MoleculesAmino acidsProteinsAntimicrobialProteinSequencesPhage-derivedImmunity2023PathwaysBiologyBiological2022InfectionSerologicSensingReceptorsRibonucleic acidLymphocytic leukemiaTherapeuticsMechanismsTherapyDiseasesAcuteInflammationTargetsStructuralInsights1998DAMPsDeoxyribonucleicMethodsHepatitisMicrobiomeDiagnosticsSpecificDepositionComplexSignalsPreventingMassesTissueReceptorMutationsResearchDiseaseHigh
Molecules6
- Microbiome-derived molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. (fnr.lu)
- Biologics are large complex molecules consisting of a combination of proteins, peptides, nucleic acids, sugars, or other cellular structures, produced within living cells The shifting focus toward biological drug products results in targeted treatments that have mechanisms of action previously unavailable from existing small molecule drugs. (bio-rad.com)
- Microbiome-derived molecules are implicated in many chronic diseases involving inflammation. (uni.lu)
- This method is used not only for the analysis and purification of very large molecules, such as proteins and nucleic acids, but also for easier pregnant molecules, including pregnant sugars, amino acids, peptides, nucleotides, and simple ions. (pasteurlab.ir)
- Polymorphism and peptide-binding specificities of porcine major histocompatibility complex (MHC) class I molecules. (tci-thaijo.org)
- It is well known that molecules with a higher relative molecular mass promote wound healing. (biotechnolabs.com)
Amino acids3
- Proteins are composed of covalent amino acids and have different sizes and electrical loads, so they can be isolated electrochemically. (pasteurlab.ir)
- All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
- Roles of neuroactive amino acids in ammonia neurotoxicity. (cdc.gov)
Proteins3
- The established cerebrolysin peptides were shown to be competitive inhibitors of the seven targeted proteins. (ima-press.net)
- A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
- Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. (mdpi.com)
Antimicrobial1
- The antimicrobial wasp Polybia-MP1 peptide selectively kills bacterial cells! (biosyn.com)
Protein3
- Facilities include those for protein-sequence analysis, peptide and oligonucleotide synthesis, access to the synchrotron at Lawrence Berkeley National Lab for X-ray crystallography, and NMR spectrometry. (berkeley.edu)
- Molecular diagnostics are used to asses an individual's health condition at the molecular level, analyzing specific genetic sequences in DNA, ribonucleic acid (RNA), or the material or protein that is encoded in these genetic sequences, says Jiang. (medicaldesignbriefs.com)
- Hyaluronic acid (HA) is a non-protein glycosaminoglycan (GAG) having unique physico-chemical properties, produced by chondrocytes, fibroblasts, and synoviocytes.HA is synthesised by hyaluronan synthase (HAS), of which vertebrates have three isozymes (HAS-1, HAS-2, and HAS-3). (biotechnolabs.com)
Sequences2
- A group of scientists at the Wyss Institute for Biologically Inspired Engineering at Harvard University and MIT are convinced that automated machine learning (autoML) is going to revolutionize biology by removing many of the technical barriers to using computational models to answer fundamental questions about sequences of nucleic acids, peptides, and glycans. (bio-itworld.com)
- Serology in the Digital Age: Using Long Synthetic Peptides Created from Nucleic Acid Sequences as Antigens in Microarrays. (cdc.gov)
Phage-derived1
- A research group led by Moghimi developed NanoLigand Carriers, induced self-assemblies of phage-derived display peptides that on intravenous injection rapidly target two receptors on the blood brain-barrier. (wikipedia.org)
Immunity1
- Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. (cancerindex.org)
20231
- The global nucleic acid therapeutics CDMO market was valued at $3.88 billion in 2022 and is expected to reach $14.19 billion by 2033, growing at a CAGR of 12.55% during the forecast period 2023-2033. (gii.tw)
Pathways4
- One critical mechanism in CLE is the chronic reactivation of innate and adaptive immune pathways. (frontiersin.org)
- The interactions between this "expobiome" and human immune pathways are specifically illustrated in the context of chronic diseases. (uni.lu)
- According to the studies, higher- and lower-MW HA interact with CD44 receptors to produce several biological effects through different molecular and cellular pathways. (biotechnolabs.com)
- DAMPs, damage-associated tissues and the molecular target structures and pathways. (cdc.gov)
Biology1
Biological2
- The peptide composition of cerebrolysin underwent a comprehensive mass spectrometric analysis, followed by a systemic biological assessment. (ima-press.net)
- Our increased understanding of the underlying biological processes that inform human health and the changes that happen during disease or chronic illness have helped spur the development of novel biological drugs targeted to provide treatment and relief for patients. (bio-rad.com)
20221
- Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis Experimental & Molecular Medicine 2022, 54: 639-652. (yalemedicine.org)
Infection2
Serologic2
- However, for anti-HCV, the majority of laboratories report a positive result based on a positive screening test result only, and do not verify these results with more specific serologic or nucleic acid testing unless ordered by the requesting physician. (cdc.gov)
- Serologic and molecular tests for HEV are designed primarily to detect HEV-A, and they might miss HEV-C infections. (cdc.gov)
Sensing1
