• In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). (cdc.gov)
  • Ciliary body melanomas can push the iris diaphragm anteriorly, or they can infiltrate the trabecular meshwork, producing acute angle closure. (medscape.com)
  • Ciliary body melanomas are mostly found in Whites, particularly in those with light-colored irides. (medscape.com)
  • These include melanomas that develop in the gastrointestinal tract, vagina, the mucous membranes that line the mouth, and other locations around the body. (cancer.net)
  • 6 ] Most uveal tract melanomas originate in the choroid. (cigna.com)
  • Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is a tumour until the ophthalmologist looks into the eye with an ophthalmoscope during a routine test). (wikidoc.org)
  • This strangely named structure is a ridged area at the front of the eye that attaches the ciliary muscles. (eyehelp.co.uk)
  • During accommodation, the ciliary muscles adjust lens shape to properly focus images. (merckmanuals.com)
  • The ciliary muscles within the ciliary body allow for the viewing of objects at varying distances and regulate the flow of fluid (aqueous humor) throughout the eye. (viteyes.com)
  • It is held in place by the ciliary muscles, which allow the lens to change shape depending on the amount of light that hits it so it can be properly focused. (md-health.com)
  • A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. (cancer.net)
  • The ciliary body is a ring of tissue with muscle fibers that change the shape of the lens . (cancer.gov)
  • Ciliary body is a ring-shaped tissue which holds and controls the movement of the eye lens, and thus, it helps to control the shape of the lens. (md-health.com)
  • When this type of tumor grows to a significant size, it may extend beyond its site of origin (ie, from the choroid to the ciliary body and vice versa). (aao.org)
  • This tumor can grow around the eye but rarely spreads to other parts of the body. (wikidoc.org)
  • The ciliary muscle receives parasympathetic fibers from the short ciliary nerves that arise from the ciliary ganglion. (wikipedia.org)
  • The postganglionic parasympathetic innervation arises from the ciliary ganglion. (wikipedia.org)
  • Presynaptic parasympathetic signals that originate in the Edinger-Westphal nucleus are carried by cranial nerve III (the oculomotor nerve) and travel through the ciliary ganglion via the postganglionic parasympathetic fibers which travel in the short ciliary nerves and supply the ciliary body and iris. (wikipedia.org)
  • We have examined how peptide transmitter expression is controlled in a simple model system, the avian ciliary ganglion (CG). (jneurosci.org)
  • This parasympathetic ganglion contains 2 distinct types of neurons: choroid neurons, which project to vasculature in the eye's choroid layer and use somatostatin as a co-transmitter with ACh, and ciliary neurons, which innervate the ciliary body and iris and use ACh but no known peptide co-transmitter. (jneurosci.org)
  • In cell culture, CG neurons expressed SOM-IR in co-culture with choroid cells, but not when cultured with striated muscle myotubes or with ganglion non-neuronal cells. (jneurosci.org)
  • The choroid is packed with tiny blood vessels and these are responsible for taking oxygen and nutrients into the photoreceptor cells and taking away the waste metabolites and carbon dioxide. (eyehelp.co.uk)
  • It is connected to the lens with a network of many tiny ligaments (called ciliary zonules or zonules of Zinn) that suspend the lens in place behind the pupil. (allaboutvision.com)
  • The ciliary body is a muscle behind the iris that changes the size of your pupil and the shape of your lens to help your eye focus. (cancer.ie)
  • These locations of 50-NT indicate strategically important production sites of adenosine regulating choroid and ciliary body functions (e.g., blood flow, aqueous fluid production, and immune response). (uaeu.ac.ae)
  • The parasympathetic postganglionic fibers are part of cranial nerve V1 (Nasociliary nerve of the trigeminal), while presynaptic parasympathetic fibers to the ciliary ganglia travel with the oculomotor nerve. (wikipedia.org)
  • Parasympathetic activation of the M3 muscarinic receptors causes ciliary muscle contraction. (wikipedia.org)
