• Contusive SCI in rats at T10 results in hyperexcitability of primary sensory neurons, which contributes to chronic pain. (johnshopkins.edu)
  • Second, treatment with retigabine, a specific KCNQ channel opener, profoundly decreased spontaneous activity in primary sensory neurons of SCI animals both in vitro and in vivo without changing the peripheral mechanical threshold. (johnshopkins.edu)
  • These events might also impact central processes of primary sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that drive behavioral hypersensitivity and pain. (johnshopkins.edu)
  • We show that small DRG neurons from rats (Rattus norvegicus) receiving thoracic spinal injury3dto8months earlier and recorded 1 d after dissociation exhibit an elevated incidence of SA coupled with soma hyperexcitability compared with untreated and sham-treated groups. (johnshopkins.edu)
  • Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries, plays an essential role in the induction and maintenance of chronic pain. (jneurosci.org)
  • Using patch-clamp recordings in lamina II neurons of isolated spinal cord slices, we compared the effects of IL-1β, IL-6, and TNFα on excitatory and inhibitory synaptic transmission. (jneurosci.org)
  • Furthermore, all the PICs increased cAMP response element-binding protein (CREB) phosphorylation in superficial dorsal horn neurons and produced heat hyperalgesia after spinal injection. (jneurosci.org)
  • We used patch-clamp recording in dorsal horn neurons in isolated spinal cord slices to investigate whether PICs have similar or different effects on synaptic transmission in lamina II neurons in which nociceptive information is modulated and conveyed to projection neurons. (jneurosci.org)
  • Additionally, the spontaneous activity of WDR neurons was decreased after A-967079 injection in CFA-inflamed rats but was unaltered in uninjured, OA, and OA-sham animals. (biomedcentral.com)
  • In order to further delineate the role of TRPA1 receptors in normal and pathological mechanotransmission, we administered a selective TRPA1 receptor antagonist, A-967079 (Figure 1 ), to examine its effects on spinal nociceptive neurons in uninjured, inflamed, and osteoarthritic (OA) rats. (biomedcentral.com)
  • We also examined the actions of A-967079 on the spontaneous firing of spinal wide dynamic range (WDR) neurons in each of the animal models examined. (biomedcentral.com)
  • Spontaneous activity of WDR neurons is heightened following a chronic injury and is an indication of central sensitization and possibly non-evoked or ongoing pain [ 22 - 27 ]. (biomedcentral.com)
  • 2016 ) Chronic Recordings Reveal Tactile Stimuli Can Suppress Spontaneous Activity of Neurons in Somatosensory Cortex of Awake and Anesthetized Primates. (neurotree.org)
  • Hemorrhage affecting the spinal cord is rare. (medscape.com)
  • Spinal cord hemorrhage can be divided based on etiology, into two types: (1) traumatic and (2) non-traumatic. (medscape.com)
  • [ 1 ] Spinal cord hemorrhage is most commonly caused by trauma, vascular malformations, or bleeding diatheses. (medscape.com)
  • Spinal cord hemorrhage usually presents as sudden, painful myelopathy, which may reflect the anatomic level of the hemorrhage. (medscape.com)
  • The most common cause of spinal cord hemorrhage is traumatic injury. (medscape.com)
  • With trauma, shear forces acting upon the spinal cord and surrounding structures may lead to hemorrhage and vascular damage. (medscape.com)
  • Hematomyelia is defined as the presence of a well-defined focus of hemorrhage within the spinal cord itself. (medscape.com)
  • Summary of intramedullary spinal cord hemorrhage etiologies, with history and associated clues, common imaging findings, and representative management. (medscape.com)
  • Head CT scan (noncontrast): Assess spontaneous or traumatic hemorrhage. (medscape.com)
  • Assess spontaneous or traumatic hemorrhage. (medscape.com)
  • Head and spinal column MRI: Further assess spontaneous or traumatic hemorrhage. (medscape.com)
  • Spinal Cord Arteriovenous Malformations (AVMs) Arteriovenous malformations (AVMs) in or around the spinal cord can cause cord compression, ischemia, parenchymal hemorrhage, subarachnoid hemorrhage, or a combination. (msdmanuals.com)
  • Chronic SDH SDH Subdural hemorrhage (SDH) is bleeding into the space between the dural and arachnoid meningeal layers surrounding the brain. (lecturio.com)
  • Often unique radiologic signs can be used to distinguish these types of spinal hemorrhage. (caserepclinradiol.org)
  • It is occasionally due to abscess and rarely due to spontaneous epidural hematoma. (msdmanuals.com)
  • The incidence of spontaneous spinal epidural hematoma is about one in one million individuals per year with a male preponderance of 3:1, occurring most commonly between the ages of 42 to 52 years. (ruralneuropractice.com)
