Chronic myeloid leukemia clinical hematopoietic myeloid cells. Medical search. Frequent questions

Pfizer Oncology has a robust hematology pipeline, with biologics and small molecules in clinical development across a number of hematologic malignancies. (salesandmarketingnetwork.com)
Self-renewal and differentiation processes in hematopoietic stem cells need to be highly regulated in order to maintain homeostasis and to avoid the growing of blood cell malignancies. (wikipedia.org)
CLASSIFICATION OF HEMATOLOGIC MALIGNANCIES - The hematopoietic pluripotent stem cell is capable of both self-renewal and stepwise differentiation into either the lymphoid or myeloid lineage (which appears to be determined stochastically) [ 1 ]. (medilib.ir)
We have developed a genetically modified tumor cell vaccine for the treatment of myeloid malignancies. (acgtfoundation.org)
The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. (ox.ac.uk)
The major focus of our research programme is to identify and genetically model leukaemic and pre-leukaemic stem cells in myeloid malignancies. (ox.ac.uk)
1. Development of genetically engineered models of myeloid malignancies in order to study the impact of specific driver mutation(s) on the establishment, evolution and propagation of leukaemic stem cells. (ox.ac.uk)
3. Identification of somatic and germline genetic abnormalities associated with the development of myeloid malignancies. (ox.ac.uk)
Our particular focus is to refine risk stratification of patients using these molecular markers and also to gain a better understanding of how germline mutations might disrupt stem/progenitor cell populations to promote the development of myeloid malignancies. (ox.ac.uk)
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) constitute a heterogeneous group of clonal myeloid malignancies with clinical, laboratory, morphologic and genetic features that overlap with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). (encyclopedia.pub)
As previously mentioned, MDS/MPN represents a heterogeneous group of myeloid malignancies that share clinicopathological features with both MDS and MPN. (encyclopedia.pub)
Hematological and hematopoietic cells malignancies of the genes and hematopoietic cells are associated with the genetic mutation, often at the chromosomal level. (scielo.br)
Cancer stem cells in haematological malignancies. (scielo.br)
The functional diversity of cells that compose myeloid malignancies, i.e., the respective roles of genetic and epigenetic heterogeneity in this diversity, remains poorly understood. (philinbiomed.org)
Cohesin mutations in myeloid malignancies. (dana-farber.org)
Dr. Shahzad's clinical interests are in the surgical management of advanced gynecologic malignancies, including cytoreductive surgery for ovarian cancer, complex minimally invasive laparoscopic and robotic surgery for endometrial and cervical cancers as well as fertility sparing surgical techniques. (moffitt.org)
Our study demonstrated that persistent use of statins is associated with a lower overall cancer risk and particularly the risk of incident hematopoietic malignancies. (cdc.gov)

The team was instrumental in the discovery of the first approved apoptosis-targeted agent called venetoclax (Venclexta) for use in chronic lymphocytic leukemia and, more recently, for elderly patients with acute myeloid leukemia (AML). (lls.org)
PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here? (haematologica.org)
Amongst them we can distinguish chronic lymphocytic leukemia, in which there is an increase in leukocytes and lymphocytes in peripheral blood and lymphomas, which are diseases of the lymph nodes with different histologies, clinical behavior and course and requiring very different treatment modalities. (bloodcellbarcelona.com)
Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
9. Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature. (whocc.org.cn)
Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages. (cshlpress.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. (nature.com)
Chronic myeloid neoplasms are malignant clonal hematopoietic stem cell disorders driven by recurrent genetic events, with an inherent risk of transformation to acute myeloid leukemia (AML) 1 , 2 . (nature.com)
Within myeloid neoplasms, chronic myelomonocytic leukemia (CMML) represents an attractive disease model since it is characterized by both myelodysplastic and myeloproliferative features, while retaining a relatively simple clonal composition 3 . (nature.com)
CMML shares the typical repertoire of genetic driver lesions with other myeloid neoplasms and is particularly enriched in truncating mutations involving ASXL1 (prevalence ~40%) 3 . (nature.com)
INTRODUCTION - An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. (medilib.ir)
Myeloproliferative neoplasms (MPN), unlike MDS, usually exhibit terminal myeloid cell expansion in the peripheral blood [ 7 ]. (medilib.ir)
Our overarching aim is to improve the management of myeloproliferative neoplasms and related conditions through better monitoring and therapeutic targeting of malignant stem cell populations. (ox.ac.uk)
4. Characterisation of cell-extrinsic regulators of haematopoietic stem/progenitor cells, including bone marrow niche populations, and how they are disrupted during the development of myeloproliferative neoplasms and related conditions. (ox.ac.uk)
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are myeloid neoplasms characterized by the presentation of overlapping features from both myelodysplastic syndromes and myeloproliferative neoplasms. (encyclopedia.pub)
Although the classification of MDS/MPN relies largely on clinical features and peripheral blood and bone marrow morphology, studies have demonstrated that a large proportion of patients (~90%) with this disease harbor somatic mutations in a group of genes that are common across myeloid neoplasms. (encyclopedia.pub)
Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype. (cdc.gov)
The Prognostic Ability of RAS Pathway-Related Gene Mutations in Patients with Myeloid Neoplasms Treated with Hypomethylating Agents. (cdc.gov)

