ObesityDiabeticOverweight or obeseGlucoseProteinuriaInflammationMetabolic syndromeInsulin resistanceAdults2018MiceCardiovascular diseaseAerobic exerciseDiabetesDiseasesPeripheralAntioxidantIntakePharmacologicalMetabolismKidney diseaseRenalGeneticTreatmentEffectsExtractMildAsthmaHeartExercisePatientsSubjectsChildrenEffect
Obesity11
- In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
- Varying degrees of metabolic abnormalities mediated by chronic inflammation are implicated in the chronic glomerular injuries associated with obesity. (shengsci.com)
- Our primary interest is to investigate the role of insulin resistance as an underlying cause of chronic disease, including obesity, type 2 diabetes, non-alcoholic steatohepatitis, asthma, and chronic kidney failure. (pbrc.edu)
- Cooper L, Ryan CG, Ells LJ, Hamilton S, Atkinson G, Cooper K, Johnson MI, Kirwan JP, Martin D. Weight loss interventions for adults with overweight/obesity and chronic musculoskeletal pain: a mixed methods systematic review . (pbrc.edu)
- In addition to diabetes, another chronic disease is obesity. (jmedicalcasereports.org)
- One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
- were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
- Although the physiological actions of GALP are yet to be fully elucidated, it is possible, given the anti-obesity effect of GALP seen in relation to food intake and body weight loss in obese mice, that GALP could be applied clinically to combat obesity in humans. (walshmedicalmedia.com)
- In addition to discussing the physiological actions of GALP, this review also summarizes results from studies in which GALP was administered intranasally (i.n.) to obese mice, thereby providing insights into how GALP might be used clinically to treat obesity in humans. (walshmedicalmedia.com)
- Not all obese children develop obesity-hypoventilation syndrome (OHS). (medscape.com)
- Less than 10% of children who are obese have endogenous obesity. (medscape.com)
Diabetic3
- 6. Kanter M, Aksu F, Takir M, Kostek O, Kanter B, Oymagil A. Effects of low intensity exercise against apoptosis and oxidative stress in Streptozotocin-induced diabetic rat heart. (ac.ir)
- Aloe had an antioxidant effect in the liver and kidney of diabetic rats. (earthtokathy.com)
- The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Overweight or obese1
- The US Preventive Services Task Force (USPSTF) recommends offering or referring adults who are overweight or obese and have additional cardiovascular disease (CVD) risk factors to intensive behavioral counseling interventions to promote a healthful diet and physical activity for CVD prevention. (cdc.gov)
Glucose5
- Alpha-Linolenic Acid Supplementation Prevents Exercise-Induced Improvements in White Adipose Tissue Mitochondrial Bioenergetics and Whole-Body Glucose Homeostasis in Obese Zucker Rats. (uoguelph.ca)
- 2014). Loss of ovarian estrogens causes only mild deterioration of glucose homeostasis in female ZDF rats preventable by voluntary running exercise. (umontreal.ca)
- Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. (jci.org)
- Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
- In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
Proteinuria1
- Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats. (shengsci.com)
Inflammation4
- The interstitium also shows evidence of chronic inflammation with infiltration by macrophages and lymphocytes. (docksci.com)
- Effects of zinc status on age-related T cell dysfunction and chronic inflammation. (oregonstate.edu)
- Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated nuclear factor- κ B, nuclear factor- κ B, and SMAD signaling pathways, respectively. (aspetjournals.org)
- Like many chronic degenerative diseases, inflammation plays a significant role in cardiovascular disease pathogenesis. (whydontyoutrythis.com)
Metabolic syndrome3
- Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese Zucker rats. (rush.edu)
- The presence of sleep-disordered breathing is an additional risk factor for cardiovascular morbidity in obese individuals and has been independently linked to metabolic syndrome. (medscape.com)
- The results suggest that a combination of PPAR agonists and S-Amlodipine has partial benefits in improving the cardiovascular risk factors such as reduction in triglyceride levels, associated with chronic type 2 diabetes, and therefore may be utilized as an approach for addressing some of these devastating metabolic syndrome complications. (biomedcentral.com)
Insulin resistance1
- 1471 Abstract The effects of aerobic exercise training, chronic administration of the selective beta 2-adrenergic agonist clenbuterol, and the combination of these two treatments on muscle insulin resistance were compared in female obese (fa/fa) Zucker rats. (svoidom-nsk.ru)
Adults1
- The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. (medlineplus.gov)
20181
- 2018). Eun H.K. and colleagues found that intake of 1800 mg/day of ALA led to modest weight loss in obese subjects (Koh et al . (jmedicalcasereports.org)