  • Background We report a retrospective analysis of a two-level, variable-volume epidural blood patch (EBP) technique for the treatment of spontaneous intracranial hypotension (SIH). (bmj.com)
  • A 55-year-old female, with known idiopathic intracranial hypertension, presented with disabling chronic low-pressure symptoms after having a lumboperitoneal shunt removed 5 years previously. (surgicalneurologyint.com)
  • A majority of people who have sustained spinal cord injury (SCI) experience chronic pain after injury, and this pain is highly resistant to available treatments. (johnshopkins.edu)
  • Mechanisms underlying chronic pain that develops after spinal cord injury (SCI) are incompletely understood. (johnshopkins.edu)
  • Therefore, a sensory level to light touch may be absent unless both of these are involved (e.g., a complete injury that involves all spinal cord tracts). (emcrit.org)
  • Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα), are induced in the spinal cord under various injury conditions and contribute to pain hypersensitivity. (jneurosci.org)
  • Our findings reveal an unappreciated circadian machinery affecting pain hypersensitivity caused by peripheral nerve injury, thus opening up novel approaches to the management of chronic pain. (nature.com)
  • TRPA1 receptors also contribute to the transmission of low-intensity mechanical stimulation, and to the modulation of spontaneous WDR firing, but only after an inflammatory injury. (biomedcentral.com)
  • Bladder dysfunction is a common complication after chronic spinal cord injury (SCI). (mdpi.com)
  • 2018 ) Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys. (neurotree.org)
  • 2016 ) Plasticity and Recovery After Dorsal Column Spinal Cord Injury in Nonhuman Primates. (neurotree.org)
  • 2016 ) Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury. (neurotree.org)
  • Spinal hematoma is a rare condition but can cause significant spinal injury and resultant morbidity. (caserepclinradiol.org)
  • Substance P, NK1, and NMDA receptor 1 increase in spinal cord dorsal horns in a rat model of repetitive motion injury. (cdc.gov)
  • Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (bvsalud.org)
  • We present a case of a 42-year-old male, an old case of deep vein thrombosis on warfarin and other drugs like quetiapine, aspirin, diclofenac sodium, fenofibrate, atorvastatin, propanolol and citalopram for concurrent illnesses, who presented with widespread mucocutaneous bleeding and epidural spinal hematoma. (ruralneuropractice.com)
  • This case highlights the problem of drug interaction on warfarin therapy and also an unusual spontaneous recovery of spinal hematoma. (ruralneuropractice.com)
  • Spinal hematoma has been described as a clinical entity since 1850 by Tellegen and in autopsy studies as early as 1682. (ruralneuropractice.com)
  • There is paucity of data to estimate the incidence of spinal hematoma, perhaps due to the rarity of this disorder. (ruralneuropractice.com)
  • Shanmuga Jayanthan S, Rupesh G, Vimalan P, Nadanasadharam K. Two rare cases of idiopathic spontaneous extra-axial spinal hematoma. (caserepclinradiol.org)
  • Herein, we report two cases of rare idiopathic spontaneous extra-axial hematoma highlighting the role of MRI in the diagnosis. (caserepclinradiol.org)
  • [ 1 ] Among these subtypes, spontaneous epidural and subdural spinal hematoma are rare and differentiating them is a diagnostic challenge. (caserepclinradiol.org)
  • First, PICs are induced in the spinal cord, especially in glial cells (e.g., microglia and astrocytes), in different chronic pain conditions. (jneurosci.org)
  • DI mice showed an anxiodepressive-like phenotype associated with extended mechanical pain hypersensitivity and spontaneous pain when compared to SI mice . (bvsalud.org)
  • Pain hypersensitivity and spontaneous pain develop quickly after the implantation of tumor cells, a time when tumor volume is still insignificant. (nih.gov)
  • A spinal implant procedure, also known as a vertebral implant or spine jack, can restore a patient's vertebral height and significantly reduce the pain associated with compressed or fractured vertebrae. (hopkinsmedicine.org)
  • Note that the spinal cord level doesn't line up precisely with the corresponding vertebrae, especially caudal to the thoracic spine. (emcrit.org)
  • Immediate care Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. (msdmanuals.com)
  • Between the spinal vertebrae there are soft, jelly-like compressible discs that act as shock absorbers. (skepdoc.info)