1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
Clonal studies in the chronic myeloid disorders - Genetic and enzyme studies based upon X-chromosome inactivation patterns have revealed a multipotent progenitor cell origin for the neoplastic clone in both MDS [ 8 ] and MPN [ 9 ]. (medilib.ir)
The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)
The myelodysplastic syndromes (MDS) are a group of clonal neoplastic hematologic disorders characterized by varying degrees of bone marrow failure, abnormal hematopoiesis, and proliferation of myeloid blast cells. (acgtfoundation.org)
Thought to be disorders of hematopoietic stem cells, clonal cytogenetic abnormalities are frequently identified. (acgtfoundation.org)
The disorder has some clinical and laboratory features that resemble those seen in the clonal multipotent stem cell disorders chronic myelogenous leukemia, polycythemia vera, and agnogenic myeloid metaplasia. (ashpublications.org)
These data indicate that the disorders in these three patients are clonal and involve multipotent stem cells. (ashpublications.org)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. (msdmanuals.com)
2. Granulocytic dysplasia: an indicator of clonal evolution in patients with chronic myeloid leukemia. (whocc.org.cn)
The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g. (cshlpress.com)

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors. (ox.ac.uk)
These mutations play a role in the clinical heterogeneity of these diseases and their clinical evolution. (encyclopedia.pub)
01 mol Animal studies did or x Females more common the treatment (like any prescription or even non Progesterone plays mutations that cause cancer Hormone the uncontrolled growth of cells, to treatment according to the side our partner Centers of Excellence, the Norman Parathyroid Center. (rl-hard.hu)
Hematological disorders are typically associated with hematopoietic stem cells mutations and chromosomal aberrations such as aneuploidy or euploidy ( Zagozdzon and Golab, 2015 ZAGOZDZON, R. and GOLAB, J., 2015. (scielo.br)
To generate induced pluripotent stem cell clones, we reprogrammed CD34 + cells collected from a patient with a chronic myelomonocytic leukemia in which whole exome sequencing of peripheral blood monocyte DNA had identified 12 gene mutations, including a mutation in KDM6A and two heterozygous mutations in TET2 in the founding clone and a secondary KRAS (G12D) mutation. (philinbiomed.org)
These analyses suggest that, beyond the coding mutations, several levels of intraclonal heterogeneity may participate in the yet unexplained clinical heterogeneity of the disease. (philinbiomed.org)
These mutations are found across the full spectrum of myeloid neoplasia, including pediatric Down Syndrome-associated acute megakaryoblastic leukemia (DS-AMKL), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), and de-novo and secondary acute myeloid leukemia (AML). (dana-farber.org)
in other words, the leukemic mutations may affect any stage of hematopoietic differentiation, and the type of leukemia can be characterized by the type of affected cell. (pocketdrugguide.com)
Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients. (cdc.gov)
Looking for somatic mutations in UBA1 in patients with chronic myelomonocytic leukemia associated with systemic inflammation and autoimmune diseases. (cdc.gov)
Mutations in chronic myelomonocytic leukemia and their prognostic relevance. (cdc.gov)
2423}. Whole-genome sequencing has ing has shown that more than half of all shown that more than half of all cases cases of MDS-MLD carry mutations in of MDS-MLD carry mutations in genes genes that are also mutated in MDS with that are also mutated in MDS with excess excess blasts and acute myeloid leukae- blasts and acute myeloid leukaemia. (who.int)

