• Centrioles, from which basal bodies are derived, act as anchoring sites for proteins that in turn anchor microtubules, and are known as the microtubule organizing center (MTOC). (wikipedia.org)
  • Mutations in proteins that localize to basal bodies are associated with several human ciliary diseases, including Bardet-Biedl syndrome, orofaciodigital syndrome, Joubert syndrome, cone-rod dystrophy, Meckel syndrome, and nephronophthisis. (wikipedia.org)
  • Based on our analysis of requirements for CLS-2, a member of the CLASP family of proteins that stabilize microtubules, we recently proposed that a balance of actomyosin-mediated tension and microtubule-mediated stiffness limits membrane ingression throughout the oocyte during meiosis I polar body extrusion. (bvsalud.org)
  • Regulation of basal body production and spatial orientation is a function of the nucleotide-binding domain of γ-tubulin. (wikipedia.org)
  • When centrosomes fail to recruit γ-tubulin complexes, they still nucleate microtubules via the TOG domain protein Mini-spindles (Msps), but these microtubules have different dynamic properties. (bvsalud.org)
  • Centrioles, from which basal bodies are derived, act as anchoring sites for proteins that in turn anchor microtubules, and are known as the microtubule organizing center (MTOC). (wikipedia.org)
  • Cilia arise from the centrosome, a cellular organelle composed of two barrel-shaped microtubule-based structures called the centrioles. (biorxiv.org)