  • Although NST can be applied to any condition that the human organism is capable of manifesting its effectiveness is most dramatically obvious in the resolution of all spinal and structural conditions including back pain, neck pain, conditions of the articulations, cranial and TMJ disorders, headaches, sporting injuries, respiratory and digestive conditions, menstrual conditions, chronic fatigue and emotional depression. (nsthealth.com)
  • Other factors that may result in sustained venous hypertension are those that impede the pumping function of the leg muscles, such as conditions that reduce spontaneous movements (Parkinson's disease, stroke, spinal cord injuries or excessive sedation). (biomedcentral.com)
  • Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure from high spinal cord injuries should only be used with special arrangements for clinical governance, consent, and audit or research. (bvsalud.org)
  • Se seleccionaron artículos en inglés y español de 2017 a 2021. (bvsalud.org)
  • Intramedullary spinal cord tumors, both primary CNS and metastatic (especially renal cell carcinoma), can also bleed and lead to hematomyelia. (medscape.com)
  • Compression is caused far more commonly by lesions outside the spinal cord (extramedullary) than by lesions within it (intramedullary). (msdmanuals.com)
  • The spinal hematomas can be classified based on the anatomical location as follows: Epidural, subdural, subarachnoid, and intramedullary (spinal cord) hematomas. (caserepclinradiol.org)
  • Further, whether leakage of the C4 solution from the capsules after prostate brachytherapy would potentiate systemic inflammatory effects or produce acute or chronic toxicity is unknown. (hindawi.com)
  • Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS) with hallmarks of myelin degeneration and axonopathy [ 1 ]. (medsci.org)
  • Though both chronic inflammatory demyelinating polyneuropathy ( CIDP ) and multiple sclerosis (MS) cause damage to the nerves and can coexist in rare cases, they are different diagnoses. (ameripharmaspecialty.com)
  • Hematomyelia can also be spontaneous, and has been reported in patients with hereditary coagulation disorders and/or patients on antiplatelet and anti-coagulation therapies. (medscape.com)
  • Following a spinal implant procedure, patients report a significant decrease in pain and are often able to return to previous activity levels. (hopkinsmedicine.org)
  • Patients with cancer or noncancer pain requiring chronic therapy are monitored closely to optimize treatment and to minimize the likelihood of complications of opioid use, including misuse or abuse. (tri-kobe.org)
  • Most infections were pulmonary, but pleural and spinal infections (spinal in HIV-infected patients) were also noted. (cdc.gov)
  • Pain is one of the first presenting symptoms in patients with head and neck cancer, who often develop chronic and debilitating pain as the disease progresses. (nih.gov)
  • ˆ ` ´ ´ Jerome De Seze Gilles Defer Frederic Sedel Carl Arndt Published online: 28 May 2018 The Author(s) 2018 Abstract Objective The aim of this study was to evaluate whether Background Chronic visual loss is a disabling feature in MD1003 improves vision compared with placebo in MS patients with multiple sclerosis (MS). It was recently patients with chronic visual loss. (deepdyve.com)
  • Adult patients with MS-related chronic visual loss of at least one eye [visual acuity (VA) below 0.5 decimal chart] were randomized 2:1 to oral MD1003 300 mg/day or placebo. (deepdyve.com)
  • 0.029 logMAR) with placebo with progressive chronic optic neuropathy (p = 0.45) in the subgroup of patients with PON. (deepdyve.com)
  • Conclusions MD1003 did not signi﫿cantly improve VA compared with placebo in patients with MS experiencing 1 Introduction chronic visual loss. (deepdyve.com)
  • Pain is the most common reason for hospitalization among chronic pancreatitis patients, and as many as 40% require 3 or more admissions during their lifetime for pain management (72). (pancreapedia.org)
  • The possibility that activators of KCNQ channels could be useful for treating SCI-induced chronic pain is strongly supported by the following findings. (johnshopkins.edu)
  • Third, retigabine reversed SCI-induced reflex hypersensitivity, adding to our previous demonstration that retigabine supports the conditioning of place preference after SCI (an operant measure of spontaneous pain). (johnshopkins.edu)
  • In contrast to SCI animals, naïve animals showed no effects of retigabine on reflex sensitivity or conditioned place preference by pairing with retigabine, indicating that a dose that blocks chronic pain-related behavior has no effect on normal pain sensitivity or motivational state. (johnshopkins.edu)
  • Most research on SCI pain mechanisms has focused on neuronal alterations within pain pathways at spinal and supraspinal levels associated with inflammation and glial activation. (johnshopkins.edu)