The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care. (mayo.edu)
The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)
This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. (mdanderson.org)
Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)
Allogeneic hematopoietic stem cell transplant (allo-HCT), especially if offered in first remission, may result in longer remissions. (lls.org)
The drug candidate is also under development for bone marrow conditioning before a hematopoietic stem cell transplant (HSCT), in relapsed/refractory elderly AML patients. (pharmaceutical-technology.com)

DJ34-mediated c-Myc depletion occurred in a wide range of tumor cell types, including lymphoma, lung, glioblastoma, breast cancer, and several forms of leukemia, with primary LSCs being particularly sensitive to DJ34. (uib.no)
The team is now testing multiple new approaches to boost apoptosis in other leukemias, as well as lymphoma and myeloma. (lls.org)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (lls.org)
3 , 4 Since 2020, older or unfit patients are treated by a non-intensive approach combining the hypomethylating agent azacitidine and the B-cell lymphoma 2 (BCL2) inhibitor venetoclax given orally until progression. (dovepress.com)
For personalized disease and treatment information, or to learn about clinical trials, contact one of The Leukemia & Lymphoma Society's (LLS's) Information Specialists at (800) 955-4572. (lls.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) was previously known as natural killer (NK) cell leukemia/lymphoma. (lls.org)
Most often, BPDCN presents with features of both lymphoma and leukemia. (lls.org)
Common misdiagnoses for BPCDN include non-Hodgkin lymphoma (NHL), acute myeloid leukemia (AML), leukemia cutis (a nonspecific term used for cutaneous [skin] manifestation of any type of leukemia), melanoma (a type of skin cancer), and lupus erythematosus (chronic inflammatory disease that occurs when your body's immune system attacks your own tissues and organs). (lls.org)
Treatment sometimes includes therapies that are used for AML, acute lymphoblastic leukemia (ALL), or lymphoma. (lls.org)
Leukemia & lymphoma 2021 9 63 (1): 250-252. (cdc.gov)
20. Long-term control of refractory follicular lymphoma after treatment of secondary acute promyelocytic leukemia with arsenic trioxide (As₂O₃) and all-trans retinoic acid (ATRA). (whocc.org.cn)
Leukemia and lymphoma are cancers that affect white blood cells. (cshlpress.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. (cshlpress.com)
MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma. (cshlpress.com)
In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. (cshlpress.com)
Each chapter provides in-depth analysis of a particular aspect of leukemia and/or lymphoma, contributing to a comprehensive review on current biological and clinical understandings of leukemia and lymphoma. (cshlpress.com)

Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
In this proposal, we seek to evaluate the integration of K562/GM-CSF vaccination with systemic therapies for MDS that alter host immunity and/or hematopoietic cellular differentiation. (acgtfoundation.org)
Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
Hematopoietic differentiation of these clones recapitulated the main features of the patient's disease, including overproduction of granulomonocytes and dysmegakaryopoiesis. (philinbiomed.org)
Leukemia occurs when a genetic mutation arises in a single cell that interferes with the normal maturation and differentiation of developing leukocytes. (pocketdrugguide.com)
maturation arrest in myeloid differentiation results in myeloid leukemias (e.g., chronic myelogenous leukemia, acute myelogenous leukemia). (pocketdrugguide.com)
In chronic myelogenous leukemia, maturation arrest in myeloid differentiation is caused by a genetic mutation that results in increasing numbers of circulating myeloid cells: neutrophils, basophils, and eosinophils, collectively known as granulocytes (which are themselves a type of leukocyte). (pocketdrugguide.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells (LSCs), the cancer-initiating cells that compete with normal hematopoietic stem cells for the bone marrow niche. (uib.no)

See "Clinical manifestations and diagnosis of polycythemia vera" . (medilib.ir)
MPNs include polycythemia vera, essential thrombocythemia, chronic myeloid leukemia (CML), primary myelofibrosis, chronic neutrophilic leukemia, and other less well defined entities such as chronic eosinophilic leukemia, not otherwise categorized. (medilib.ir)
These are diseases in which bone marrow hematopoietic stem cells produce more mature elements than normal: leukocytes (chronic myeloid leukemia), red blood cells or erythrocytes (polycythemia vera) and platelets (essential thrombocythemia). (bloodcellbarcelona.com)

