.m. - 4:00 p.m., and Monday, September 18th , 2023, from 12:00 p.m. - 4:00 p.m. (nih.gov)
Gait Detection from a Wrist-Worn Sensor Using Machine Learning Methods: A Daily Living Study in Older Adults and People with Parkinson’s Disease. (crossref.org)

Anatomy28

Organisms13

Diseases50

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology1

Phenomena and Processes37

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Named Groups2

Health Care11

Metabolism21

Clocks23

Disruption10

Normal circadian1

Liver's circadian2

Genes8

Regulates3

Field of circadian1

Melatonin1

Body's circadian2

Internal circadian2

Disorders9

Mice11

Rhythm of the liver2

Suprachiasmatic3

Tissues2

Mammals3

Biological3

Disrupt3

Entrainment1

Mammalian1

Metabolic diseases4

Molecular2

Disruptions1

Cycles4

Obesity2

Disturbances1

Exposure3

Time9

Transcript1

Shift workers2

Patterns1

Glucose1

Hypothalamus1

Dynamics1

Advances2

Phase shift1

Fatty liver disease1

BMAL11

Variations1

Metrics1

Food intake1

Homeostasis2

Protein2

Synchronization2

Obese1

Gene Expression1

Dysfunction2

Disease3