  • SCI promotes the entry of primary nociceptors into a chronic hyperexcitable-SA state that may provide a useful therapeutic target in some forms of persistent pain. (johnshopkins.edu)
  • We know that spinal fractures cause severe pain and can impact your daily life. (hopkinsmedicine.org)
  • Weakness in the legs or loss of bowel or bladder control in the presence of thoracic spine pain can indicate spinal cord compression and should be investigated. (wikipedia.org)
  • The most common causes of upper back pain are unknown but theorized to originate from muscular irritation, intervertebral discs, spinal facet joints, ribs or soft tissue (e.g. ligament/fascia) problems. (wikipedia.org)
  • Often thoracic pain can be aggravated twisting, side bending and with prolonged bent spinal postures. (wikipedia.org)
  • A compression fracture of the vertebra can also cause acute and/or chronic pain in the upper back. (wikipedia.org)
  • Other, less common causes of thoracic back pain include a spinal disc herniation which often may have radicular pain (wrapping around the ribs associated with numbness and burning pain), spinal tumors and rib fractures may mimic thoracic pain/radicular pain. (wikipedia.org)
  • Functional neurorehabilitation promotes neural reorganization by stimulating subjects without deep pain perception, leading to a faster recovery when compared to spontaneous recovery, and achieving fewer compensatory errors, or even deviations to neuropathic or adaptive pain pathways, such as spasticity. (mdpi.com)
  • Evaluating for a sensory level using a pin to detect pain sensation is more sensitive to detect a spinal level originating from a lesion in the spinothalamic tract. (emcrit.org)
  • Blockade of PIC signaling could be an effective way to suppress central sensitization and alleviate chronic pain. (jneurosci.org)
  • Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the underlying mechanisms are enigmatic. (nature.com)
  • Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • Therefore, our findings reveal an underlying mechanism of diurnal exacerbation of neuropathic mechanical allodynia and also provide novel approaches to the management of chronic pain. (nature.com)
  • Is the pain acute or chronic? (tri-kobe.org)
  • NST is a sublimely effective spinal integration technique, designed for efficient removal of an impressive list of spinal and health conditions, that is notably headed by back and neck pain. (nsthealth.com)
  • We previously reported that immune activation in the spinal dorsal horn contributes to pain induced by chronic pancreatitis (CP). (biomedcentral.com)
  • These data highly suggest that RvD1 could be a novel and effective treatment for CP-induced chronic pain. (biomedcentral.com)
  • Recurrent and serious abdominal pain is one of the most common symptoms in chronic pancreatitis (CP) [ 1 ]. (biomedcentral.com)
  • These results highly suggest that neuroplastic changes in the CNS are probably important contributors to the CP-induced chronic pain. (biomedcentral.com)
  • These data suggest that neuron-immune interactions in the spinal dorsal horn play a pivotal role in neuroplastic changes and CP-induced pain. (biomedcentral.com)
  • It must be suspected in any patient on anticoagulant agents who complains of local or referred spinal pain associated with neurological deficits. (ruralneuropractice.com)
  • Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain. (bvsalud.org)
  • Acute pain has been associated with persistent pain sensitization of nociceptive pathways increasing the risk of transition from acute to chronic pain . (bvsalud.org)
  • ranging in age from 39 to 83 who had chronic back pain and had already tried other treatments. (skepdoc.info)
  • [3] Complications may include aortic dissection , joint dislocations , scoliosis , chronic pain , or early osteoarthritis . (wikipedia.org)
  • In general, people with this variant have skin that is soft, smooth, and velvety and bruises easily, and may have chronic muscle and/or bone pain. (wikipedia.org)
  • Spontaneous pain was assessed via the facial grimace scale. (nih.gov)
  • IBS features chronic abdominal pain and abnormal bowel habits presenting as IBS with diarrhea, constipation, or a combination of both ( Longstreth, 2005 ). (aspetjournals.org)
  • Severe, disabling abdominal pain is the hallmark of chronic pancreatitis. (pancreapedia.org)
  • Improved treatments depend on a better understanding of the mechanisms of chronic visceral pain, a subject that has gained attention recently with the development of suitable animal models and reproducible experimental measures of sustained pancreatic pain. (pancreapedia.org)