BCR-ABL expression is also associated with activation of anti-apoptotic pathways (and hence resistance to apoptosis) and with downregulation of expression of cell adhesion proteins which leads to reduced adhesion to the bone marrow extracellular matrix and increased cell motility [6]. (healthcarecoremeasures.com)
The paradox of proliferative bone marrow together with peripheral blood cytopenias in MDS may be explained by increased intramedullary myeloid precursor cell apoptosis [ 6 ]. (medilib.ir)
This SCOR paves the way for therapies that harness the body's own cell death machinery, called apoptosis, the normal process that causes impaired cells to self-destruct. (lls.org)
The bcr-abl oncoprotein has uncontrolled tyrosine kinase activity, which deregulates cellular proliferation, decreases adherence of leukemia cells to the bone marrow stroma, and protects leukemic cells from normal programmed cell death (apoptosis). (msdmanuals.com)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
These changes produce "immortal" white blood cells, in which the mechanisms of programmed cell death (apoptosis) are inactivated. (pocketdrugguide.com)
[ 10 , 12 ] G-CSF suppresses apoptosis and prolongs the survival of neutrophils in vivo in a CD34 + cell population. (medscape.com)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
The image shows single cell RNA-sequencing analysis of haematopoietic stem/progenitor cells from a patient with a myeloproliferative neoplasm. (ox.ac.uk)
As understanding of the biology and origin of this malignancy has improved, the World Health Organization (WHO) established the term blastic plasmacytoid dendritic cell neoplasm (BPDCN) in 2008. (lls.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is very often misdiagnosed and under-reported. (lls.org)
This question is addressed in chronic myelomonocytic leukemia, a myeloid neoplasm in which clinical diversity contrasts with limited genetic heterogeneity. (philinbiomed.org)

A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
Therapy often involves several cycles of chemotherapy, targeted biological treatment, immunological, immunosuppressive and instrument treatment (TPE and depletion procedures performed in cooperation with the IHBT Apheresis Department ), as well as different forms of hematopoietic stem cell transplantation . (uhkt.cz)
Gene therapy is under development for the treatment of acute leukaemia such as relapsed and refractory acute myeloid leukemia (AML), acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) after allogeneic hematopoietic stem cell transplantation. (globaldata.com)
75 years old) followed by cytarabine consolidations and/or allogeneic stem-cell transplantation (ASCT). (dovepress.com)
The company's pipeline products include Iomab-B for hematopoietic stem cell transplantation, Iomab-ACT for the treatment of GeneTx and Cell therapy conditioning, Actimab-A(CD33) for the treatment of relapsed/refractory AML. (pharmaceutical-technology.com)
Myelosuppressive drugs (eg, hydroxyurea), stem cell transplantation, and interferon alfa are also sometimes used. (msdmanuals.com)
Impact of natural killer cells on outcomes after allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis. (moffitt.org)
A prognostic score including mutation profile and clinical features for patients with CMML undergoing stem cell transplantation. (cdc.gov)
11. Allogeneic hematopoietic stem cell transplantation in congenital hemoglobinopathies with myeloablative conditioning and rabbit anti-thymocyte globulin. (whocc.org.cn)
17. Busulfan plus melphalan versus high-dose melphalan as conditioning regimens in autologous stem cell transplantation for newly diagnosed multiple myeloma. (whocc.org.cn)
The patient was treated with corticosteroids for acute graft versus host disease following bone marrow transplantation for chronic myeloid leukemia. (medscape.com)

We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
According to the 2017 World Health Organization (WHO) classification, this category currently includes four adult subtypes: chronic myelomonocytic leukemia (CMML), BCR-ABL1 -negative atypical chronic myeloid leukemia (aCML), MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), MDS/MPN-unclassifiable (MDS/MPN-U), and one pediatric entity: juvenile myelomonocytic leukemia (JMML) [ 1 ] . (encyclopedia.pub)

A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL Rochester, Minn., Jacksonville, Fla. (mayo.edu)
EA9181, A Phase III Randomized Trial of Steroids+Tyrosine Kinase Inhibitor Induction With Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults Rochester, Minn. This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. (mayo.edu)
This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)
Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia. (mayo.edu)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Drugs used in chemotherapy, such as busulfan, fludarabine phosphate and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mdanderson.org)
ONUREG is a nucleoside metabolic inhibitor indicated for continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following intensive induction chemotherapy and are not able to complete intensive curative therapy ( 1 ). (nih.gov)

