Chrysene is estimated to have about 1% of the toxicity of benzo(a)pyrene. (wikipedia.org)
In this study, we assess potential differences in mechanism of action for two PAHs, benzo[a]pyrene (BAP) and dibenzo-[def,p]chrysene (DBC), in a primary human 3D bronchial epithelial culture (HBEC) model based on short-term biosignatures identified from global transcriptional profiling. (nih.gov)
Fully differentiated bronchial epithelial cells (n=4 replicates) were treated with 500 µg/ml (19.80 nanomoles) benzo[a]pyrene (BAP), 10 µg/ml (0.35 nanomoles) dibenzo[def,p]chrysene (DBC) or acetone vehicle control for 48 hrs and isolated mRNA were sequenced on Illumina HiSeq 3000. (nih.gov)
The ability of prostaglandin synthetase (PGS) to cooxidize benzo( a )pyrene, benzo( a )anthracene, chrysene, and several of their dihydrodiol derivatives to mutagenic products was tested with Salmonella typhimurium strains TA98 and TA100. (aacrjournals.org)
The microsomal fraction of ram seminal vesicles, a known source of PGS, in the presence of the PGS substrate arachidonic acid, metabolized benzo( a )pyrene-7,8-dihydrodiol, benzo( a )anthracene-3,4-dihydrodiol, and chrysene-1,2-dihydrodiol to mutagenic products. (aacrjournals.org)
PAHs1
As with other PAHs, chrysene is suspected to be a human carcinogen. (wikipedia.org)
Molecular formula1
Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C 18H 12 that consists of four fused benzene rings. (wikipedia.org)
Derivatives1
Derivatives of chrysene include tetrahydrochrysene and 2,8-dihydroxyhexahydrochrysene, which are estrogenic compounds. (wikipedia.org)
Activity1
Since mid-2017, Dragos has been tracking a group it has named Chrysene, whose activity focuses on North America, Western Europe, Israel and Iraq, particularly organizations in the electricity generation and oil&gas sectors. (securityweek.com)
Active2
Selective covalent binding of the active sulfate ester of the carcingen 5-(hydroxymethyl)chrysene to the adenine residue of calf thymus DNA. (nii.ac.jp)
Chrysene, which continues to be active, has used a unique variation of a framework associated with the Iran-linked cyber espionage groups known as OilRig and Greenbug . (securityweek.com)
Pyrene2
Serum PAHs did not appear to be related to bladder cancer risk, although the profile of contamination by PAHs was different between patients and controls: pyrene (Pyr) was solely detected in controls and chrysene (Chry) was exclusively detected in the cases. (nih.gov)
The organic material is made up of phenanthrene, pyrene, chrysene, benzopyrene and anthanthracene [ R6 ]. (astronomyonline.org)
Dibenzo2
Another hexacyclic aromatic hydrocarbon, dibenzo[c,p]chrysene (DBC), is a unique PAH that possesses one bay region and two fjord regions within the same molecule. (psu.edu)
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. (nih.gov)
Colorless2
However, high purity chrysene is colorless, the yellow hue being due to the traces of its yellow-orange isomer tetracene, which cannot be separated easily. (wikipedia.org)
New Jersey officials indicate that Ford Motors intentionally concealed information about dumping large amounts of toxic waste across more than 500 acres in Passaic County from 1967 and 1974, including lead, arsenic, benzene, polychlorinated biphenyls (PCBs), semi-volatile organic compounds, chrysene and 1,4 dioxane, a colorless solvent believed to be a carcinogen, as well as other pollutants. (aboutlawsuits.com)
Benzene1
Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C 18H 12 that consists of four fused benzene rings. (wikipedia.org)
Diesel1
Nonetheless, we recognize that a noteworthy contribution to our analyses of PAH derived from ETS ( eg , chrysene) instead of from diesel emission cannot be completely ruled out. (medscape.com)
Effects1
10. Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells. (nih.gov)