  • The effect of contraction is to decrease the diameter of the ring of ciliary muscle causing relaxation of the zonule fibers, the lens becomes more spherical, increasing its power to refract light for near vision. (wikipedia.org)
  • We have found that the earliest developmental stage in which neurons with somatostatinlike immunoreactivity (SOM-IR) are consistently found in vivo is stage 30 (embryonic day 6.5), a time shortly after the extension of neurites to targets in the eye's choroid layer. (jneurosci.org)
  • Ciliary body - Located at the front (anterior) and the middle (intermediate) portion of the uvea. (allaboutvision.com)
  • The word uvea comes from the Latin word ' uva ', which means 'grape' as defined by early anatomists based on the tissue color and geometry and consists of the iris, ciliary body and the choroid. (medscape.com)
  • Symptoms that suggest corneal involvement (eg, rather than simple conjunctivitis) include unilateral involvement, pain (foreign body sensation and ache-not just a gritty sensation), particularly with exposure to light (photophobia), and decreased visual acuity. (merckmanuals.com)
  • In the middle portion of the eyeball is the choroid, atunic thatis well-supplied with blood andholds a darkish pigment. (allhealthsite.com)
  • The choroid is a layer of blood vessels that bring oxygen and nutrients to the eye. (cancer.gov)
  • The inner layer of the choroid is the lamina vitrea. (histology-world.com)
  • Thus, the expression of somatostatin in cultured CG neurons is regulated by a macromolecule produced by cells in the choroid layer, a target normally innervated in vivo by CG neurons expressing somatostatin. (jneurosci.org)
  • According to Hermann von Helmholtz's theory, the circular ciliary muscle fibers affect zonular fibers in the eye (fibers that suspend the lens in position during accommodation), enabling changes in lens shape for light focusing. (wikipedia.org)
  • The ciliary muscle develops from mesenchyme within the choroid and is considered a cranial neural crest derivative. (wikipedia.org)
  • Braun, JS 2010, ' Ecto-5′-nucleotidase-positive cells in the choroid and ciliary body of the rat eye ', Anatomical Record , vol. 293, no. 3, pp. 379-382. (uaeu.ac.ae)
  • When the ciliary muscle contracts, it pulls itself forward and moves the frontal region toward the axis of the eye. (wikipedia.org)
  • Conversely, relaxation of the ciliary muscle causes the zonular fibers to become taut, flattening the lens, increasing the focal distance, increasing long range focus. (wikipedia.org)
  • The ciliary body contains the ciliary muscle. (histology-world.com)
  • The ciliary muscle is responsible for adjusting the lens. (histology-world.com)
  • The sagittal section of the eye also reveals the lens which is a transparent body located behind the iris. (utah.edu)
  • This report provides evidence that 50-NT is expressed in the choroid and in the ciliary body (and its processes) of the rat eye, predominantly in endothelial cells. (uaeu.ac.ae)
  • The stimulation of somatostatin expression was also specific in that other neuropeptides commonly found in autonomic neurons [neuropeptide Y (NPY), substance P (SP), vasoactive intestinal polypeptide (VIP)] were not induced in the presence of choroid cells. (jneurosci.org)
  • The ability to stimulate SOM-IR was not contact dependent because a macromolecule of greater than or equal to 10 kDa in choroid-conditioned medium (ChCM) was found to stimulate somatostatin expression in a dosage-dependent fashion. (jneurosci.org)
  • Or, it may spread (metastasize) to another location in the body, most commonly the liver. (medlineplus.gov)
  • The ciliary body is less commonly a site of origin, and the iris is the least common. (cigna.com)
  • The different parts of the eye allow the body to take in light and perceive objects around us in the proper color, detail and depth. (md-health.com)
  • You will find some basic information about this disease and the parts of the body it may affect. (cancer.net)
  • Both methotrexate and mycophenolate mofetil, which are systemic and affect multiple cell types in the body, can cause side effects such as fatigue, nausea and headaches, but serious side effects are rare. (nih.gov)