  • Traditional theories of the origin of pancreatic pain in chronic pancreatitis focused on structural abnormalities causing ductal hypertension (11). (pancreapedia.org)
  • Among the many clinical sequelae of chronic pancreatitis, pain has been shown to be the most important factor affecting quality of life (78). (pancreapedia.org)
  • In the largest study of pain in chronic pancreatitis, Mullady et al showed that those who exhibit more type B pain of a more constant nature, have lower quality of life measures (72). (pancreapedia.org)
  • The mainstay therapy for chronic pancreatitis is the symptomatic treatment of pain. (pancreapedia.org)
  • Since we have a limited understanding of the pathogenesis of chronic pancreatic pain, treatment is limited to a supportive care regimen targeting symptoms rather than etiologies of the pain (40). (pancreapedia.org)
  • Examples of this include the addition of the gabapentoid pregabalin, as well as the antioxidant methionine, both of which have been shown to improve pain in chronic pancreatitis (75, 90). (pancreapedia.org)
  • Many people with Marfan syndrome suffer from chronic muscle and joint pain. (medlineplus.gov)
  • Tryptophan did not change the reflex in either acute or chronic spinal rats but it produced a facilitative trend in acute spinal rats. (erowid.org)
  • Granulomatous anterior uveitis, either acute or chronic, is the most common ocular manifestation of sarcoidosis. (aao.org)
  • However, little is known as to how PICs alter synaptic transmission and neuronal activity in the spinal cord. (jneurosci.org)
  • In order to enhance understanding of TRPA1 contributions to mechanotransmission, we examined the effects a selective TRPA1 receptor antagonist, A-967079, on spinal neuronal activity following peripheral mechanical stimulation in uninjured, CFA-inflamed, and osteoarthritc (OA) rats. (biomedcentral.com)
  • Blood flows from the anterior spinal artery into medullary branches of the intradural vertebral arteries, and subsequently into segmental radiculomedullary arteries. (medscape.com)
  • The blood flow to the posterior spinal arteries originates from intradural vertebral arteries, which are from medullary segments of the posterior inferior cerebellar arteries and segmental radiculopial arteries. (medscape.com)
  • Trauma may cause a fracture, but in women over age 50 without significant trauma or someone known to have osteoporosis, a spontaneous vertebral compression fracture is possible. (wikipedia.org)
  • Temporal elevations in glucocorticoid levels enhance the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
  • Behavioral exaggeration was associated with peripheral and spinal changes including increased microglia activation after DI versus SI. (bvsalud.org)
  • In conclusion, a single intramuscular dose of C4 produced no acute or chronic systemic toxicity or inflammation in rats, suggesting that C4 may be toxicologically safe for clinical use in cancer brachytherapy. (hindawi.com)
  • The effects of noradrenergic, tryptaminergic and serotonergic agonists and-an antagonist on the flexor reflex of acute and chronic spinal rats were studied. (erowid.org)
  • 277 Female Wistar rats (180-200g) had the T4-T6 spinal cord segment removed by suction under ether anesthesia. (erowid.org)
  • Acute ex - periments were carried out after 40-48 hr later in 130 rats (180-200g) and chronic experiments were carried out 2 mth after transection in the remainder (250-280g). (erowid.org)
  • However, i.v. 3.0 mg/kg tryptamine in acute spinal rats produced tonic extension of the hip and knee on which was superimposed knee flexion produced by the stimulus. (erowid.org)
  • In chronic spinal rats i.p, 2 mg/kg amphetamine, 0.875 mg/kg methoxamina, 2.5 Mg/kg LSD, 6 mg/kg tryptamine and 3.75 mg/kg 5-HTP facilitated the reflex and also produced spontaneous movements. (erowid.org)
  • Cyproheptadine did not change refex amplitude itself but completely antagonized the facilitative effect of LSD and tryptamine in chronic rats, while failing to affect the result of 5-HTP administration. (erowid.org)
  • Blockade of TRPA1 receptors disrupts transmission of high-intensity mechanical stimulation to the spinal cord in both uninjured and injured rats indicating that TRPA1 receptors have an important role in noxious mechanosensation in both normal and pathological conditions. (biomedcentral.com)
  • Western blot analysis showed that compared with that of naïve group, phosphorylated NR1 (pNR1) and pNR2B in TNBS rats were significantly increased in the spinal cord (pNR1: 3.87±0.31 folds of naïve control, pNR2B: 4.17 ± 0.24 folds of naïve control). (biomedcentral.com)
  • Chronic exposure to stretch-shortening contractions results in skeletal muscle adaptation in young rats and maladaption in old rats. (cdc.gov)