Within the hematopoietic system, MSI2 is highly expressed in the most primitive progenitors, in stem cell compartments, and its overexpression has been found in myeloid leukemia cell lines. (wikipedia.org)
These are the LSK cells, which are composed by long-term hematopoietic stem cells (LT-HSCs), short-term HSCs (ST-HCSs) and multipotent progenitors (MPPs). (wikipedia.org)
Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the various types of mature blood cells [ 2 ]. (medilib.ir)

Hematologic cancers are a complex group of diseases, with over 70 different types of lymphomas, leukemias or myelomas. (salesandmarketingnetwork.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

CML, one of the four main types of leukemia,1 accounts for 15 percent of all leukemias worldwide.2 Despite the availability of existing treatments, there remains a need for additional options for CML patients, given observed treatment related toxicities and resistance. (salesandmarketingnetwork.com)

These analyses also disclosed significant discrepancies in the behavior of hematopoietic cells derived from induced pluripotent stem cell clones with similar genetic background, correlating with limited epigenetic changes. (philinbiomed.org)
The contributors review the normal functions of hematopoietic stem cells-the precursors to white blood cells-and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. (cshlpress.com)
1976. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. (cdc.gov)

In the IHBT we deal with hematopoietic disorders in their whole variety. (uhkt.cz)
Thus, our care covers congenital or acquired non-tumor diseases (anemias, coagulation disorders, etc.), as well as tumor diseases such as leukemia or myelodysplastic syndrome. (uhkt.cz)
bone marrow or peripheral blood blasts of 20 percent or more) and the chronic myeloid disorders (bone marrow or peripheral blood blasts less than 20 percent). (medilib.ir)
The chronic myeloid disorders - The chronic myeloid disorders encompass several clinicopathologic entities. (medilib.ir)
Acute myeloid leukemia (AML) is a severe heterogeneous group of neoplastic disorders driven by several molecular alterations. (dovepress.com)
In this study, clinical characteristics were retrospectively reviewed and their correlation with outcome was evaluated to identify prognostic factors in patients with hematological disorders and IFS. (biomedcentral.com)

Essential thrombocythemia is characterized by proliferation of hematopoietic tissue predominantly involving megakaryocytes and resulting in marked thrombocytosis. (ashpublications.org)
However, without knowledge of the numbers and types of cells that are involved in essential thrombocythemia, this suggestion remains speculative. (ashpublications.org)

The encoded protein is translational regulator that targets genes involved in development and cell cycle regulation. (wikipedia.org)
The colour of each dot represents expression of myeloid (blue), erythroid (red) and platelet (green) lineage-associated genes. (ox.ac.uk)
FMS-like tyrosine kinase 3 ( FLT3 ) is one of the most frequently mutated genes in acute myeloid leukemia (AML). (dovepress.com)
Like splicing factors, genes encoding components of the cohesin complex are frequently mutated in cancer, including myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (AML), where they are associated with poor outcomes. (dana-farber.org)
To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating the basal and interferon (IFN)-inducible cell surface levels of PD-L1. (dana-farber.org)

Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)
In early phase clinical trials for both acute and chronic myeloid leukemias, we have observed the induction of anti-tumor immunity and associated clinical responses following K562/GM-CSF vaccination (see preliminary data). (acgtfoundation.org)
2. Conduct a clinical trial in MDS testing K562/GM-CSF vaccination integrated with the systemic agent(s) identified in aim 1 as being most active in combination with GM-CSF tumor vaccines (years 2 and 3). (acgtfoundation.org)
Melanoma, an immunogenic tumor, is the first indication where oncolytic viruses are now becoming part of clinical practice. (transcurebioservices.com)
ONCOS-102, a transgened adenovirus, has shown to act as a primer of relevant tumor targeting immune cells both in preclinical and clinical melanoma studies. (transcurebioservices.com)
Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator (CFTRm) that targets the underlying cause of CF. Based on safety and efficacy demonstrated in clinical trials, ELX/TEZ/IVA is approved in the US for the treatment of CF in people aged ≥ 2 years who have ≥ 1 F508del-CFTR mutation or a CFTR mutation that is responsive to ELX/TEZ/IVA based on in vitro data. (bvsalud.org)
While ELX/TEZ/IVA demonstrated unprecedented improvements in lung function and dramatic reductions in pulmonary exacerbations (PEx) and associated hospitalizations in clinical trials, a limited number of studies have examined the impact of ELX/TEZ/IVA on healthcare resource utilization (HCRU) and associated costs in a real-world setting. (bvsalud.org)
Disease progression with standard care was derived from published registry studies and the expected impact of ivacaftor on clinical characteristics was derived from clinical trials. (bvsalud.org)
The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
BC Cancer Research strives to improve the lives of patients through the integration of basic biomedical research, genomics, clinical trials, health services research, cancer surveillance, population health, and the development of innovative new technology, programs, and interventions. (bccrc.ca)
Patients should consider clinical trials as treatment options. (lls.org)
Currently, there are a few clinical trials for BPDCN. (lls.org)
Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)
A number of these kinase inhibitors have entered clinical trials, and two products-dasatinib (Sprycel®, Bristol-Myers Squibb) and nilotinib (Tasigna®, Novartis)-have recently been approved by health authorities in the US and Europe for use in patients with CML experiencing imatinib resistance or intolerance. (touchoncology.com)
Moffitt participates in over 350 clinical trials. (moffitt.org)