- Sensing the change from molecular genetics to personalized medicine. (ima-press.net)
Receptors1
- An important step in this process is the recognition of endogenous nucleic acids released from dying cells by various pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and other cytosolic receptors. (frontiersin.org)
Ribonucleic acid3
Lymphocytic leukemia1
- BTK mutations in patients with chronic lymphocytic leukemia (CLL) receiving tirabrutinib. (le.ac.uk)
Therapeutics4
- RNA-based pharmaceutical therapeutics and vaccines are a new approach to treating chronic and rare diseases, including COVID-19. (biosyn.com)
- Global Nucleic Acid Therapeutics CDMO Market to Reach $14.19 Billion by 2033. (gii.tw)
- The key factors driving the growth of the global nucleic acid therapeutics CDMO market include the growing demand for nucleic acid therapeutics applications to treat chronic and genetic diseases, manufacturing advancement for producing nucleic acid by CDMO (a contract development and manufacturing organization), increasing FDA (Food and Drug Administration) approvals of nucleic acid therapeutics, and increasing investment for the expansion of CDMO manufacturing units. (gii.tw)
- According to BIS Research , the nucleic acid therapeutics CDMO market refers to the products and services provided by CDMO companies for the manufacturing of nucleic acid therapeutics. (gii.tw)
Mechanisms3
- Not only the molecular differences leading to the different clinical presentations need to be better understood, but also the pathogenic mechanisms of CLE in general: the precise role of involved cell types, the impact of different cytokines described in the disease, and their interaction and regulation in a complex network need further exploration. (frontiersin.org)
- Both of these peptide families have important local actions in maintaining tissue homeostasis and repair after injury, and when mechanisms governing their regulation are disrupted they may contribute to disease progression. (embl.de)
- So far, there is a lack in understanding the underlying molecular mechanisms and involved cell types. (mdpi.com)
Therapy4
- He is associate editor of Molecular Therapy and Drug Delivery, and serves on the editorial boards of journals such as Advanced Drug Delivery Reviews, Journal of Controlled Release, and Nanomedicine-UK. (wikipedia.org)
- In the long term, this could help to select a targeted therapy taking the individual molecular profile of a patient into account. (frontiersin.org)
- The presence of biofilms in DFO may explain why non-surgical treatment of DFO, relying on systemic antibiotic therapy, may not resolve some chronic infections caused by biofilm-producing strains. (diabetesfeetaustralia.org)
- A therapy with the noble gas radon can be used in the treatment of painful, chronic inflammatory diseases as patients report long-lasting analgesic effects. (mdpi.com)
Diseases4
- Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. (fnr.lu)
- This gap in knowledge is limiting mechanistic understanding of the microbiome's functional impact on chronic diseases such as Parkinson's disease and rheumatoid arthritis. (fnr.lu)
- Background: Alterations to the gut microbiome have been linked to multiple chronic diseases. (uni.lu)
- Biomedical diagnostics and biosensors are becoming more important due to the aging and growing global population as well as the increasing concerns brought on by chronic lifestyle diseases," says Jiang. (medicaldesignbriefs.com)
Acute2
- CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
- Comparison of Acute and Chronic Toxicity Laboratory Bioassay Endpoints with Benthic Community Responses in Field-Exposed Contaminated Sediments. (yale.edu)
Inflammation2
- This, in turn, establishes chronic inflammation and tissue pathology in mice with important ramifications for DNA repair-deficient, progeroid syndromes and aging. (nature.com)
- Using mice with an engineered ERCC1-XPF defect in tissue-infiltrating macrophages, we provide evidence for a fundamental mechanism by which irreparable DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in NER progeroid syndromes and likely also during aging. (nature.com)
Targets2
- The prognosis of lung carcinoma has changed since the discovery of molecular targets and their specific drugs. (bio-itworld.com)
- Large biologic drugs, in contrast, are designed to bind with extreme precision to specific targets and in doing so can target molecular processes that small molecule drugs cannot. (bio-rad.com)
Structural2
- Structural mechanism of molecular motors. (berkeley.edu)
- The Horvath Lab applies structural methods and biochemistry to make discoveries in two broad areas: (1) DNA Repair and (2) Chronic Neuropathic Pain. (utah.edu)
Insights2
- By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system. (fnr.lu)
- These animal models have provided us with important new insights into the molecular pathophysiology of CML and answered directly many questions regarding this disease. (eurekaselect.com)
19981
- Moghimi was the senior lecturer of Biopharmacy and Molecular Pharmaceutics at the School of Pharmacy, University of Brighton from 1998 until 2008. (wikipedia.org)
DAMPs1
- BACKGROUND: Immunogenic cell death (ICD)is a kind of regulatory cell death, which causes a series of antigen-specific adaptive immune responses by generating and emitting some danger signals or damage-associated molecular patterns (DAMPs). (bvsalud.org)
Deoxyribonucleic2
Methods1
- There are three methods for making chronic myelogenous leukemia (CML) mouse models: xenotransplantation of primary Ph-positive CML cells into immunodeficient mice, BCR/ABL-expressing transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. (eurekaselect.com)