  • Anterior and posterior median spinal veins drain the anterior and posterior regions of the spinal cord, respectively. (medscape.com)
  • Johns Hopkins Interventional Neuroradiology team aims to offer the best minimally invasive treatment and diagnostic imaging for adults and children with a wide range of conditions involving the brain, the head and neck region, and the spine and spinal cord. (hopkinsmedicine.org)
  • We also specialize in diagnostic cerebral and head and neck angiography and spinal angiography. (hopkinsmedicine.org)
  • Autopsy studies demonstrate the hemorrhagic necrosis of the spinal cord that is caused by trauma. (medscape.com)
  • Primary spontaneous pneumothorax (PSP) is the presence of air in the pleural space, occurring in the absence of trauma and known lung disease. (bvsalud.org)
  • Preconception Periodontitis and Risk of Spontaneous Abortion Is there a link between periodontitis and risk of spontaneous abortion? (medscape.com)
  • 2020 ) Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys. (neurotree.org)
  • Altogether our results show that the repetition of peripheral lesions facilitate not only exaggerated nociceptive behaviors but also induced anxiodepressive disorders supported by spinal central changes that can be blocked by targeting peripheral FLT3. (bvsalud.org)
  • The condition is chronic and progressive, leading to muscle fibrosis and atrophy as well as potential joint contractures, limb and spinal deformities, mobility difficulties, and exercise intolerance. (wisdompanel.com)
  • For perfusion, three longitudinal vessels form an anastomotic network that supplies the spinal cord: two posterior spinal arteries, and the anterior spinal artery. (medscape.com)
  • The posterior spinal arteries give rise to the "vasocorona," which eventually branches into peripheral arteries and mainly supplies the white matter of the spinal cord. (medscape.com)
  • Lhermitte's sign (an electric-shock sensation elicited by neck flexion that runs down the spine and sometimes into the limbs) suggests involvement of the posterior columns of the cervical spinal cord. (emcrit.org)
  • Ischemia results from mass effect and disruption of blood flow, which may cause infarction of the spinal cord. (medscape.com)
  • Spinal Cord Infarction Spinal cord infarction usually results from ischemia originating in an extravertebral artery. (msdmanuals.com)
  • Chronic degenerative joint disease is often present. (medscape.com)
  • The cross-sectional blood supply of the spinal cord can be divided into (1) central and (2) peripheral systems, which supply the grey and white matter, respectively (with some degree of overlap). (medscape.com)
  • Histopathological examination of the cyst revealed thick fibrous connective tissue interspersed with areas of chronic inflammation. (bvsalud.org)
  • High-resolution melting (HRM) analysis as a feasible method for detecting spinal muscular atrophy via dried blood spots. (cdc.gov)
  • Spinal and circulating IL-1β levels are significantly elevated in tumor-bearing mice. (nih.gov)
  • SGK-1 protein levels in spinal astrocytes are increased in response to glucocorticoid stimuli and enhanced ATP release by opening the pannexin-1 hemichannels. (nature.com)
  • Although some respiratory disorders, such as sleep apnea, occur only during sleep, virtually all respiratory disorders-including upper airway obstruction, central hypoventilation, and chronic lung disease-are worse during sleep than wakefulness. (atsjournals.org)
  • Our neuro-interventional radiologists use high-precision diagnostic techniques to identify the location and degree of spinal fractures, and they are some of the first in the nation to perform the spinal implant procedure. (hopkinsmedicine.org)
  • Incidence, Recurrence of Deep Spine Surgical Site Infections How often do deep surgical site infections occur after spinal surgery, and what are the risk factors for recurrence? (medscape.com)
  • Investigation of genetic risk factors for chronic adult diseases for association with preterm birth. (cdc.gov)
  • effect spinal manipulation might have on certain disease states. (researchgate.net)
  • This may be harder than it sounds, because spinal cord disease is uncommon and not generally high on our list of considerations. (emcrit.org)
  • Multiple sclerosis is a chronic (long-lasting), unpredictable disease. (ameripharmaspecialty.com)
  • FLOW, a Kidney Outcomes Trial of Semaglutide in T2D and CKD What have we learned from the FLOW trial about the effects of semaglutide among people with type 2 diabetes and chronic kidney disease? (medscape.com)
  • Weakness is the primary contributor to impairment in chronic stroke ( 1 ). (frontiersin.org)