abstract = "Chronic myeloid leukemia (CML) is characterized by the presence of a BCR-ABL fusion gene, which is the result of a reciprocal translocation between chromosomes 9 and 22, and is cytogenetically visible as a shortened chromosome 22 (Philadelphia). (tau.ac.il)

Chronic myeloid leukemia (CML) is characterized by the uncontrolled proliferation of hematopoietic cells carrying the Philadelphia chromosome (Ph), the product of reciprocal translocation between chromosomes 9 and 22, t(9;22)(q34.1;q11.2). (touchoncology.com)

The positive opinion for bosutinib was based on data from Study 200, a global, single-arm, open-label, multi-cohort, Phase 1/2 study of bosutinib in more than 500 patients with Ph+ CML with separate cohorts for chronic, accelerated and blast phase disease previously treated with one or more prior TKIs. (aol.com)
However intervention during the chronic phase of the disease can prolong/prevent progression to the accelerated stage and the ultimate progression Dihydroartemisinin to the rapidly fatal blast crisis phase [11]. (healthcarecoremeasures.com)
Although the disease can evolve toward acute leukemia, morbidity and mortality most frequently result from a marrow failure syndrome. (acgtfoundation.org)
Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). (mdanderson.org)
We are also applying this approach to analyse patients receiving novel targeted therapies in order to better understand mechanisms of resistance to molecularly targeted therapy in stem cell populations and pathways of transformation to more aggressive forms of disease. (ox.ac.uk)
Chronic myeloid leukemia (CML) is a chronic disease resulting in myeloid cell expansion through expression of the BCR-ABL1 fusion transcript. (transcurebioservices.com)
Ammad Ud Din M, Saeed H, Shahzad M, Liaqat H, Sweet K. The impact of mild-to-moderate chronic kidney disease on hospitalization outcomes in patients with acute myeloid leukemia. (moffitt.org)
The word leukemia derives from the Latin word for white blood and refers to the proliferation of white blood cells (leukocytes) in people with this disease. (pocketdrugguide.com)
In the chronic phase of the disease, these cells are functionally mature and the initial clinical features of the disease are a result of high levels of these granulocytes. (pocketdrugguide.com)
Chronic myelogenous leukemia is primarily a disease of adulthood. (pocketdrugguide.com)
Invasive fungal sinusitis (IFS) is a rare disease largely attributable to Aspergillus and Mucor in patients with stem cell transplants and hematological disease [ 9 ]. (biomedcentral.com)
[ 1 ] Fungi may colonize body sites without producing disease or they may be a true pathogen, generating a broad variety of clinical syndromes. (medscape.com)
This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)

CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)

Response to treatment is certainly measured with regards to hematologic cytogenetic and molecular variables as described in Desk 2 [2 13 Desk 2 Procedures of response in chronic myeloid leukemia and prognostic significance [2 13 Imatinib was initially approved in america in 2001 for the treating the advanced stages of CML. (healthcarecoremeasures.com)
However, resistance to imatinib occurs in about 20 - 30% of patients with newly diagnosed CML in chronic phase [ 7 ]. (jcancer.org)
Its favorable pharmacokinetic and toxicity profile, paired with its excellent clinical results, rapidly made imatinib the standard frontline therapy for all chronic-phase CML patients. (touchoncology.com)
1,2 In the International Randomized Study of Interferon and STI571 (IRIS), imatinib was found to be superior to interferon-alpha as initial therapy for patients in the early chronic phase. (touchoncology.com)
4 Imatinib (400mg/day) is now considered by both the US National Comprehensive Cancer Network (NCCN) and the European LeukemiaNet to be the standard approach for the initial treatment of chronic-phase CML. (touchoncology.com)
5. Peripheral neuropathy associated with imatinib therapy for chronic myeloid leukemia. (whocc.org.cn)