Mice4
- Protective effect of sex on chronic stress- and depressive behavior-induced vascular dysfunction in BALB/cJ mice. (rush.edu)
- Isingrini E, Surget A, Belzung C, Freslon JL, Frisbee J, O'Donnell J, Camus V, d'Audiffret A. Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh. (rush.edu)
- Isingrini E, Belzung C, d'Audiffret A, Camus V. Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging. (rush.edu)
- In this study, we aimed to examine whether TBS can inhibit high-fat diet (HFD)-induced adipogenesis in the liver and epididymal adipose tissue of obese mice. (biomedcentral.com)
Cardiovascular disease1
- Some studies have seen that oxidative stress, caused by the presence of fress radicals, is related to the onset of cardiovascular disease, diabetes, tumors and other chronic diseases. (jmedicalcasereports.org)
Aerobic exercise1
- Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise. (ac.ir)
Diabetes2
- 2006). PPARg Agonism Prevents the Onset of Type 2 Diabetes in ZDF Rats : A Comparison to PPARaAgonism. (umontreal.ca)
- Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. (earthtokathy.com)
Diseases2
- In contrast, activation of the renal CB 2 receptors reduces the deleterious effects of these chronic diseases. (degruyter.com)
- In the present article, we aimed to critically review experimental evidence regarding the active components and the molecular bases underlying the beneficial role of coffee against chronic liver diseases. (mdpi.com)
Peripheral1
- The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence? (rush.edu)
Antioxidant1
- The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)
Intake2
- Furthermore, there was less body weight gain and food intake with S-Amlodipine and Pioglitazone combination in Zucker fa/fa rats. (biomedcentral.com)
- 1961 - Trinidad - 1/3rd of women over 25 were obese with an average Calorie intake below 2000/day. (physicality.info)
Pharmacological1
- We employ lifestyle, pharmacological, and surgical interventions to identify key regulatory pathways associated with disease progression, with the goal of identifying novel therapeutic targets capable of altering the treatment and management of chronic conditions. (pbrc.edu)
Metabolism1
- Sodium Nitrate Supplementation Alters Mitochondrial H 2 O 2 Emission but Does Not Improve Mitochondrial Oxidative Metabolism in the Heart of Healthy Rats. (uoguelph.ca)
Kidney disease2
- Chinese herbal medicine in the treatment of chronic kidney disease. (earthtokathy.com)
- Advances in chronic kidney disease , 12 (3), 276-281. (earthtokathy.com)
Renal2
- Chronic renal failure: pathophysiology. (docksci.com)
- Rat models of renal disease have been adopted to explore mechanisms responsible for progression and to test the efficacy of various therapeutic interventions. (docksci.com)
Genetic1
- 2011). Bradley C. and other authors have shown in Zucker rat models that ALA has protective effects against hypercholesterolemia and the accumulation of hepatic fat in conditions of overeating and in case of genetic predisposition. (jmedicalcasereports.org)
Treatment1
- In the present study, we evaluated the effects of chronic treatment with CXA-10 (10-nitro-9(E)-octadec-9-enoic acid) in the uninephrectomized deoxycorticosterone acetate-high-salt mouse model of CKD. (aspetjournals.org)
Effects2
- 2001. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. . (oregonstate.edu)
- 13. Hsieh S-F, Hu G-C, Chuang Y-C, Chen C-Y, Hu Y-N. The effects and safety of exercise training in subjects with chronic heart failure-do elder subjects gain similar benefits? (ac.ir)
Extract1
- The aim of this study was to evaluate the effect of 12 weeks aerobic training and oral green tea extract on cardiac caspase-3 expression in aged male rats. (ac.ir)
Mild1
- An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents. (rush.edu)
Asthma2
- People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier. (svoidom-nsk.ru)
- In some parts of the world, it is used to treat breathing difficulties caused by conditions such as asthma or chronic obstructive pulmonary disease (COPD). (svoidom-nsk.ru)
Heart2
Exercise3
- Alpha-Linolenic Acid Supplementation and Exercise Training Reveal Independent and Additive Responses on Hepatic Steatosis in Obese Rats. (uoguelph.ca)
- Methodology: In this study, 32 aged male rats were randomly divided into 4 groups: control, exercise, supplement and exercise + supplement. (ac.ir)
- 3. Ko I-G, Kim S-E, Kim C-J, Jee Y-S. Treadmill Exercise Alleviates Aging-induced Apoptosis in Rat Cardiac Myocytes. (ac.ir)
Patients1
- Progress in this field is underscored by Belviq (lorcaserin) and Qsymia (phentermine/topiramate), the first agents in more than 10 years to achieve regulatory approval for chronic weight management in obese patients. (eddoctor24h.com)
Subjects1
- Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Children2
- [ 10 ] Up to 20% of obese children have OHS. (medscape.com)
- Tidal volume is often decreased in obese children. (medscape.com)
Effect1
- 1999. Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)