Hepatitis1
- HEV variants that have been reported to infect humans belong to Orthohepevirus A (HEV-A). Five genotypes within HEV-A (HEV-1-4 and -7) cause hepatitis in humans, and 3 genotypes (HEV-3, -4, and -7) can cause chronic hepatitis in immunocompromised patients after foodborne zoonotic transmission ( 2 , 6 , 9 , 10 ). (cdc.gov)
Microbiome3
- With his team, Wilmes has more recently studied microbiome-host molecular interactions. (fnr.lu)
- The ExpoBiome project aims at deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease. (fnr.lu)
- We employed a suite of molecular and microscopic approaches to investigate the microbiome, and phenotypic state of microorganisms involved in DFO. (diabetesfeetaustralia.org)
Diagnostics3
- A suite of assays published today in The Journal of Molecular Diagnostics tackles issues with genetic testing, making it more robust and affordable. (genomeweb.com)
- Lab-on-a-chip and molecular diagnostics are the emerging new technologies. (medicaldesignbriefs.com)
- Emerging molecular diagnostics will have a big impact on our healthcare system. (medicaldesignbriefs.com)
Specific7
- More precise knowledge of how CLE subtypes differ pathophysiologically may allow a tailored pharmacotherapy in the future, taking into account the specific molecular signature in relation to the morphologic subtype. (frontiersin.org)
- PAMP (pathogen associated molecular pattern) is the molecule that is specific and common to the pathogen. (freezingblue.com)
- in 2007, showed that mass spectrometry allows the measurement of the apparent gas-phase equilibrium dissociation constants (Kd) values for the specific molecular binding events. (biosyn.com)
- According to the National Centre for Biotechnology Information (NCBI), therapeutic nucleic acids (TNAs) are a subset of nucleic acids that are closely related compounds used to cure disease through the sequence-specific recognition of endogenous nucleic acids. (gii.tw)
- BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)
- We tested the hypothesis that individual trefoil peptides are uniquely localised with specific mucins in the UACL and normal gastrointestinal epithelia. (embl.de)
- Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)
Deposition1
- 1987. Ammonia emissions and their role in acid deposition. (cdc.gov)
Complex2
- Complex proteomic analysis of the 'light' peptide fraction of Cerebrolysin. (ima-press.net)
- Figure 3 shows molecular models of the cystal structure of eIF4E, in complex with the cap m7GpppA, and a 4EBP1 peptide. (biosyn.com)
Signals2
- Researchers at the Laureate Institute for Brain Research (Tulsa, Oklahoma) are repurposing a vibrating capsule that is FDA-cleared for treating chronic constipation to study how people sense the hidden signals originating in their gastrointestinal (GI) system. (bio-itworld.com)
- A biomarker is any type of molecular indicator that signals the presence of a disease or indicates whether a patient has a predisposition to getting that type of disease in the future. (medicaldesignbriefs.com)
Preventing1
- Recommendations for preventing trans- mission of infections among chronic hemodialysis patients. (cdc.gov)
Masses1
- Only HA particles with low relative molecular masses, with sizes ranging from 20 kDa to 450 kDa, have a significant role in growth. (biotechnolabs.com)
Tissue2
- It was found that the presence of HA with a reduced molecular weight caused less scar tissue. (biotechnolabs.com)
- Higher molecular mass HA has been shown to support tissue integrity by forming minute fragments that initiate linkages that nurse an inflammatory response throughout an injury. (biotechnolabs.com)
Receptor3
- X. Trefoil peptide and EGF receptor/ligand transgenic mice. (embl.de)
- This review highlights some of the major findings pertinent to the epidermal growth factor (EGF) receptor and its ligands, particularly the major gut ligand transforming growth factor-alpha, as well as the trefoil peptides. (embl.de)
- Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. (embl.de)
Mutations1
Research2
- Much of his research is related to the management and treatment of chronic conditions associated with population ageing including cancer, neurological disorders such as Parkinson's disease and Alzheimer's disease, cardiovascular disease, allergies and arthritis. (wikipedia.org)
- Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)
Disease4
- Carenostics is a healthcare AI startup founded with the mission of addressing the underdiagnosis, undertreatment, and health inequities of chronic disease using AI and ML on existing healthcare data. (bio-itworld.com)
- Atherosclerosis is defined as a chronic progressive disease of the arterial wall having a long asymptomatic phase. (bmrat.org)
- The ulcer associated cell lineage (UACL) occurs at sites of chronic ulceration in Crohn's disease, expresses all three trefoil peptides, and is implicated in mucosal restitution. (embl.de)
- 1 ). The disease causes chronic hepatic HCV genotype 4 prevails ( 12 ) and ( 13,14 ). (who.int)
High2
- With the ExpoBiome project, Wilmes and his team will for the first time integrate a combination of advanced high-resolution methodologies with HuMiX-based experiments to comprehensively identify the constituents of this molecular soup and their impact on the human immune system. (fnr.lu)
- However, there is currently no molecular risk prediction model that accurately identifies patients at high risk for EAC. (oncotarget.com)