Our results confirm several variations between Helps and non-AIDS individuals in clinical demonstration and outcomes linked to PCP, as explained by Kovacs et al. (bioinbrief.com)
Findings support the validity of modeling CF to predict long-term survival and estimate clinical and economic outcomes of CFTRm. (bvsalud.org)
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
Clinical characteristics and outcomes with their associated radiographic and microbiological findings were analyzed. (biomedcentral.com)
13. Clinical characteristics and outcomes of thrombotic microangiopathy in Malaysia. (whocc.org.cn)

The development of bosutinib is evidence of our commitment to bringing meaningful new medicines to patients with hematologic cancers,' said Mace Rothenberg, MD, senior vice president of Clinical Development and Medical Affairs, Pfizer Oncology Business Unit. (aol.com)
4 Bosutinib was first approved as BOSULIF ® in the United States (U.S.) in September 2012 for the treatment of adult patients with chronic, accelerated, or blast phase Ph+ CML with resistance, or intolerance to prior therapy. (aol.com)
NEW YORK--(Healthcare Sales & Marketing Network)-- Pfizer Inc. announced today that the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for standard review of bosutinib as a treatment option for adult patients with previously treated Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML). (salesandmarketingnetwork.com)
At the same time, we often include patients in suitable clinical studies, if they are available. (uhkt.cz)
Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. (medscimonit.com)
PURPOSE: This phase II trial is studying how well giving vorinostat together with gemtuzumab ozogamicin works in treating older patients with previously untreated acute myeloid leukemia. (stanfordhealthcare.org)
Table 1 MD Anderson and World Health Organization definitions of accelerated phase and blast crisis in chronic myeloid leukemia [7-9] The majority of patients diagnosed with CML initially present in the chronic phase. (healthcarecoremeasures.com)
This award will support research focused on improving adoptive cell therapies for patients with multiple myeloma and developing the next generation of promising myeloma therapies for patients. (lls.org)
Led by principal investigator Madhav Dhodapkar, MBBS, director of the Winship Center for Cancer Immunology, the SCOR team will seek to improve chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma patients. (lls.org)
1 , 7-9 In the 2017 European Leukemia network (ELN) classification, prognosis of FLT3 -ITD mutation on the survival of AML patients was dependent on the co-occurrence of the nucleophosmin 1 gene mutation ( NPM1 mut) and the FLT3 -ITD mutation burden. (dovepress.com)
Later, survival prolongation was achieved through recombinant interferon-alpha alone or in combination with cytarabine and, in some patients, allogeneic stem cell transplants. (touchoncology.com)
Forty-six patients with IFS and 64 patients with chronic non-invasive sinusitis were enrolled as comparsion. (biomedcentral.com)
Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
During the 2022 global monkeypox (mpox) outbreak, some patients have experienced severe clinical manifestations. (cdc.gov)
A CDC clinical team began providing consultations § to U.S. clinicians caring for patients with mpox, developing guidance and other online clinical resources for health care providers, and issuing health alerts ¶ when emerging clinical concerns (e.g., severe infections in patients with advanced HIV infection) were detected. (cdc.gov)

See "Clinical manifestations and diagnosis of primary myelofibrosis" . (medilib.ir)

Iodine i 131 apamistamab is under clinical development by Actinium Pharmaceuticals and currently in Phase II for Myelodysplastic Syndrome. (pharmaceutical-technology.com)
18. Del(5q) myelodysplastic syndrome combined with pure red cell aplasia. (whocc.org.cn)

CML accounts for 15 percent of all leukemia cases. (aol.com)

Table 1 lists laboratory features characteristic of chronic myelogenous leukemia. (pocketdrugguide.com)
In addition to increasing the number of circulating granulocytes, chronic myelogenous leukemia affects the maturation of bone marrow stem cells and causes an increase in blasts in the bloodstream and marrow. (pocketdrugguide.com)

A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (medlineplus.gov)

Leukemias are cancers of the hematopoietic (blood-producing) system. (pocketdrugguide.com)

in turn, each of these categories is classified as either acute or chronic, depending on the proportion of morphologically and immunophenotypically immature precursors (blasts) in the bone marrow or peripheral blood. (medilib.ir)
This is a group of diseases with varied clinical evolution and prognosis that are produced to abnormalitiers in the functioning of the hematopoietic stem cells that produce less mature elements in peripheral blood, with a defective function. (bloodcellbarcelona.com)

In a similar way to MSI1, MSI2 is also active in the proliferation of pluripotent neural precursors cells of the embryo, during which both MSI1 and MSI2 are strongly co-expressed. (wikipedia.org)
The hematopoietic cascade: development of mature blood cells from pluripotent stem cells. (pocketdrugguide.com)

Aberrant activation of multiple intracellular signaling pathways has been exhibited in response to the presence of BCR-ABL resulting in accelerated cell cycle progression and inhibition of DNA repair which lead to abnormal maturation and genomic instability of hematopoietic stem cells [5]. (healthcarecoremeasures.com)
shows the different lineages of blood cells and the stages involved in their maturation. (pocketdrugguide.com)

They are usually asymptomatic and diagnosis occurs following a routine blood test or one conducted for unrelated reasons that reveals an elevated white blood cell count. (healthcarecoremeasures.com)
See "Clinical manifestations and diagnosis of chronic myeloid leukemia" . (medilib.ir)
8. The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult. (whocc.org.cn)
The diagnosis of Sweet syndrome is based on fulfillment of both clinical and histopathologic criteria. (medscape.com)

Our overarching aim is to better characterise the cellular and molecular biology of these key populations of cells in order to understand how malignant stem cell populations might be more effectively targeted and eradicated. (ox.ac.uk)
We have developed new methods to study the molecular signatures of normal and malignant stem cell populations at the single-cell level. (ox.ac.uk)
This is crucial in order to unravel the intratumoural heterogeneity within any phenotypically defined malignant stem cell population. (ox.ac.uk)
Загальні відомості про лейкоз Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)

The objective of this study is to assess the safety and tolerability, including the maximum tolerated dose, of ASP2215 in subjects with relapsed or treatment-refractory acute myeloid leukemia (AML). (mayo.edu)
A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE Antibody Blinatumomab in Adult Subjects With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia (Alcantara Study) Rochester, Minn. This study seeks adult subjects with R/R Ph+ B-precursor ALL. (mayo.edu)

The clinical oral findings described in the literature include periodontal changes, such as gingivitis and aggressive periodontitis, recurrent aphthous ulcers and traumatic lesions. (bvsalud.org)

Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)

10. The incidence of atypical patterns of BCR-ABL1 rearrangement and molecular-cytogenetic response to tyrosine kinase inhibitor therapy in newly diagnosed cases with chronic myeloid leukemia (CML). (whocc.org.cn)

Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)

Amongst the last ones, MSI2 is expressed in early stages of development, in the ventricular and subventricular zone, in cells of the astrocyte lineage. (wikipedia.org)

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2021 4 23 (9): 1731-1742. (cdc.gov)

Anatomy34

Organisms12

Diseases48

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes53

Disciplines and Occupations1

Information Science6

Named Groups1

Health Care12

Malignancies17

Lymphocytic leukemia7

Neoplasms12

Clonal11

Mutations12

Stem cell trans6

Lymphoma18

Differentiation15

Normal hematopoietic stem1

Polycythemia vera3

Apoptosis8

HSCT7

Neoplasm5

Transplantation11

CMML2

Chemotherapy8

Progenitors3

Lymphomas2

Percent of all leukemias1

Genetic3

Disorders6

Essential thrombocythemia2

Genes5

Tumor8

Trials11

Abstract1

Proliferation of hematopoietic1

Disease13

Progenitor cell1

Imatinib6

Outcomes5

Patients16

Primary myelofibrosis1

Myelodysplastic syndrome2

Accounts for 15 percent1

Myelogenous2

Transplant1

Cancers1

Peripheral blood2

Pluripotent2

Maturation2

Diagnosis4

Malignant5

Refractory2

Lesions1

Leukaemia1

Tyrosine kinase in1

Leukemic stem cells2

Lineage1

20211